Entry
Name
ubiquinol oxidase (non-electrogenic);
plant alternative oxidase;
cyanide-insensitive oxidase;
AOX (gene name);
ubiquinol oxidase;
ubiquinol:O2 oxidoreductase (non-electrogenic)
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
ubiquinol:oxygen oxidoreductase (non-electrogenic)
Reaction(IUBMB)
2 ubiquinol + O2 = 2 ubiquinone + 2 H2O [RN:
R09504 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, described from the mitochondria of plants and some fungi and protists, is an alternative terminal oxidase that is not sensitive to cyanide inhibition and does not generate a proton motive force. Unlike the electrogenic terminal oxidases that contain hemes (cf. EC
1.10.3.10 and EC
1.10.3.14 ), this enzyme contains a dinuclear non-heme iron complex. The function of this oxidase is believed to be dissipating excess reducing power, minimizing oxidative stress, and optimizing photosynthesis in response to changing conditions.
History
EC 1.10.3.11 created 2011, modified 2014
Orthology
Genes
ATH : AT1G32350(AOX1D) AT3G22360(AOX1B) AT3G22370(AOX1A) AT3G27620(AOX1C) AT4G22260(IM) AT5G64210(AOX2)
ALY : 110229098 9298607 9305902 9313132 9319425 9319426 9329781
CRB : 111828553 17875368 17880621 17886519 17891810 17898298
CSAT : 104710604 104718090 104722813 104731285 104741834 104742221 104746686 104746687 104757604 104762574 104766131 104766133 104777266 104780006 104787386 104787393 104790417
EUS : EUTSA_v10005697mg EUTSA_v10009342mg EUTSA_v10021013mg EUTSA_v10022022mg EUTSA_v10025624mg
BRP : 103834617 103837518 103859909 103859953 103869089(AOX) 103874740
BNA : 106352817 106356141 106364143 106366938 106376504 106380619 106388251 106433618 106437635 106439632 125575219 125608740
BOE : 106292816 106298984 106317810 106323943 106328733 106343297
RSZ : 108813292 108824261 108837952 108843694 108857628 108862190
THJ : 104809077 104812984 104814432 104819331 104822275
CPAP : 110808060 110816160 110821598
CIT : 102578048 102608494 102609832 102611121
CIC : CICLE_v10001766mg CICLE_v10003687mg CICLE_v10015546mg CICLE_v10028835mg
PVY : 116110837 116116474 116125142 116125158 116136735 116137590
MINC : 123196095 123196741 123219161 123223971 123224335 123224353 123224405 123226951
TCC : 18597243 18606960 18608293
GRA : 105765740 105770523 105780363 105795072
GHI : 107887447 107888202 107905673 107905897 107908962 107908964 107939301 107939782 107949133 121215954
GAB : 108452931 108457892 108474728 108475249 108479304 108479661
HSYR : 120115883 120137073 120171490 120175403 120190470 120194770 120201429 120208811 120214942
DZI : 111278299 111289976 111295179 111309104
EGR : 104419907 104444218 104445658 120293631
GMX : 100807967 100813378(PTOX) 547897(AOX2) 547924(AOX1) 548077(AOX3)
GSJ : 114368022 114388597 114409415 114421401 114421402
PVU : PHAVU_002G127100g PHAVU_002G209100g PHAVU_002G209200g PHAVU_006G144800g
VRA : 106772944 106773529 106774530 106777273
VAR : 108332191 108335287 108335802 108341996
VUN : 114170318 114176891 114179937 114186666
VUM : 124829695 124832981 124847427 124847428
CCAJ : 109804385 109805240 109805330 109815807
APRC : 113857796 113860171 113868554 113868828
MTR : 11410953 11415591 11416562 11446887 25493270
TPRA : 123881818 123898935 123907572 123917100
CAM : 101497212 101497767 101498303 101504014 101515463
PSAT : 127077257 127105882 127118564 127119866
VVO : 131595413 131603153 131617080 131620733 131631992 131634870 131651369 131651861
LJA : Lj2g3v1549830.1(Lj2g3v1549830.1) Lj4g3v0341090.1(Lj4g3v0341090.1) Lj4g3v0341100.1(Lj4g3v0341100.1) Lj6g3v1787880.1(Lj6g3v1787880.1)
ADU : 107470798 107481775 107481779 107481780 107482958 107487093 107487094
AIP : 107631638 107631640 107631641 107638666 107642421 107642422
AHF : 112734427 112734429 112734430 112741264 112747545 112792238 112792241 112792242 112795962 112800152
LANG : 109331437 109332312 109333478 109345355
PCIN : 129284320 129284950 129304988 129322720 129322753
QSA : O6P43_011972 O6P43_012336 O6P43_012337 O6P43_025052 O6P43_031298 O6P43_031610 O6P43_033430
