Entry
Name
columbamine O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:columbamine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine [RN:
R03721 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
columbamine [CPD:
C01795 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
palmatine [CPD:
C05315 ]
Comment
The product of this reaction is a protoberberine alkaloid that is widely distributed in the plant kingdom. This enzyme is distinct in specificity from EC
2.1.1.88 , 8-hydroxyquercetin 8-O-methyltransferase.
History
EC 2.1.1.118 created 1999
Pathway
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13398 columbamine O-methyltransferase
Reference
1
Authors
Rueffer, M., Amann, M., Zenk, M.H.
Title
S-Adenosyl-L-methionine:columbamine O-methyltransferase, a compartmentalized enzyme in protoberberine biosynthesis.
Journal
Plant Cell Reports 3:182-185 (1986)
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.118