| Entry |
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| Name |
23S rRNA (uridine2552-2'-O)-methyltransferase;
Um(2552) 23S ribosomal RNA methyltransferase;
heat shock protein RrmJ;
RrmJ;
FTSJ;
Um2552 methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:23S rRNA (uridine2552-2'-O-)-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + uridine2552 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
uridine2552 in 23S rRNA
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
2'-O-methyluridine2552 in 23S rRNA
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| Comment |
The enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA [3].
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| History |
EC 2.1.1.166 created 2010
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| Orthology |
| K02427 | 23S rRNA (uridine2552-2'-O)-methyltransferase |
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| Genes |
| CJC: | 100399987(MRM2) 118150627 |
| SBQ: | 101046754(FTSJ2) 101048657 |
| MORG: | 121446148(Mrm2) 121464958 |
| PSIU: | 116740347(MRM2) 116750521 |
| DNM: | 101418670(MRM2) 101426533 |
| ASAO: | 132779986 132782156(MRM2) |
| SANH: | 107674604 107703397 |
| SASA: | 106601122 106607333 |
| OTW: | 112226027(mrm2) 112245989 |
| OMY: | 100305295(rrmj2) 110538234(mrm2) |
| CCLU: | 121550610 121569545 |
| PSPA: | 121294088 121300943(mrm2) |
| DME: | Dmel_CG11447(Mrm2) Dmel_CG7009(Trm7-34) |
| DSI: | Dsimw501_GD19317(Dsim_GD19317) Dsimw501_GD28117(Dsim_GD28117) |
| DYA: | Dyak_GE11211 Dyak_GE25011 Dyak_GE25629 |
| CQU: | CpipJ_CPIJ001336 CpipJ_CPIJ018014 |
| MQU: | 128999223 129001131 129001254 129001883 |
| CSEC: | 111866490 117282013 |
| PPOI: | 119095087 119095091 |
| CEL: | CELE_F45G2.9(F45G2.9) |
| DPOL: | 127847504 127847959 |
| CCAC: | CcaHIS019_0207390(MRM2) |
| ABP: | AGABI1DRAFT108362(AGABI1DRAFT_108362) |
| ABV: | AGABI2DRAFT122996(AGABI2DRAFT_122996) |
| SCM: | SCHCO_02518303(SCHCODRAFT_02518303) |
| SMIN: | v1.2.006933.t1(symbB.v1.2.006933.t1) |
| ECOO: | ECRM13514_4138(rrmJ) |
| ECOH: | ECRM13516_3942(rrmJ) |
| ELR: | ECO55CA74_18625(rrmJ) |
| ECW: | EcE24377A_3664(rrmJ) |
| EDJ: | ECDH1ME8569_3068(rrmJ) |
| ECOI: | ECOPMV1_03488(rlmE) |
| SEM: | STMDT12_C33520(rrmJ) |
| SETC: | CFSAN001921_00525(rrmJ) |
| SEEN: | SE451236_22585(rrmJ) |
| SENH: | CFSAN002069_15690(rrmJ) |
| SEEH: | SEEH1578_02585(rrmJ) |
| SENJ: | CFSAN001992_17070(rrmJ) |
| SEEC: | CFSAN002050_23450(rrmJ) |
| SEEB: | SEEB0189_003385(rrmJ) |
| SENC: | SEET0819_00085(rrmJ) |
| REE: | electrica_00505(rlmE) |
| RTG: | NCTC13098_00694(rlmE) |
| SENM: | TRABTM_A_02150(rlmE) |
| CLAP: | NCTC11466_00356(rlmE) |
| KIE: | NCTC12125_04445(rlmE) |
| BAGE: | BADSM9389_04960(rlmE) |
| CMIK: | PMARG_ME00040(rlmE) |
| AHN: | NCTC12129_04349(ftsJ) |
| METY: | MRY16398_05940(rlmE) |
| PTF: | PROFFT_A_03400(rlmE) |
| PSHI: | SAMEA2665130_2573(rlmE) |
| YPG: | YpAngola_A3984(rrmJ) |
| YPI: | YpsIP31758_3603(rrmJ) |
