| Entry |
|
|---|
| Name |
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase;
(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase;
terephthalate 1,2-cis-dihydrodiol dehydrogenase;
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)
|
|---|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
|
|---|
| Sysname |
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase
|
|---|
| Reaction(IUBMB) |
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH [RN: R01633]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate [CPD: C06318];
NAD+ [CPD: C00003]
|
|---|
| Product |
|
|---|
| Comment |
Requires FeII. Involved in the terephthalate degradation pathway in bacteria [2].
|
|---|
| History |
EC 1.3.1.53 created 1999 (EC 1.3.1.61 created 2000, incorporated 2007)
|
|---|
| Pathway |
| ec00624 | Polycyclic aromatic hydrocarbon degradation |
| ec01120 | Microbial metabolism in diverse environments |
|
|---|
| Orthology |
| K18076 | 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase |
|
|---|
| Genes |
|
|---|
| Reference |
1 |
|---|
| Authors |
Saller, E., Laue, H.R., Schlafli Oppenberg, H.R. and Cook, A.M. |
|---|
| Title |
Purification and some properties of (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase from Comamonas testosteroni T-2. |
|---|
| Journal |
FEMS Microbiol Lett 130:97-102 (1996) |
|---|
| Reference |
|
|---|
| Authors |
Wang YZ, Zhou Y, Zylstra GJ |
|---|
| Title |
Molecular analysis of isophthalate and terephthalate degradation by Comamonas testosteroni YZW-D. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.53 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.53 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.3.1.53 |
|
|---|
