KEGG ENZYME: 1.1.99.28

ENZYME: 1.1.99.28

Entry

EC 1.1.99.28                Enzyme

Name

glucose-fructose oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors

Sysname

D-glucose:D-fructose oxidoreductase

Reaction(IUBMB)

D-glucose + D-fructose = D-gluconolactone + D-glucitol [RN:R00874]

Reaction(KEGG)

R00874

Substrate

D-glucose [CPD:C00031];
D-fructose [CPD:C00095]

Product

D-gluconolactone [CPD:C00198];
D-glucitol [CPD:C00794]

Comment

D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. The ketose substrate must be in the open-chain form. The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. The enzyme from Zymomonas mobilis contains tightly bound NADP+.

History

EC 1.1.99.28 created 1999

Orthology

K00118

glucose-fructose oxidoreductase

Genes

XCC:	XCC0815(gfo)

XCB:

XC_3415

XCA:	xcc-b100_3538(gfo)

XCP:

XCR_0995

XCV:	XCV0923(gfo)

XAX:	XACM_0869(gfo)

XAC:	XAC0888(gfo)

XCI:	XCAW_03692(gfo)

XCT:	J151_01015

XCJ:	J158_01012

XCU:	J159_01012

XCN:	J169_01011

XCW:	J162_01011

XCR:	J163_01011

XCM:	J164_01011

XCF:	J172_01006

XFU:	XFF4834R_chr08940

XAO:	XAC29_04520

XOM:	XOO3515(XOO3515)

XOO:	XOO3722(gfo)

XOP:

PXO_04621

XOY:	AZ54_05280

XOR:

XOC_0940

XOZ:	BE73_19695

XAL:

XALC_2749

XSA:	SB85_08640

XTN:	FD63_03505

XFR:	BER92_04815

XVE:	BJD12_17355

XPE:	BJD13_12355

XHR:	XJ27_10955

XGA:	BI317_05265

XPH:	XppCFBP6546_07070(XppCFBP6546P_07070)

XVA:	C7V42_04805

XAN:	AC801_04490

XAR:	XB05_21290

XHY:	FZ025_04985

XCZ:	EBN15_03405

XEU:	XSP_000874

XHD:	LMG31886_34530(gfo)

XPR:	MUG10_05635

XAG:	HEP73_03472

XDY:	NYR95_05125

XAS:	HEP74_03282

PSU:	Psesu_0603

PSUW:

WQ53_11880

PMEX:

H4W19_17515

PDD:	MNQ95_10395

LUM:	CNR27_08945

TCN:	H9L16_08825

AMC:	MADE_1016150

AMH:	I633_16820

AMAA:

amad1_16280

AMAL:

I607_15425

AMAE:

I876_15725

AMAO:

I634_15670

AMAD:

I636_15595

AMAI:

I635_16235

AMAG:

I533_15250

AMAC:

MASE_15230

AMB:	AMBAS45_15740

AMG:	AMEC673_15610

AMK:	AMBLS11_15060

ALT:	ambt_01340

ASP:

AOR13_243

ASQ:	AVL57_17255

AAW:	AVL56_16140

ALR:	DS731_19815

ALE:	AV939_16195

ALZ:	AV940_15950

APEL:

CA267_007875

SALM:

D0Y50_17860

SALK:

FBQ74_01450

SALH:

HMF8227_00200

CJA:	CJA_2424(gfo)

CEB:	B0D95_03725

CELL:

CBR65_01910

CEK:	D0B88_12150

CEG:	D0C16_01970

TTU:	TERTU_4571

MARQ:

MARGE09_P0252

GIL:	NHM04_16710

MKE:	OOT55_14135

URU:	DSM104443_00507(gfo_1)

UPL:	DSM104440_01440(gfo)

CCR:

CC_1225

ZMO:

ZMO0689

ZMN:

Za10_0578

ZMM:

Zmob_0591

ZMB:

ZZ6_0591

ZMI:

ZCP4_0604

ZMC:	A265_00597(gfo)

ZMR:	A254_00597(gfo)

ZMP:	Zymop_0543

SINA:

KNJ79_13705

SDH:	H9L15_07475

SMOR:

LHA26_01770

SQO:	NMP03_03215

SRAD:

LLW23_09185

RCV:	PFY06_05125

PARZ:

DTQ13_08765

PSTI:

SOO65_14240

KRH:	KRH_21840(gfo)

AMAZ:

LUW76_15440

NPU:	Npun_R3642

OTE:

Oter_0724

OBG:	Verru16b_01649(gfo_4)

SLOM:

PXH66_02805 PXH66_20100

PPHT:

GA004_00370

LUO:	HHL09_12855

VEG:	SAMN05444156_1690

LCRE:

Pla8534_00460(iolG_1) Pla8534_25270(iolG_10)

GPN:	Pan110_50000

MRI:	Mal4_32450(iolG_11)

SDYN:

Mal52_39150

PLON:

Pla110_07500

ACAF:

CA12_19090(gfo_4)

CCOP:

Mal65_52430(gfo_5)

GMS:	SOIL9_11520

TIM:	GMBLW1_29200

ULI:	ETAA1_28570(iolG_6)

GRW:	FTO74_13740

EDA:	GWR55_06740

ADIN:

H7849_07885

PFER:

IRI77_17140

AOK:	A3BBH6_15940

ACOU:

