KEGG   ENZYME: 1.13.11.8
Entry
EC 1.13.11.8                Enzyme                                 
Name
protocatechuate 4,5-dioxygenase;
protocatechuate 4,5-oxygenase;
protocatechuic 4,5-dioxygenase;
protocatechuic 4,5-oxygenase;
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing);
protocatechuate:oxygen 4,5-oxidoreductase (ring-opening)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
3,4-dihydroxybenzoate:oxygen 4,5-oxidoreductase (ring-opening)
Reaction(IUBMB)
3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde [RN:R01632]
Reaction(KEGG)
R01632;
(other) R03550 R04280 R09272 R09565
Substrate
3,4-dihydroxybenzoate [CPD:C00230];
O2 [CPD:C00007]
Product
4-carboxy-2-hydroxymuconate semialdehyde [CPD:C04484]
Comment
Requires Fe2+.
History
EC 1.13.11.8 created 1965 as EC 1.13.1.8, transferred 1972 to EC 1.13.11.8
Pathway
ec00362  Benzoate degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04100  protocatechuate 4,5-dioxygenase, alpha chain
K04101  protocatechuate 4,5-dioxygenase, beta chain
Genes
VNAPN96_18545 PN96_18550
VEJVEJY3_18111 VEJY3_18116
VFLAL536_10310 AL536_10315
VZIG5S32_20190 G5S32_20195
VOSKNV97_07830 KNV97_07835
GKDK6Q96_09545 K6Q96_09550(ligA)
PVRPverR02_14345
PQIKH389_15770
AVNAvin_42210
AVLAvCA_42210
AVDAvCA6_42210
EMODM558_04785 DM558_04790(ligA)
PCARPC2016_2100 PC2016_2101
AAWAVL56_08860 AVL56_08865
ALRDS731_01510 DS731_01515
PATPatl_3885 Patl_3886
ALIIQR722_00525(ligA) QR722_00530
MPAFR5R33_07700(ligA) R5R33_07705
CSACsal_0324 Csal_0325
MMWMmwyl1_0508 Mmwyl1_0509 Mmwyl1_3920 Mmwyl1_3921 Mmwyl1_3938 Mmwyl1_3939
MMEMarme_0835 Marme_0836
MPCMar181_0383 Mar181_0384
MPRIMP3633_0340 MP3633_0341 MP3633_0451 MP3633_0452 MP3633_3158
MARDIBG28_02225(ligA) IBG28_02230 IBG28_02960 IBG28_02965
MFOIJSY38_11025(ligA) JSY38_11030 JSY38_12245 JSY38_12250
MPRFJ8N69_06125 J8N69_06130 J8N69_09425(ligA) J8N69_09430
MRHIKDW99_17795 KDW99_17800 KDW99_17840 KDW99_17845
MPONMACH16_03370 MACH16_03380(pcaH_1) MACH16_05320(ligA_1) MACH16_05330(pcaH_2) MACH16_05430 MACH16_05440(pcaH_3)
MGEOCFI10_06005 CFI10_14870 CFI10_14875
MSECLN244_04470
MARLHH196_02855 HH196_02860
AJPAMJAP_1182 AMJAP_1183(ligB)
GSNYC6258_04092 YC6258_04093
RFOREIFOR_00545(ligA) REIFOR_00546(ligB)
FCEJN531_005665
GBIPG2T_11290 PG2T_11315
NAQD0T90_09305 D0T90_09310(ligA)
NBLGJV52_09125 GJV52_09130(ligA)
KKIKKKWG1_0313(ligB)
VFFVITFI_CDS0352 VITFI_CDS0353 VITFI_CDS3223 VITFI_CDS3224
VITADP71_27560 ADP71_27570
VSTLVJ81_00710 LVJ81_00715(ligA)
VMSLVJ82_10325 LVJ82_10330(ligA)
AMAHDLM_2151 DLM_2152 DLM_2155 DLM_2156
AQSDKK66_18640 DKK66_18645 DKK66_18665 DKK66_18670(ligA)
RPJN234_29205
CUHBJN34_26380
CCUPBKK81_23725
CUPBKK80_32575
CUUBKK79_23540
BPHBphy_3204 Bphy_3205
BPXBUPH_02687 BUPH_06639(ligA)
PARABTO02_23045 BTO02_23050
PPULRO07_25060
PTXABW99_00710 ABW99_00715
HYFDTO96_100892(ligA_1) DTO96_100893(ligB)
BOJCBF45_01515 CBF45_01520 CBF45_11680 CBF45_13150 CBF45_13155
AISBUW96_12500
PUDG9Q38_00385 G9Q38_01305
CDNBN940_08481 BN940_08486 BN940_08551 BN940_08556
AFQAFA_05515 AFA_05520(ligA)
AAQUD3M96_07055 D3M96_07060(ligA)
PHNPAEH1_07110 PAEH1_07115
OUEI6G29_08390
PIGEGT29_01985 EGT29_01990 EGT29_16575 EGT29_16580 EGT29_23920
KGYEHF36_01700 EHF36_01705 EHF36_11935(ligA) EHF36_13170 EHF36_13175(ligA)
RFRRfer_0294 Rfer_0295 Rfer_0330 Rfer_0331
RSBRS694_12675 RS694_12680
RHYRD110_08820 RD110_08825 RD110_16980 RD110_16985
RHFEUB48_07540 EUB48_07545 EUB48_12925 EUB48_12930(ligA)
RHOAHZ993_17885 HZ993_17890(ligA)
RHOBHTY51_09895 HTY51_09900 HTY51_09960 HTY51_09965(ligA)
PNAPnap_2027 Pnap_2028 Pnap_2733 Pnap_2734
PVACHC248_00683(ligA_1) HC248_00684(ligB)
ACKC380_22700 C380_22705 C380_22805 C380_22810
ACRABSY15_1237 BSY15_1238
ACIDCBP33_05245 CBP33_05250
ACIPCBP36_05695 CBP36_05700 CBP36_20285 CBP36_20290
ACINCBP34_05080 CBP34_05085
ACISCBP35_13245 CBP35_20360 CBP35_20365
ACIOEAG14_01090 EAG14_01095 EAG14_01255(ligA) EAG14_01260
ARADKI609_21440 KI609_21445(ligA)
ATEMPQV96_01120(ligA) PQV96_01125
AMONH9L24_06080 H9L24_06085(ligA)
DACDaci_0914 Daci_0915 Daci_3813 Daci_3814 Daci_4445 Daci_4446
DELDelCs14_1672 DelCs14_1673 DelCs14_2358 DelCs14_2359 DelCs14_3008 DelCs14_3009 DelCs14_5611 DelCs14_5612
DTSBI380_01390 BI380_01395 BI380_05115 BI380_05120 BI380_20115 BI380_20120
DHKBO996_04630 BO996_04635 BO996_17335 BO996_17340 BO996_20100 BO996_20105
DLAI6G47_02130(ligA) I6G47_02135 I6G47_05175(ligA) I6G47_05180 I6G47_20060 I6G47_20065
CTTCtCNB1_2414 CtCNB1_2415 CtCNB1_2741 CtCNB1_2742
CTESO987_16260 O987_16265
COFFOZ74_08485(ligA) FOZ74_08490
CODOLAD35_20150
AANTHUK68_10975 HUK68_10980(ligA)
CRJQMY55_10900(ligA) QMY55_10905
RTARta_24760 Rta_24770
RTEAHK414_00075 HK414_20760 HK414_26085
LIML103DPR2_01497(ligA_1) L103DPR2_01498(ligB_1) L103DPR2_01514(ligA_2) L103DPR2_01515(ligB_2)
LIHL63ED372_01144(ligA_1) L63ED372_01145(ligB)
