KEGG ENZYME: 1.3.1.84

ENZYME: 1.3.1.84

Entry

EC 1.3.1.84                 Enzyme

Name

acrylyl-CoA reductase (NADPH)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

propanoyl-CoA:NADP+ oxidoreductase

Reaction(IUBMB)

propanoyl-CoA + NADP+ = acryloyl-CoA + NADPH + H+ [RN:R00919]

Reaction(KEGG)

R00919

Substrate

propanoyl-CoA [CPD:C00100];
NADP+ [CPD:C00006]

Product

acryloyl-CoA [CPD:C00894];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA [2]. Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16. Contains Zn2+.

History

EC 1.3.1.84 created 2009, modified 2014

Pathway

ec00720

Carbon fixation pathways in prokaryotes

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14469

acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase

K15020

acryloyl-coenzyme A reductase

Genes

BNG:	EH206_02650

TCI:	A7K98_04000

PCI:	PCH70_27690

PLIJ:

KQP88_13360

PFS:

PFLU_2204

PSES:

PSCI_5565

PVW:	HU752_019175

HJA:	BST95_10575

PAQM:

E0F26_07705

PIG:	EGT29_20960

DOE:	DENOEST_2465

NIY:	FQ775_13560

SRAD:

LLW23_04770

BLAS:

BSY18_2664

BFW:	B5J99_04275

PALG:

HFP57_16695

SAND:

H3309_14800

POQ:	KZX46_11635

PMEA:

KTC28_17240

ELQ:	Ga0102493_111749

ERK:	CD351_07815

PNS:	A9D12_09050

PORL:

BG023_111318

PHZ:	CHX26_07195

POT:	E2E27_15415

GOY:	GLS_c14560(adhT)

APER:

A0U91_09345

ABS:	AZOBR_160075

ABQ:	ABAZ39_03340

ABF:	AMK58_10665

AZT:	TSH58p_14860

AZZ:	DEW08_10205

AARE:

D3093_05870

MXA:

MXAN_4266

MSD:	MYSTI_03692

MYM:	A176_002621

MFB:	MFUL124B02_26250

CCX:	COCOR_03605(adhP)

MFU:	LILAB_29490

MMAS:

MYMAC_004185

SUR:	STAUR_8160

AGE:	AA314_03269

AVM:	JQX13_52660

MBD:	MEBOL_000911

CFUS:

CYFUS_007357

LLU:	AKJ09_03010

ASOC:

CB4_03834(acs)

AEB:	C6I20_03415

AACD:

LWP59_17500

ARHD:

VSH64_20800

PDX:

Psed_3739

PBRO:

HOP40_32830

RMAR:

GBA65_02000

BSOL:

FSW04_20500

RRS:	RoseRS_3202

RCA:

Rcas_2930

CAU:

Caur_0613

CHL:	Chy400_0662

CAG:

Cagg_3394

CTM:	Cabther_B0610

CVL:	J8C06_12460

CHLO:

J8C02_11660

GGR:	HKW67_05055

CTS:

Ctha_1050

HAKZ:

J0X25_09315

NAY:	HYG81_22555

NOU:	Natoc_3706

NARA:

QQ977_05470

TAC:

Ta0841

TVO:	TVG0995648(TVG0995648)

PTO:

PTO1151

FAC:	FACI_IFERC01G0984

FAI:

FAD_0007

CDIV:

CPM_0774

STO:

STK_04800

SOH:	D1869_02215

SSO:	SSO0764(adh-2) SSO2494(adh-8)

SOL:	Ssol_0305 Ssol_1823

SSOA:

SULA_0298 SULA_1853

SSOL:

SULB_0300 SULB_1854

SSOF:

SULC_0298 SULC_1852

SSHI:

J5U23_01281 J5U23_02641

SCAS:

SACC_07300 SACC_17810

SAI:	Saci_0911(adh)

SACN:

SacN8_04415 SacN8_05425

SACR:

SacRon12I_04405 SacRon12I_05415

SACS:

SUSAZ_04165 SUSAZ_05205

SIS:	LS215_0315 LS215_1474

SIA:	M1425_0286 M1425_1378

SIM:	M1627_0286 M1627_1428

SID:	M164_0304 M164_1370

SIY:	YG5714_0289 YG5714_1372

SIN:	YN1551_1469 YN1551_2895

SII:	LD85_0292 LD85_1501

SIH:	SiH_0293 SiH_1323

SIR:	SiRe_0291 SiRe_1239

SIC:	SiL_0277 SiL_1236

SULA:

BFU36_02155 BFU36_06670

SULE:

GFS03_02995 GFS03_07700

SULO:

GFS33_08240 GFS33_13105

SULL:

EWF20_03740

MSE:

Msed_1426

MEMJ:

MJ1HA_1639

MCN:

Mcup_0809

MHK:	DFR87_11745

MPRU:

DFR88_11185

MTEN:

GWK48_03460

MJN:	MjAS7_2497

AHO:

Ahos_2283

AMAN:

B6F84_02680

ABRI:

DFR85_01205

ASUL:

DFR86_02685

AAMB:

D1866_06505

ACIH:

HS5_11830

SACD:

HS1genome_1083

SAZO:

D1868_01515

CSTY:

KN1_18030

STEP:

IC006_1239

SMET:

RQ359_000671

SAHS:

HS7_00830

PAI:

PAE1921

PIS:

Pisl_1770

PCL:

Pcal_0882

PAS:

Pars_2114

PYR:

P186_0181

POG:

Pogu_2773

TNE:

Tneu_0785

PYW:	PYWP30_00861

CMA:

Cmaq_1615

TTN:	TTX_1731(adhP)

TUZ:

TUZN_1795

VDI:

Vdis_0393

VMO:

VMUT_1233

VSO:	Vsou_05630

» show all

Reference

1 [PMID:18079405]

Authors

Berg IA, Kockelkorn D, Buckel W, Fuchs G

Title

A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.

Journal

Science 318:1782-6 (2007)
DOI:10.1126/science.1149976

Reference

2 [PMID:19429610]

Authors

Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G

Title

3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.

Journal

J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09

Sequence

[sto:STK_04800]

Other DBs

ExplorEnz - The Enzyme Database:

1.3.1.84

IUBMB Enzyme Nomenclature:

1.3.1.84

ExPASy - ENZYME nomenclature database:

1.3.1.84

BRENDA, the Enzyme Database:

1.3.1.84

DBGET integrated database retrieval system