KEGG   ENZYME: 1.14.13.135
Entry
EC 1.14.13.135              Enzyme                                 
Name
1-hydroxy-2-naphthoate hydroxylase;
1-hydroxy-2-naphthoic acid hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
1-hydroxy-2-naphthoate,NAD(P)H:oxygen oxidoreductase (2-hydroxylating, decarboxylating)
Reaction(IUBMB)
1-hydroxy-2-naphthoate + NAD(P)H + H+ + O2 = 1,2-dihydroxynaphthalene + NAD(P)+ + H2O + CO2 [RN:R05632 R09818]
Reaction(KEGG)
R05632 R09818
Substrate
1-hydroxy-2-naphthoate [CPD:C03203];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
1,2-dihydroxynaphthalene [CPD:C03012];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
The enzyme is involved in the catabolic pathway for the degradation of chrysene in some bacteria [2].
History
EC 1.14.13.135 created 2011
Reference
1  [PMID:20727010]
  Authors
Deveryshetty J, Phale PS
  Title
Biodegradation of phenanthrene by Alcaligenes sp. strain PPH: partial purification and characterization of 1-hydroxy-2-naphthoic acid hydroxylase.
  Journal
FEMS Microbiol Lett 311:93-101 (2010)
DOI:10.1111/j.1574-6968.2010.02079.x
Reference
2  [PMID:21545490]
  Authors
Nayak AS, Sanjeev Kumar S, Santosh Kumar M, Anjaneya O, Karegoudar TB
  Title
A catabolic pathway for the degradation of chrysene by Pseudoxanthomonas sp. PNK-04.
  Journal
FEMS Microbiol Lett 320:128-34 (2011)
DOI:10.1111/j.1574-6968.2011.02301.x
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.135
IUBMB Enzyme Nomenclature: 1.14.13.135
ExPASy - ENZYME nomenclature database: 1.14.13.135
BRENDA, the Enzyme Database: 1.14.13.135

  All links  
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
All databases (13)   

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