KEGG ENZYME: 1.1.99.6

ENZYME: 1.1.99.6

Entry

EC 1.1.99.6                 Enzyme

Name

D-lactate dehydrogenase (acceptor);
D-2-hydroxy acid dehydrogenase;
D-2-hydroxy-acid dehydrogenase;
(R)-2-hydroxy-acid:acceptor 2-oxidoreductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors

Sysname

(R)-lactate:acceptor 2-oxidoreductase

Reaction(IUBMB)

(R)-lactate + acceptor = pyruvate + reduced acceptor [RN:R00297]

Reaction(KEGG)

R00297

Substrate

(R)-lactate [CPD:C00256];
acceptor [CPD:C00028]

Product

pyruvate [CPD:C00022];
reduced acceptor [CPD:C00030]

Comment

The zinc flavoprotein (FAD) from the archaeon Archaeoglobus fulgidus cannot utilize NAD+, cytochrome c, methylene blue or dimethylnaphthoquinone as acceptors. In vitro it is active with artificial electron acceptors such as 2,6-dichlorophenolindophenol, but the physiological acceptor is not yet known.

History

EC 1.1.99.6 created 1965, modified 2013

Pathway

ec00620

Pyruvate metabolism

ec01100

Metabolic pathways

Orthology

K21836

D-lactate dehydrogenase (acceptor)

Genes

AFU: