KEGG   ENZYME: 1.14.99.48
Entry
EC 1.14.99.48               Enzyme                                 
Name
heme oxygenase (staphylobilin-producing);
haem oxygenase (ambiguous);
heme oxygenase (decyclizing) (ambiguous);
heme oxidase (ambiguous);
haem oxidase (ambiguous);
heme oxygenase (ambiguous);
isdG (gene name);
isdI (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
protoheme,hydrogen-donor:oxygen oxidoreductase (delta/beta-methene-oxidizing, hydroxylating)
Reaction(IUBMB)
(1) protoheme + 5 reduced acceptor + 4 O2 = beta-staphylobilin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O [RN:R10468];
(2) protoheme + 5 reduced acceptor + 4 O2 = delta-staphylobilin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O [RN:R10510]
Reaction(KEGG)
R10468 R10510
Substrate
protoheme [CPD:C00032];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
beta-staphylobilin [CPD:C20667];
Fe2+ [CPD:C14818];
formaldehyde [CPD:C00067];
acceptor [CPD:C00028];
H2O [CPD:C00001];
delta-staphylobilin [CPD:C20666]
Comment
This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin. The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % delta-staphylobilin, respectively.
History
EC 1.14.99.48 created 2013
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K07145  heme oxygenase (staphylobilin-producing)
Genes
VITADP71_24520
VSTLVJ81_01930
VMSLVJ82_12060
SDOSD1155_00595
BSUBSU07150(yetG)
BSRI33_0806
BSLA7A1_1759
BSHBSU6051_07150(yetG)
BSYI653_03610
BSUTBSUB_00788(hmoA)
BSULBSUA_00788(hmoA)
BSUSQ433_04020
BSOBSNT_07101
BSNBSn5_15480
BSQB657_07150(hmoA)
BSXC663_0743(yetG)
BSPU712_03610
BSSBSUW23_03645(yetG)
BSTGYO_0975
BITBIS30_14200
BAYRBAM_007300
BAQBACAU_0699(yetG)
BYABANAU_0651(yetG)
BAMPB938_03450
BQYMUS_0716(yetG)
BAMLBAM5036_0649(hmoA)
BAMARBAU_0713(hmoA)
BAMNBASU_0690(hmoA)
BAMBBAPNAU_0661(yetG)
BAMTAJ82_04065
BAMYV529_06760(yetG)
BMPNG74_00725(hmoA)
BAOBAMF_0686(yetG)
BAZBAMTA208_03235(yetG)
BQLLL3_00735(yetG)
BXHBAXH7_00680(yetG)
BAMIKSO_016125
BAMCU471_07060
BAMFU722_03630
BSIACWD84_18370
BAEBATR1942_01160
BVMB9C48_03645
BSONS101395_01740(isdG)
BHTDIC78_06215
BMOJHC660_07630(hmoA)
BTEQG4P54_03795(hmoA)
BIQAN935_03760
BSTRQI003_03965(hmoA)
BANBA_2987 BA_4782(isdG)
BARGBAA_2987 GBAA_4782
BATBAS2776 BAS4437
BAHBAMEG_1617 BAMEG_4814(isdG)
BAIBAA_3041 BAA_4795(isdG)
BAXH9401_2849 H9401_4564
BANTA16_30140 A16_47730
BANRA16R_30600 A16R_48410
BANSBAPAT_2864 BAPAT_4588
BANHHYU01_14770 HYU01_23305
BANVDJ46_1749 DJ46_3451(isdG)
BCEBC2969 BC4542
BCABCE_3024 BCE_4666
BCZBCE33L2706(yetG) BCE33L4287
BCRBCAH187_A3023 BCAH187_A4669(isdG)
BCBBCB4264_A2988 BCB4264_A4651(isdG)
BCUBCAH820_2983 BCAH820_4656(isdG)
BCGBCG9842_B0586(isdG) BCG9842_B2256
BCQBCQ_2805(yetG) BCQ_4348
BCXBCA_3058 BCA_4648(isdG)
BALBACI_c29410 BACI_c45330
BNCBCN_2829 BCN_4443
BCFbcf_14575 bcf_22735
BCERBCK_12535 BCK_19975
BCEFBcrFT9_02339
BCYBcer98_2029
BTKBT9727_2725(yetG) BT9727_4276
BTLBALH_2673 BALH_4126
BTBBMB171_C2672 BMB171_C4187(isdG)
BTTHD73_3002 HD73_4836
BTHRYBT1520_14770 YBT1520_23995
BTHIBTK_14870 BTK_23835
BTCCT43_CH2970 CT43_CH4562(isdG)
BTFYBT020_14855 YBT020_22325
BTMMC28_2172 MC28_3822(isdG)
BTGBTB_c30980(yetG) BTB_c46910(isdG)
BTIBTG_04480 BTG_26165
BTNBTF1_12380 BTF1_21250
BTHTH175_ch3021 H175_ch4635
BTHUYBT1518_16415 YBT1518_25125
BTWBF38_295(isdG) BF38_4139
BTHYAQ980_07180 AQ980_16125
BWEBcerKBAB4_2781 BcerKBAB4_4370
BWWbwei_0354(isdG) bwei_2040
BMYOBG05_1501(isdG) BG05_3039
BTYBtoyo_0267 Btoyo_1780
BMYCDJ92_71
BBYCY96_13690 CY96_21850
BWDCT694_15945 CT694_24270
BTROFJR70_04240 FJR70_16455(isdG)
BMOBMLA2C4_15715 MLA2C4_23605
BNTGSN03_14395 GSN03_21575
BPACLMD38_04210(isdG) LMD38_12180(hmoA)
BPANNLJ82_14005(hmoA) NLJ82_22225(isdG)
BALUQRY64_16990(hmoA) QRY64_25600(isdG)
BIFN288_04365
BWHA9C19_20435
BCABEFK13_04130(hmoA)
BRYM0696_04110(hmoA)
BJSMY9_0807
GSTHW35_12025
BACPSB24_06200
BACBOY17_06315
BACOOXB_2435
BACYQF06_02480
BACLBS34A_08140(yetG)
BALMBsLM_0754
BACSAUL54_07150
BACQDOE78_03345
BZHNF868_16190
BCAOLC087_11600
BARDQRY57_15020
BCOBcell_0394 Bcell_1360
BCOHBC6307_02495 BC6307_08775
BCIRC2I06_18370
NTXNQZ71_12910 NQZ71_16890
PKSIE339_13780 IE339_16400
BHABH3293 BH3883
BKWBkAM31D_25155(hmoA)
BCLABC1472 ABC1946 ABC3425
BLEBleG1_3399
SHUAPQ477_04645 PQ477_14950
BGIBGM20_18740
BPFBpOF4_08900(yetG) BpOF4_11030
BONA361_02340
BKOCKF48_02480 CKF48_11485 CKF48_17440
CSUAIM538_06905
CFIRNAF01_02335
CSOALIS82_19825
CSPGLS684_19930
CPSSM5V91_19855
OCNCUC15_03770
OCBCV093_03880
GTMGT3921_04975 GT3921_15985
GLIGLN3_13780
GCTGC56T3_2845
GMCGY4MC1_3571
GEJA0V43_00950
GZAIC807_17130
GTHGeoth_3684
PTLAOT13_04560
AFLAflv_2491
AGNAFK25_12830
ASEDIRT44_16690
LSPBsph_3066 Bsph_4360 Bsph_4673
LGYT479_21725 T479_23240
LFUHR49_00590 HR49_02385
LYSLBYS11_20915 LBYS11_22505
LYBC3943_24620 C3943_26455
LYZDCE79_05315 DCE79_17140
LYGC1N55_18660
LPAKGDS87_22120 GDS87_23775
LAGRFJQ98_24045 FJQ98_25930
LMACI6G82_19470 I6G82_21435
LYCFH508_0021980 FH508_0023325
LCAPICJ70_00925 ICJ70_02875
LYPMTP04_35780(hmoA)
LIUOU989_20350 OU989_21955
LLBR6U77_07350 R6U77_07380
HSANMUN89_11475
TAPGZ22_12845
VIRX953_07825
VHLBME96_06720
VIGBKP57_15785
VPNA21D_01200(isdG)
VIKKFZ58_07785
APAKAP3564_01100 AP3564_01135
ACOPRI196_16445 RI196_16515
BSJUP17_24860
BMURABE28_003985 ABE28_023625
PBUTDTO10_11530
PASABAOM_5089(isdG)
PPSRI6J18_13400 I6J18_14750
PFRIL8956_04465 L8956_26355
PSYHD0S48_12670 D0S48_20300
