KEGG   ENZYME: 1.13.11.34
Entry
EC 1.13.11.34               Enzyme                                 
Name
arachidonate 5-lipoxygenase;
leukotriene-A4 synthase;
Delta5-lipoxygenase;
5Delta-lipoxygenase;
arachidonic 5-lipoxygenase;
arachidonic acid 5-lipoxygenase;
C-5-lipoxygenase;
LTA synthase;
leukotriene A4 synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 5-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = leukotriene A4 + H2O (overall reaction) [RN:R08527];
(1a) arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate [RN:R01595];
(1b) (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O [RN:R03058]
Reaction(KEGG)
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
Product
leukotriene A4 [CPD:C00909];
H2O [CPD:C00001];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
History
EC 1.13.11.34 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00461  arachidonate 5-lipoxygenase
Genes
HSA240(ALOX5)
PTR450428(ALOX5)
PPS100979027(ALOX5)
GGO101135686(ALOX5)
PON100460538(ALOX5)
NLE100584513(ALOX5)
HMH116461149(ALOX5)
MCC707926(ALOX5)
MCF102132853(ALOX5)
MTHB126963209
MNI105486634(ALOX5)
CSAB103215810(ALOX5)
CATY105576135(ALOX5)
PANU101004229(ALOX5)
TGE112632137(ALOX5)
MLEU105532332(ALOX5)
RRO104678173(ALOX5)
RBB108522174(ALOX5)
TFN117082071(ALOX5)
PTEH111529801(ALOX5)
CANG105517726(ALOX5)
CJC100386217(ALOX5)
SBQ101031793(ALOX5)
CIMI108296336(ALOX5)
CSYR103256562(ALOX5)
MMUR105860128 105860129
LCAT123650024(ALOX5)
PCOQ105821653(ALOX5)
OGA100952067(ALOX5)
MMU11689(Alox5)
MCAL110297094(Alox5)
MPAH110315917(Alox5)
RNO25290(Alox5)
MCOC116099451(Alox5)
ANU117714890(Alox5)
MUN110563694(Alox5)
CGE100772492(Alox5)
MAUA101839970(Alox5)
PROB127236199(Alox5)
PLEU114689650(Alox5)
MORG121438814(Alox5)
MFOT126505462
AAMP119807525(Alox5)
NGI103737907(Alox5)
HGL101700210(Alox5)
CPOC100718093(Alox5)
CCAN109700324(Alox5)
DORD106001013(Alox5)
DSP122122367(Alox5)
PLOP125346580(Alox5)
NCAR124975507 124985161 124985243 124985624
MMMA107153379(Alox5)
OCU100341714
OPI101534185(ALOX5)
TUP102480526(ALOX5)
GVR103597659(ALOX5)
CFA477753(ALOX5)
CLUD112671999(ALOX5)
VVP112913415(ALOX5)
VLG121483983(ALOX5)
NPO129522715(ALOX5)
AML100476416(ALOX5)
UMR103668062(ALOX5)
UAH113243124(ALOX5)
UAR123800343(ALOX5)
ELK111144974
LLV125085017
MPUF101684572(ALOX5)
MNP132016591(ALOX5)
MLK131828702(ALOX5)
NVS122900884(ALOX5)
ORO101381769(ALOX5)
EJU114205241(ALOX5)
ZCA113923418(ALOX5)
MLX118023026(ALOX5)
NSU110589221(ALOX5)
LWW102747716(ALOX5)
FCA101097422(ALOX5)
PYU121036944(ALOX5)
PCOO112854352(ALOX5)
PBG122492984(ALOX5)
LRUF124506966
PTG102973009(ALOX5)
PPAD109264579(ALOX5)
PUC125933342
AJU106989649
HHV120232804(ALOX5)
BTA404074(ALOX5)
BOM102270550(ALOX5)
BIU109553923(ALOX5)
BBUB102400249(ALOX5)
BBIS104999056(ALOX5)
CHX102168425(ALOX5)
