Entry |
|
Name |
tRNA-dihydrouridine20 synthase [NAD(P)+];
Dus2p;
tRNA-dihydrouridine synthase 2
|
Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase
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Reaction(IUBMB) |
5,6-dihydrouracil20 in tRNA + NAD(P)+ = uracil20 in tRNA + NAD(P)H + H+
|
Substrate |
5,6-dihydrouracil20 in tRNA;
NAD+ [CPD: C00003];
NADP+ [CPD: C00006]
|
Product |
|
Comment |
A flavoenzyme [3]. The enzyme specifically modifies uracil20 in tRNA.
|
History |
EC 1.3.1.91 created 2011
|
Orthology |
K05543 | tRNA-dihydrouridine synthase 2 |
|
Genes |
SHAB: | 115601256(DUS2) 115619298 |
MASI: | 127436299 127437462 |
TBEN: | 117479849 117479864 |
MSAM: | 119894056(dus2) 119894061 |
SSEN: | 122762479 122764775 |
DSI: | Dsimw501_GD17163(Dsim_GD17163) |
RZE: | 108372486 108375668 108380103 |
BCOO: | 119073235 119073236 119081345 |
APLN: | 112904204 112904206 |
SGRE: | 126315302 126337035 |
CSCU: | 111631385 111631387 |
CEL: | CELE_Y54E5A.6(dus-2) |
BMY: | BM_BM12225(Bma-dus-2) |
DPOL: | 127846088 127846435 |
CSAT: | 104711482 104780784 104791189 |
BNA: | 106347407 106347408 106418663 |
MINC: | 123205570 123209187 |
HSYR: | 120126716 120131009 120141729 120216346 |
LJA: | Lj0g3v0165759.1(Lj0g3v0165759.1) |
PSOM: | 113335322 113340280 |
DOSA: | Os04t0531300-01(Os04g0531300) |
TAES: | 123046033 123053909 123189803 |
PVIR: | 120642640 120683704 |
SMO: | SELMODRAFT_132390 SELMODRAFT_174143 |
MPP: | MICPUCDRAFT_35954(DUS) |
NCS: | NCAS_0A04620(NCAS0A04620) |
NDI: | NDAI_0K01680(NDAI0K01680) |
TPF: | TPHA_0D03720(TPHA0D03720) |
TBL: | TBLA_0A06710(TBLA0A06710) |
TDL: | TDEL_0A07250(TDEL0A07250) |
KAF: | KAFR_0F00830(KAFR0F00830) |
KNG: | KNAG_0D00530(KNAG0D00530) |
CAL: | CAALFM_C209890WA(SMM1) |
NTE: | NEUTE1DRAFT125714(NEUTE1DRAFT_125714) |
BFU: | BCIN_01g02930(Bcsmm1) |
ACHE: | ACHE_31407S ACHE_70100S |
CCAC: | CcaHIS019_0701580(dus2) |
ABP: | AGABI1DRAFT110775(AGABI1DRAFT_110775) |
ABV: | AGABI2DRAFT189317(AGABI2DRAFT_189317) |
SCM: | SCHCO_02459677(SCHCODRAFT_02459677) |
EHI: | EHI_023240(444.t00003) |
EDI: | EDI_247840 EDI_265860 |
SMIN: | v1.2.036354.t1(symbB.v1.2.036354.t1) |
SPAR: | SPRG_04550 SPRG_11083 |
TVA: | TVAG_2v0216450 TVAG_2v0869230 |
» show all
|
Reference |
|
Authors |
Xing F, Hiley SL, Hughes TR, Phizicky EM |
Title |
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Xing F, Martzen MR, Phizicky EM |
Title |
A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Rider LW, Ottosen MB, Gattis SG, Palfey BA |
Title |
Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction. |
Journal |
|
Reference |
|
Authors |
Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y |
Title |
A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.91 |
ExPASy - ENZYME nomenclature database: | 1.3.1.91 |
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