KEGG   ENZYME: 1.5.1.30
Entry
EC 1.5.1.30                 Enzyme                                 
Name
flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
reduced-riboflavin:NADP+ oxidoreductase
Reaction(IUBMB)
reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Reaction(KEGG)
R05707;
(other) R09520
Substrate
reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]
Product
riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.
History
EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K05901  biliverdin reductase / flavin reductase
Genes
HSA645(BLVRB)
PTR456039(BLVRB)
PPS100989093(BLVRB)
GGO101142015(BLVRB)
PON100446184(BLVRB)
NLE100587172(BLVRB)
HMH116480674(BLVRB)
MCC703020(BLVRB)
MCF102142962(BLVRB)
MTHB126942092
MNI105495336(BLVRB)
CSAB103234707(BLVRB)
CATY105597983(BLVRB)
PANU101021963(BLVRB)
TGE112613110(BLVRB)
MLEU105542622(BLVRB)
RRO104676113(BLVRB)
RBB108539085(BLVRB)
TFN117091948(BLVRB) 117092438
PTEH111553962(BLVRB)
CANG105519183(BLVRB)
CJC100391206(BLVRB)
SBQ101043206(BLVRB)
CIMI108285782(BLVRB)
CSYR103272286(BLVRB)
MMUR105876763(BLVRB)
LCAT123624314(BLVRB)
PCOQ105820481(BLVRB)
OGA100956880(BLVRB)
MMU233016(Blvrb)
MCAL110297893(Blvrb)
MPAH110331802(Blvrb)
RNO292737(Blvrb)
MCOC116101881(Blvrb)
ANU117698969(Blvrb)
MUN110556744(Blvrb)
CGE100768929(Blvrb)
MAUA101844617(Blvrb)
PROB127238361(Blvrb)
PLEU114681553(Blvrb)
MORG121449703(Blvrb) 121453592
MFOT126492547
AAMP119821315 119821342(Blvrb)
NGI103750766(Blvrb)
HGL101697384(Blvrb)
CPOC100723970(Blvrb)
CCAN109688540(Blvrb)
DORD105998024(Blvrb)
DSP122097439(Blvrb)
PLOP125368345(Blvrb)
NCAR124966872
MMMA107151453(Blvrb)
OCU100340115
OPI101535891(BLVRB)
TUP102490802(BLVRB)
GVR103598605(BLVRB)
CFA476456(BLVRB)
CLUD112645456(BLVRB)
VVP112928368(BLVRB)
VLG121485710(BLVRB)
NPO129500870(BLVRB)
AML100467254(BLVRB)
UMR103661047(BLVRB)
UAH113243564(BLVRB)
UAR123784022(BLVRB)
ELK111161593
LLV125088933 125098045
MPUF101682683(BLVRB)
MNP132005993(BLVRB)
MLK131818594(BLVRB)
NVS122912043(BLVRB)
ORO101371765(BLVRB)
EJU114202467(BLVRB)
ZCA113936395(BLVRB)
MLX118022653(BLVRB)
NSU110590243(BLVRB)
LWW102749984(BLVRB)
FCA101092315(BLVRB)
PYU121011436(BLVRB)
PBG122494035(BLVRB)
LRUF124511113
PTG102957700(BLVRB)
PPAD109256587(BLVRB)
PUC125915658
AJU106979604
HHV120240932(BLVRB)
BTA281650(BLVRB)
BOM102277747(BLVRB)
BIU109572681(BLVRB)
BBUB102402107(BLVRB)
BBIS104995362(BLVRB)
CHX102187796(BLVRB)
OAS101119750(BLVRB)
BTAX128063605(BLVRB)
ODA120872449(BLVRB)
CCAD122420884(BLVRB) 122443458
MBEZ129546807(BLVRB)
SSC100625219(BLVRB)
CFR102522968(BLVRB)
CBAI105062862(BLVRB)
CDK105093394(BLVRB)
VPC102543677(BLVRB)
BACU103014515(BLVRB)
LVE103082225(BLVRB)
OOR101269881(BLVRB)
DLE111180848(BLVRB)
PCAD102992855(BLVRB)
PSIU116743687(BLVRB)
NASI112415632(BLVRB)
ECB100068145(BLVRB)
EPZ103560493(BLVRB)
EAI106843297(BLVRB)
MYB102251416(BLVRB)
MYD102759928(BLVRB)
MMYO118674559(BLVRB)
MLF102432652(BLVRB)
MNA107534172(BLVRB)
PKL118702235(BLVRB)
EFUS103284696(BLVRB) 103290292
HAI109374869(BLVRB)
DRO112320111(BLVRB)
SHON118988083(BLVRB)
AJM119040590(BLVRB)
PDIC114511105(BLVRB)
PHAS123823786(BLVRB)
MMF118639318(BLVRB)
RFQ117035103(BLVRB)
PPAM129076686(BLVRB)
PALE102879551(BLVRB)
PGIG120595620(BLVRB)
PVP105300209(BLVRB)
RAY107521823(BLVRB)
MJV108404844(BLVRB)
TOD119249327(BLVRB)
SARA101557111(BLVRB)