OAS101117390(ALOX5)
BTAX128048043(ALOX5)
ODA120865494(ALOX5)
CCAD122446293(ALOX5)
MBEZ129555613(ALOX5)
SSC100156205(ALOX5)
CFR102507744(ALOX5)
CBAI105075631(ALOX5)
CDK105093424(ALOX5)
VPC102544906(ALOX5)
BACU103009115(ALOX5)
LVE103081267(ALOX5)
OOR101283796(ALOX5)
DLE111172567(ALOX5)
PCAD102987975(ALOX5) 114485528
PSIU116741371(ALOX5)
NASI112395753(ALOX5)
ECB100062042(ALOX5)
EPZ103553660(ALOX5)
EAI106846725(ALOX5)
MYB102249760(ALOX5)
MYD102754419(ALOX5)
MMYO118679341(ALOX5)
MLF102418693(ALOX5)
MNA107527950(ALOX5)
PKL118732103(ALOX5)
EFUS103292839(ALOX5)
HAI109389501(ALOX5)
DRO112305481(ALOX5)
SHON118994142(ALOX5)
AJM119035943(ALOX5)
PDIC114496046(ALOX5)
PHAS123821021(ALOX5)
MMF118632052(ALOX5)
RFQ117036416(ALOX5)
PPAM129073187(ALOX5)
PALE102898772(ALOX5)
PGIG120609662(ALOX5)
PVP105288958(ALOX5)
RAY107508911(ALOX5)
MJV108400689(ALOX5)
TOD119234526(ALOX5)
SARA101551293(ALOX5)
LAV100661336(ALOX5)
TMU101345496
ETF101653110(ALOX5)
DNM101433807(ALOX5)
MDO100013954(ALOX5)
GAS123236481(ALOX5)
SHR100932471(ALOX5)
PCW110213916(ALOX5)
OAA100077066(ALOX5)
GGA423769(ALOX5)
PCOC116238154(ALOX5)
MGP100542129(ALOX5)
CJO107315916(ALOX5)
TPAI128078157(ALOX5)
LMUT125692891(ALOX5)
NMEL110399270(ALOX5)
APLA101801930(ALOX5)
ACYG106049001(ALOX5)
CATA118254963(ALOX5)
AFUL116491605(ALOX5)
TGU100231888(ALOX5)
LSR110475663(ALOX5)
SCAN103813960(ALOX5)
PMOA120502228(ALOX5)
OTC121341694(ALOX5)
PRUF121350062(ALOX5)
GFR102035554(ALOX5)
FAB101813553(ALOX5)
OMA130254740(ALOX5)
PHI102112541(ALOX5)
PMAJ107207120(ALOX5)
CCAE111931122(ALOX5)
CCW104697933(ALOX5)
CBRC103624590(ALOX5)
ETL114054707(ALOX5)
ZAB102062876(ALOX5)
ACHL103800605(ALOX5)
SVG106852593(ALOX5)
MMEA130578798(ALOX5)
HRT120756195(ALOX5)
FPG101914238(ALOX5)
FCH102053142(ALOX5)
CLV102085004(ALOX5)
EGZ104129027(ALOX5)
NNI104014074(ALOX5)
PCRI104029677(ALOX5)
PLET104626025(ALOX5)
EHS104506301(ALOX5)
PCAO104042894(ALOX5)
ACUN113481652(ALOX5)
TALA104365651(ALOX5)
PADL103914082(ALOX5)
AFOR103897820(ALOX5)
ACHC115348416(ALOX5)
HALD104320512(ALOX5)
HLE104829333(ALOX5)
AGEN126043077
GCL127017658
CCRI104162138(ALOX5)
CSTI104560045(ALOX5)
CMAC104486519(ALOX5)
MUI104535976(ALOX5)
BREG104631879(ALOX5)
FGA104076430(ALOX5)
GSTE104256524(ALOX5)
MNB103781231(ALOX5)
OHA104330385(ALOX5)
NNT104403581(ALOX5)
SHAB115608655(ALOX5)
DPUB104297702(ALOX5)
ACAR104521858(ALOX5)
CPEA104391514(ALOX5)
AVIT104276083(ALOX5)
CVF104289812(ALOX5)
RTD128911621(ALOX5)
CUCA104067974(ALOX5)
BRHI104501850(ALOX5)
AAM106497785(ALOX5)
AROW112963900(ALOX5)
NPD112957209(ALOX5)
TGT104577674(ALOX5)
DNE112990662(ALOX5)
SCAM104146056(ALOX5)
ASN102371605(ALOX5)
AMJ102568608(ALOX5)
CPOO109324293(ALOX5)
GGN109287144(ALOX5)
PSS102462244(ALOX5)
CMY102944803(ALOX5)
CCAY125640309(ALOX5)
DCC119859437(ALOX5)
CPIC101932214(ALOX5)
TST117880642(ALOX5)
