Entry
Name
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)
Reaction(IUBMB)
L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde [RN:
R02076 ]
Reaction(KEGG)
Substrate
Product
5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde [CPD:
C04797 ]
Comment
The intermediate product undergoes ring closure and oxidation, with NAD(P)+ as acceptor, to stizolobinic acid. The enzyme requires Zn2+.
History
EC 1.13.11.30 created 1978
Pathway
Reference
Authors
Saito K, Komamine A.
Title
Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo.
Journal
Reference
Authors
Saito K, Komamine A.
Title
Biosynthesis of stizolobinic acid and stizolobic acid in higher plants.
Journal
Other DBs