KEGG   ENZYME: 1.5.3.18
Entry
EC 1.5.3.18                 Enzyme                                 
Name
L-saccharopine oxidase;
FAP2
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
L-saccharopine:oxygen oxidoreductase (L-glutamate-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + H2O + O2 = (S)-2-amino-6-oxohexanoate + L-glutamate + H2O2 [RN:R09495]
Reaction(KEGG)
R09495
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
L-glutamate [CPD:C00025];
H2O2 [CPD:C00027]
Comment
The enzyme is involved in pipecolic acid biosynthesis. A flavoprotein (FAD).
History
EC 1.5.3.18 created 2011
Orthology
K17833  L-saccharopine oxidase
Genes
SPO: SPAC139.04c(fap2)
Reference
1  [PMID:16233628]
  Authors
Yoshida N, Akazawa S, Katsuragi T, Tani Y
  Title
Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe.
  Journal
J Biosci Bioeng 97:278-80 (2004)
DOI:10.1016/S1389-1723(04)70204-2
  Sequence
[spo:SPAC139.04c]
Reference
2  [PMID:2394693]
  Authors
Wickwire BM, Wagner C, Broquist HP
  Title
Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis.
  Journal
J Biol Chem 265:14748-53 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.18
IUBMB Enzyme Nomenclature: 1.5.3.18
ExPASy - ENZYME nomenclature database: 1.5.3.18
BRENDA, the Enzyme Database: 1.5.3.18

  All links  
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (16)   

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