CABI116823588(ALOX5)
MRV120369164(ALOX5)
ACS100556313(alox5)
ASAO132774296(ALOX5)
PVT110090785
SUND121927518(ALOX5)
PMUR107292379(ALOX5)
CTIG120300245(ALOX5)
TSR106553343(ALOX5)
PGUT117661247(ALOX5)
APRI131194940(ALOX5) 131195008
PTEX113448132(ALOX5)
NSS113426131(ALOX5)
VKO123029661(ALOX5)
PMUA114601080(ALOX5)
PRAF128417991(ALOX5)
ZVI118079372(ALOX5)
HCG128324892(ALOX5)
GJA107113129(ALOX5)
STOW125443871(ALOX5)
EMC129333365(ALOX5)
XLA108696220(alox5.L) 108697207(alox5.S)
XTR100036609(alox5)
NPR108800085(ALOX5)
RTEM120947174(ALOX5)
BBUF121004372(ALOX5)
BGAR122940049(ALOX5)
MUO115470372 115470373
GSH117358965 117358966
DRE567204(alox5a) 573013(alox5b.1) 724056(alox5b.2)
SRX107708393 107713771 107747471
SANH107671382 107677802 107678516 107684374 107690200
SGH107571808 107572920 107575181 107575442 107582511 107589586
CCAR109049814 109052610 109065335 109081069 109101776 109108493
CAUA113048375 113048377 113057166 113066049 113066078 113112941
CGIB127955930 127967689 127970034 128026407
PTET122342996 122342997 122342998 122343010 122357073(alox5a)
LROH127160167 127175177(alox5a)
OMC131538449 131538622 131538839 131539153 131539371 131552688(alox5a)
PPRM120460470 120463765 120463775 120478382 120479775(alox5a) 120492594
RKG130070411 130070412 130070436 130070437 130070439 130070440 130076720 130076750 130076753 130076754 130083106(alox5a)
MAMB125257158 125265844 125276632(alox5a) 125279367 125279782
CIDE127508776 127516455 127517370
MASI127412305 127413837 127420989 127420992
TROS130559644(alox5a) 130565158
TDW130417024 130421067 130430244 130430247 130430795 130431384(alox5a)
MANU129415496(alox5a) 129439374 129439376 129439390 129439603 129439605 129439607 129439610 129439611
IPU108263823(alox5a)
IFU128605533(alox5a)
PHYP113546154(alox5)
SMEO124378204(alox5a)
TFD113639934(alox5a)
TVC132847235(alox5a)
AMEX103035394(alox5)
CMAO118810335(alox5a)
EEE113587960(alox5)
CHAR105909748(alox5a)
TRU101066485 101077167(alox5) 101077844 115249685
TFS130533608 130533609 130533610 130533611 130533612
TNGGSTEN00016500G001
LCO104930113(alox5)
NCC104946287(alox5)
TBEN117499400(alox5a)
CGOB115020076(alox5)
PGEO117459737(alox5a)
GACU117538242(alox5a)
ELY117248563
EFO125903456(alox5a)
PLEP121954568 121954569
SLUC116054107(alox5a)
ECRA117960578(alox5a)
ESP116704939(alox5)
PFLV114572645(alox5)
GAT120820912(alox5a)
PPUG119213967(alox5a)
AFB129092018(alox5a)
CLUM117743732 117743733
MSAM119916966(alox5a)
SCHU122884911
CUD121510776 121511083 121511143 121511190
ALAT119034095(alox5a)
MZE101482427(alox5)
ONL100693453(alox5)
OAU116316616(alox5a)
OLA101160835(alox5) 101165738
OML112162158(alox5a)
XMA102230376(alox5)
XCO114137934(alox5)
XHE116712547(alox5)
PRET103476884(alox5)
PFOR103147712(alox5)
PLAI106955189(alox5)
PMEI106907603(alox5)
