KEGG   ENZYME: 1.3.7.4
Entry
EC 1.3.7.4                  Enzyme                                 
Name
phytochromobilin:ferredoxin oxidoreductase;
HY2;
PPhi B synthase;
phytochromobilin synthase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
(3Z)-phytochromobilin:ferredoxin oxidoreductase
Reaction(IUBMB)
(3Z)-phytochromobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin [RN:R03678]
Reaction(KEGG)
R03678
Substrate
(3Z)-phytochromobilin [CPD:C05913];
oxidized ferredoxin [CPD:C00139]
Product
biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]
Comment
Catalyses the two-electron reduction of biliverdin IXalpha. Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum. The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm. Flavodoxins can be used instead of ferredoxin.
History
EC 1.3.7.4 created 2002
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K08101  phytochromobilin:ferredoxin oxidoreductase
Genes
ATHAT3G09150(HY2)
ALY9320783
CRB17892864
CSAT104745078 104749614 104764610
EUSEUTSA_v10011657mg
BRP103859309 103870559
BNA106352983 106439211 125587929
BOE106295900 106331861
RSZ108863089
THJ104799118
CPAP110811856
CIT102609362
CICCICLE_v10015899mg
PVY116135627
MINC123205883
TCC18589938
GRA105783974
GHI107939449 107945135
GAB108450615
HSYR120117492 120143576
DZI111302716 111303932
EGR104421483
GMX100791053
GSJ114385397 114403479
PVUPHAVU_008G284200g
VRA106765267
VAR108338713
VUN114193684
CCAJ109795293
APRC113846963
MTR11434871
TPRA123881987 123919836
CAM101503524 101506703 101510774 105851316
PSAT127117521
VVO131617749
LJALj0g3v0050649.1(Lj0g3v0050649.1) Lj2g3v3337330.1(Lj2g3v3337330.1)
ADU107496238
AIP107609834
AHF112701760 112766749
LANG109342143
PCIN129317400 129318213 129318261
QSAO6P43_013988
FVE101309029
RCN112202176
PPER18778367
PMUM103326785
PAVI110761571
PDUL117624673
MDM103426911
MSYL126615439
PXB103929552 103934579
ZJU107406401
MNT21385429
CSAV115721362
CSV101217650
CMO103492001
BHJ120071771
MCHA111021651
CMAX111485492
CMOS111461368
CPEP111779700
RCU8261167
JCU105647226
HBR110634414
MESC110610189
POP7467396 7478520
PEU105131030
PALZ118032978 118035177
JRE108994596
CILL122292677
CAVE132164719 132183158
QSU111997816
QLO115981670
TWL120001734
VVI100267105
VRI117916930
SLY778324(AUREA)
SPEN107008239
SOT102604691
SSTN125863480
SDUL129887656
CANN107875610
LBB132626409
NTA107761635 107823317
NSY104250102
NTO104118127
NAU109228690
INI109160056
ITR116003618 116004293
SIND105170921
EGT105958969
SSPL121749680 121750085
SMIL131006824
APAN127260061
HAN110878838 110930825
ECAD122599805
LSV111883501
CCAV112529391
DCR108193224
CSIN114263854
RVL131314522
AEW130770127
BVG104889193
SOE110796859
CQI110689478 110704564 110734512
ATRI130815023
MOF131148975
NNU104612006
MING122091181
TSS122671382
PSOM113308909 113321152
OSA4325761
DOSAOs01t0949400-01(Os01g0949400)
OBR102708119
OGL127756402
BDI100829998
ATS109784146
TDC119270459 119278613
TAES123059393 123066605 123075631
TUA125546046
LPER127345746
LRD124661795
SBI8081332
ZMA542164
SITA101767227
SVS117857311
PVIR120672659 120709242
PHAI112893571
PDA103705671
EGU105047124
MUS103976148
ZOF122041944 122046470
DCT110105041
PEQ110018338
AOF109850042
MSIN131226777
NCOL116246629
ATR18433244
SMOSELMODRAFT_151708(HY2-2) SELMODRAFT_83654(HY2-1)
PPP112290529
 » show all
Reference
1  [PMID:11283349]
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant Cell 13:965-78 (2001)
DOI:10.1105/tpc.13.4.965
Reference
2  [PMID:11500553]
  Authors
McDowell MT, Lagarias JC.
  Title
Purification and biochemical properties of phytochromobilin synthase from etiolated oat seedlings.
  Journal
Plant Physiol 126:1546-54 (2001)
DOI:10.1104/pp.126.4.1546
Reference
3  [PMID:8215388]
  Authors
Terry MJ, Wahleithner JA, Lagarias JC.
  Title
Biosynthesis of the plant photoreceptor phytochrome.
  Journal
Arch Biochem Biophys 306:1-15 (1993)
DOI:10.1006/abbi.1993.1473
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.4
IUBMB Enzyme Nomenclature: 1.3.7.4
ExPASy - ENZYME nomenclature database: 1.3.7.4
BRENDA, the Enzyme Database: 1.3.7.4
CAS: 138263-99-7

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