KEGG   ENZYME: 1.5.8.3
Entry
EC 1.5.8.3                  Enzyme                                 
Name
sarcosine dehydrogenase;
sarcosine N-demethylase;
monomethylglycine dehydrogenase;
sarcosine:(acceptor) oxidoreductase (demethylating);
sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor
Sysname
sarcosine, 5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)
Reaction(IUBMB)
sarcosine + 5,6,7,8-tetrahydrofolate + oxidized [electron-transfer flavoprotein] = glycine + 5,10-methylenetetrahydrofolate + reduced [electron-transfer flavoprotein] [RN:R00611]
Reaction(KEGG)
R00611
Substrate
sarcosine [CPD:C00213];
5,6,7,8-tetrahydrofolate [CPD:C00101];
oxidized [electron-transfer flavoprotein] [CPD:C04253]
Product
glycine [CPD:C00037];
5,10-methylenetetrahydrofolate [CPD:C00143];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
A flavoprotein (FMN) found in eukaryotes. In the absence of tetrahydrofolate the enzyme produces formaldehyde. cf. EC 1.5.3.1, sarcosine oxidase (formaldehyde-forming), and EC 1.5.3.24, sarcosine oxidase (5,10-methylenetetrahydrofolate-forming).
History
EC 1.5.8.3 created 1972 as EC 1.5.99.1, transferred 2012 to EC 1.5.8.3, modified 2022
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K00314  sarcosine dehydrogenase
Genes
HSA1757(SARDH)
PTR464828(SARDH)
PPS100986136(SARDH)
GGO101126679(SARDH)
PON100172073(SARDH)
NLE100581547(SARDH)
HMH116475832(SARDH)
MCC713289(SARDH)
MCF102139165(SARDH)
MTHB126936903
MNI105471877(SARDH)
CSAB103239675(SARDH)
CATY105578092 105580522(SARDH)
PANU101015658(SARDH)
TGE112608502(SARDH) 112632442
MLEU105547817(SARDH)
RRO104669713(SARDH)
RBB108513254(SARDH)
TFN117099201(SARDH)
PTEH111524002(SARDH)
CANG105503971(SARDH)
CJC100396240(SARDH)
SBQ101038416(SARDH)
CIMI108292304(SARDH)
CSYR103273376(SARDH)
MMUR105880753(SARDH)
LCAT123645984(SARDH)
PCOQ105826695(SARDH)
OGA100950320(SARDH)
MMU192166(Sardh)
MCAL110310298(Sardh)
MPAH110318656(Sardh)
RNO114123(Sardh)
MCOC116089881(Sardh)
ANU117704184(Sardh)
MUN110557507(Sardh)
CGE100761121(Sardh)
MAUA101837481(Sardh)
PROB127222657(Sardh)
PLEU114684225(Sardh)
MORG121462827(Sardh)
MFOT126509210
AAMP119818433(Sardh)
NGI103742819(Sardh)
HGL101717296(Sardh)
CPOC100718504(Sardh)
CCAN109695047(Sardh)
DORD105995659(Sardh)
DSP122108903(Sardh)
PLOP125353290(Sardh)
NCAR124964225
MMMA107159138(Sardh)
OPI101531608(SARDH)
TUP102468288(SARDH)
GVR103581999 103607776
CFA491277(SARDH)
CLUD112677395(SARDH)
VVP112935890(SARDH)
VLG121472927(SARDH)
NPO129505342(SARDH)
AML100477821(SARDH)
UMR103679941(SARDH)
UAH113266576(SARDH)
UAR123775645(SARDH)
ELK111146213
LLV125083188
MPUF101689810(SARDH)
MNP132024271(SARDH)
MLK131812505(SARDH)
NVS122917099(SARDH)
ORO101363163(SARDH)
EJU114200995(SARDH)
ZCA113933946(SARDH)
MLX118017541(SARDH)
NSU110581413(SARDH)
LWW102727859(SARDH)
FCA101082702(SARDH)
PYU121021238(SARDH)
PBG122475224(SARDH)
LRUF124522436
PTG102959524(SARDH)
PPAD109258271(SARDH)
PUC125923035
AJU106988257
HHV120247321(SARDH)
BTA614603(SARDH)
BOM102286478(SARDH)
BIU109566616(SARDH)
BBUB102407897(SARDH)
BBIS104983331(SARDH)
CHX102176539(SARDH)
OAS101110407(SARDH)
BTAX128056075(SARDH)
ODA120852212(SARDH)
CCAD122442336(SARDH)
MBEZ129539422(SARDH)