| SMW: | SMWW4_v1c04240(rlmE) |
| SERS: | SERRSCBI_01955(rrmJ) |
| SFJ: | SAMEA4384070_0502(rlmE) |
| SOF: | NCTC11214_01120(rlmE) |
| PAQU: | DMB82_0003500(rlmE) |
| DIC: | Dpoa569_003340(rlmE) |
| EHD: | ERCIPSTX3056_525(rlmE) |
| BAPF: | BUMPF009_CDS00214(ftsj) |
| BAPG: | BUMPG002_CDS00214(ftsj) |
| BAPU: | BUMPUSDA_CDS00214(ftsj) |
| BAPW: | BUMPW106_CDS00214(ftsj) |
| TPTY: | NCTC11468_00317(rlmE) |
| PHEI: | NCTC12003_03630(rlmE) |
| PRJ: | NCTC6933_03640(rlmE) |
| LRI: | NCTC12151_03057(rlmE) |
| HIC: | NTHIC486_01245(rlmE) |
| HPIT: | NCTC13334_01802(rrmJ) |
| HHZ: | NCTC10839_01344(rlmE) |
| HAEG: | NCTC8502_01677(rlmE) |
| PDAG: | 4362423_00664(rlmE) |
| ADP: | NCTC12871_00399(rrmJ) |
| ALIG: | NCTC10568_00861(rrmJ) |
| ASEG: | NCTC10977_01511(rlmE) |
| AVT: | NCTC3438_01317(rlmE) |
| RPNE: | NCTC8284_02198(rlmE) |
| PAET: | NCTC13378_01072(rlmE) |
| XFU: | XFF4834R_chr27800(rlmE) |
| XPH: | XppCFBP6546_18940(rlmE) |
| XHD: | LMG31886_25780(rlmE) |
| LLZ: | LYB30171_01935(rlmE) |
| VAU: | VANGNB10_cI0535(rrmJ) |
| VPL: | SA104470976_02092(rrmJ) |
| PAEB: | NCGM1900_5485(rrmJ) |
| PPSE: | BN5_0920(rrmJ) BN5_3954(ftsJ) |
| PVD: | CFBP1590__4505(rlmE) |
| PPRC: | PFLCHA0_c08490(rlmE) |
| PMUD: | NCTC8068_00764(rrmJ) |
| PFW: | PF1751_v1c47110(rrmJ) |
| PFF: | PFLUOLIPICF712430(rrmJ) |
| PPUU: | PputUW4_00698(rlmE) |
| PSET: | THL1_1695 THL1_4927 |
| PTRT: | HU722_0025100(rlmE) |
| PWZ: | J7655_16625(rlmE) J7655_19570(rlmE) |
| PTW: | TUM18999_34880(rlmE) |
| PTAE: | NCTC10697_03807(rlmE) |
| MSHE: | MAALD49_26430(rlmE) |
| PSYC: | DABAL43B_2318(ftsJ) |
| ACUM: | C9E88_016455(rlmE) C9E88_17370(rlmE) |
| MCAT: | MC25239_00451(rlmE) |
| MCUN: | NCTC10297_00944(rlmE) |
| SCAA: | TUM17387_28960(rlmE) |
| PLZ: | S4054249_15465(rrmJ) |
| CBS: | COXBURSA331_A1508(rrmJ) |
| LLG: | 44548918_02516(rrmJ) |
| LJR: | NCTC11533_02669(rrmJ) |
| LCJ: | NCTC11976_00342(rrmJ) |
| LWA: | SAMEA4504053_3297(rlmE) |
| LSS: | NCTC12082_01854(rlmE) |
| LADL: | NCTC12735_01588(rlmE) |
| LANT: | TUM19329_33000(rlmE) |
| MISZ: | MishRS11D_28280(rlmE) |
| TIB: | THMIRHAM_15080(rlmE) |
| TSE: | THMIRHAS_17450(rlmE) |
| TZO: | THMIRHAT_16940(rlmE) |
| RHEI: | ATY27_10520(rrmJ) ATY27_19135(rrmJ) |
| TFRI: | Thiofri_01509(rlmE) |
| TNI: | TVNIR_3132(rlmE_[H]) |
| GAI: | IMCC3135_11030(rlmE) |
| THIC: | TspCOW1_09590(rlmE) |
| HAXI: | HAALTHF_04060n(rlmE) |
| ALCA: | ASALC70_01586(rlmE) |
| AEL: | NCTC12917_01019(rrmJ) |
| CHJ: | NCTC10426_00288(rlmE) |
| CDIZ: | CEDIAZO_02688(rlmE) |
| NMQ: | NMBM04240196_1366(rrmJ) |
| NMZ: | NMBNZ0533_0848(rrmJ) |
| NMX: | NMA510612_1131(ftsJ) |
| NWE: | SAMEA3174300_0759(rlmE) |
| NZO: | SAMEA4504057_1874(rlmE) |
| NCI: | NCTC10296_01447(rlmE) |
| NCZ: | NCTC10294_00443(rlmE) |
| NANI: | NCTC12227_00640(rlmE) |
| ECOR: | SAMEA4412678_1457(rlmE) |
| BMV: | BMASAVP1_A1287(rrmJ) |
| BML: | BMA10229_A0581(rrmJ) |
| BPM: | BURPS1710b_1614(rrmJ) |
| BPL: | BURPS1106A_1511(rrmJ) |
| BYI: | BYI23_A018620(rrmJ_ftsJ) |