GAF122843057(alox5a)
PPRL129360011(alox5a)
CVG107091526(alox5)
CTUL119788547(alox5a)
GMU124858722(alox5a)
NFU107375698(alox5)
KMR108243211
ALIM106529456(alox5)
NWH119418429(alox5a)
AOCE111564375(alox5)
MCEP125018433(alox5a)
CSEM103387317(alox5)
POV109631496(alox5)
SSEN122781462(alox5a)
HHIP117775306(alox5a)
HSP118118901(alox5a)
LCF108884347(alox5a)
SDU111235185(alox5)
SLAL111654678(alox5)
XGL120796514(alox5a)
HCQ109509924 109509925(alox5)
SSCV125978684 125978685
SBIA133509411(alox5a) 133510141
PEE133409389 133409390(alox5a)
PTAO133485328 133485329
BPEC110164412(alox5)
MALB109961016(alox5)
BSPL114870428(alox5a)
SJO128372695(alox5a)
SASA100194803(lox5) 106613187
STRU115153372 115193564
OTW112253187 112256283
OMY110502637 110532793
OGO124037261 124041114
ONE115113091 115134961
OKI109890066 109899823
OKE118366116(alox5a) 118369426
SALP111978799
SNH120017762 120045686
CCLU121553196 121583968
ELS105010608(alox5)
SFM108921027(alox5) 108937538
PKI111837191 111846223 111846232 111849566(alox5)
AANG118218047 118218049 118218050 118218460
LOC102697549(alox5)
PSPA121325182(alox5a)
ARUT117416027 117417615(alox5a)
PSEX120516309(alox5a)
LCM102353934(ALOX5)
CMK103185827(alox5a)
RTP109921931(alox5)
CPLA122541744
HOC132835112(alox5a)
LERI129694146 129713061 129713062
PMRN116938187 116938188 116938189 116945048(ALOX5) 116946267 116954498 116954558
LRJ133340592 133341923 133357456 133357457 133357459 133357461 133357468
BFO118407044 118407190 118410745 118416628 118419219 118419222 118423903 118424144
BBEL109463619 109467523 109473009 109474494 109474550 109474633 109476869 109478405 109478532 109479429 109480412 109481529 109483336 109486824 109487021 109487229 109487274 109487288
CIN100176198 100176411 100176744 100178151 100178342 100178563 100179479
SCLV120327656 120328067 120330915 120339739 120339931 120339932 120342283 120342991
SPU115918885 574670 575389 579368 583823 584481 584789 585142 591845 754628 763828 764400
LPIC129260605 129274105 129274606 129275104 129276415 129276420 129276477 129276781
APLC110975305 110975972 110976201 110977737 110977751
SKO100369676 100369827 102805620
TPAL117644657
IEL124162033
PVM113804806
PCLA123760292
PTRU123516860
ESN127001279
PPOI119091807 119096450
DSV119449406
RSAN119382445
RMP119178021
CSCU111636555 111636558
PTEP107442379
UDV129231431
SDM118200660
LPOL106471422
PMEO129593708
HROHELRODRAFT_66521
LGILOTGIDRAFT_137999 LOTGIDRAFT_171808 LOTGIDRAFT_209217 LOTGIDRAFT_224684
PVUL126829853 126829854
PCAN112558951
BGT106067963 106069395
GAE121374655 121392860
HRF124111845 124113998 124114830 124115001 124115002 124123794 124143720
HRJ124254639 124259952 124261755 124261766 124285520
CRG105319481 105324873 105327235 105327236 105327296 105327652 105333405 105333406 105336201 117683956