FVE : 101301585 101302164 101307016 101307464
RCN : 112166681 112176449 112176452 112198377 112199960
PPER : 18777958 18781255 18788949 18789640 18790385
PMUM : 103323701 103323702 103323746 103324454 103336721
PAVI : 110750877 110750878 110750925 110764513 110766349
PDUL : 117616440 117624141 117624159 117626355 117629209 117629216
MDM : 103425743 103446886 103453652 114823167
MSYL : 126587241 126597182 126608316 126608534 126623963
PXB : 103935164 103937089 103948237 103952209 103959414
ZJU : 107414637 107430972 125418374
MNT : 112094824 21384247 21400208
CSAV : 115695987 115707392 115716827
CSV : 101214461 101214499 101214740
CMO : 103498235 103498237 103503097
BHJ : 120069087 120082577 120084228
MCHA : 111011576 111012743
CMAX : 111483245 111490026 111493985
CMOS : 111430458 111447902 111457254
CPEP : 111787957 111789745 111809803
HBR : 110639915 110654493 110656266
MESC : 110602811 110616869 110617452
POP : 18097290 7453837 7465478 7485412 7489823 7493180
PEU : 105108148 105109009 105109010 105111775 105128176 105141481
PALZ : 118028717 118033311 118033320 118049387 118057278 118058409 118061269
JRE : 108981915 108990883 109010628
CILL : 122277162 122289422 122310642
CAVE : 132170701 132178986 132191442 132191443 132191444 132192274
QSU : 111991777 111995784 111997416 112023453
QLO : 115968829 115969363 115970928 115978713 115992542
TWL : 119982354 119984151 119989740 119995277 120003747 120005191 120013746
VVI : 100233056(AOX2) 100247765 100252878 100258527
VRI : 117922931 117924230 117926987 117927928 117928708
SLY : 101247941 543670(PTOX) 543824(AOX1a) 543825 543892
SPEN : 107005063 107008128 107027961 107028189 107028932
SOT : 102581100 102588786(AOX) 102589114 102602662 102605095
SSTN : 125841616 125841617 125842092 125844149 125875743
SDUL : 129885794 129889572 129889573 129896254
CANN : 107840039 107842015 107851304 107853552 107863340 107870439 107873755
LBB : 132598788 132612360 132613780 132635442 132635443
NTA : 107763286 107763364(AOX) 107773225 107781761(AOX2) 107797824 107817403 107827194
NSY : 104217661 104220541 104228212 104249990
NTO : 104110383 104117580 104118264
NAU : 109209469 109221577 109225642 109240453
INI : 109149409 109165689 109167304 109177352
ITR : 116002503 116021846 116028562 116032641
SIND : 105159718 105172604 105172762 105175310
OEU : 111377163 111378439 111378723 111398599 111402416
EGT : 105956127 105963611 105967057 105969125
SSPL : 121742085 121742223 121743132 121744920 121753594 121757055 121761100 121775021 121777743 121796037
SMIL : 130985825 130987104 131003296 131018305
SHIS : 125188954 125202789 125213700 125220711 125223759
APAN : 127246662 127249555 127260760 127265772
HAN : 110899230 110899231 110918686 110930044 110930058 110939593
ECAD : 122596563 122599744 122599871
LSV : 111890961 111897513 111899535 111907784
CCAV : 112516930 112521089 112529242 112529243
DCR : 108197195 108202203 108209989 108224450
CSIN : 114264165 114293671 114294098 114307940 114323836
RVL : 131306652 131306653 131308893 131315225 131327171 131333651
AEW : 130755088 130765014 130765109 130765415 130779188 130780588 130782606 130782830
BVG : 104893119 104900924 104904018
SOE : 110777271 110799189 110801356
CQI : 110687422 110692800 110718624 110732687 110740144
ATRI : 130799299 130799305 130799880 130800965 130823829
MOF : 131153086 131155422 131156320 131163809 131163812
NNU : 104596340(NnAOX1b) 104596341(NnAOX1a) 104606512 104609466 104612870 104612872 104612873
MING : 122058637 122063757 122070119 122070402 122072081 122076922 122083865 122084625
TSS : 122641836 122644639 122644640 122646656 122646658 122667313
PSOM : 113282328 113287001 113318505 113331790 113348533 113358643
OSA : 4329156 4330432 4336874 4336875 4337339
DOSA : Os02t0318100-00(Os02g0318100) Os02t0700400-01(Os02g0700400) Os04t0600200-01(Os04g0600200) Os04t0600300-01(Os04g0600300) Os04t0668900-01(Os04g0668900)
OBR : 102702730 102704952 102707579 102708236 102708516
OGL : 127761726 127761759 127769352 127771366 127771831
BDI : 100830584 100832724 100833030 100836303 100841536