| BUE: | BRPE67_ACDS19250(rrmJ_ftsJ) |
| PLG: | NCTC10937_04522(rlmE) |
| LMIR: | NCTC12852_01299(rlmE) |
| VTR: | MYVALT_C_00050(rlmE) |
| BTRM: | SAMEA390648702261(ftsJ) |
| AXX: | ERS451415_04829(rlmE) |
| LIM: | L103DPR2_02037(rlmE) |
| LIH: | L63ED372_01539(rlmE) |
| URU: | DSM104443_03415(rlmE) |
| UPL: | DSM104440_02929(rlmE) |
| FPHO: | SHINM1_004700(rlmE) |
| SSDC: | SSDC_00515(rrmJ_ftsJ) |
| APHA: | WSQ_02435 WSQ_02455 |
| ERW: | ERWE_CDS_05160(rrmJ) |
| ERG: | ERGA_CDS_05070(rrmJ) |
| RBS: | RHODOSMS8_00649(rlmE) |
| SMEL: | SM2011_c00811(rrmJ) |
| SFD: | USDA257_c04710(rlmE) |
| SAME: | SAMCFNEI73_Ch0792(rlmE) |
| AGR: | AGROH133_04089(ftsJ) |
| AVV: | RvVAT039_22710(rlmE) |
| AVF: | RvVAR031_10010(rlmE) |
| REC: | RHECIAT_CH0000875(ftsJ) |
| REL: | REMIM1_CH00799(rlmE) |
| REP: | IE4803_CH00798(rlmE) |
| REI: | IE4771_CH00824(rlmE) |
| RTR: | RTCIAT899_CH03730(rrmJ2) |
| RGA: | RGR602_CH00848(rlmE) |
| RPHA: | AMC79_CH00815(rlmE) |
| NEN: | NCHU2750_03440(rlmE) |
| BIO: | BR141012304_20337(rrmJ) |
| VGO: | GJW-30_1_02745(rlmE) |
| BHS: | BM1374165_00164(ftsJ) |
| BBK: | BARBAKC583_0316(rrmJ) |
| BTX: | BM1374166_00153(ftsJ) |
| BEZ: | NCTC12898_00045(rlmE) |
| MAQU: | Maq22A_c00045(ftsJ) |
| MTUN: | MTUNDRAET4_4021(rlmE) |
| FIL: | BN1229_v1_2252(rlmE) |
| FIY: | BN1229_v1_2251(rlmE) |
| BVY: | NCTC9239_01993(rlmE) |
| TSV: | DSM104635_02375(rlmE) |
| RLI: | RLO149_c013810(rrmJ) |
| PHP: | PhaeoP97_01617(rrmJ) |
| PPIC: | PhaeoP14_01510(rrmJ) |
| SINL: | DSM14862_01467(rlmE) |
| SPSE: | SULPSESMR1_01470(rlmE) |
| RMM: | ROSMUCSMR3_00010(rlmE) |
| AHT: | ANTHELSMS3_03198(rlmE) |
| LALG: | LentiSH36_01312(rrmJ) |
| LVS: | LOKVESSMR4R_01308(rlmE) |
| SBIN: | SBA_ch1_09950(rlmE) |
| SFLA: | SPHFLASMR4Y_00538(rlmE) |
| PMAS: | NCF86_00090 NCF86_15485(rlmE) |
| SROE: | JL101_010325 JL101_030215 |
| PPOR: | JCM14722_07760(rlmE) |
| DALK: | DSCA_11160 DSCA_27870(rlmE) |
| BAFH: | BafHLJ01_0341(ftsJ) |
| TVO: | TVG0303954(TVG0303954) |
| LOKI: | Lokiarch_25100(rlmE) |
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| Reference |
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| Authors |
Caldas T, Binet E, Bouloc P, Costa A, Desgres J, Richarme G |
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| Title |
The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hager J, Staker BL, Bugl H, Jakob U |
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| Title |
Active site in RrmJ, a heat shock-induced methyltransferase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hager J, Staker BL, Jakob U |
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| Title |
Substrate binding analysis of the 23S rRNA methyltransferase RrmJ. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U |
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| Title |
RNA methylation under heat shock control. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.166 |
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