PSYOPB01_20345 PB01_20455
PSYBKD050_08565
PRDF7984_11975 F7984_16060
SCIAHUG15_08160
NDTL1999_14880
MLITKDJ21_008435
BLENNCTC4824_03741(isdI)
RAZU9J35_02960
BAGBcoa_2560
BOUI5818_11645
BBEVBBEV_2100
BSEBsel_2560
SLMSMM221_02285 MM221_11730
MJOFOF60_03680
FHLOE105_02135
FAFOE104_09005
ECTOMUG87_15600
ALKLMM271_02645 MM271_15145
PHJLC071_14680
DOMRRU94_04490 RRU94_11400
AHALFTX54_006045
SAUSA0160 SA0983(isdG)
SAVSAV0165 SAV1136
SAWSAHV_0164 SAHV_1127
SAHSaurJH1_0156 SaurJH1_1217
SAJSaurJH9_0151 SaurJH9_1195
SAMMW0140 MW1018(isdG)
SASSAS0140 SAS1070
SARSAR0167 SAR1109
SACSACOL0152 SACOL1146
SAXUSA300HOU_0179(isdG1) USA300HOU_1069(isdG2)
SAASAUSA300_0168 SAUSA300_1035
SAOSAOUHSC_00130 SAOUHSC_01089
SAENWMN_0111 NWMN_1047(isdG)
SADSAAV_0133 SAAV_1102
SUUM013TW_0155(isdI) M013TW_1069(isdG)
SUVSAVC_00595 SAVC_04845
SUESAOV_0112 SAOV_1132
SUJSAA6159_00149(isdI) SAA6159_00990(isdG)
SUKSAA6008_00143(isdI) SAA6008_01090(isdG)
SUCECTR2_129 ECTR2_990
SUTSAT0131_00156 SAT0131_01176
SUQHMPREF0772_10333(isdI) HMPREF0772_12097(isdG)
SUZMS7_0159(isdI) MS7_1092(isdG)
SUDST398NM01_0179 ST398NM01_1132
SUXSAEMRSA15_01310 SAEMRSA15_09650
SUWSATW20_01760(isdI) SATW20_11300(isdG)
SUGSAPIG0179 SAPIG1132
SUFSARLGA251_01390(isdI) SARLGA251_10480(isdG)
SAUASAAG_00648 SAAG_02244
SAUERSAU_000119(isdI) RSAU_001020(isdG)
SAUNSAKOR_00145 SAKOR_01057
SAUSSA40_0132(isdI) SA40_1006(isdG)
SAUUSA957_0147(isdI) SA957_1021(isdG)
SAUGSA268_0144(isdI) SA268_1024(isdG)
SAUZSAZ172_0175 SAZ172_1135(isdI)
SAUFX998_0148(isdI) X998_1133(isdG)
SABSAB1000
SUYSA2981_0166(isdI) SA2981_1092(isdG)
SAUBC248_0154 C248_1162
SAUMBN843_10400 BN843_1710
SAUCCA347_1050(isdI) CA347_177(isdI)
SAURSABB_00362(isdG) SABB_01676(isdI)
SAUIAZ30_00865 AZ30_05430
SAUDCH52_00210 CH52_04900
SAMSNI36_00760 NI36_05470
SUHSAMSHR1132_01390 SAMSHR1132_09820
SERSERP1773
SEPSE_1764
SEPPSEB_01773
SEPSDP17_717
SHASH0867
SHHShL2_00760(isdI)
SSPSSP0713
SCASCA_0030 SCA_1676
SLGSLGD_00072 SLGD_00101
SLNSLUG_01000(isdG)
SSDSPSINT_2202
SDTSPSE_0265(isdI)
SDPNCTC12225_00319(isdI)
SWAA284_03620
SPASSTP1_0602(isdG)
SXYBE24_08420
SXLSXYLSMQ121_0745
SXOSXYL_00755(isdG)
SHUSHYC_11695(isdI)
SCAPAYP1020_0461(isdG) AYP1020_1366(isdI)
SSCHLH95_01615
SSCZRN70_01955
SAGQEP23_10475
SEQOSE1039_18640
SSIFAL483_01460 AL483_06750
SCVA4G25_07625 A4G25_11745
SPETCEP67_04900 CEP67_09800
SLZB5P37_04670
SCOHBZ166_07990
SNLBJD96_03890
SKLC7J89_05070
SFQC7J90_04415
SHOMEGX58_07775
SCARDWB96_03785 DWB96_08955
SCHRDWB92_11750
SARLSAP2_07790(isdG)
SPICSAMEA4384060_0856(isdI)
SSHNCTC13712_00120(isdI) NCTC13712_01080(isdG)
SDBCNQ82_10340
SLLOISP08_03735
SAULI6G39_09720
SSACI6I31_00895
SRAILN051_11000
SPSDJMB28_04225
STASHYI43_04075
SURYMUA21_09170
