KEGG   ENZYME: 1.14.99.11
Entry
EC 1.14.99.11               Enzyme                                 
Name
estradiol 6beta-monooxygenase;
estradiol 6beta-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)
Reaction(IUBMB)
estradiol-17beta + reduced acceptor + O2 = 6beta-hydroxyestradiol-17beta + acceptor + H2O [RN:R03086]
Reaction(KEGG)
R03086
Substrate
estradiol-17beta [CPD:C00951];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
6beta-hydroxyestradiol-17beta [CPD:C03935];
acceptor [CPD:C00028];
H2O [CPD:C00001]
History
EC 1.14.99.11 created 1965 as EC 1.14.1.10, transferred 1972 to EC 1.14.99.11
Pathway
ec00140  Steroid hormone biosynthesis
Reference
1
  Authors
Haines, W.J.
  Title
The biosynthesis of adrenal cortex hormones.
  Journal
Recent Progr Hormone Res 7:255-305 (1952)
Reference
2
  Authors
Mueller, G.C. and Rumney, G.
  Title
Formation of 6beta-hydroxy and 6-keto derivatives of estradiol-16-C14 by mouse liver microsomes.
  Journal
J Am Chem Soc 79:1004-1005 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.11
IUBMB Enzyme Nomenclature: 1.14.99.11
ExPASy - ENZYME nomenclature database: 1.14.99.11
BRENDA, the Enzyme Database: 1.14.99.11
CAS: 9029-70-3

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (10)   

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