KEGG   ENZYME: 2.1.1.155
Entry
EC 2.1.1.155                Enzyme                                 
Name
kaempferol 4'-O-methyltransferase;
S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase;
F 4'-OMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + kaempferide [RN:R06807]
Reaction(KEGG)
R06807
Substrate
S-adenosyl-L-methionine [CPD:C00019];
kaempferol [CPD:C05903]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
kaempferide [CPD:C10098]
Comment
The enzyme acts on the hydroxy group in the 4'-position of some flavones, flavanones and isoflavones. Kaempferol, apigenin and kaempferol triglucoside are substrates, as is genistein, which reacts more slowly. Compounds with an hydroxy group in the 3' and 4' positions, such as quercetin and eriodictyol, do not act as substrates. Similar to EC 2.1.1.75, apigenin 4'-O-methyltransferase and EC 2.1.1.83, 3,7-dimethylquercetin 4'-O-methyltransferase.
History
EC 2.1.1.155 created 2004
Pathway
ec00944  Flavone and flavonol biosynthesis
Reference
1  [PMID:12899699]
  Authors
Curir P, Lanzotti V, Dolci M, Dolci P, Pasini C, Tollin G.
  Title
Purification and properties of a new S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase from carnation (Dianthus caryophyllus L.).
  Journal
Eur J Biochem 270:3422-31 (2003)
DOI:10.1046/j.1432-1033.2003.03729.x
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.155
IUBMB Enzyme Nomenclature: 2.1.1.155
ExPASy - ENZYME nomenclature database: 2.1.1.155
BRENDA, the Enzyme Database: 2.1.1.155
CAS: 80747-20-2

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