HYRBSY239_1242 BSY239_1243(ligA) BSY239_2222 BSY239_2223(ligA)
HYBQ5W_06745 Q5W_06750 Q5W_10740 Q5W_10745
HYLLPB072_15985 LPB072_15990 LPB072_16065 LPB072_16070
HYCE5678_08755 E5678_08760(ligA)
HPSEHPF_08080(ligA1) HPF_08085(ligB1) HPF_08185(ligA2) HPF_08190(ligB2)
HYNF9K07_12200(ligA) F9K07_12205 F9K07_15790 F9K07_15795
HTNKI616_18035 KI616_18040 KI616_18170 KI616_18175(ligA)
HCZG9Q37_09990 G9Q37_09995(ligA)
DIHG7047_27835(ligA) G7047_27840
CBAASRAA_1066 SRAA_1067 SRAA_1350 SRAA_1351
CBABSMCB_0794 SMCB_0795 SMCB_0831 SMCB_0832
MIUABE85_08000
SNNEWH46_19140(ligA) EWH46_19145
LCHLcho_3636 Lcho_3637 Lcho_3698 Lcho_3699
RGUA4W93_06660
TMJP0M04_30120
XYGR9X41_02005
SHDSUTH_01241 SUTH_01242 SUTH_01245 SUTH_01246
RBUPG1C_06460
ABREpbN1_38930 pbN1_38940
DARDaro_3248
AZOazo2522(ligB1) azo2523(ligA1) azo2537(ligB2) azo2538(ligA2)
AOAdqs_2679 dqs_2680 dqs_2694 dqs_2695
AZRCJ010_15915 CJ010_15920 CJ010_16060 CJ010_16065(ligA)
THUAC731_016805 AC731_016810 AC731_016885 AC731_016890
THAUC4PIVTH_0864(ligB) C4PIVTH_0865 C4PIVTH_0880(ligB) C4PIVTH_0881
TCLTchl_1061 Tchl_1062
TAKTharo_1102 Tharo_1103
DDZDSYM_13550 DSYM_13560
MESOBSQ44_06570
AMISAmn_pa01620
NIYFQ775_20870
ORMHTY61_00090 HTY61_00095 HTY61_01660(ligA) HTY61_01665
NGLRG1141_CH01050 RG1141_CH01060
NGGRG540_CH00990 RG540_CH01000
OCHCES85_3143
BRABRADO2341(ligA) BRADO2342(ligB) BRADO2379 BRADO2380(mhpB)
BBTBBta_2701(ligA) BBta_2702(ligB) BBta_2733 BBta_2734(mhpB)
AOLS58_52220 S58_52230 S58_52570 S58_52580
BROBRAD285_4958(ligB) BRAD285_4959(ligA) BRAD285_4995(ligB) BRAD285_4996(ligA)
BSEIKMZ68_25390 KMZ68_25395 KMZ68_25430 KMZ68_25435(ligA)
RPATX73_005175 TX73_005180 TX73_024425(ligA) TX73_024430
RPBRPB_0872 RPB_0873 RPB_1060 RPB_1061
RPDRPD_0982 RPD_0983
RPERPE_0750 RPE_0751
RPTRpal_1198 Rpal_1199 Rpal_5182 Rpal_5183
RPXRpdx1_1168 Rpdx1_1169 Rpdx1_4876 Rpdx1_4877
MOCBB934_00240
MTEZHPT29_013230
RHZRHPLAN_00100 RHPLAN_00110 RHPLAN_69860 RHPLAN_69870
MAADAZF01_14285 AZF01_20305 AZF01_20310
MMEDMame_04593(ligB)
MLUTJET14_00505 JET14_00510 JET14_15920
BRND1F64_20790 D1F64_22045 D1F64_22050
BSBBresu_2114 Bresu_2115
BGOEIFJ75_11175 IFJ75_11180(ligA)
MALGMALG_02286 MALG_02287
CONTQ29_16210
OCDFHY55_07525 FHY55_07530 FHY55_07565(ligA) FHY55_07570 FHY55_12780 FHY55_12785
TGLHFZ77_17690 HFZ77_17695(ligA) HFZ77_17790 HFZ77_17795
PAROCUV01_03890 CUV01_03895
RBGBG454_07640 BG454_07645
SEDIEBB79_03595 EBB79_03600 EBB79_22515