A5CBH24_06470

MCOS:

GM418_15645

CHIT:

FW415_14685

NKO:	Niako_4178

NYN:	U0035_01095

PSEG:

D3H65_15755

PGO:	FSB84_13035

FLC:	KJS93_11465

HHY:	Halhy_3652

MUP:	A0256_21570

MUC:

MuYL_3756

MUH:	HYN43_014230

MGIN:

FRZ54_12810

MROB:

HH214_04245

MJJ:	PQO05_01175

CMR:	Cycma_2931

CAMU:

CA2015_2893

EVI:	Echvi_2803

EST:	DN752_20355

ECHI:

FKX85_13290

EMAI:

KZP23_21005

SLI:

Slin_2554

SRD:	SD10_08825

SMON:

AWR27_10070

SPIR:

CWM47_20150

SPIK:

EXU85_13865 EXU85_33895

SPIB:

G8759_29440 G8759_35500

STAE:

HNV11_15655 HNV11_21090

SRHO:

HH216_15675

SOQ:	LQ777_18675 LQ777_22365

SFOL:

H3H32_14170 H3H32_29430

SENF:

GJR95_08115 GJR95_15945 GJR95_27115

RHOZ:

GXP67_05405 GXP67_15140

DFE:

Dfer_1598

DSN:	HWI92_04575 HWI92_10050

DYC:	NFI80_02285

DFQ:	NFI81_08315

DCN:	MUK70_09970

DPF:	ON006_05810 ON006_05930 ON006_12345

RSI:	Runsl_5400

RUN:	DR864_26820

RUP:	DTQ70_07810

EOL:	Emtol_3209

EMZ:	MB380_16455 MB380_21425

FAE:	FAES_1039 FAES_2065

FIB:	A6C57_13445 A6C57_13885

ALS:	DJ013_16440

MAQA:

LAG90_12020

HYG:	AUC43_05455

HYJ:	FHG12_14835

HMT:	MTP16_10230

HTB:	MTX78_16060

HSK:	H4317_06595

HSB:	MWH26_11995

HAEI:

MUN82_03295

HCU:	MUN79_24965

HVL:	MUN86_15890

HCF:	MUN80_22790

PKO:	PKOR_19915

PACT:

CA264_05440

ADD:	HUW48_24185

ASWU:

HUW51_08180

CLIT:

OQ292_15630

IRO:	RT717_06415 RT717_19345

FBT:	D770_08465

CHK:	D4L85_25800

FMM:	LVD15_19550

FLW:	LVD16_18850

PRHO:

PZB74_06965 PZB74_08135 PZB74_14785

TPEL:

P0M28_03830 P0M28_12785 P0M28_22295

RSR:	T7867_00410

GFO:	GFO_2195(gfo)

GFL:

GRFL_0260

GRS:	C7S20_18200

RBI:	RB2501_15414

MARB:

CJ263_04615

MLIO:

NYZ99_08745

ZGA:	ZOBELLIA_4647(gfoA)

ZLA:	Q5W13_18070

SALT:

AO058_15165

SMIS:

LDL76_11320

AALG:

AREALGSMS7_04166

AQB:	D1818_12605

AQA:	D1815_18440

AQD:	D1816_14140

EMAR:

D1013_12875 D1013_20125

MUR:	EQY75_06810

AFLA:

FHG64_16135

ANP:	FK178_07515

GAA:	HX109_00995

CAGG:

HYG79_17645

LPAL:

LDL79_07235

SINH:

LS482_21250

ASAG:

FGM00_06510

FLG:	LV716_17135

FLB:	LV704_18960

MRS:	Murru_3045

MLT:

VC82_2686

MUT:	GVT53_07130

MAQI:

LDL77_17840

SPON:

HME9304_03015

FBM:	MQE35_11965

SAHN:

JRG66_06545

LUY:	QZH61_09910

MANG:

RBH95_08345

RBAR:

AWN76_012750

SRU:	SRU_0850(gfo)

SRM:	SRM_01033(gfo)

DTH:	DICTH_0475

DTU:

Dtur_0639

NALL:

PP769_11650

NNEO:

PQG83_02480

» show all

Reference

1 [PMID:3745122]

Authors

Zachariou M, Scopes RK.

Title

Glucose-fructose oxidoreductase, a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production.

Journal

J Bacteriol 167:863-9 (1986)
DOI:10.1128/JB.167.3.863-869.1986

Reference

2 [PMID:3356190]

Authors

Hardman MJ, Scopes RK.

Title

The kinetics of glucose-fructose oxidoreductase from Zymomonas mobilis.

Journal

Eur J Biochem 173:203-9 (1988)
DOI:10.1111/j.1432-1033.1988.tb13985.x

Reference

3 [PMID:1537789]

Authors

Kanagasundaram V, Scopes RK

Title

Cloning, sequence analysis, and expression of the structural gene encoding glucose-fructose oxidoreductase from Zymomonas mobilis.

Journal

J Bacteriol 174:1439-47 (1992)
DOI:10.1128/JB.174.5.1439-1447.1992

Sequence

[ag:AAA27690]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.99.28

IUBMB Enzyme Nomenclature:

1.1.99.28

ExPASy - ENZYME nomenclature database:

1.1.99.28

BRENDA, the Enzyme Database:

1.1.99.28

CAS:	94949-35-6

DBGET integrated database retrieval system