KEGG ENZYME: 1.13.11.62

ENZYME: 1.13.11.62

Entry

EC 1.13.11.62               Enzyme

Name

linoleate 10R-lipoxygenase;
10R-DOX;
(10R)-dioxygenase;
10R-dioxygenase

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

linoleate:oxygen (10R)-oxidoreductase

Reaction(IUBMB)

linoleate + O2 = (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [RN:R09811]

Reaction(KEGG)

R09811

Substrate

linoleate [CPD:C01595];
O2 [CPD:C00007]

Product

(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate [CPD:C19937]

Comment

The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp.

History

EC 1.13.11.62 created 2011

Pathway

ec00591

Linoleic acid metabolism

Orthology

K17862

linoleate 10R-lipoxygenase

Genes

NCR:

NCU05858

NTE:	NEUTE1DRAFT86742(NEUTE1DRAFT_86742)

SMP:	SMAC_09193

PAN:	PODANSg1229

PBEL:

QC761_501240

PPSD:

QC762_501240

PPSP:

QC763_501240

PPSA:

QC764_501240

MTM:	MYCTH_2094824

CTHR:

CTHT_0019380

MGR:

MGG_10859

PPEI:

PpBr36_03958

PGRI:

PgNI_09087

TMN:	UCRPA7_3198

SSCK:

SPSK_03862

FGR:	FGSG_02668 FGSG_10960

FPU:	FPSE_00375 FPSE_10969

FPOA:

FPOAC1_009706

FVN:	FVRRES_10347

FVR:	FVEG_09294 FVEG_11670

FOX:	FOXG_10645 FOXG_12909

NHE:	NECHADRAFT_40259

FFC:	NCS54_00640400

FKR:	NCS57_00680600

FMU:	J7337_010070

TRE:	TRIREDRAFT_51893

TRR:	M419DRAFT_115103

MAW:

MAC_00208

MAJ:

MAA_04954

PCHM:

VFPPC_07783

CMT:

CCM_08032

AMUS:

LMH87_010707

PLJ:	VFPFJ_01842

PTKZ:

JDV02_004154

VAL:	VDBG_03337

VDA:	VDAG_02241 VDAG_07521

CFJ:	CFIO01_08347

CLUP:

CLUP02_13035

CHIG:

CH63R_09711

SAPO:

SAPIO_CDS10179

SSL:	SS1G_10705

BFU:	BCIN_04g05000

PSCO:

LY89DRAFT_737544

ANI:	ANIA_05028

AFM:	AFUA_3G12120 AFUA_4G00180

ACT:	ACLA_039980

NFI:	NFIA_045480 NFIA_065200

AOR:	AO090003000772 AO090010000591

ANG:	An02g07930

AFV:	AFLA_000908 AFLA_014077

ACHE:

ACHE_20321A

APUU:

APUU_30756S

PCS:	N7525_000945

PDP:	PDIP_75470

POU:	POX_b02996

TMF:	EYB26_006288

TRG:	TRUGW13939_08648

CIM:	CIMG_00042

CPW:	CPC735_060720

URE:	UREG_00168

PBL:	PAAG_03986

PBN:	PADG_03472

ABE:

ARB_07881

TVE:

TRV_00942

AJE:	HCAG_01100

BGH:	BDBG_06551

BCOM:

BAUCODRAFT_34798

NPA:	UCRNP2_8049

TML:	GSTUM_00000322001

PPL:	POSPLDRAFT_98495

TVS:	TRAVEDRAFT_64780(LDO2)

DSQ:	DICSQDRAFT_80992(LDO1)

PCO:	PHACADRAFT_259331 PHACADRAFT_260261

SHS:	STEHIDRAFT_131231 STEHIDRAFT_171396

HIR:	HETIRDRAFT_155921

PSQ:	PUNSTDRAFT_107209 PUNSTDRAFT_146616

ADL:	AURDEDRAFT_114269

FME:	FOMMEDRAFT_101793 FOMMEDRAFT_15962 FOMMEDRAFT_161482

GTR:	GLOTRDRAFT_138220 GLOTRDRAFT_140957

RSX:	RhiXN_04882 RhiXN_05342 RhiXN_05531

LBC:	LACBIDRAFT_305274 LACBIDRAFT_315146

CCI:	CC1G_00844 CC1G_09914

ABP:	AGABI1DRAFT114975(AGABI1DRAFT_114975) AGABI1DRAFT90139(AGABI1DRAFT_90139)

ABV:	AGABI2DRAFT143643(AGABI2DRAFT_143643) AGABI2DRAFT195360(AGABI2DRAFT_195360)

MRR:	Moror_11351 Moror_14920

E1B28_003838 E1B28_009504

SCM:	SCHCO_02517480(SCHCODRAFT_02517480) SCHCO_02619114(SCHCODRAFT_02619114)

CPUT:

CONPUDRAFT_83601(LDO2)

SLA:	SERLADRAFT_416857 SERLADRAFT_439529

MLR:	MELLADRAFT_116583 MELLADRAFT_76882

» show all

Reference

1 [PMID:19289462]

Authors

Garscha U, Oliw EH

Title

Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity.

Journal

J Biol Chem 284:13755-65 (2009)
DOI:10.1074/jbc.M808665200

Sequence

[afm:AFUA_3G12120]

Reference

2 [PMID:20045744]

Authors

Jerneren F, Garscha U, Hoffmann I, Hamberg M, Oliw EH

Title

Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.

Journal

Biochim Biophys Acta 1801:503-7 (2010)
DOI:10.1016/j.bbalip.2009.12.012

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.62

IUBMB Enzyme Nomenclature:

1.13.11.62

ExPASy - ENZYME nomenclature database:

1.13.11.62

BRENDA, the Enzyme Database:

1.13.11.62

DBGET integrated database retrieval system