KEGG ENZYME: 1.14.18.3

ENZYME: 1.14.18.3

Entry

EC 1.14.18.3                Enzyme

Name

methane monooxygenase (particulate)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

methane,quinol:oxygen oxidoreductase

Reaction(IUBMB)

methane + quinol + O2 = methanol + quinone + H2O [RN:R09518]

Reaction(KEGG)

R09518

Substrate

methane [CPD:C01438];
quinol [CPD:C15603];
O2 [CPD:C00007]

Product

methanol [CPD:C00132];
quinone [CPD:C15602];
H2O [CPD:C00001]

Comment

Contains copper. It is membrane-bound, in contrast to the soluble methane monooxygenase (EC 1.14.13.25).

History

EC 1.14.18.3 created 2011

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

Orthology

K10944

methane/ammonia monooxygenase subunit A

Genes

MCA:	MCA1797(pmoA) MCA2854(pmoA2)

METU:

GNH96_03570 GNH96_09690

MMEO:

OOT43_00490 OOT43_14055

MMT:	Metme_0304

MDN:	JT25_004545 JT25_012445

MDH:	AYM39_18580 AYM39_19770

MKO:	MKLM6_3758 MKLM6_3997

METL:

U737_00525 U737_22530

MPAD:

KEF85_05595 KEF85_15100

MELL:

IVG45_01190 IVG45_17415

MRP:	NM686_001765

MMOT:

QZJ86_01655(amoA)

MAH:	MEALZ_0515(pmoA)

MBUR:

EQU24_19305

MPSY:

CEK71_17435

MMAI:

sS8_1788 sS8_3977

MSZE:

MSZNOR_3294(pmoA) MSZNOR_4515(pmoA)

MMOB:

F6R98_01475 F6R98_16060

MEIN:

methR_P0112

MOZ:	MoryE10_29180 MoryE10_29210

MISZ:

MishRS11D_20920 MishRS11D_40480 MishRS11D_42080

MESL:

KKZ03_06640

MEIY:

MIN45_P0548 MIN45_P2284

MCAU:

MIT9_P0452 MIT9_P0923

NOC:

Noc_2502

NHL:

Nhal_0676

NWA:

Nwat_0632

NWR:	E3U44_00915

NTT:	TAO_1521(amoA)

NTG:	NSCAC_1278(amoA)

HPSE:

HPF_13160(pmoA1)

NEU:	NE0944(amoA1) NE2063(amoA2)

NET:	Neut_2077 Neut_2318

NIT:	NAL212_0798 NAL212_1387 NAL212_2605

NII:	Nit79A3_0472 Nit79A3_1080 Nit79A3_2885

NCO:	AAW31_01085 AAW31_05380

NUR:	ATY38_01310 ATY38_07255 ATY38_13755

NST:	Nstercoris_00328 Nstercoris_01426

NMU:	Nmul_A0799 Nmul_A2325 Nmul_A2765

NLC:	EBAPG3_006230 EBAPG3_014830 EBAPG3_15005

NIZ:	NNRS527_00820 NNRS527_02502 NNRS527_03102

AZR:	CJ010_10955

BAUT:

QA635_32490

MEDK:

QEV83_09615(amoA)

MSC:	BN69_0203(pmoA2) BN69_2827(pmoA) BN69_3534(pmoA)

MBRY:

B1812_00565 B1812_13465 B1812_14775 B1812_18680

MROS:

EHO51_01980 EHO51_08605

MHEY:

H2LOC_006300 H2LOC_011625 H2LOC_017530

MPAR:

F7D14_03105 F7D14_11665 F7D14_16695

MIWA:

SS37A_06920 SS37A_17860 SS37A_28170

MTW:	CQW49_01220 CQW49_10255

MECQ:

MSC49_20790 MSC49_22310 MSC49_34660

MDX:	BTO20_38255

MCB:	Mycch_5910

MRH:	MycrhN_3041

MIN:	Minf_1507(pmoA) Minf_1510(pmoA) Minf_1590(pmoA)

MKC:	kam1_1359(pmoA3) kam1_1509(pmoA2) kam1_1512(pmoA1) kam1_1972(pmoA4)

MFH:	MFUM_1605(pmoA3) MFUM_1792(pmoA1) MFUM_1795(pmoA2)

MCAO:

IT6_09400 IT6_09940 IT6_09955

MEAP:

MTHMO_0894(pmoA1) MTHMO_0897(pmoA2)

NIO:	NITINOP_1853(amoA)

NKF:	Nkreftii_003170

MOX:	DAMO_2450(pmoA)

NMR:

Nmar_1500

NIR:	NSED_08255

NKR:	NKOR_08170

NID:	NPIRD3C_2147(amoA)

NIN:	NADRNF5_0394(amoA)

NIW:	Nisw_06415

NCL:	C5F47_07870

NOX:	C5F49_07755

NUE:	C5F50_11085

NIP:	NsoK4_00795

NZT:	NZOSNM25_000290

NCT:

NMSP_0259

NIC:	DSQ20_08765

NGA:	Ngar_c25350(amoA)

NVN:	NVIE_027270(amoA)

NEV:

NTE_00961

TAA:	NMY3_03280

NFN:	NFRAN_0675(amoA)

NCV:	NCAV_0492(amoA)

CSY:	CENSYa_0402

NBV:

T478_0302

TAH:	SU86_008325

NIU:	DSQ19_08460

NCK:	QVH35_01005

NDV:	NDEV_1777(amoA)

» show all

Reference

1 [PMID:7646068]

Authors

Shiemke AK, Cook SA, Miley T, Singleton P

Title

Detergent solubilization of membrane-bound methane monooxygenase requires plastoquinol analogs as electron donors.

Journal

Arch Biochem Biophys 321:421-8 (1995)
DOI:10.1006/abbi.1995.1413

Sequence

[mca:MCA1797 MCA2854]

Reference

2 [PMID:12379148]

Authors

Basu P, Katterle B, Andersson KK, Dalton H

Title

The membrane-associated form of methane mono-oxygenase from Methylococcus capsulatus (Bath) is a copper/iron protein.

Journal

Biochem J 369:417-27 (2003)
DOI:10.1042/BJ20020823

Sequence

[mca:MCA1797 MCA2854]

Reference

3 [PMID:16101279]

Authors

Kitmitto A, Myronova N, Basu P, Dalton H

Title

Characterization and structural analysis of an active particulate methane monooxygenase trimer from Methylococcus capsulatus (Bath).

Journal

Biochemistry 44:10954-65 (2005)
DOI:10.1021/bi050820u

Sequence

[mca:MCA1797 MCA2854]

Reference

4 [PMID:17444606]

Authors

Balasubramanian R, Rosenzweig AC

Title

Structural and mechanistic insights into methane oxidation by particulate methane monooxygenase.

Journal

Acc Chem Res 40:573-80 (2007)
DOI:10.1021/ar700004s

Other DBs

ExplorEnz - The Enzyme Database:

1.14.18.3

IUBMB Enzyme Nomenclature:

1.14.18.3

ExPASy - ENZYME nomenclature database:

1.14.18.3

BRENDA, the Enzyme Database:

1.14.18.3

DBGET integrated database retrieval system