KEGG ENZYME: 1.10.3.11

ENZYME: 1.10.3.11

Entry

EC 1.10.3.11                Enzyme

Name

ubiquinol oxidase (non-electrogenic);
plant alternative oxidase;
cyanide-insensitive oxidase;
AOX (gene name);
ubiquinol oxidase;
ubiquinol:O2 oxidoreductase (non-electrogenic)

Class

Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor

Sysname

ubiquinol:oxygen oxidoreductase (non-electrogenic)

Reaction(IUBMB)

2 ubiquinol + O2 = 2 ubiquinone + 2 H2O [RN:R09504]

Reaction(KEGG)

R09504

Substrate

ubiquinol [CPD:C00390];
O2 [CPD:C00007]

Product

ubiquinone [CPD:C00399];
H2O [CPD:C00001]

Comment

The enzyme, described from the mitochondria of plants and some fungi and protists, is an alternative terminal oxidase that is not sensitive to cyanide inhibition and does not generate a proton motive force. Unlike the electrogenic terminal oxidases that contain hemes (cf. EC 1.10.3.10 and EC 1.10.3.14), this enzyme contains a dinuclear non-heme iron complex. The function of this oxidase is believed to be dissipating excess reducing power, minimizing oxidative stress, and optimizing photosynthesis in response to changing conditions.

History

EC 1.10.3.11 created 2011, modified 2014

Orthology

K17893

ubiquinol oxidase

Genes

ATH:	AT1G32350(AOX1D) AT3G22360(AOX1B) AT3G22370(AOX1A) AT3G27620(AOX1C) AT4G22260(IM) AT5G64210(AOX2)

ALY:	110229098 9298607 9305902 9313132 9319425 9319426 9329781

CRB:	111828553 17875368 17880621 17886519 17891810 17898298

CSAT:

104710604 104718090 104722813 104731285 104741834 104742221 104746686 104746687 104757604 104762574 104766131 104766133 104777266 104780006 104787386 104787393 104790417

EUS:	EUTSA_v10005697mg EUTSA_v10009342mg EUTSA_v10021013mg EUTSA_v10022022mg EUTSA_v10025624mg

BRP:	103834617 103837518 103859909 103859953 103869089(AOX) 103874740

BNA:	106352817 106356141 106364143 106366938 106376504 106380619 106388251 106433618 106437635 106439632 125575219 125608740

BOE:	106292816 106298984 106317810 106323943 106328733 106343297

RSZ:	108813292 108824261 108837952 108843694 108857628 108862190

THJ:	104809077 104812984 104814432 104819331 104822275

CPAP:

110808060 110816160 110821598

CIT:	102578048 102608494 102609832 102611121

CIC:	CICLE_v10001766mg CICLE_v10003687mg CICLE_v10015546mg CICLE_v10028835mg

PVY:	116110837 116116474 116125142 116125158 116136735 116137590

MINC:

123196095 123196741 123219161 123223971 123224335 123224353 123224405 123226951

TCC:	18597243 18606960 18608293

GRA:	105765740 105770523 105780363 105795072

GHI:	107887447 107888202 107905673 107905897 107908962 107908964 107939301 107939782 107949133 121215954

GAB:	108452931 108457892 108474728 108475249 108479304 108479661

HSYR:

120115883 120137073 120171490 120175403 120190470 120194770 120201429 120208811 120214942

DZI:	111278299 111289976 111295179 111309104

EGR:	104419907 104444218 104445658 120293631

GMX:	100807967 100813378(PTOX) 547897(AOX2) 547924(AOX1) 548077(AOX3)

GSJ:	114368022 114388597 114409415 114421401 114421402

PVU:	PHAVU_002G127100g PHAVU_002G209100g PHAVU_002G209200g PHAVU_006G144800g

VRA:	106772944 106773529 106774530 106777273

VAR:	108332191 108335287 108335802 108341996

VUN:	114170318 114176891 114179937 114186666

VUM:	124829695 124832981 124847427 124847428

CCAJ:

109804385 109805240 109805330 109815807

APRC:

113857796 113860171 113868554 113868828

MTR:	11410953 11415591 11416562 11446887 25493270

TPRA:

123881818 123898935 123907572 123917100

CAM:	101497212 101497767 101498303 101504014 101515463

PSAT:

127077257 127105882 127118564 127119866

VVO:	131595413 131603153 131617080 131620733 131631992 131634870 131651369 131651861

LJA:	Lj2g3v1549830.1(Lj2g3v1549830.1) Lj4g3v0341090.1(Lj4g3v0341090.1) Lj4g3v0341100.1(Lj4g3v0341100.1) Lj6g3v1787880.1(Lj6g3v1787880.1)

