KEGG ENZYME: 1.21.99.4

ENZYME: 1.21.99.4

Entry

EC 1.21.99.4                Enzyme

Name

thyroxine 5'-deiodinase;
diiodothyronine 5'-deiodinase [ambiguous];
iodothyronine 5'-deiodinase;
iodothyronine outer ring monodeiodinase;
type I iodothyronine deiodinase;
type II iodothyronine deiodinase;
thyroxine 5-deiodinase [misleading];
L-thyroxine iodohydrolase (reducing)

Class

Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With unknown physiological acceptors

Sysname

3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

Reaction(IUBMB)

3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor [RN:R03734]

Reaction(KEGG)

R03734

Substrate

3,3',5-triiodo-L-thyronine [CPD:C02465];
iodide [CPD:C00708];
acceptor [CPD:C00028];
H+ [CPD:C00080]

Product

L-thyroxine [CPD:C01829];
reduced acceptor [CPD:C00030]

Comment

The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.

History

EC 1.21.99.4 created 1984 as EC 3.8.1.4, transferred 2003 to EC 1.97.1.10, transferred 2015 to EC 1.21.99.4

Orthology

K01562

type I thyroxine 5'-deiodinase

K17904

type II thyroxine 5'-deiodinase

Genes

HSA:	1733(DIO1) 1734(DIO2)

PTR:	467521(DIO2) 469331(DIO1)

PPS:	100972089(DIO2) 100980739(DIO1)

GGO:	101124806(DIO2) 101154004(DIO1)

PON:	100440998(DIO1) 100449335(DIO2)

NLE:	100586423(DIO1) 100606409(DIO2)

HMH:	116457781(DIO1) 116484994(DIO2)

MCC:	707484(DIO2) 714739(DIO1)

MCF:	102122576(DIO2) 102128623(DIO1)

MTHB:

126957933 126962453

MNI:	105495089(DIO1) 105495819(DIO2)

CSAB:

103224787(DIO1) 103229434(DIO2)

CATY:

105590919(DIO2) 105596015(DIO1)

PANU:

100997384(DIO1) 101016937(DIO2)

TGE:	112629280(DIO2) 112633267(DIO1)

MLEU:

105531715(DIO2) 105534880(DIO1)

RRO:	104669397(DIO1) 104677628(DIO2)

RBB:	108530802(DIO2) 108531213(DIO1)

TFN:	117069245(DIO2) 117092556(DIO1)

PTEH:

111523527(DIO1) 111554703(DIO2)

CANG:

105500695(DIO1) 105517099(DIO2)

CJC:	100385960(DIO1) 100406379(DIO2)

SBQ:	101030674(DIO1) 101037342(DIO2)

CIMI:

108286533(DIO1) 108287488(DIO2)

CSYR:

103261496(DIO2)

MMUR:

105867863(DIO2) 105877594(DIO1)

LCAT:

123635626(DIO1) 123640208(DIO2)

PCOQ:

105806366(DIO1) 105819938(DIO2)

OGA:	100944413(DIO1) 100964445(DIO2)

MMU:	13370(Dio1) 13371(Dio2)

MCAL:

110293582(Dio1) 110307003(Dio2)

MPAH:

110323703(Dio1) 110324869(Dio2)

RNO:	25430(Dio1) 65162(Dio2)

MCOC:

116080635(Dio2) 116095481(Dio1)

ANU:	117697413(Dio2) 117709149(Dio1)

MUN:	110551834(Dio2) 110564009(Dio1)

CGE:	100765192(Dio1) 100774757(Dio2)

MAUA:

101835104(Dio2) 101839024(Dio1)

PROB:

127225115(Dio1) 127230855(Dio2)

PLEU:

114697681(Dio2) 114707566(Dio1)

MORG:

121448732(Dio1) 121452546(Dio2)

MFOT:

126497952 126507778

AAMP:

119817304(Dio1) 119819662(Dio2)

NGI:	103732556(Dio2) 103734117(Dio1)

HGL:	101697296(Dio2) 101704592(Dio1)

CPOC:

100715950(Dio1) 100721073(Dio2)

CCAN:

109674806(Dio2) 109684245(Dio1)

DORD:

105984595(Dio2) 105990013(Dio1)

DSP:	122099113(Dio1) 122118891(Dio2)

PLOP:

125355185(Dio1) 125363236(Dio2)

NCAR:

124978289 124991557

MMMA:

107141745(Dio1) 107149676(Dio2)

OCU:	100101570(DIO1) 100354221(DIO2)

OPI:	101519356(DIO2) 101524720(DIO1)

TUP:	102480600(DIO2) 102482647(DIO1)

GVR:	103597970(DIO1) 103603451(DIO2)

CFA:	403635(DIO1) 490813(DIO2)

CLUD:

112647057(DIO1) 125752081(DIO2)

VVP:	112926114(DIO1) 112934900(DIO2)

VLG:	121493787(DIO2) 121499752(DIO1)

NPO:	129496288(DIO2) 129496692(DIO1)

AML:	100466148(DIO1) 100478833(DIO2)

UMR:	103670636(DIO2) 103670695(DIO1)

UAH:	113254643(DIO1) 113270276(DIO2)

UAR:	123793670(DIO1) 123798929(DIO2)

ELK:	111143355 111148782

LLV:	125098953 125103734

MPUF:

101684270(DIO2) 101687410(DIO1)

MNP:	132000126(DIO2) 132000897(DIO1)

MLK:	131809943(DIO1) 131836811(DIO2)

NVS:	122893679(DIO2) 122898706(DIO1)

ORO:	101370186(DIO2) 101370991(DIO1)

EJU:	114201393(DIO2) 114212046(DIO1)

ZCA:	113910440(DIO2) 113925118(DIO1)

MLX:	118002570(DIO2) 118019390(DIO1)

NSU:	110571486(DIO2) 110575062(DIO1)

LWW:	102740976(DIO2) 102749577(DIO1)

FCA:	101088170(DIO2) 493798(DIO1)

PYU:	121027160(DIO1) 121032131(DIO2)

PCOO:

112856155(DIO2) 112871752(DIO1)

PBG:	122469402(DIO2) 122480529(DIO1)

PVIV:

125167172(DIO2) 125172456(DIO1)

LRUF:

124512219 124516410

PTG:	102948967(DIO1) 102963335(DIO2)

PPAD:

109260795(DIO2) 109266846(DIO1)

PUC:	125908981 125912589

AJU:	106975081 106983577

HHV:	120236285(DIO1) 120248619(DIO2)

BTA:	494548(DIO2) 782446(DIO1)

BOM:	102274791(DIO1) 102284841(DIO2)

BIU:	109556270(DIO1) 109565391(DIO2)

BBUB:

102398529(DIO1) 102407472(DIO2)

BBIS:

104991799(DIO2) 104993760(DIO1)

CHX:	102178591(DIO1) 102179571(DIO2)

OAS:	100310792(DIO1) 100310793(DIO2)

BTAX:

128045481(DIO1) 128054567(DIO2)

ODA:	120853618(DIO2) 120856112(DIO1)

CCAD:

122436948(DIO1) 122443921(DIO2)

MBEZ:

129541591(DIO1) 129562940(DIO2)

SSC:	414379(DIO2) 414380(DIO1)

CFR:	102507259(DIO2) 102518353(DIO1)

CBAI:

105066431(DIO1) 105069686(DIO2)

CDK:	105086052(DIO2) 105092845(DIO1)

VPC:	102534145(DIO1) 102541981(DIO2)

BACU:

103005103(DIO1) 103007605(DIO2)

BMUS:

118886745(DIO1) 118891068(DIO2)

LVE:	103074814 103080109(DIO1)

OOR:	101275852(DIO1) 101276046(DIO2)

DLE:	111175838(DIO1) 111176195(DIO2)

PCAD:

102975485(DIO2) 102991668(DIO1)

PSIU:

116749423(DIO2) 116752684(DIO1)

NASI:

112394895(DIO2) 112395896(DIO1)

ECB:	100050359(DIO1) 100052547(DIO2)

EPZ:	103541011(DIO1) 103561958(DIO2)

EAI:	106833199(DIO1) 106834802(DIO2)

MYB:	102248197(DIO2) 102261233(DIO1)

MYD:	102756562(DIO2)

MMYO:

118658770(DIO2) 118674992(DIO1)

MLF:	102424378(DIO2) 102435093(DIO1)

PKL:	118714543(DIO2) 118724627(DIO1)

EFUS:

103284001(DIO1) 103292213(DIO2)

MNA:	107542495(DIO1) 107542686(DIO2)

DRO:	112311947(DIO2) 112314579(DIO1)

SHON:

118976800(DIO2) 118984971(DIO1)

