KEGG   ENZYME: 1.1.3.39
Entry
EC 1.1.3.39                 Enzyme                                 
Name
nucleoside oxidase (H2O2-forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
nucleoside:oxygen 5'-oxidoreductase (H2O2-forming)
Reaction(IUBMB)
adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2 (overall reaction) [RN:R05695];
(1a) adenosine + O2 = 5'-dehydroadenosine + H2O2 [RN:R05696];
(1b) 5'-dehydroadenosine + O2 + H2O = 9-riburonosyladenine + H2O2 [RN:R05697]
Reaction(KEGG)
R05695 R05696 R05697
Substrate
adenosine [CPD:C00212];
O2 [CPD:C00007];
H2O [CPD:C00001];
5'-dehydroadenosine [CPD:C11500]
Product
9-riburonosyladenine [CPD:C11501];
H2O2 [CPD:C00027];
5'-dehydroadenosine [CPD:C11500]
Comment
A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water.
History
EC 1.1.3.39 created 2001
Reference
1  [PMID:16535726]
  Authors
Koga S, Ogawa J, Cheng L, Choi Y, Yamada H, Shimizu S.
  Title
Nucleoside Oxidase, a Hydrogen Peroxide-Forming Oxidase, from Flavobacterium meningosepticum.
  Journal
Appl Environ Microbiol 63:4282-4286 (1997)
DOI:10.1128/AEM.63.11.4282-4286.1997
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.39
IUBMB Enzyme Nomenclature: 1.1.3.39
ExPASy - ENZYME nomenclature database: 1.1.3.39
BRENDA, the Enzyme Database: 1.1.3.39

  All links  
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (6)   
   KEGG REACTION (3)   
   KEGG RCLASS (3)   
All databases (12)   

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