KEGG ENZYME: 1.8.1.14

ENZYME: 1.8.1.14

Entry

EC 1.8.1.14                 Enzyme

Name

CoA-disulfide reductase;
CoA-disulfide reductase (NADH2);
NADH2:CoA-disulfide oxidoreductase;
CoA:NAD+ oxidoreductase (misleading);
CoADR;
coenzyme A disulfide reductase

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor

Sysname

CoA:NADP+ oxidoreductase

Reaction(IUBMB)

2 CoA + NADP+ = CoA-disulfide + NADPH + H+ [RN:R07175]

Reaction(KEGG)

R07175

Substrate

CoA [CPD:C00010];
NADP+ [CPD:C00006]

Product

CoA-disulfide [CPD:C02015];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

A flavoprotein. Not identical with EC 1.8.1.6 (cystine reductase), EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.13 (bis-gamma-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1].

History

EC 1.8.1.14 created 1992 as EC 1.6.4.10, transferred 2002 to EC 1.8.1.14, modified 2005, modified 2013

Orthology

K08255

CoA-disulfide reductase

Genes

SDO:	SD1155_07235

SAU:	SA0831(cdr)

SAV:	SAV0970(cdr)

SAW:	SAHV_0965(cdr)

SAH:	SaurJH1_0989

SAJ:	SaurJH9_0970

SAM:	MW0852(cdr)

SAS:

SAS0840

SAR:

SAR0933

SAC:

SACOL0975

SAX:	USA300HOU_0929(cdr)

SAA:	SAUSA300_0873(cdr)

SAO:	SAOUHSC_00908

SAE:	NWMN_0841(cdr)

SAD:

SAAV_0931

SUU:	M013TW_0889

SUV:	SAVC_04025

SUE:	SAOV_0917c

SUJ:	SAA6159_00830

SUK:	SAA6008_00923

SUC:	ECTR2_826(cdr)

SUT:	SAT0131_01003

SUQ:	HMPREF0772_12275(cdr)

SUZ:	MS7_0926(cdr)

SUD:	ST398NM01_0970

SUX:	SAEMRSA15_08000

SUW:	SATW20_09700

SUG:	SAPIG0970(cdr)

SUF:	SARLGA251_08880

SAUA:

SAAG_01324

SAUE:

RSAU_000847

SAUN:

SAKOR_00886

SAUS:

SA40_0837

SAUU:

SA957_0852

SAUG:

SA268_0852

SAUZ:

SAZ172_0911

SAUT:

SAI1T1_2006800(cdr)

SAUJ:

SAI2T2_1006820(cdr)

SAUK:

SAI3T3_1006810(cdr)

SAUQ:

SAI4T8_1006800(cdr)

SAUV:

SAI7S6_1006810(cdr)

SAUW:

SAI5S5_1006770(cdr)

SAUX:

SAI6T6_1006780(cdr)

SAUY:

SAI8T7_1006810(cdr)

SAUF:

X998_0969

SAB:

SAB0839c

SUY:	SA2981_0925(cdr)

SAUB:

C248_0996

SAUM:

BN843_8750

SAUC:

CA347_891(cdr)

SAUR:

SABB_00939(cdr)

SAUI:

AZ30_04610

SAUD:

CH52_01025

SAMS:

NI36_04595

SUH:	SAMSHR1132_08220

SER:

SERP0560

SEP:

SE_0669

SEPP:

SEB_00649

SEPS:

DP17_1962(cdr)

SHA:	SH1979(cdr)

SHH:	ShL2_01842

SSP:

SSP1804

SCA:	SCA_0578(cdr)

SLG:	SLGD_01888

SLN:	SLUG_18820

SSD:	SPSINT_0657

SDT:	SPSE_1865(cdr)

SDP:	NCTC12225_02092(cdr)

SWA:	A284_08865

SPAS:

STP1_2052

SXY:	BE24_02255

SXL:	SXYLSMQ121_1802

SXO:	SXYL_01950(cdr)

SHU:	SHYC_09425(cdr)

SCAP:

AYP1020_0240(cdr)

SSCH:

LH95_08910

SSCZ:

RN70_09390

SAGQ:

EP23_00565

SEQO:

SE1039_07350

SSIF:

AL483_07085

SCV:	A4G25_05030

SPET:

CEP67_11705

SLZ:	B5P37_08835

SCOH:

BZ166_00940

SNL:	BJD96_09995

SKL:	C7J89_11105

SFQ:	C7J90_06605

SHOM:

EGX58_01970

SMUS:

C7J88_10125

SCAR:

DWB96_09730

SCHR:

DWB92_09185

SARL:

SAP2_18420(cdr)

SPIC:

SAMEA4384060_1990(cdr)

SSH:	NCTC13712_00915(cdr)

SSIM:

SAMEA4384339_0828(cdr)

SDB:	CNQ82_04635

SLLO:

ISP08_09075

SAUL:

I6G39_08385

SRAI:

LN051_08385

SPSD:

JMB28_09785

STAS:

HYI43_09265

SURY:

MUA21_03430

SEDA:

MNY58_09655

SCAQ:

QMO72_09690

SDEV:

Q2T90_10110

SROT:

ML435_04365

STAP:

AOB58_1017

SSCU:

CEP64_08820

SFF:	FOB90_10580

SSTE:

SAMEA4384403_1887(cdr)

MLEN:

H3V22_13190

MVT:	I6J10_01935

MACR:

BHM04_06480

MARY:

LAU42_03495

MBRU:

MGG13_03740

MEPI:

KFV12_04505

MEQU:

KFV11_03495

MBOC:

QSV55_03650

MCL:	MCCL_0597(cdr)

MCAK:

MCCS_08170(cdr_2)

MBOE:

HT586_04335

SHV:	AAT16_03300

JEA:	JEM45_04705

NAMP:

KPF49_01840

NMY:	CJ229_008385

SBAC:

BVH56_06530

» show all

Reference

1 [PMID:410791]

Authors

Setlow B, Setlow P.

Title

Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium.

Journal

J Bacteriol 132:444-52 (1977)
DOI:10.1128/JB.132.2.444-452.1977

Reference

2 [PMID:9488707]

Authors

delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE

Title

Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme.

Journal

J Biol Chem 273:5744-51 (1998)
DOI:10.1074/jbc.273.10.5744

Sequence

[sao:SAOUHSC_00908]

Reference

3 [PMID:10052943]

Authors

Luba J, Charrier V, Claiborne A.

Title

Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides.

Journal

Biochemistry 38:2725-37 (1999)
DOI:10.1021/bi9825899