Entry
Name
L-methionine (S)-S-oxide reductase;
fSMsr;
methyl sulfoxide reductase I and II;
acetylmethionine sulfoxide reductase;
methionine sulfoxide reductase;
L-methionine:oxidized-thioredoxin S-oxidoreductase;
methionine-S-oxide reductase;
free-methionine (S)-S-oxide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
L-methionine:thioredoxin-disulfide S-oxidoreductase
Reaction(IUBMB)
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin [RN:
R07606 ]
Reaction(KEGG)
Substrate
Product
L-methionine (S)-S-oxide [CPD:
C15999 ];
thioredoxin [CPD:
C00342 ]
Comment
Requires NADPH [2]. The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC
1.8.4.14 , L-methionine (R)-S-oxide reductase].
History
EC 1.8.4.13 created 1984 as EC 1.8.4.5, part transferred 2006 to EC 1.8.4.13
Pathway
ec00270 Cysteine and methionine metabolism
Reference
1
Authors
Black, S., Harte, E.M., Hudson, B. and Wartofsky, L.
Title
A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides.
Journal
J Biol Chem 235:2910-2916 (1960)
Reference
Authors
Ejiri SI, Weissbach H, Brot N.
Title
Reduction of methionine sulfoxide to methionine by Escherichia coli.
Journal
Reference
Authors
Ejiri SI, Weissbach H, Brot N.
Title
The purification of methionine sulfoxide reductase from Escherichia coli.
Journal
Reference
Authors
Weissbach H, Resnick L, Brot N.
Title
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.13
ExPASy - ENZYME nomenclature database: 1.8.4.13