| Entry |
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| Name |
all-trans-8'-apo-beta-carotenal 15,15'-oxygenase;
Diox1;
ACO;
8'-apo-beta-carotenal 15,15'-oxygenase
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
all-trans-8'-apo-beta-carotenal:oxygen 15,15'-oxidoreductase (bond-cleaving)
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| Reaction(IUBMB) |
all-trans-8'-apo-beta-carotenal + O2 = all-trans-retinal + (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial [RN: R09601]
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| Reaction(KEGG) |
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| Substrate |
all-trans-8'-apo-beta-carotenal [CPD: C19728];
O2 [CPD: C00007]
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| Product |
all-trans-retinal [CPD: C00376];
(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial [CPD: C19729]
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| Comment |
Contains an Fe2+-4His arrangement. The enzyme is involved in retinal biosynthesis in bacteria [2].
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| History |
EC 1.13.11.75 created 2010 as EC 1.14.99.41, transferred 2013 to EC 1.13.11.75
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| Orthology |
| K00464 | all-trans-8'-apo-beta-carotenal 15,15'-oxygenase |
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| Genes |
| CRE: | CHLRE_12g488350v5 CHLRE_16g657800v5 |
| VCN: | VOLCADRAFT_88605 VOLCADRAFT_95405 |
| CSL: | COCSUDRAFT_16838 COCSUDRAFT_62551 |
| OLU: | OSTLU_30717 OSTLU_48352 |
| OTA: | OT_ostta01g04480 OT_ostta03g03900 |
| BPG: | Bathy01g03480 Bathy09g04190 |
| MIS: | MICPUN_107321(LSD1) MICPUN_56538 |
| MPP: | MICPUCDRAFT_13068(JGI:MicpuC2_13068) MICPUCDRAFT_49450(JGI:MicpuC2_49450) |
| OSG: | BST96_04740 BST96_14205 BST96_16795 |
| MCHT: | MCHIJ_00260 MCHIJ_05630 MCHIJ_52680 |
| MAUB: | MAUB_28810 MAUB_40380 |
| MDF: | K0O62_03090 K0O62_06730 |
| MKR: | MKOR_22060 MKOR_24160 MKOR_31540 |
| MPAK: | MIU77_00390 MIU77_14725 |
| MSAL: | DSM43276_00047 DSM43276_04122 |
| MHIB: | MHIB_18640 MHIB_27260 |
| SYY: | SYNGTS_1854(sll1541) |
| SYT: | SYNGTI_1854(sll1541) |
| SYS: | SYNPCCN_1853(sll1541) |
| SYQ: | SYNPCCP_1853(sll1541) |
| CYN: | Cyan7425_3964 Cyan7425_4222 |
| AMR: | AM1_0661 AM1_0925 AM1_3102 |
| CHON: | NIES4102_20140 NIES4102_30980 |
| SYP: | SYNPCC7002_A1425 SYNPCC7002_A2200 |
| SYV: | AWQ23_07310 AWQ23_10990 |
| SYL: | AWQ21_07235 AWQ21_11135 |
| LEP: | Lepto7376_2824 Lepto7376_3423 |
| MIQ: | B5D77_08610 B5D77_23470 |
| MVZ: | myaer102_32700 myaer102_43470 |
| HAO: | PCC7418_1592 PCC7418_3622 |
| ENN: | FRE64_08910 FRE64_11700 |
| CYT: | cce_2515 cce_2665 cce_4927 |
| CYP: | PCC8801_0015 PCC8801_4340 |
| CYH: | Cyan8802_0013 Cyan8802_4402 |
| CYC: | PCC7424_0449 PCC7424_5321 |
| CYJ: | Cyan7822_1968 Cyan7822_5002 |
| PLP: | Ple7327_2351 Ple7327_2968 |
| SCS: | Sta7437_1482 Sta7437_2350 |
| STAN: | STA3757_02100 STA3757_40070 |
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| Reference |
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| Authors |
Ruch S, Beyer P, Ernst H, Al-Babili S |
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| Title |
Retinal biosynthesis in Eubacteria: in vitro characterization of a novel carotenoid oxygenase from Synechocystis sp. PCC 6803. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Kloer DP, Ruch S, Al-Babili S, Beyer P, Schulz GE |
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| Title |
The structure of a retinal-forming carotenoid oxygenase. |
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| Journal |
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| Sequence |
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| Other DBs |
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