SEDAMNY58_03790
SCAQQMO72_03735
SDEVQ2T90_03585 Q2T90_07335
SROTML435_00655(isdI) ML435_05185(isdG)
STAPAOB58_2571
SSCUCEP64_00990 CEP64_01350
SFFFOB90_06180
SSTESAMEA4384403_0335(isdG)
MLENH3V22_06945 H3V22_07340
MVTI6J10_09370
MACRBHM04_08380
MARYLAU42_01910
MBRUMGG13_02205
MEPIKFV12_02495
MEQUKFV11_01900
MBOCQSV55_02205
MCLMCCL_0304
MCAKMCCS_04680(isdG)
MBOEHT586_02430
SHVAAT16_00590
LMOlmo0484
LMNLM5578_0507
LMYLM5923_0506
LMTLMRG_00165
LMOCLMOSLCC5850_0477
LMOEBN418_0554
LMOBBN419_0559
LMODLMON_0484
LMOWAX10_10940
LMOQLM6179_00783(isdG)
LMRLMR479A_0491(isdG)
LMOMIJ09_07955
LMFLMOf2365_0511
LMCLm4b_00504
LMOGBN389_05190(isdG)
LMPMUO_02665
LMOLLMOL312_0486
LMOJLM220_06802
LMOZLM1816_10672(isdG)
LMOXAX24_15315
LMHLMHCC_2158
LMQLMM7_0504(isdG)
LMLlmo4a_0489
LMGLMKG_01417
LMSLMLG_2751
LMJLMOG_02285
LMWLMOSLCC2755_0482
LMXLMOSLCC2372_0492
LMZLMOSLCC2482_0478
LMONLMOSLCC2376_0465
LMOSLMOSLCC7179_0457
LMOOLMOSLCC2378_0506
LMOYLMOSLCC2479_0491
LMOTLMOSLCC2540_0489
LMOALMOATCC19117_0511
LMOKCQ02_02645
LMVY193_13320(isdG)
LINlin0487
LWElwe0452
LSGlse_0393
LIVLIV_0383
LIIJL52_02250
LIWAX25_02300
LIAJL58_02320
LIOJL53_02630
LGZNCTC10812_00640(isdG)
LMARLAX80_002200(isdG)
BTHSCNY62_04265
ESIExig_1574 Exig_2978
EATEAT1b_1853
EANEab7_1452 Eab7_2788
EXMU719_06025 U719_08705 U719_16210
EXUESP131_01830 ESP131_10790
EAPKB235_01020
EACEKKI46_08595 KKI46_16075
EAURNMQ00_15160
EMMPTI97_00420
EPFOE059_14400
BBEBBR47_55400
BLRBRLA_c025910(hmoA)
BFMBP422_23370
BAGRBA6348_04585
BRWGOP56_05490
BCHSJNE38_22715
BPABPSE45_26340
BHUILOK74_22480
BAYDBSPP4475_08670
BBORRFB14_19695
BRUMNDK47_20450
PJDPjdr2_1740 Pjdr2_5714
GYMGYMC10_2490 GYMC10_6028
PPYPPE_04042
PPMPPSC2_21345(isdG)
PPOPPM_4254(isdG)
PPOLX809_37370
PPQPPSQR21_043140
PPOYRE92_15910
PMSKNP414_04593 KNP414_07671
PMQPM3016_7201
PMWB2K_36325
PTAHPL003_02775
PLVERIC2_c04680 ERIC2_c36970
PSABPSAB_22785
PDUPDUR_25720
PBDPBOR_16395 PBOR_34135
PGMPGRAT_30540
PODPODO_29020
PAENP40081_16645 P40081_35465
PAEFR50345_29115
PAEQR50912_32090
PSTEPSTEL_25545
PAEAR70723_14230
PAEER70331_13695 R70331_22600
PAEHH70357_15740 H70357_33225
PAEJH70737_28735
PBJVN24_12485
PIHUB51_23290
PRIPRIO_6394
PSONJI735_06715
PPEOABE82_21300
PNPIJ22_07840
POWIJ21_31410
PBVAR543_16015 AR543_21280
PSWUSY83_12315
PIBBBD41_02425 BBD41_15810
PCXLPB68_12905 LPB68_20995
PKBB4V02_04110
PAIHASL14_16680
PVOPVOR_00360
PLWD5F53_17200 D5F53_31640
PLENEIM92_05810
PLUTEI981_04000
PCHIPC41400_13760 PC41400_26280
PBKBack11_53110
PPRTET464_05885
PRZGZH47_21285
PLYCGXP70_25260
PSOPKP014_01355
PTRIKDC22_31100
PALOE6C60_2147 E6C60_3995
PCELHUB94_13105 HUB94_26575
PTJJRJ22_11670 JRJ22_27440
PALRHGI30_02855 HGI30_11610
PTHINDS46_19535 NDS46_20230
