KEGG ENZYME: 2.1.1.164

ENZYME: 2.1.1.164

Entry

EC 2.1.1.164                Enzyme

Name

demethylrebeccamycin-D-glucose O-methyltransferase;
RebM

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase

Reaction(IUBMB)

4'-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine [RN:R09569]

Reaction(KEGG)

R09569

Substrate

4'-demethylrebeccamycin;
S-adenosyl-L-methionine [CPD:C00019]

Product

rebeccamycin [CPD:C19701];
S-adenosyl-L-homocysteine [CPD:C00021]

Comment

Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers [1]. The enzyme is a member of the general acid/base-dependent O-methyltransferase family [2].

History

EC 2.1.1.164 created 2010

Pathway

ec00404

Staurosporine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19889

demethylrebeccamycin-D-glucose O-methyltransferase