ATS : 109739648 109747192 109753365 109755905 109756954 109782933 109786050
TDC : 119317542 119323498 119351919 119356319 119356320 119356327 119356990 119361119 119361120 119361406 119365494 119365495 119365496 119366255
TAES : 100037522 123046561 123046562 123047283 123049909 123054419 123054420 123055085 123055920 123076103 123137885 123145188 123185979 123185982 123190292 123190937 542793 542794
TUA : 125507894 125514229 125529480 125529481 125539594 125539596 125551505
LPER : 127306545 127323386 127323387 127330436 127336346 127336351
LRD : 124669132 124670062 124670064 124671162 124671290 124672033 124672042 124672043 124673809 124675691 124676051 124676173 124692931
SBI : 110436369 8063921 8070294 8071109 8071110 8073874
ZMA : 100273671 100281353 100284413 542073 542074 542676
SITA : 101753990 101759278 101769278 101770088 101775175
SVS : 117834373 117849475 117863973 117865586 117865587
PVIR : 120639743 120641657 120641659 120642800 120656920 120682052 120682354 120682732 120682988 120698278
PHAI : 112878726 112898844 112899931 112900226 112901186
PDA : 103703812 103703813 103703814 103715864
EGU : 105033543 105033544 105037380 105042507 105042535 105050185
MUS : 103981188 103983858 103986636 103986650 104000117 104000125
ZOF : 121975985 121991496 121994487 122001772 122006056 122008801 122011817 122016654 122017191 122034841
DCT : 110092347 110104392 110108805 110113915
PEQ : 110020193 110021969 110026236 110034693
AOF : 109824753 109837011 109837014 109841082
MSIN : 131219601 131233542 131233551 131247935 131247936
NCOL : 116252962 116258074 116258695 116266464
ATR : 18424868 18442881 18443930
SMO : SELMODRAFT_112145 SELMODRAFT_112767 SELMODRAFT_120335 SELMODRAFT_126113 SELMODRAFT_175925 SELMODRAFT_180978 SELMODRAFT_231845 SELMODRAFT_232012 SELMODRAFT_421378 SELMODRAFT_446465 SELMODRAFT_80767 SELMODRAFT_98486
PPP : 112276407 112276483 112278476 112281193
CRE : CHLRE_03g172500v5 CHLRE_07g350750v5
VCN : VOLCADRAFT_65634 VOLCADRAFT_79367 VOLCADRAFT_90709
MNG : MNEG_10375 MNEG_7495
OLU : OSTLU_10319 OSTLU_5300
OTA : OT_ostta11g01500 OT_ostta16g00930
BPG : Bathy13g01840 Bathy16g00610
MIS : MICPUN_69994 MICPUN_92108
MPP : MICPUCDRAFT_4815(JGI:MicpuC2_4815) MICPUCDRAFT_5889(JGI:MicpuC2_5889)
CME : CYME_CMI072C CYME_CMI243C CYME_CMI244C
GSL : Gasu_23240 Gasu_36260 Gasu_41150
CCP : CHC_T00000162001 CHC_T00008172001 CHC_T00008174001
CCAC : CcaHIS019_0105610(AOX2)
ABP : AGABI1DRAFT74427(AOX)
ABV : AGABI2DRAFT152135(AOX)
SCM : SCHCO_014899(SCHCODRAFT_014899)
DPP : DICPUDRAFT_44721 DICPUDRAFT_74305
DFA : DFA_05792(aoxA) DFA_05796
SMIN : v1.2.019638.t1(symbB.v1.2.019638.t1)
FCY : FRACYDRAFT_244179(PTOX3) FRACYDRAFT_246693(PTOX1) FRACYDRAFT_264103(AOX1) FRACYDRAFT_291556(PTOX2)
AAF : AURANDRAFT_14460 AURANDRAFT_20495
NGR : NAEGRDRAFT_30919 NAEGRDRAFT_76066 NAEGRDRAFT_81108
PGB : H744_1c1560 H744_2c0741
SPSR : EGC80_11565 EGC80_12605
BMED : GYM46_10775 GYM46_14205
BRES : E4341_08015 E4341_12440
OAR : OA238_c29430 OA238_c33080
SMAG : AN936_02455 AN936_06265
SBIN : SBA_pBAR3_0250(aox)
SHYD : CJD35_18080 CJD35_21195
AMR : AM1_0483 AM1_1551 AM1_A0138
ONI : Osc7112_0370 Osc7112_4313
» show all
Taxonomy
Reference
Authors
Bendall DS, Bonner WD
Title
Cyanide-insensitive Respiration in Plant Mitochondria.
Journal
Reference
Authors
Siedow JN, Umbach AL, Moore AL
Title
The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center.
Journal
Sequence
Reference
Authors
Berthold DA, Andersson ME, Nordlund P
Title
New insight into the structure and function of the alternative oxidase.
Journal
Reference
Authors
Williams BA, Elliot C, Burri L, Kido Y, Kita K, Moore AL, Keeling PJ
Title
A broad distribution of the alternative oxidase in microsporidian parasites.
Journal
Sequence
Reference
Authors
Gandin A, Duffes C, Day DA, Cousins AB
Title
The absence of alternative oxidase AOX1A results in altered response of photosynthetic carbon assimilation to increasing CO(2) in Arabidopsis thaliana.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.10.3.11