LAV100665167(BLVRB)
TMU101354315
ETF101645971(BLVRB)
DNM101437673(BLVRB)
MDO100017892(BLVRB)
GAS123255652(BLVRB)
SHR100930351(BLVRB)
AFZ127556203
PCW110202810(BLVRB)
OAA100073853(BLVRB)
MGP100303679(BLVRB)
APLA113841036(BLVRB)
CATA118261579(BLVRB)
PHI102113532(BLVRB)
CCAE111943368(BLVRB)
ACHC115337712
HALD104321959(BLVRB)
AGEN126036625 126037224
BREG104641217(BLVRB)
SHAB115603330(BLVRB)
RTD128903851(BLVRB)
AAM106493723(BLVRB)
AROW112960997(BLVRB)
NPD112955489(BLVRB)
TGT104572768(BLVRB)
DNE112996331(BLVRB)
ASN102387963(BLVRB)
AMJ102574563(BLVRB)
CMY114022374(BLVRB)
CCAY125628119(BLVRB)
DCC119847368(BLVRB)
CPIC101948417(BLVRB)
TST117888630(BLVRB)
CABI116833857(BLVRB)
MRV120388171(BLVRB)
ACS100564796(blvrb)
ASAO132780135(BLVRB)
PVT110075662(BLVRB)
SUND121916153(BLVRB)
PBI103053858(BLVRB)
PMUR107285666(BLVRB)
CTIG120316372(BLVRB)
TSR106541075(BLVRB)
PGUT117677851(BLVRB)
APRI131204274(BLVRB)
PTEX113450296(BLVRB)
NSS113425551(BLVRB)
VKO123021032(BLVRB)
PMUA114603071(BLVRB)
PRAF128418178(BLVRB)
ZVI118078075 118086651(BLVRB)
HCG128332650(BLVRB)
GJA107107369(BLVRB)
STOW125430722(BLVRB)
EMC129343090(BLVRB)
XLA443881(blvrb.L)
XTR100124834(blvrb) 116406791
NPR108791950(BLVRB)
RTEM120913299(BLVRB)
BBUF120977966(BLVRB)
BGAR122923946(BLVRB)
MUO115480591(BLVRB)
GSH117364657(BLVRB)
DRE436959(blvrb)
SRX107717620(blvrb)
SANH107670601 107692505
SGH107602119(blvrb)
CCAR109109302 109109306
CAUA113061728 113082608 113118645
CGIB127934336 127977858
PTET122323140(blvrb)
LROH127180549(blvrb)
OMC131523974(blvrb)
PPRM120460021 120460038
RKG130069968(blvrb)
MAMB125254500(blvrb)
CIDE127499299
MASI127455779
TROS130562861(blvrb)
TDW130435551(blvrb)
MANU129419592(blvrb)
IPU124626957
IFU128606874(blvrb)
PHYP113526426(blvrb)
SMEO124396010(blvrb)
TFD113638812(blvrb)
TVC132851041(blvrb)
AMEX103040962(blvrb)
CMAO118818247(blvrb)
EEE113580124(blvrb)
CHAR105909718(blvrb)
TRU101061122(blvrb)
TFS130534656(blvrb)
TNGGSTEN00035152G001
LCO104927805(blvrb)
NCC104965039(blvrb)
TBEN117471124(blvrb)
CGOB115018241(blvrb)
PGEO117457425(blvrb)
GACU117555581(blvrb)
ELY117259444(blvrb)
EFO125888677(blvrb)
PLEP121943190(blvrb)
SLUC116053283(blvrb)
ECRA117942519(blvrb)
ESP116687001(blvrb)
PFLV114552606(blvrb)
GAT120829425(blvrb)
PPUG119222042(blvrb)
AFB129090654(blvrb)
CLUM117741131(blvrb)
MSAM119882831(blvrb)
SCHU122879513(blvrb)
CUD121526977(blvrb)
ALAT119033096(blvrb)
MZE101484658(blvrb)
ONL100702669(blvrb)
OAU116320348(blvrb)
OLA101163919(blvrb)
OML112149783(blvrb)
XMA102228591(blvrb)
XCO114133538(blvrb)
XHE116707592 116707593
PRET103475161(blvrb)
PFOR103138303(blvrb)
PLAI106947919(blvrb)
PMEI106921476(blvrb)
GAF122832913(blvrb)
PPRL129358719(blvrb)
CVG107094869(blvrb)
CTUL119796633(blvrb)
GMU124883659(blvrb)
NFU107379787(blvrb)
KMR108247879(blvrb)
ALIM106522783(blvrb)
NWH119411413(blvrb)
AOCE111586211(blvrb)
MCEP125012958(blvrb)
CSEM103377891(blvrb)
POV109630121(blvrb)
SSEN122773296(blvrb)
HHIP117773323(blvrb)
HSP118105862(blvrb)
LCF108876241
SDU111216890(blvrb)
SLAL111662215(blvrb)
XGL120792571(blvrb)
HCQ109529422(blvrb)
SSCV125972512
SBIA133504585(blvrb)
PEE133405512(blvrb)
PTAO133482614(blvrb)
BPEC110172712(blvrb)
MALB109963258(blvrb)
BSPL114867627(blvrb)
SJO128360742(blvrb)
SASA106580739(blvrb) 106612705(BLVRB)
STRU115163034(blvrb) 115205994
OTW112265119 112266772
