Entry
Name
glutaryl-CoA dehydrogenase (acceptor);
GDHDes;
nondecarboxylating glutaryl-coenzyme A dehydrogenase;
nondecarboxylating glutaconyl-coenzyme A-forming GDH;
glutaryl-CoA dehydrogenase (non-decarboxylating)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)
Reaction(IUBMB)
glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor [RN:
R05579 ]
Reaction(KEGG)
Substrate
Product
(E)-glutaconyl-CoA [CPD:
C02411 ];
reduced acceptor [CPD:
C00030 ]
Comment
The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC
1.3.8.6 ), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.
History
EC 1.3.99.32 created 2012, modified 2013
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K16173 glutaryl-CoA dehydrogenase (non-decarboxylating)
Genes
DAT : HRM2_38550(acd11) HRM2_38670(acd12)
DOV : DSCO28_15290 DSCO28_44640(acdB_2) DSCO28_67840(acdB_3)
DALK : DSCA_21130(acdB_1) DSCA_32440(acdB_2) DSCA_37830
DML : Dmul_25030(acdA5) Dmul_34900(acdA13)
DTI : Desti_2252 Desti_4873
PCAL : BV455_01302(acdA_2)
HHD : HBHAL_1540 HBHAL_1901
HMN : HM131_06360 HM131_13220
GAJ : MY490_01955 MY490_05105
PANC : E2636_09140 E2636_14105
DOR : Desor_1180 Desor_1198 Desor_2984
DKU : Desku_0803 Desku_2606
DGI : Desgi_0512 Desgi_4610
ACIT : HPK19_11375 HPK19_20125
NCN : BZZ01_15490 BZZ01_17415
ABAC : LuPra_03850(acdA_2)
» show all
Taxonomy
Reference
Authors
Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M
Title
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria.
Journal
Sequence
Reference
Authors
Wischgoll S, Demmer U, Warkentin E, Gunther R, Boll M, Ermler U
Title
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.3.99.32