AJM:	119056394(DIO2) 119061272(DIO1)

PDIC:

114491345(DIO2) 114497342(DIO1)

PHAS:

123808645(DIO2) 123830443(DIO1)

MMF:	118627096(DIO1) 118638365(DIO2)

PPAM:

129065855(DIO2) 129070436(DIO1)

HAI:	109384683(DIO2) 109395429(DIO1)

RFQ:	117023789(DIO2) 117027433(DIO1)

PALE:

102879053(DIO2) 102888357(DIO1)

PGIG:

120619567(DIO2) 120621471(DIO1)

PVP:	105290106(DIO2) 105298962(DIO1)

RAY:	107497931(DIO1) 107506706(DIO2)

MJV:	108394944(DIO2) 108395886(DIO1)

TOD:	119236623(DIO1) 119239315(DIO2)

SARA:

101549554(DIO2)

LAV:	100658761(DIO2) 100675470(DIO1)

TMU:	101342540 101353539

ETF:	101650089(DIO2) 101655004(DIO1)

DNM:	101438480 101440823(DIO2)

MDO:	100016991(DIO2) 100617416(DIO1)

GAS:	123237820(DIO2) 123245408(DIO1)

SHR:	100917546(DIO2) 100923092(DIO1)

AFZ:	127549443 127563296

PCW:	110200922(DIO2) 110209375(DIO1)

OAA:	100073387(DIO2) 100088984(DIO1)

GGA:	373903(DIO2) 395940(DIO1)

PCOC:

116228787(DIO2) 116235010(DIO1)

MGP:	100546412(DIO1) 100547728(DIO2)

CJO:	107315160(DIO2) 107317722(DIO1)

TPAI:

128072215(DIO1) 128085722(DIO2)

LMUT:

125693068(DIO1) 125695032(DIO2)

NMEL:

110401421(DIO2) 110402385(DIO1)

APLA:

101798258(DIO1) 101798494(DIO2)

ACYG:

106033047(DIO1) 106044546(DIO2)

CATA:

118243267(DIO1) 118244630(DIO2)

AFUL:

116489880(DIO2) 116492025(DIO1)

TGU:	100224791(DIO2) 100231867(DIO1)

LSR:	110470209(DIO1) 110477260(DIO2)

SCAN:

103815040(DIO1) 103826496(DIO2)

PMOA:

120500423(DIO2) 120503156(DIO1)

OTC:	121333794(DIO2) 121345137(DIO1)

PRUF:

121356005(DIO2) 121362099(DIO1)

GFR:	102037547(DIO1) 102042772(DIO2)

FAB:	101808928(DIO1) 101813353(DIO2)

OMA:	130254045(DIO2) 130255934(DIO1)

PHI:	102107712(DIO1) 102112539(DIO2)

PMAJ:

107206229(DIO2) 107208501(DIO1)

CCAE:

111929932(DIO2) 111933026(DIO1)

CCW:	104685655(DIO2) 104695177(DIO1)

CBRC:

103615045(DIO1) 103621129(DIO2)

ETL:	114055206(DIO1) 114065458(DIO2)

ZAB:	102062222(DIO1) 102075444(DIO2)

ACHL:

103797289(DIO2) 103810651(DIO1)

SVG:	106849308(DIO2) 106849763(DIO1)

MMEA:

130574044(DIO1) 130582263(DIO2)

HRT:	120754748(DIO2) 120756831(DIO1)

FPG:	101918266(DIO1) 101920459(DIO2)

FCH:	102050452(DIO2) 102054399(DIO1)

CLV:	102088777(DIO1) 102092044(DIO2)

EGZ:	104131488(DIO1) 104133264(DIO2)

NNI:	104009277(DIO1) 104023416(DIO2)

PCRI:

104028932(DIO1) 104038662(DIO2)

PLET:

104616823(DIO2) 104622521(DIO1)

EHS:	104505543(DIO1) 104506227(DIO2)

PCAO:

104040845(DIO2) 104040868(DIO1)

ACUN:

113480623(DIO2) 113482767(DIO1)

TALA:

104356820(DIO1) 104360359(DIO2)

PADL:

103912981(DIO2) 103913306(DIO1)

AFOR:

103900139(DIO2) 103905645(DIO1)

ACHC:

115349079(DIO1) 115352985(DIO2)

HALD:

104312814(DIO1) 104317655(DIO2)

HLE:	104841004(DIO1) 104841842(DIO2)