SSC100154338(SARDH)
CFR102524074(SARDH)
CBAI105068574(SARDH)
CDK105102809(SARDH)
VPC102539312(SARDH)
BACU103001806(SARDH)
LVE103082579(SARDH)
OOR101269445(SARDH)
DLE111177031(SARDH)
PCAD114487445
PSIU116755110(SARDH)
NASI112411329(SARDH)
ECB100069193(SARDH)
EPZ103564041(SARDH)
EAI106845348(SARDH)
MYB102263827(SARDH)
MYD102763367(SARDH)
MMYO118666898(SARDH)
MNA107524617(SARDH)
PKL118708904(SARDH)
EFUS103296146(SARDH)
HAI109381141(SARDH)
DRO112306574(SARDH)
SHON118980108(SARDH)
AJM119036072(SARDH)
PDIC114502600(SARDH)
PHAS123823382(SARDH)
MMF118629383(SARDH)
RFQ117032350(SARDH)
PPAM129079162(SARDH)
PALE102882489(SARDH)
PGIG120618873(SARDH)
PVP105308211(SARDH)
RAY107506266(SARDH)
MJV108388196(SARDH)
TOD119231222(SARDH)
SARA101550003(SARDH)
LAV100677707
TMU101344177
ETF101656739(SARDH)
DNM101446999(SARDH)
MDO100018850(SARDH)
GAS123237208(SARDH)
SHR100925921(SARDH)
AFZ127550957
PCW110205373(SARDH)
OAA100073946(SARDH)
GGA417146(SARDH)
PCOC116234304(SARDH)
MGP100544931(SARDH)
CJO107321866(SARDH)
TPAI128073307(SARDH)
LMUT125702507(SARDH)
NMEL110406941(SARDH)
APLA101793569(SARDH)
ACYG106044083(SARDH)
CATA118252264(SARDH)
AFUL116496886(SARDH)
TGU100221431(SARDH)
LSR110477625(SARDH)
SCAN103819130(SARDH)
PMOA120512467(SARDH)
OTC121337015(SARDH)
PRUF121362436(SARDH)
GFR102042792(SARDH)
FAB101807275(SARDH)
OMA130260255(SARDH)
PHI102100623(SARDH)
PMAJ107211981(SARDH)
CCAE111937046(SARDH)
CCW104688488(SARDH)
ETL114059122(SARDH)
ZAB102072207(SARDH)
ACHL103807317(SARDH)
SVG106851371(SARDH)
MMEA130576689(SARDH)
HRT120761614(SARDH)
FPG101910621(SARDH)
FCH102055614(SARDH)
CLV102089708(SARDH)
EGZ104129358(SARDH)
NNI104023287(SARDH)
PCRI104028748(SARDH)
EHS104510227(SARDH)
ACUN113486534(SARDH)
TALA104358507(SARDH)
PADL103915344(SARDH)
AFOR103905337(SARDH)
ACHC115335020(SARDH)
HLE104834021(SARDH)
AGEN126052419
GCL127023702
CCRI104161252(SARDH)
CSTI104559665(SARDH)
CMAC104484056(SARDH)
MUI104537222(SARDH)
BREG104632937(SARDH)
LDI104353408(SARDH)
OHA104329475(SARDH)
NNT104401845(SARDH)
SHAB115617139(SARDH)
DPUB104296481(SARDH)
PGUU104462250(SARDH)
ACAR104524269(SARDH)
CPEA104389905(SARDH)
AVIT104275305(SARDH)
CVF104292890(SARDH)
RTD128917707(SARDH)
CUCA104066940(SARDH)
TEO104375627(SARDH)
BRHI104496130(SARDH)
AAM106484478(SARDH)
AROW112964334(SARDH)
NPD112955996(SARDH)
TGT104568109(SARDH)
DNE112979933(SARDH)
SCAM104138293(SARDH)
ASN102387705
AMJ102565496(SARDH)
CPOO109313993(SARDH)
GGN109293014(SARDH)
PSS102455800(SARDH)
CMY102936719(SARDH)
CCAY125623620(SARDH)
DCC119844196(SARDH)
CPIC101938284(SARDH)
TST117867214(SARDH)
CABI116817467(SARDH)
MRV120386569(SARDH)
ACS100567227 103281982(sardh)
ASAO132763715(SARDH)
PVT110089290(SARDH)
SUND121937135(SARDH)
PBI103065615
PMUR107291024(SARDH)
CTIG120310204(SARDH)
TSR106552855(SARDH)
PGUT117671326(SARDH)
APRI131186144(SARDH)
PTEX113448476(SARDH)
NSS113426289(SARDH)
VKO123035146(SARDH)
PMUA114588913(SARDH)
PRAF128406238(SARDH)
ZVI118083953(SARDH)
HCG128338781(SARDH)
GJA107106570(SARDH)
STOW125441578(SARDH)
EMC129342011(SARDH)
XLA108698171(sardh.L)
XTR100492087(sardh)
NPR108793117
RTEM120913855(SARDH)
BBUF120978222(SARDH)
BGAR122946102(SARDH)
MUO115473063(SARDH)
GSH117368407(SARDH)
DRE394103(sardh)
