KEGG   ENZYME: 1.14.13.146
Entry
EC 1.14.13.146              Enzyme                                 
Name
taxoid 14beta-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
10beta-hydroxytaxa-4(20),11-dien-5alpha-yl-acetate,NADPH:oxygen 14-oxidoreductase
Reaction(IUBMB)
10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O [RN:R09867]
Reaction(KEGG)
R09867
Substrate
10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate [CPD:C11898];
O2 [CPD:C00007];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate [CPD:C20151];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Requires cytochrome P450. From the yew Taxus cuspidata. Also acts on taxa-4(20),11-dien-5alpha-yl acetate.
History
EC 1.14.13.146 created 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20512  taxoid 14beta-hydroxylase
Reference
1  [PMID:12729625]
  Authors
Jennewein S, Rithner CD, Williams RM, Croteau R
  Title
Taxoid metabolism: Taxoid 14beta-hydroxylase is a cytochrome P450-dependent monooxygenase.
  Journal
Arch Biochem Biophys 413:262-70 (2003)
DOI:10.1016/S0003-9861(03)00090-0
  Sequence
[ag:AAO66199]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.146
IUBMB Enzyme Nomenclature: 1.14.13.146
ExPASy - ENZYME nomenclature database: 1.14.13.146
BRENDA, the Enzyme Database: 1.14.13.146

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (3)   
   UniProt (2)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (22)   

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