KEGG ENZYME: 1.1.3.13

ENZYME: 1.1.3.13

Entry

EC 1.1.3.13                 Enzyme

Name

alcohol oxidase;
ethanol oxidase;
alcohol:oxygen oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

Sysname

alcohol:oxygen oxidoreductase (H2O2-forming)

Reaction(IUBMB)

a primary alcohol + O2 = an aldehyde + H2O2 [RN:R00637]

Reaction(KEGG)

R00637 > R00608

Substrate

primary alcohol [CPD:C00226];
O2 [CPD:C00007]

Product

aldehyde [CPD:C00071];
H2O2 [CPD:C00027]

Comment

The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism [4]. The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.

History

EC 1.1.3.13 created 1972

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K17066

alcohol oxidase

Genes

PPA:	PAS_chr4_0152 PAS_chr4_0821

OPA:	HPODL_03886

NCR:

NCU01853

NTE:	NEUTE1DRAFT54808(NEUTE1DRAFT_54808)

SMP:	SMAC_06860

PAN:	PODANSg3545 PODANSg873

PBEL:

QC761_121970(AOX1)

PPSD:

QC762_000340 QC762_121970(AOX1)

PPSP:

QC763_000340 QC763_121970(AOX1)

PPSA:

QC764_000340 QC764_121970(AOX1)

TTT:	THITE_2049403 THITE_2059741

MTM:	MYCTH_98458

MGR:	MGG_02127 MGG_09072

PPEI:

PpBr36_02177 PpBr36_10517

PGRI:

PgNI_02560 PgNI_05302

TMN:	UCRPA7_6115 UCRPA7_6633

FGR:	FGSG_03638 FGSG_07530

FPU:	FPSE_01898 FPSE_07499

FPOA:

FPOAC1_006031

FVN:	FVRRES_06632 FVRRES_12357

FVR:	FVEG_08817 FVEG_12768

FOX:	FOXG_09652 FOXG_15437 FOXG_17301

NHE:	NECHADRAFT_101489 NECHADRAFT_92276 NECHADRAFT_94976 NECHADRAFT_96512 NECHADRAFT_98136

FFC:	NCS54_00459000 NCS54_00932400 NCS54_01113300 NCS54_01502300

FKR:	NCS57_00463700 NCS57_00951900 NCS57_01103700 NCS57_01191300

FMU:	J7337_003221(AOX1_2) J7337_012509

TRE:	TRIREDRAFT_123978 TRIREDRAFT_80659

TRR:	M419DRAFT_114133 M419DRAFT_115868

MAW:

MAC_01220

MAJ:

MAA_09229

PCHM:

VFPPC_14802

CMT:

CCM_09512

AMUS:

LMH87_002913 LMH87_011435

PLJ:	VFPFJ_07642 VFPFJ_10346

PTKZ:

JDV02_003482

VAL:	VDBG_05015 VDBG_07713 VDBG_09553

VDA:	VDAG_04784 VDAG_09583

CFJ:	CFIO01_02658 CFIO01_03820 CFIO01_05227

CLUP:

CLUP02_07150 CLUP02_09558 CLUP02_18297

CHIG:

CH63R_13356 CH63R_13520

SAPO:

SAPIO_CDS2494 SAPIO_CDS4124 SAPIO_CDS9833

ELA:	UCREL1_1366 UCREL1_2684 UCREL1_2837 UCREL1_2912 UCREL1_5121 UCREL1_5231 UCREL1_6194

PFY:	PFICI_00437 PFICI_03822 PFICI_03888 PFICI_04164 PFICI_13413 PFICI_13749

SSL:	SS1G_00840 SS1G_01984

BFU:	BCIN_03g00640 BCIN_07g03040

MBE:	MBM_01886 MBM_07247

PSCO:

LY89DRAFT_332428 LY89DRAFT_608108

GLZ:	GLAREA_02973 GLAREA_06765 GLAREA_10773 GLAREA_12622

ANI:	ANIA_00567

AOR:	AO090001000447 AO090003000309

ANG:	An15g02200 An18g05480

AFV:	AFLA_001379 AFLA_012560

ALUC:

AKAW2_31084S(AOX1_1) AKAW2_60482A

ACHE:

ACHE_11121S(AOX1_3)

APUU:

APUU_11514A(AOX1_2) APUU_30796S

PCS:	N7525_001575

TMF:	EYB26_006397

TRG:	TRUGW13939_02544 TRUGW13939_03395 TRUGW13939_05386

PBL:	PAAG_01979 PAAG_12459(PAAG_07884)

PBN:	PADG_00649

AJE:	HCAG_00023

BGH:	BDBG_06282

PNO:	SNOG_03029 SNOG_12980 SNOG_13701

PTE:	PTT_02545 PTT_15531

BZE:	COCCADRAFT_85893 COCCADRAFT_90144

BSC:	COCSADRAFT_188647 COCSADRAFT_88742

BOR:	COCMIDRAFT_33906 COCMIDRAFT_9949

AALT:

CC77DRAFT_928434 CC77DRAFT_947839

ARAB:

EKO05_0000220 EKO05_0000681

ZTR:	MYCGRDRAFT_67933 MYCGRDRAFT_72883

PFJ:	MYCFIDRAFT_126524 MYCFIDRAFT_166262

FFU:	CLAFUR5_01283 CLAFUR5_06983 CLAFUR5_10605

CBET:

CB0940_02226 CB0940_10218 CB0940_10783

BCOM:

BAUCODRAFT_122385

NPA:	UCRNP2_7026

TML:	GSTUM_00004141001

PPL:	POSPLDRAFT_91693

TVS:	TRAVEDRAFT_144610 TRAVEDRAFT_167157 TRAVEDRAFT_170473 TRAVEDRAFT_43286

DSQ:	DICSQDRAFT_149587 DICSQDRAFT_157363 DICSQDRAFT_173648 DICSQDRAFT_181599

PCO:	PHACADRAFT_121157 PHACADRAFT_126707 PHACADRAFT_213078 PHACADRAFT_252324

SHS:	STEHIDRAFT_120848 STEHIDRAFT_138413 STEHIDRAFT_138938 STEHIDRAFT_155230 STEHIDRAFT_162979 STEHIDRAFT_60502 STEHIDRAFT_68504

HIR:	HETIRDRAFT_102327(gor6) HETIRDRAFT_181240(gor3) HETIRDRAFT_48370(gor15)

PSQ:	PUNSTDRAFT_112855 PUNSTDRAFT_142948 PUNSTDRAFT_143572 PUNSTDRAFT_64842

ADL:	AURDEDRAFT_112303 AURDEDRAFT_115327 AURDEDRAFT_138513 AURDEDRAFT_170540 AURDEDRAFT_182614 AURDEDRAFT_68428

FME:	FOMMEDRAFT_142298 FOMMEDRAFT_169827 FOMMEDRAFT_169831

GTR:	GLOTRDRAFT_106260 GLOTRDRAFT_139980

RSX:	RhiXN_02362 RhiXN_07502 RhiXN_11061 RhiXN_11125

LBC:	LACBIDRAFT_252832 LACBIDRAFT_318049

CCI:	CC1G_07862 CC1G_07964

ABP:	AGABI1DRAFT114404(AGABI1DRAFT_114404) AGABI1DRAFT114408(AGABI1DRAFT_114408) AGABI1DRAFT116682(AGABI1DRAFT_116682) AGABI1DRAFT85725(AGABI1DRAFT_85725) AGABI1DRAFT85732(AGABI1DRAFT_85732)

ABV:	AGABI2DRAFT191438(AGABI2DRAFT_191438) AGABI2DRAFT191444(AGABI2DRAFT_191444) AGABI2DRAFT191450(AGABI2DRAFT_191450) AGABI2DRAFT195553(AGABI2DRAFT_195553)

PCUB:

JR316_0005765 JR316_0005766 JR316_0012151

MRR:	Moror_10379 Moror_10380 Moror_11464 Moror_11910 Moror_12916 Moror_9184

E1B28_003002 E1B28_005490 E1B28_011071

SCM:	SCHCO_02607677(SCHCODRAFT_02607677) SCHCO_02643025(SCHCODRAFT_02643025) SCHCO_02643062(SCHCODRAFT_02643062)

CPUT:

CONPUDRAFT_110608 CONPUDRAFT_127178 CONPUDRAFT_130356 CONPUDRAFT_52372 CONPUDRAFT_67656

SLA:	SERLADRAFT_361508 SERLADRAFT_471949 SERLADRAFT_491423 SERLADRAFT_491425 SERLADRAFT_491427

MLR:	MELLADRAFT_93496

» show all

Reference

1 [PMID:5636370]

Authors

Janssen FW, Ruelius HW.

Title

Alcohol oxidase, a flavoprotein from several Basidiomycetes species. Crystallization by fractional precipitation with polyethylene glycol.

Journal

Biochim Biophys Acta 151:330-42 (1968)
DOI:10.1016/0005-2744(68)90100-9

Reference

Authors

Nishida, A., Ishihara, T. and Hiroi, T.

Title

Studies on enzymes related to lignan biodegradation.

Journal

Baiomasu Henkan Keikaku Kenkyu Hokoku 38-59 (1987)

Reference

3 [PMID:9142745]

Authors

Suye S.

Title

Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003.

Journal

Curr Microbiol 34:374-7 (1997)
DOI:10.1007/s002849900198

Reference

4 [PMID:26680532]

Authors

Yin DT, Urresti S, Lafond M, Johnston EM, Derikvand F, Ciano L, Berrin JG, Henrissat B, Walton PH, Davies GJ, Brumer H

Title

Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.

Journal

Nat Commun 6:10197 (2015)
DOI:10.1038/ncomms10197

Other DBs

ExplorEnz - The Enzyme Database:

1.1.3.13

IUBMB Enzyme Nomenclature:

1.1.3.13

ExPASy - ENZYME nomenclature database:

1.1.3.13

BRENDA, the Enzyme Database:

1.1.3.13

CAS:

9073-63-6

DBGET integrated database retrieval system