KEGG ENZYME: 1.2.7.6

ENZYME: 1.2.7.6

Entry

EC 1.2.7.6                  Enzyme

Name

glyceraldehyde-3-phosphate dehydrogenase (ferredoxin);
GAPOR;
glyceraldehyde-3-phosphate Fd oxidoreductase;
glyceraldehyde-3-phosphate ferredoxin reductase

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor

Sysname

D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase

Reaction(IUBMB)

D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin [RN:R07159]

Reaction(KEGG)

R07159

Substrate

D-glyceraldehyde-3-phosphate;
H2O [CPD:C00001];
oxidized ferredoxin [CPD:C00139]

Product

3-phospho-D-glycerate [CPD:C00197];
H+ [CPD:C00080];
reduced ferredoxin [CPD:C00138]

Comment

Contains tungsten-molybdopterin and iron-sulfur clusters. This enzyme is thought to function in place of glyceralde-3-phosphate dehydrogenase and possibly phosphoglycerate kinase in the novel Embden-Meyerhof-type glycolytic pathway found in Pyrococcus furiosus [1]. It is specific for glyceraldehyde-3-phosphate.

History

EC 1.2.7.6 created 2003

Pathway

ec00010

Glycolysis / Gluconeogenesis

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K11389

glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)

Genes

HTL:

HPTL_0438

GBZ:	JZM60_01480

GUR:

Gura_2648

GSB:	GSUB_04300

GHC:	L9S41_05750

DVE:	DESUT3_35540

DEP:

AOP6_1474

DOL:

Dole_2101

TOP:	TOPB45_0887

TCM:	HL41_05125

THET:

F1847_01705

ATM:

ANT_14840

TTZ:	FHG85_03385

TAM:	Theam_0376

MJA:

MJ_1185

MFE:	Mefer_0232

MVU:	Metvu_1517

MFS:	MFS40622_0815

MIF:	Metin_0063

MJH:	JH146_0660

MESG:

MLAUSG7_1051

MESA:

MLASG1_0727

MIG:	Metig_1727

MMP:

MMP0945

MMQ:	MmarC5_0752

MMX:	MmarC6_1710

MMZ:	MmarC7_0192

MMD:

GYY_05445

MMAK:

MMKA1_10440(gor)

MMAO:

MMOS7_10210(gor)

MMAD:

MMJJ_00460

MAE:

Maeo_0444

MVN:	Mevan_0244

MVO:

Mvol_0992

MOK:	Metok_1283

METF:

CFE53_04735

PFU:

PF0464

PFI:

PFC_01435

PHO:	PH0457(PH0457)

PAB:

PAB1315

PYN:

PNA2_1087

PYA:	PYCH_18690

PYS:

Py04_0640

PYC:	TQ32_02200

TKO:

TK2163

TON:

TON_1498

TGA:	TGAM_0122(gor)

TSI:

TSIB_1686

TBA:	TERMP_01833

THE:

GQS_07935

THA:

TAM4_1410

THM:

CL1_1206

TLT:

OCC_05826

THS:

TES1_1819

TNU:

BD01_1964

TEU:

TEU_01570

TGY:	X802_04465

THV:	ADU37_CDS17140

TCH:	CHITON_1291

TPEP:

A0127_04735

TPIE:

A7C91_04780

TGG:	A3K92_09145

TCE:	A3L02_06445

TBS:	A3L01_08355

THH:	CDI07_07175

TSL:	A3L11_01785

TTD:	A3L14_10725

TPRF:

A3L09_00285

TRL:	A3L10_07815

TPAF:

A3L08_01460

THY:	A3L12_04140

TIC:	FH039_11960

TCQ:	TIRI35C_2006(gor)

THEM:

FPV09_09545

THEI:

K1720_01135

PPAC:

PAP_09975

MEV:	Metev_1886

SMR:

Smar_1582

SHC:	Shell_0821

IHO:

Igni_0296

IIS:

EYM_02335

IPC:

IPA_05820

DKA:

DKAM_0499

DFD:	Desfe_0557

DMU:	Desmu_0616

TAG:

Tagg_0452

IAG:

Igag_1482

THG:	TCELL_0959

PFM:	Pyrfu_0662

PDL:	Pyrde_0538

PABI:

PABY_02940

PARE:

PYJP_14890

PAI:

PAE1029

PIS:

Pisl_1226

PCL:

Pcal_0664

PAS:

Pars_0189

PYR:

P186_2447

POG:

Pogu_2290

TNE:

Tneu_0174

CMA:

Cmaq_0263

TTN:	TTX_2037(gor)

TUZ:

TUZN_1446

VDI:

Vdis_2526

VMO:

VMUT_0871

VSO:	Vsou_23470

ASC:

ASAC_0245

ACIA:

SE86_02005

CLG:	Calag_1301

NAA:

Nps_00740

» show all

Reference

1 [PMID:7721730]

Authors

Mukund S, Adams MW

Title

Glyceraldehyde-3-phosphate ferredoxin oxidoreductase, a novel tungsten-containing enzyme with a potential glycolytic role in the hyperthermophilic archaeon Pyrococcus furiosus.

Journal

J Biol Chem 270:8389-92 (1995)
DOI:10.1074/jbc.270.15.8389

Sequence

[pfu:PF0464]

Reference

2 [PMID:11265456]

Authors

Roy R, Menon AL, Adams MW.

Title

Aldehyde oxidoreductases from Pyrococcus furiosus.

Journal

Methods Enzymol 331:132-44 (2001)
DOI:10.1016/S0076-6879(01)31052-2