AGEN:

126042313 126049347

GCL:	127017238 127019379

CCRI:

104159933(DIO2) 104162981(DIO1)

CSTI:

104554433(DIO2) 104558222(DIO1)

CMAC:

104475523(DIO1) 104484983(DIO2)

MUI:	104538131 104541817

BREG:

104632030(DIO2) 104638608(DIO1)

FGA:	104072360(DIO1) 104074990(DIO2)

GSTE:

104253187(DIO1) 104254531(DIO2)

LDI:	104342168(DIO1) 104353366(DIO2)

MNB:	103769953(DIO1) 103778292(DIO2)

OHA:	104332867(DIO2) 104334157(DIO1)

NNT:	104405298(DIO1) 104407934(DIO2)

SHAB:

115607222(DIO2) 115611295(DIO1)

DPUB:

104304531(DIO2) 104307013(DIO1)

PGUU:

104460751(DIO2) 104467727(DIO1)

ACAR:

104526232 104532027(DIO1)

CPEA:

104385151(DIO1) 104385455(DIO2)

AVIT:

104269864(DIO1) 104274342(DIO2)

CVF:	104286063(DIO1) 104296067(DIO2)

RTD:	128909333(DIO2) 128913567(DIO1)

CUCA:

104059074(DIO1) 104064447(DIO2)

TEO:	104371532(DIO1) 104376719(DIO2)

BRHI:

104496101(DIO1) 104496635(DIO2)

AAM:	106483152(DIO2) 106497641(DIO1)

AROW:

112974809(DIO2) 112976019(DIO1)

NPD:	112943354(DIO1) 112955018(DIO2)

TGT:	104566351(DIO1) 104570308(DIO2)

DNE:	112986483(DIO1) 112990013(DIO2)

SCAM:

104141269(DIO2) 104149593(DIO1)

ASN:	102372564(DIO1) 102378920(DIO2)

AMJ:	102566890(DIO1) 102570384(DIO2)

CPOO:

109307499(DIO1) 109321489(DIO2)

GGN:	109286631(DIO1) 109298562(DIO2)

PSS:	102445607(DIO1) 102449273(DIO2)

CMY:	102936687(DIO2) 102946702(DIO1)

CCAY:

125638688(DIO2) 125641032(DIO1)

DCC:	119857982(DIO2) 119859885(DIO1)

CPIC:

101940661(DIO2) 101942692(DIO1)

TST:	117876675(DIO2) 117881410(DIO1)

CABI:

116817135(DIO1) 116837495(DIO2)

MRV:	120370494(DIO1) 120403550(DIO2)

ACS:	100553484(dio2) 100561694(dio1)

ASAO:

132763633(DIO2) 132773949(DIO1)

PVT:	110079367(DIO2) 110082244(DIO1)

SUND:

121929412(DIO1) 121931250(DIO2)

PBI:	103054347(DIO1) 103061704(DIO2)

PMUR:

107283018(DIO1) 107283948(DIO2)

CTIG:

120297356(DIO1) 120311723(DIO2)

TSR:	106540457(DIO1) 106547214(DIO2)

PGUT:

117664259(DIO1) 117665881(DIO2)

APRI:

131187817(DIO2) 131194313(DIO1)

PTEX:

113440619(DIO1) 113444061(DIO2)

NSS:	113410007(DIO2) 113411042(DIO1)

VKO:	123023516(DIO1) 123026794(DIO2)

PMUA:

114591388(DIO2) 114598972(DIO1)

PRAF:

128408324(DIO2) 128415744(DIO1)

ZVI:	118081379(DIO2) 118088763(DIO1)

HCG:	128324084(DIO1) 128340963(DIO2)

GJA:	107123704(DIO2) 107124276(DIO1)

STOW:

125426841(DIO2) 125432437(DIO1)

EMC:	129324678(DIO2) 129329939(DIO1)

XLA:	108699835(dio2.S) 373842(dio2.L) 733447(dio1.L)

XTR:	100036737(dio2) 100497874(dio1)

NPR:	108793077(DIO1) 108802676(DIO2)

RTEM:

120921138(DIO2) 120945892

BBUF:

120979317(DIO1) 120982052(DIO2)

BGAR:

122921559 122943044(DIO1)

MUO:	115471911(DIO1) 115477612(DIO2)

GSH:	117363371(DIO2)

DRE:	352937(dio2) 799937(dio1)

SRX:

107751736

SANH:

107680786 107700640

SGH:	107577812 107585920(dio1) 107588276

CCAR:

109070220 109076656

CGIB:

127976580 128018805

PTET:

122361700(dio2)

LROH:

127169540(dio1) 127179429(dio2)

OMC:	131523245(dio2) 131545781 131546363

PPRM:

120479019(dio2) 120482267(dio1)

RKG:	130086119(dio1) 130101442(dio2)

MAMB:

125268512(dio2) 125279278(dio1)

CIDE:

127498874 127517230

MASI:

127415072 127454690

TROS:

130560207(dio2) 130567818(dio1)

TDW:	130437428(dio2) 130440207(dio1)

MANU:

129413902(dio1) 129417842(dio2)

IPU:

108270487

IFU:	128613028(dio2)

PHYP:

113533701(dio2)

SMEO:

124390526(dio2)

TFD:	113649323(dio2)

TVC:	132852950(dio2)

AMEX:

103026954(dio1) 103034785(dio2)

CMAO:

118813944(dio1) 118823442(dio2)

EEE:	113572165(dio2) 113586860(dio1)

CHAR:

105895094(dio1) 105908351(dio2)

TRU:	100191067(dio1) 100191068(dio2)

TFS:	130529234(dio1) 130539690(dio2)

TNG:	GSTEN00020212G001

LCO:	104918439(dio1) 104922564(dio2)

NCC:	104953535(dio2) 104955483 104965519(dio1)

TBEN:

117486325(dio2) 117495411(dio1)

CGOB:

115007479(dio1) 115027761(dio2)

PGEO:

117445681(dio1) 117467405(dio2)

GACU:

117550921(dio1) 117556535(dio2)

EMAC:

134869252(dio1) 134881114(dio2)

ELY:	117253550(dio1)

EFO:	125895389(dio1)

PLEP:

121941229(dio1)

SLUC:

116036769(dio2) 116063484(dio1)

ECRA:

117935962(dio2) 117950951(dio1)

ESP:	116670625(dio2) 116696104(dio1)

PFLV:

114547023(dio2) 114561570(dio1)

GAT:	120824453(dio1) 120833313(dio2)

PPUG:

119216338(dio1) 119227296(dio2)

AFB:	129094520(dio1) 129103631(dio2)

CLUM:

117725486(dio2) 117730120(dio1)

PSWI:

130193690(dio1) 130201822(dio2)

MSAM:

119900835 119909973(dio2) 119918671

SCHU:

122861647(dio2) 122878085(dio1)

CUD:	121512862(dio1) 121526461(dio2)

ALAT:

119028180(dio1) 119034237(dio2)

MZE:	101482729(dio1) 101487411(dio2)

ONL:	100534571(dio1) 100694978(dio2)

OAU:	116318063(dio2) 116333327(dio1)

OLA:	100192348(dio2) 101160798(dio1)

OML:	112136905(dio1) 112147170(dio2)

CSAI:

133458093(dio1) 133462742(dio2)

XMA:	102232010(dio2) 102232075(dio1)

XCO:	114134239(dio2) 114150762(dio1)

XHE:	116709155(dio2) 116725429(dio1)

PRET:

103458987(dio2) 103463606(dio1)

PFOR:

103138738 103138740 103142552(dio1)

PLAI:

106935489(dio2) 106963564(dio1)

PMEI:

106925908(dio1) 106926081 106932062(dio2)

GAF:	122838228(dio1) 122846658(dio2)

PPRL:

129365482(dio2) 129371565(dio1)

CVG:	107081946(dio1) 107096556(dio2)

CTUL:

119772964(dio1) 119787038(dio2)

GMU:	124855266(dio2) 124873849(dio1)

NFU:	107391683(dio2) 107393250(dio1)

KMR:	108230578(dio1) 108244999(dio2)

ALIM:

106513875(dio1) 106519991(dio2)

NWH:	119427800(dio2)

AOCE:

111563633(dio2) 111583913(dio1)

MCEP:

125009014(dio1) 125023122(dio2)

CSEM:

103383367(dio2)

POV:	109625310(dio1) 109627784(dio2)

SSEN:

122780710(dio1) 122783269(dio2)

HHIP:

117755784(dio2) 117759728(dio1)

HSP:	118116908(dio2) 124854833(dio1)

SMAU:

118286600(dio2) 118318791(dio1)