SRX107713264 107744257
SANH107685122(sardh)
SGH107595553(sardh)
CCAR109052549 109064274
CAUA113109650 113109661
CGIB127966273
PTET122352742(sardh)
LROH127171925(sardh)
OMC131548321(sardh)
PPRM120482668(sardh)
RKG130073503(sardh)
MAMB125257695(sardh)
CIDE127521118
MASI127432966
TROS130546400(sardh)
TDW130411579(sardh)
MANU129447250(sardh)
IPU108276635
IFU128620169 128620698(sardh)
PHYP113544041(sardh)
SMEO124393246(sardh)
TFD113653074(sardh)
TVC132863207(sardh)
AMEX103038491(sardh)
CMAO118824921(sardh)
EEE113576323(sardh)
CHAR105906040(sardh)
TRU101066393(sardh)
TFS130517643(sardh)
TNGGSTEN00024728G001
LCO104923713(sardh)
NCC104968189(sardh)
TBEN117476396(sardh)
CGOB115016604(sardh)
PGEO117456399(sardh)
GACU117534085(sardh)
ELY117270080(sardh)
EFO125905775(sardh)
PLEP121959519(sardh)
SLUC116034954(sardh)
ECRA117959051(sardh)
ESP116704714(sardh)
PFLV114571014(sardh)
GAT120832222(sardh)
PPUG119226499(sardh)
AFB129102463(sardh)
CLUM117740414(sardh)
MSAM119914706(sardh)
SCHU122865194(sardh)
CUD121525654(sardh)
ALAT119030407(sardh)
MZE101464347(sardh)
ONL100708425(sardh)
OAU116335193(sardh)
OLA101171504(sardh)
OML112162906(sardh)
XMA102218956(sardh)
XCO114149434(sardh)
XHE116724090(sardh)
PRET103473627(sardh)
PFOR103147877(sardh)
PLAI106948297(sardh)
PMEI106921877(sardh)
GAF122847257(sardh)
PPRL129366447(sardh)
CVG107088710(sardh)
CTUL119782613(sardh)
GMU124872392(sardh)
NFU107372413(sardh)
KMR108232690(sardh)
ALIM106514558(sardh)
NWH119424550(sardh)
AOCE111567010(sardh)
MCEP124996692(sardh)
CSEM103389066(sardh)
POV109626083(sardh)
SSEN122758351(sardh)
HHIP117771594(sardh)
HSP118125404(sardh)
LCF108879253
SDU111238764(sardh)
SLAL111666073(sardh)
XGL120806360(sardh)
HCQ109517069(sardh)
SSCV125980042
SBIA133490562(sardh)
PEE133414082(sardh)
PTAO133489894(sardh)
BPEC110174148(sardh)
MALB109963453(sardh)
BSPL114866771(sardh)
SJO128380397(sardh)
SASA106561570(sardh)
STRU115159137(sardh)
OTW112235511(sardh)
OMY110523941(sardh)
OGO124048581(sardh)
ONE115127526(sardh)
OKI109868567(sardh)
OKE118387955(sardh)
SALP111961266(sardh)
SNH120026194(sardh)
CCLU121582864(sardh)
ELS105014778(sardh)
SFM108932522(sardh)
PKI111854167(sardh)
AANG118212851(sardh)
LOC102683068(sardh)
PSPA121303520(sardh) 121307070
ARUT117396956 117422502
PSEX120535140(sardh)
LCM102358838(SARDH)
CMK103183089(sardh)
HOC132825979(sardh)
LERI129712112(sardh)
PMRN116953236(SARDH)
LRJ133354673(SARDH)
BFO118421387
BBEL109465509
CIN100179924 100182727 100184925
SCLV120326566 120326837 120326875 120343979
SPU576973
LPIC129278088
APLC110984820
AJC117102826
SKO100374616(Sardh)
DMEDmel_CG6385(Sardh)
DER6546660
DSE6609685
DSIDsimw501_GD25443(Dsim_GD25443)
DYADyak_GE13964
DAN6496069
DSR110191126
DPO4805367
DPE6592810
DMN108159573 117193886
DWI6652181
DGR6562281
DMODmoj_GI23785
DAZ108610357
DNV115562207
DHE111600959
DVI6628364
CCAT101460422
BOD106618894
BDR105228945
RZE108359402
AOQ129245314
TDA119680841
MDE101899451
SCAC106091682
LCQ111688870
LSQ119613729 119614622
GFS119641567
ECOE129951912
HIS119655277
AGA1269983
ACOZ120951228
AARA120907545
AMER121591818
ASTE118511380
AFUN125767575
AMOU128304153
AALI118465372
AAG5565677 5572760
AALB109403674 109407988
CQUCpipJ_CPIJ004591 CpipJ_CPIJ016929