PKAPQ456_13650 PQ456_18600
PUIPUW25_15000
PMAHPTQ21_19935
PDYQJQ58_01890 QJQ58_02460
PMAELMZ02_10340 LMZ02_10555
PWNQNH46_08540 QNH46_20850
PSPNL1F29_29830 L1F29_31405
PPOGQPK24_14725
PHKSK066_09840 SK066_19690
PNKAASFL403_00475 AASFL403_05420
PPABKET34_15890
PKPSK3146_00083(hmoA) SK3146_04304(isdG)
COHNKCTCHS21_04450 KCTCHS21_40840(isdG)
CCHLFPL14_01030 FPL14_15930
CHEBHH215_08055 HH215_10700 HH215_25200
AFXJZ786_17525
SIVSSIL_0376 SSIL_2825
SSILSOLI23_04510 SOLI23_16930
SOBCSE16_05455 CSE16_19850
PKUAUO94_00980
PRTAUC31_10905
PLLI858_008175
PANABBH88_03675
PDGBCM40_00610
PHCBBI08_11820
PMARB0X71_18150
PPLABBI15_11125
PFAEAJGP001_16750
PLXCW734_17510
PMATBBI11_00290
PDECH1Q58_15825
PGQFK545_16750
KURASO14_2756 ASO14_689 ASO14_969
KZONCTC404_00637(isdI_1) NCTC404_02707(isdG) NCTC404_03056(isdI_2)
SPSYAZE41_20890
SURESporoP32a_01985 SporoP32a_12550 SporoP32a_12910
SPOSDV702_00455
RSTATY39_05175 ATY39_15730
PLAYDNR44_001150
VIJJNUCC6_13145 JNUCC6_16270
UTHDKZ56_02600 DKZ56_08620
KEBGXN75_11305
ESSATZ33_06225
ASANAWM72_03805
CMLBN424_3514(isdG)
CDJBFC22_01655
DMTDESME_06340
DAIDesaci_3127
DMIDesmer_2655
ROCHF520_02730
ERHERH_0453
ERSK210_00215
ERIEEI45_07660
ERDG7062_02660
EIOH9L01_07045
ACLACL_0959
AOCAocu_05200
AHKNCTC10172_00044
ABRABN85311450
APALBN85405740
AAXANCTC10138_01404(isdG)
SFKKY5_6671c
SKACP970_07275
ACITHPK19_13845
RRDRradSPS_1219
RUBGBA63_09020
KBSEPA93_21140
KBBccbrp13_45780
PBTING2E5B_1869
PSACPSM36_1783
HALMFCF25_01275
HTUHtur_4641
HXAHalxa_0670
 » show all
Reference
1  [PMID:20180905]
  Authors
Reniere ML, Ukpabi GN, Harry SR, Stec DF, Krull R, Wright DW, Bachmann BO, Murphy ME, Skaar EP
  Title
The IsdG-family of haem oxygenases degrades haem to a novel chromophore.
  Journal
Mol Microbiol 75:1529-38 (2010)
DOI:10.1111/j.1365-2958.2010.07076.x
  Sequence
[sau:SA0160]
Reference
2  [PMID:23600533]
  Authors
Matsui T, Nambu S, Ono Y, Goulding CW, Tsumoto K, Ikeda-Saito M
  Title
Heme degradation by Staphylococcus aureus IsdG and IsdI liberates formaldehyde rather than carbon monoxide.
  Journal
Biochemistry 52:3025-7 (2013)
DOI:10.1021/bi400382p
Reference
3  [PMID:26534961]
  Authors
Streit BR, Kant R, Tokmina-Lukaszewska M, Celis AI, Machovina MM, Skaar EP, Bothner B, DuBois JL
  Title
Time-resolved Studies of IsdG Protein Identify Molecular Signposts along the Non-canonical Heme Oxygenase Pathway.
  Journal
J Biol Chem 291:862-71 (2016)
DOI:10.1074/jbc.M115.666560
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.48
IUBMB Enzyme Nomenclature: 1.14.99.48
ExPASy - ENZYME nomenclature database: 1.14.99.48
BRENDA, the Enzyme Database: 1.14.99.48

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