LCF:	108877349 108897919

SDU:	111225744(dio2) 111232163(dio1)

SLAL:

111656316(dio1) 111667262(dio2)

XGL:	120791201(dio1) 120795388(dio2)

HCQ:	109524400(dio2) 109532358(dio1)

SSCV:

125970829 125980850

SBIA:

133503615(dio1) 133512837(dio2)

PEE:	133406273(dio1) 133412956(dio2)

PTAO:

133481163(dio1) 133488330(dio2)

BPEC:

110167782(dio1)

MALB:

109964010(dio1)

BSPL:

114848503(dio2) 114853908(dio1)

SJO:	128362168(dio1) 128375900(dio2)

SASA:

106603085 106613537(dio1)

STRU:

115158005 115161951(dio2) 115172204

OTW:	112250646(dio1) 112261480

OMY:	100135896(dio2) 110524052(dio1)

OGO:	123996528(dio1) 124001150(dio2)

ONE:	115107365(dio1) 115145884

OKI:	109894226 109902290(dio1)

OKE:	118362808(dio2) 118371923 118387223(dio1)

SALP:

111963588 111968967(dio2) 111975862(dio1) 112080277

SNH:	120054632(dio1) 120060525(dio2)

CCLU:

121532767 121539637(dio2)

ELS:	105006471(dio1) 105015440(dio2)

SFM:	108919387(dio2)

PKI:	111852657(dio2)

AANG:

118210941(dio2) 118224590(dio1) 118229914

LOC:	102695201(dio2) 102695995(dio1)

PSPA:

121323980 121326804(dio1) 121330326

ARUT:

117417108(dio1) 117422569 117424881

PSEX:

120515002(dio1) 120518765(dio2)

LCM:	102351745(DIO2) 102358780(DIO1)

CMK:	103186780(dio2) 103188836(dio1)

RTP:	109926630(dio2) 109928949(dio1)

CPLA:

122553368(dio2) 122554502

HOC:	132818223(dio2) 132819016(dio1)

LERI:

129700037(dio2) 129701175(dio1)

PMRN:

116947117 116948247

LRJ:	133352535 133360916

BFO:

118432103

CIN:

100180523

SPU:	100893862 105442478 115928194

PVM:	113800196 113807377

HAME:

121858234

PCLA:

123765862

EAF:

111706484

LPOL:

106473772

PCAN:

112567673

CRG:

105326271

CVN:

111131833

CANU:

128178678

MYI:

110463568

PMAX:

117325569 117325570 117325571

MMER:

123549955

RPHI:

132758715

DPOL:

127852796 127877499

LAK:

106151249

NVE:	5497581 5516446 5521975

ATEN:

116307432

ADF:	107327158 107331052 107331106 107333022

AMIL:

114952550 114969602 114969646 114972854 114974175

PDAM:

113675601 113679027 113679272 113679273 113686683

SPIS:

111338827

DGT:	114516609 114516716 114516753 114534415

XEN:	124436954 124454118 124454816 124454890 124454939 124454960

TAD:	TRIADDRAFT_56187 TRIADDRAFT_58190 TRIADDRAFT_58193

DPP:	DICPUDRAFT_43625

ACAN:

ACA1_046490

» show all

Reference

1 [PMID:7053997]

Authors

Chopra IJ, Chua Teco GN.

Title

Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.

Journal

Endocrinology 110:89-97 (1982)
DOI:10.1210/endo-110-1-89

Reference

2 [PMID:6176242]

Authors

Goswami A, Leonard JL, Rosenberg IN.

Title

Inhibition by coumadin anticoagulants of enzymatic outer ring monodeiodination of iodothyronines.

Journal

Biochem Biophys Res Commun 104:1231-8 (1982)
DOI:10.1016/0006-291X(82)91382-1

Reference

3 [PMID:7227308]

Authors

Smallridge RC, Burman KD, Ward KE, Wartofsky L, Dimond RC, Wright FD, Latham KR.

Title

3',5'-diiodothyronine to 3'-monoiodothyronine conversion in the fed and fasted rat: enzyme characteristics and evidence for two distinct 5'-deiodinases.

Journal

Endocrinology 108:2336-45 (1981)
DOI:10.1210/endo-108-6-2336

Reference

4 [PMID:11898402]

Authors

Kohrle J.

Title

Iodothyronine deiodinases.

Journal

Methods Enzymol 347:125-67 (2002)
DOI:10.1016/s0076-6879(02)47014-0

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