CVN111100560 111104171 111125061 111131676
CANU128163050 128163051 128175011 128175263 128177600 128177852 128177871 128178663 128184671 128184672 128184673 128192060
OED125650846 125652902 125652924 125652925 125681975
MYI110457288 110457778 110458666 110458669 110458670 110458673 110458677 110458678
PMAX117322747 117324142 117324143 117329167 117329376 117329377 117329378 117329966
MMER123539768 123540524 123541567 123553096 123557731
RPHI132725606 132736951 132754139 132757137 132759084
DPOL127832686 127836363 127838598 127841037
OBI106867440 106867441 106867443 106873090 106873091 106873092
OSN115215746 115215749 115215753 115221275 115221688 115226898 115227054
LAK106150754 106166490 106170509 106178940
OVIT265_15039
NVE5499732 5504404 5514194 5514339
EPA110239121 110242596 110248339 110250751 110253407
ATEN116286796 116290323 116294452 116296880 116301055 116304961 116304967 116307613
ADF107327113 107341953 107341972 107345340 107350206 107352928
AMIL114958630 114959396 114968909 114970008 114971001
PDAM113664617 113665281 113666770 113675130 113675559 113675883 113682318 113683498 113685341
SPIS111321744 111326629 111326882 111326890 111328829 111341264
DGT114516532 114516794 114521367 114521368 114527546 114529580 114531948 114541102
XEN124433523 124439795 124443860 124444372 124444381 124444382 124450812 124454266
HMG100200947 100209770 100213618 100215649
HSY130622682 130630034 130630315 130630536 130647477
TADTRIADDRAFT_50085 TRIADDRAFT_63720
AQU100635761
CCPCHC_T00008739001
MXAMXAN_1744
MSDMYSTI_02579
MFBMFUL124B02_14090
CCXCOCOR_02733(loxA)
MBDMEBOL_004947
 » show all
Reference
1  [PMID:2829172]
  Authors
Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B
  Title
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 85:26-30 (1988)
DOI:10.1073/pnas.85.1.26
  Sequence
[hsa:240]
Reference
2  [PMID:3038871]
  Authors
Ohishi N, Izumi T, Minami M, Kitamura S, Seyama Y, Ohkawa S, Terao S, Yotsumoto H, Takaku F, Shimizu T.
  Title
Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers.
  Journal
J Biol Chem 262:10200-5 (1987)
Reference
3  [PMID:3012557]
  Authors
Shimizu T, Izumi T, Seyama Y, Tadokoro K, Radmark O, Samuelsson B.
  Title
Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 83:4175-9 (1986)
DOI:10.1073/pnas.83.12.4175
Reference
4  [PMID:6322165]
  Authors
Shimizu T, Radmark O, Samuelsson B.
  Title
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.
  Journal
Proc Natl Acad Sci U S A 81:689-93 (1984)
DOI:10.1073/pnas.81.3.689
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.34
IUBMB Enzyme Nomenclature: 1.13.11.34
ExPASy - ENZYME nomenclature database: 1.13.11.34
BRENDA, the Enzyme Database: 1.13.11.34
CAS: 80619-02-9

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