PPSOQPJ95_03900 QPJ95_03905
PSHQF3W81_00050 F3W81_00400 F3W81_00405
CACTHZ995_05415 HZ995_05420
PBAEP8S53_03165 P8S53_03170
HBAHbal_2592 Hbal_2593
NARSaro_1233 Saro_1234 Saro_2812 Saro_2813
NPPPP1Y_Mpl10353 PP1Y_Mpl10356 PP1Y_Mpl10445 PP1Y_Mpl10448 PP1Y_Mpl6650 PP1Y_Mpl6658
NPNJI59_12230 JI59_20190 JI59_20195 JI59_20845 JI59_20850 JI59_20895 JI59_20900 JI59_21750 JI59_21840
NOVTQ38_025020 TQ38_025025(ligA) TQ38_028410(ligA) TQ38_028415
NOTC7W88_02265 C7W88_02270(ligA) C7W88_08690 C7W88_08695
NORFA702_07550 FA702_07555(ligA) FA702_13245 FA702_13250
NDRHT578_07800(ligA) HT578_07805 HT578_08935 HT578_08940(ligA) HT578_09425 HT578_09430 HT578_09605(ligA) HT578_09610
NHUMPQ457_02265 PQ457_02270 PQ457_10890 PQ457_10895(ligA)
SMAZLH19_17690 LH19_17695
SGISGRAN_1576
SINAKNJ79_13850 KNJ79_13855(ligA)
RDICMV14_06885(ligA) CMV14_06890
SPHITS85_18515 TS85_18520
SSANNX02_17500 NX02_17505
SPANAWL63_08165 AWL63_08170
SKRBRX40_12185 BRX40_12190
SPHCCVN68_17240 CVN68_17245(ligA)
SPIIG7077_01510 G7077_01515(ligA)
SSUAFPZ54_06145 FPZ54_06150(ligA) FPZ54_17705 FPZ54_17710(ligA)
SBINSBA_ch2_7410 SBA_ch2_7420(pcaH)
SGLCM1K48_07900(ligA) M1K48_07905
SHANPPZ50_15785(ligA) PPZ50_15790
SNOSK8P63_14320(ligA) K8P63_14325
SDONM9980_11035 M9980_11040(ligA)
SCHSphch_3898 Sphch_3899
SSYSLG_01790 SLG_01800 SLG_12500(ligB) SLG_12510(ligA) SLG_37520 SLG_37530
SPHBEP837_03493 EP837_03494(ligB)
SPHRBSY17_3446(ligB) BSY17_3447(ligA)
SHYDCJD35_16820(ligA) CJD35_16825 CJD35_19575(ligA) CJD35_19580
SYAA6768_17475 A6768_17480(ligA)
SPYGYGS_C2P1459 YGS_C2P1460
SAMISAMIE_1030390 SAMIE_1030400
SPHGAZE99_04500 AZE99_04505
SFLASPHFLASMR4Y_02362(ligB) SPHFLASMR4Y_02987(ligA) SPHFLASMR4Y_02988(ligB)
SPHYCHN51_00890 CHN51_00895(ligA)
BLASBSY18_3523(ligA) BSY18_3524(ligB)
BFWB5J99_08410 B5J99_08415
ACOBP0Y56_05475(ligA) P0Y56_05480 P0Y56_05925 P0Y56_05930 P0Y56_12110 P0Y56_12115(ligA) P0Y56_16110
SPHSETR14_07925 ETR14_07930(ligA)
POQKZX46_07330 KZX46_07335(ligA)
PMEAKTC28_03825(ligA) KTC28_03830 KTC28_12040 KTC28_12045(ligA)
ALBAEB_P0242 AEB_P0243 AEB_P1349 AEB_P1350 AEB_P2996 AEB_P2997
AAYWYH_01045(ligB_1) WYH_01046(ligA_2) WYH_01908(ligA_3) WYH_01909(ligB_2) WYH_03214(ligB_3) WYH_03215(ligA_4)
PMASNCF86_10620
ADOA6F68_01079(ligB) A6F68_01080(ligA_1)
TFVIDJ81_04945
CMANA9D14_17240 A9D14_17245
POTE2E27_18120(ligA) E2E27_18125
ABSAZOBR_p310188(mhpB) AZOBR_p310189
ABQABAZ39_27960 ABAZ39_27965
AZTTSH58p_32565 TSH58p_32570