CPII120420098
CNS116345252 116348710 116349036
BCOO119067948 119079361
BIM100748086
BBIF117208124
BVK117235543
BVAN117154114
BTER100643113
BAFF126916392
BPYO122565774
BPAS132905386
FVI122534812
CCAL108629225
OBB114879267
OLG117610733
MGEN117227684
NMEA116432029
CGIG122398593
SOC105195588
MPHA105835145
AEC105144562 105144729
ACEP105618338
PBAR105431690
VEM105569751
HST105184399
DQU106746182
CFO105253367
FEX115234381
LHU105673907
PGC109857207
OBO105288106
PCF106788912
PFUC122517706
VPS122638164
VCRB124426914
VVE124946579
NVI103316656
CSOL105364420
TPRE106655629
LHT122508053
LBD127280105
MDL103575471
CGLO123272457
FAS105267456
DAM107038954
AGIF122855053
CINS118064118
VCAN122410613
CCIN107273333
DSM124407662
NPT124214228
NFB124177765
NLO107217484
NVG124300370
AROA105684623
TCA656849
DPA109533033
SOY115885282
AGRG126736428
ATD109597723
CSET123310519
AGB108903272
LDC111502476
NVL108568210
APLN108738448
PPYR116169980 116169982 116172170
OTU111425006
BMOR101743034
BMAN114247185
MSEX115453464
DPLKGM_204504
BANY112050165
MJU123864905
NIQ126779451
VCD124541659
MCIX123660816
PMAC106710382
PPOT106108150
PXU106117377
PRAP110993772
PBX123707243
PNAP125055796
ZCE119830144
CCRC123703688
LSIN126965660
HAW110382187
HZE124643796
TNL113492560
SLIU111357600
OFU114360011
PXY105381895
PGW126381603
CFEL113365503 113365504 113386018
CCRN123296798
CLEC106666323
HHAL106690642
MQU128992710
PHUPhum_PHUM213030
FOC113207710
TPAL117641156
ZNE110831180 110831181
CSEC111870731 111870733
SGRE126299609
IEL124169506
FCD110856220
DPXDAPPUDRAFT_308482
DMK116930444
DPZ124338461
PVM113821151 113822901
PJA122255467 122265981
PCHN125026237 125034535
PMOO119579938 119589287
HAME121870600 121870602
PCLA123764040
CQD128701620
PTRU123508387 123508458
ESN126981425 126986885
HAZT108675385
EAF111713614
LSM121119332
PPOI119103280
ISC8034007 8036170
DSV119437074
RSAN119394083
RMP119161133
VDE111248602
VJA111265115
CSCU111628631
PTEP107449896
UDV129223402
SDM118185941
LPOL106471624
LAK106167453
NVE5503178
EPA110254849
ATEN116292581
ADF107344630
AMIL114976066
PDAM113668163
SPIS111329248
DGT114530955
HMG100197405
HSY130662453
TADTRIADDRAFT_53512
SMINv1.2.021035.t1(symbB.v1.2.021035.t1)
AAFAURANDRAFT_22613(SDH1)
SPARSPRG_03481
EHXEMIHUDRAFT_97687
 » show all
Reference
1  [PMID:13716069]
  Authors
HOSKINS DD, MACKENZIE CG.
  Title
Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J Biol Chem 236:177-83 (1961)
Reference
2  [PMID:13895406]
  Authors
FRISELL WR, MACKENZIE CG.
  Title
Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J Biol Chem 237:94-8 (1962)
Reference
3  [PMID:6163778]
  Authors
Wittwer AJ, Wagner C
  Title
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins.
  Journal
J Biol Chem 256:4109-15 (1981)
Reference
4  [PMID:6180732]
  Authors
Steenkamp DJ, Husain M
  Title
The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases.
  Journal
Biochem J 203:707-15 (1982)
DOI:10.1042/bj2030707
Other DBs
ExplorEnz - The Enzyme Database: 1.5.8.3
IUBMB Enzyme Nomenclature: 1.5.8.3
ExPASy - ENZYME nomenclature database: 1.5.8.3
BRENDA, the Enzyme Database: 1.5.8.3
CAS: 37228-65-2 93389-49-2

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