Entry
Name
androst-4-ene-3,17-dione monooxygenase;
androstene-3,17-dione hydroxylase;
androst-4-ene-3,17-dione 17-oxidoreductase;
androst-4-ene-3,17-dione hydroxylase;
androstenedione monooxygenase;
4-androstene-3,17-dione monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)
Reaction(IUBMB)
androstenedione + reduced acceptor + O2 = testololactone + acceptor + H2O [RN:
R01833 ]
Reaction(KEGG)
Substrate
Product
Comment
Has a wide specificity. A single enzyme from the ascomycete Neonectria radicicola (EC
1.14.13.54 , ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC
1.14.99.4 , progesterone monooxygenase.
History
EC 1.14.99.12 created 1972, modified 1999
Pathway
ec00140 Steroid hormone biosynthesis
Reference
Authors
PRAIRIE RL, TALALAY P.
Title
Enzymatic formation of testololactone.
Journal
Other DBs