AARED3093_31930 D3093_31935
NCBC0V82_22495(ligA) C0V82_22500
MAGXXM1_1094 XM1_1095(ligB)
MAGNWV31_13630 WV31_13635
MAGamb0257 amb0258
MAGQMGMAQ_2661(ligB) MGMAQ_2662(ligA) MGMAQ_2669(ligA) MGMAQ_2670(ligB)
TMOTMO_b0115(mhpB)
APBSAR116_0935 SAR116_0936
SNEANBZ79_04460 NBZ79_04465
GSOPH603_12840(ligA) PH603_12845
AVPAVENP_2164(ligB) AVENP_2165(ligD)
AFXJZ786_13055
SGRFSGFS_099590 SGFS_099600
SSOII1A49_02890 I1A49_02895
SGMGCM10017557_16490(ligA) GCM10017557_16500(pcaH)
SCADDN051_04005
SLSSLINC_7426 SLINC_7427
SAUOBV401_03165 BV401_03170
SNQCP978_34025
SPHVF9278_04905
SBATG4Z16_14875
SAKBK1J60_39125 K1J60_39130
YIALO772_34550
ABRYNYE86_01340
MAURBOH66_06355 BOH66_06360
MSFIT882_15440 IT882_15445(ligA)
AGYATC03_18365
AARCG127AT_14145
CARTPA27867_3406
CPHYB5808_15020
AMINAUMI_19380 AUMI_19390
AUMAURMO_01268 AURMO_01269 AURMO_01295 AURMO_01296
AUWAURUGA1_00419(ligA_1) AURUGA1_00420(ligB)
MHUMNNL39_01420
HUMDVJ78_05880
GRYD7I44_02560
ARZAUT26_02300 AUT26_02305
ARNCGK93_10095
ACAONF551_03855 NF551_03860
AGEGMUG94_01475 MUG94_03645 MUG94_03650
KRSEQG70_17000
PHWG7075_16190
PEIH9L10_14010
NBTKLP28_07270
KSLOG809_36140
ACTWF7P10_19845
AMAZLUW76_07410
NOABKM31_09195
NOWGBF35_31470
NCXNocox_12070(ligB)
NGNLCN96_32200
NFSOIE67_17270
MHAIOHB01_35505
NMLNamu_0046
NAKAH7F38_22080 H7F38_22085
BSDBLASA_2598(ligA) BLASA_2599(ligB)
MMARMODMU_2843(ligB) MODMU_2844(ligA) MODMU_3384
SVISvir_38360 Svir_38370
AMQAMETH_2153(mhpB) AMETH_2829 AMETH_2830
AACDLWP59_22355 LWP59_22705 LWP59_22710
ARHDVSH64_22995 VSH64_23000
PDXPsed_2465 Psed_2466 Psed_6533
PSEAWY02_25080
PAUTPdca_48140(pcaH_2) Pdca_48150
MICHFJK98_18050
MCABHXZ27_14810
AMSAMIS_45820
ACTNL083_0820
AFSAFR_03865
ACTRAsp14428_39700
ACTLL3i22_035320
ASICQ0Z83_016290
PLABC6361_08450
PLATC6W10_05020
PFLAPflav_029930 Pflav_029940(pcaH_1)
DVCDvina_32970
DAURDaura_34715
DMATDmats_28010
CCAZCOUCH_35870
JTLM6D93_14075 M6D93_14080(ligA)
AFOAfer_2021
VABWPS_31660 WPS_31670(pcaH)
 » show all
Reference
1
  Authors
Trippett, S., Dagley, S. and Stopher, D.A.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
Biochem J 76:9 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.8
IUBMB Enzyme Nomenclature: 1.13.11.8
ExPASy - ENZYME nomenclature database: 1.13.11.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.8
BRENDA, the Enzyme Database: 1.13.11.8
CAS: 9029-56-5

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