ADU:	107470798 107481775 107481779 107481780 107482958 107487093 107487094

AIP:	107631638 107631640 107631641 107638666 107642421 107642422

AHF:	112734427 112734429 112734430 112741264 112747545 112792238 112792241 112792242 112795962 112800152

LANG:

109331437 109332312 109333478 109345355

PCIN:

129284320 129284950 129304988 129322720 129322753

QSA:	O6P43_011972 O6P43_012336 O6P43_012337 O6P43_025052 O6P43_031298 O6P43_031610 O6P43_033430

FVE:	101301585 101302164 101307016 101307464

RCN:	112166681 112176449 112176452 112198377 112199960

PPER:

18777958 18781255 18788949 18789640 18790385

PMUM:

103323701 103323702 103323746 103324454 103336721

PAVI:

110750877 110750878 110750925 110764513 110766349

PDUL:

117616440 117624141 117624159 117626355 117629209 117629216

MDM:	103425743 103446886 103453652 114823167

MSYL:

126587241 126597182 126608316 126608534 126623963

PXB:	103935164 103937089 103948237 103952209 103959414

ZJU:	107414637 107430972 125418374

MNT:	112094824 21384247 21400208

CSAV:

115695987 115707392 115716827

CSV:	101214461 101214499 101214740

CMO:	103498235 103498237 103503097

BHJ:	120069087 120082577 120084228

MCHA:

111011576 111012743

CMAX:

111483245 111490026 111493985

CMOS:

111430458 111447902 111457254

CPEP:

111787957 111789745 111809803

RCU:	8262674 8277959

JCU:	105643957 105649278

HBR:	110639915 110654493 110656266

MESC:

110602811 110616869 110617452

POP:	18097290 7453837 7465478 7485412 7489823 7493180

PEU:	105108148 105109009 105109010 105111775 105128176 105141481

PALZ:

118028717 118033311 118033320 118049387 118057278 118058409 118061269

JRE:	108981915 108990883 109010628

CILL:

122277162 122289422 122310642

CAVE:

132170701 132178986 132191442 132191443 132191444 132192274

QSU:	111991777 111995784 111997416 112023453

QLO:	115968829 115969363 115970928 115978713 115992542

TWL:	119982354 119984151 119989740 119995277 120003747 120005191 120013746

VVI:	100233056(AOX2) 100247765 100252878 100258527

VRI:	117922931 117924230 117926987 117927928 117928708

SLY:	101247941 543670(PTOX) 543824(AOX1a) 543825 543892

SPEN:

107005063 107008128 107027961 107028189 107028932

SOT:	102581100 102588786(AOX) 102589114 102602662 102605095

SSTN:

125841616 125841617 125842092 125844149 125875743

SDUL:

129885794 129889572 129889573 129896254

CANN:

107840039 107842015 107851304 107853552 107863340 107870439 107873755

LBB:	132598788 132612360 132613780 132635442 132635443

NTA:	107763286 107763364(AOX) 107773225 107781761(AOX2) 107797824 107817403 107827194

NSY:	104217661 104220541 104228212 104249990

NTO:	104110383 104117580 104118264

NAU:	109209469 109221577 109225642 109240453

INI:	109149409 109165689 109167304 109177352

ITR:	116002503 116021846 116028562 116032641

SIND:

105159718 105172604 105172762 105175310

OEU:	111377163 111378439 111378723 111398599 111402416

EGT:	105956127 105963611 105967057 105969125

SSPL:

121742085 121742223 121743132 121744920 121753594 121757055 121761100 121775021 121777743 121796037

SMIL:

130985825 130987104 131003296 131018305

SHIS:

125188954 125202789 125213700 125220711 125223759

APAN:

127246662 127249555 127260760 127265772

HAN:	110899230 110899231 110918686 110930044 110930058 110939593

ECAD:

122596563 122599744 122599871

LSV:	111890961 111897513 111899535 111907784

CCAV:

112516930 112521089 112529242 112529243

DCR:	108197195 108202203 108209989 108224450

CSIN:

114264165 114293671 114294098 114307940 114323836

RVL:	131306652 131306653 131308893 131315225 131327171 131333651

AEW:	130755088 130765014 130765109 130765415 130779188 130780588 130782606 130782830

BVG:	104893119 104900924 104904018

SOE:	110777271 110799189 110801356

CQI:	110687422 110692800 110718624 110732687 110740144

ATRI:

130799299 130799305 130799880 130800965 130823829

MOF:	131153086 131155422 131156320 131163809 131163812

NNU:	104596340(NnAOX1b) 104596341(NnAOX1a) 104606512 104609466 104612870 104612872 104612873

MING:

122058637 122063757 122070119 122070402 122072081 122076922 122083865 122084625

TSS:	122641836 122644639 122644640 122646656 122646658 122667313

PSOM:

113282328 113287001 113318505 113331790 113348533 113358643

OSA:	4329156 4330432 4336874 4336875 4337339

DOSA:

Os02t0318100-00(Os02g0318100) Os02t0700400-01(Os02g0700400) Os04t0600200-01(Os04g0600200) Os04t0600300-01(Os04g0600300) Os04t0668900-01(Os04g0668900)

OBR:	102702730 102704952 102707579 102708236 102708516

OGL:	127761726 127761759 127769352 127771366 127771831

BDI:	100830584 100832724 100833030 100836303 100841536

ATS:	109739648 109747192 109753365 109755905 109756954 109782933 109786050

TDC:	119317542 119323498 119351919 119356319 119356320 119356327 119356990 119361119 119361120 119361406 119365494 119365495 119365496 119366255

TAES:

100037522 123046561 123046562 123047283 123049909 123054419 123054420 123055085 123055920 123076103 123137885 123145188 123185979 123185982 123190292 123190937 542793 542794

TUA:	125507894 125514229 125529480 125529481 125539594 125539596 125551505

LPER:

127306545 127323386 127323387 127330436 127336346 127336351

LRD:	124669132 124670062 124670064 124671162 124671290 124672033 124672042 124672043 124673809 124675691 124676051 124676173 124692931

SBI:	110436369 8063921 8070294 8071109 8071110 8073874

ZMA:	100273671 100281353 100284413 542073 542074 542676

SITA:

101753990 101759278 101769278 101770088 101775175

SVS:	117834373 117849475 117863973 117865586 117865587

PVIR:

120639743 120641657 120641659 120642800 120656920 120682052 120682354 120682732 120682988 120698278

PHAI:

112878726 112898844 112899931 112900226 112901186

PDA:	103703812 103703813 103703814 103715864

EGU:	105033543 105033544 105037380 105042507 105042535 105050185

MUS:	103981188 103983858 103986636 103986650 104000117 104000125

ZOF:	121975985 121991496 121994487 122001772 122006056 122008801 122011817 122016654 122017191 122034841

DCT:	110092347 110104392 110108805 110113915

PEQ:	110020193 110021969 110026236 110034693

AOF:	109824753 109837011 109837014 109841082

MSIN:

131219601 131233542 131233551 131247935 131247936

NCOL:

116252962 116258074 116258695 116266464

ATR:	18424868 18442881 18443930

SMO:	SELMODRAFT_112145 SELMODRAFT_112767 SELMODRAFT_120335 SELMODRAFT_126113 SELMODRAFT_175925 SELMODRAFT_180978 SELMODRAFT_231845 SELMODRAFT_232012 SELMODRAFT_421378 SELMODRAFT_446465 SELMODRAFT_80767 SELMODRAFT_98486

PPP:	112276407 112276483 112278476 112281193

CRE:	CHLRE_03g172500v5 CHLRE_07g350750v5

VCN:	VOLCADRAFT_65634 VOLCADRAFT_79367 VOLCADRAFT_90709

MNG:	MNEG_10375 MNEG_7495

CSL:	COCSUDRAFT_46597

CVR:	CHLNCDRAFT_12129

APRO:

F751_1604

OLU:	OSTLU_10319 OSTLU_5300

OTA:	OT_ostta11g01500 OT_ostta16g00930

BPG:	Bathy13g01840 Bathy16g00610

MIS:	MICPUN_69994 MICPUN_92108

MPP:	MICPUCDRAFT_4815(JGI:MicpuC2_4815) MICPUCDRAFT_5889(JGI:MicpuC2_5889)

CME:	CYME_CMI072C CYME_CMI243C CYME_CMI244C

GSL:	Gasu_23240 Gasu_36260 Gasu_41150

CCP:	CHC_T00000162001 CHC_T00008172001 CHC_T00008174001

PNO:	SNOG_03031

BZE:	COCCADRAFT_1780

BSC:	COCSADRAFT_188646

BOR:	COCMIDRAFT_109630

CNE:

CNA01500

CNB:

CNBA1450

CNG:	CNAG_00162

CGI:	CGB_B1710C

CDEU:

CNBG_0396

TMS:	TREMEDRAFT_28860

TASA:

A1Q1_05778

CCAC:

CcaHIS019_0105610(AOX2)

PCO:	PHACADRAFT_131107

ADL:	AURDEDRAFT_143177

RSX:	RhiXN_09244

LBC:	LACBIDRAFT_309224

CCI:	CC1G_10695

ABP:	AGABI1DRAFT74427(AOX)

ABV:	AGABI2DRAFT152135(AOX)

PCUB:

JR316_0007075

E1B28_012516

SCM:	SCHCO_014899(SCHCODRAFT_014899)

WIC:	J056_002174

UMA:	UMAG_02774

PFP:	PFL1_03910

SGRA:

EX895_005429

DDI:	DDB_G0280819(aoxA)

DPP:	DICPUDRAFT_44721 DICPUDRAFT_74305

DFA:	DFA_05792(aoxA) DFA_05796

SMIN:

v1.2.019638.t1(symbB.v1.2.019638.t1)

FCY:	FRACYDRAFT_244179(PTOX3) FRACYDRAFT_246693(PTOX1) FRACYDRAFT_264103(AOX1) FRACYDRAFT_291556(PTOX2)

AAF:	AURANDRAFT_14460 AURANDRAFT_20495

EHX:	EMIHUDRAFT_447503

GTT:	GUITHDRAFT_150423

NGR:	NAEGRDRAFT_30919 NAEGRDRAFT_76066 NAEGRDRAFT_81108

LSX:	H8B22_13255

LARE:

HIV01_013390

RGL:	CS053_17560

VHA:	VIBHAR_00951

VCA:	M892_08150

VHR:	AL538_11865

VOW:	A9237_05865

VRO:	BSZ04_20965

VBR:	A6E01_01860

VSH:	BSZ05_14355

VAQ:	FIV01_04605

VGI:	MID13_00770

VSL:	LTQ54_07970

VLE:	ISX51_00775

VFI:	VF_0578(aox)

VFM:	VFMJ11_0592

VSA:	VSAL_I0677

PGB:	H744_1c1560 H744_2c0741

PPHA:

BVH74_02035

MBS:	MRBBS_2013

MPQ:	ABA45_09485

SPSR:

EGC80_11565 EGC80_12605

LSD:	EMK97_10470

PIN:

Ping_3395

MOQ:	HWV03_05885

MCEL:

LPW13_07810

LLO:

LLO_1385

LSH:	CAB17_15220

LIB:	E4T55_11910

LCJ:	NCTC11976_01783

LADL:

NCTC12735_01955

MEC:

Q7C_1740

MPIN:

LGT42_002995

TKM:

TK90_1660

TVR:

TVD_03900

HAG:	BB497_14100

HASO:

B2G49_09035

HALW:

B6N23_07225

MARS:

A8C75_14160

NIK:	F5I99_08200

NBA:	CUN60_02690

PDQ:	CL55_00008620

PANI:

DCO16_04880

LIMN:

HKT17_00410

POS:	DT070_19830

POO:	F7R28_10730

HYR:	BSY239_744

DZO:	SR858_18330

ACTB:

RHM62_09950

TBD:

Tbd_1930

MEH:

M301_2656

MBAC:

BN1209_0072

MBAT:

BN1208_0612

NIV:	JY500_16375

AZI:	AzCIB_4721

REN:	EF513_03300

CAQ:	IM40_08760

EAA:	I862_02525

CHEA:

PVE73_21205

PMOB:

HG718_02925

PECT:

BN1012_Phect531

PCAX:

AFIC_002540

CHEL:

AL346_21240

CDQ:	BOQ54_18020

CSE:

Cseg_3042

PZU:

PHZ_c3018

BVC:	CEP68_01850

BRF:	E4M01_12860

BMED:

GYM46_10775 GYM46_14205

BVY:	NCTC9239_01364

BVIT:

JIP62_00090

BFQ:	JX001_11460

BRES:

E4341_08015 E4341_12440

APAH:

KB221_10390

RDE:	RD1_3047(aox)

RLI:	RLO149_c013870

OAT:	OAN307_c36940

OAR:	OA238_c29430 OA238_c33080

OCT:	FTO60_08470

SUAM:

BOO69_10740

RMM:	ROSMUCSMR3_02764

ROK:	RAK1035_0381

TAW:	EI545_03000

NSM:	JO391_11460

AMYL:

QBD29_10160

RHOC:

QTA57_02440

MMR:	Mmar10_2564

HBC:	AEM38_09430

NAR:

Saro_1576

NOG:	GKE62_14070

SPHK:

SKP52_22405

SMAG:

AN936_02455 AN936_06265

SGI:	SGRAN_1792(aox)

SPHO:

C3E99_09810

SPHX:

E5675_00040

SWI:

Swit_5295

STAX:

MC45_00170

SSAN:

NX02_07005

SPAN:

AWL63_00105

SPLM:

BXU08_15395

SPHA:

D3Y57_00610

SRHI:

H9L12_10155

SSED:

H9L14_08010

SPAP:

H3Z74_05170

SPII:

G7077_06985

SBIN:

SBA_pBAR3_0250(aox)

SGLC:

M1K48_06825

SQO:	NMP03_04210

SCAB:

LZK98_05055

SRAD:

LLW23_07020

SHYD:

CJD35_18080 CJD35_21195

SCLO:

SCLO_1002190

BLAS:

BSY18_2403

BFW:	B5J99_14070

SPHS:

ETR14_07040

POQ:	KZX46_01100

PMEA:

KTC28_22290

TFV:	IDJ81_05180

ERY:	CP97_00195

QCI:	NCF85_06130

ELQ:	Ga0102493_11471

ERK:	CD351_13180

ERF:	FIU90_13040

RFL:	Rmf_14130(aox)

SHUM:

STHU_47470(aox)

SVC:	STVA_37240(aox)

AOZ:	HUE56_08125

FER:	FNB15_09180

PEL:	SAR11G3_00974

PEG:	E5R92_02000

APB:	SAR116_0177

SNEA:

NBZ79_13355

SAMY:

DB32_008210

NOW:	GBF35_10090

PBRO:

HOP40_01605

AQZ:	KSP35_19775

SYE:	Syncc9902_0439

SYH:	Syncc8109_1706

SYNW:

SynWH8103_01010

SYW:

SYNW0887

PMM:

PMM0336

PMB:	A9601_03651

PMG:	P9301_03641

PMH:	P9215_03641

PRC:

EW14_0384

CEP:	Cri9333_3623

AMR:	AM1_0483 AM1_1551 AM1_A0138

LEN:	LEP3755_59370

LET:	O77CONTIG1_04149

PSEU:

Pse7367_3413

THEU:

HPC62_18735

ONI:	Osc7112_0370 Osc7112_4313

GEI:	GEI7407_0144

NOP:	Nos7524_1144

NOE:	CLI64_13450

AVA:

Ava_1055

ACY:	Anacy_4546

ANN:	EH233_19950

NMV:	NITMOv2_4000

MOX:

DAMO_2910

» show all

Reference

1 [PMID:16657603]

Authors

Bendall DS, Bonner WD

Title

Cyanide-insensitive Respiration in Plant Mitochondria.

Journal

Plant Physiol 47:236-45 (1971)
DOI:10.1104/pp.47.2.236

Reference

2 [PMID:7698344]

Authors

Siedow JN, Umbach AL, Moore AL

Title

The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center.

Journal

FEBS Lett 362:10-4 (1995)
DOI:10.1016/0014-5793(95)00196-G

Sequence

[ath:AT3G22370] [gmx:547924]

Reference

3 [PMID:11106766]

Authors

Berthold DA, Andersson ME, Nordlund P

Title

New insight into the structure and function of the alternative oxidase.

Journal

Biochim Biophys Acta 1460:241-54 (2000)
DOI:10.1016/S0005-2728(00)00149-3

Reference

4 [PMID:20169184]

Authors

Williams BA, Elliot C, Burri L, Kido Y, Kita K, Moore AL, Keeling PJ

Title

A broad distribution of the alternative oxidase in microsporidian parasites.

Journal

PLoS Pathog 6:e1000761 (2010)
DOI:10.1371/journal.ppat.1000761

Sequence

[ag:ADE43749]

Reference

5 [PMID:22848123]

Authors

Gandin A, Duffes C, Day DA, Cousins AB

Title

The absence of alternative oxidase AOX1A results in altered response of photosynthetic carbon assimilation to increasing CO(2) in Arabidopsis thaliana.

Journal

Plant Cell Physiol 53:1627-37 (2012)
DOI:10.1093/pcp/pcs107

Other DBs

ExplorEnz - The Enzyme Database:

1.10.3.11

IUBMB Enzyme Nomenclature:

1.10.3.11

ExPASy - ENZYME nomenclature database:

1.10.3.11

BRENDA, the Enzyme Database:

1.10.3.11

DBGET integrated database retrieval system