OMY110503591 110507468
OGO123993025 124005618
ONE115137042 115141548
OKI109905459 109908908
OKE118385438 118397176
SALP111982788 111982809
SNH120018812 120028367
CCLU121562566 121568255
ELS105023068(blvrb)
SFM108928749(blvrb)
PKI111844029(blvrb)
AANG118209415(blvrb)
LOC102698532(blvrb)
PSPA121303818 121304996(blvrb)
ARUT117397815 117415212
PSEX120538736(blvrb)
LCM102358034(BLVRB)
CMK103173572(blvrb)
RTP109926910(blvrb)
CPLA122542852(blvrb)
HOC132836604(blvrb)
LERI129714249(blvrb)
PMRN116953899(BLVRB)
LRJ133356338
BFO118410084 118414353 118424422
CIN100185152
SCLV120347803 120347819 120347831 120347846 120347854 120347866
SPU100889296 578603
APLC110978883 110978939
SKO100374763
DER6552273
DSIDsimw501_GD20759(Dsim_GD20759)
DYADyak_GE24730
DSR110188190
DPO4801507
DPE6588134
DMN108156553
DWI6647397
DMODmoj_GI24882
DAZ108618551
DNV108659243
DHE111602756
DVI6630042
MDE101892800
LCQ111676095
ACOZ120949584
AAG5565330
AALB109405306 109406365 115258289
CQUCpipJ_CPIJ011826
CPII120431012
AME412445
ACER107994237
ALAB122714807
ADR102680187
AFLR105736343
BIM100749252
BBIF117205099
BVK117231092
BVAN117157637
BTER100646178
BAFF126921994
BPYO122567783
BPAS132912730
FVI122538628
CCAL108630984
OBB114877540
OLG117603050
MGEN117219339
NMEA116423944
SOC105203443 105203453 105204185
MPHA105830426
AEC105144797
ACEP105624072
PBAR105426660
VEM105557622
HST105187135
DQU106744067
CFO105252649
FEX115234327
LHU105674651
PGC109861802
OBO105281931
PCF106793889
PFUC122526549
VPS122634421
VVE124947535
NVI100113525
CSOL105360908
MDL103574018
TCA664311
DPA109534878
ATD109595167
NVL108556546
BMOR101736226
BMAN114248437
DPLKGM_212873
BANY112054677
MJU123874749
NIQ126775902
VCD124538436
MCIX123662021
PMAC106708927
PPOT106101151
PXU106120319
PRAP111001233
PBX123718550
PNAP125054450
ZCE119828598
CCRC123699980
LSIN126964809
HAW110382146
HZE124640134
TNL113504959
SLIU111350206
OFU114353154
PXY105393340
PGW126375316
API100168586(Blvrb) 100574136
DNX107162985
AGS114130365
RMD113557849
ACOO126833512
DVT126906640
BTAB109043576
NLU111052374
HVI124353097 124353098 124373554
PHUPhum_PHUM514080
ZNE110828593
CSEC111868350
DPXDAPPUDRAFT_230602
DMK116929398
DPZ124311410
PVM113830326
PMOO119585705
CQD128686251
HAZT108664641
DSV119458384
RSAN119373566
RMP119167602
TUT107359695 107367634
CSCU111640897
PTEP107444427
UDV129229318
SDM118193070
LPOL106471531
LGILOTGIDRAFT_113739 LOTGIDRAFT_145414
PCAN112555334
HRJ124291888
MYI110441547 110448057
LAK106151286 106161246 106163455 106163456 106163458
NVE5503663
EPA110232712 110232713
ADF107351009
AMIL114961956
PDAM113669019 113669042 113678890 113678891
SPIS111322492 111322494 111325275 111325299
 » show all
Reference
1  [PMID:3453680]
  Authors
Yubisui T, Tamura M, Takeshita M.
  Title
Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.
  Journal
Biochem Int 15:1-8 (1987)
Reference
2  [PMID:10620517]
  Authors
Cunningham O, Gore MG, Mantle TJ
  Title
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).
  Journal
Biochem J 345 Pt 2:393-9 (2000)
DOI:10.1042/bj3450393
  Sequence
[hsa:645]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.30
IUBMB Enzyme Nomenclature: 1.5.1.30
ExPASy - ENZYME nomenclature database: 1.5.1.30
BRENDA, the Enzyme Database: 1.5.1.30
CAS: 56626-29-0

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