KEGG ENZYME: 2.1.1.2

ENZYME: 2.1.1.2

Entry

EC 2.1.1.2                  Enzyme

Name

guanidinoacetate N-methyltransferase;
GA methylpherase;
guanidinoacetate methyltransferase;
guanidinoacetate transmethylase;
methionine-guanidinoacetic transmethylase;
guanidoacetate methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine [RN:R01883]

Reaction(KEGG)

R01883

Substrate

S-adenosyl-L-methionine [CPD:C00019];
guanidinoacetate [CPD:C00581]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
creatine [CPD:C00300]

History

EC 2.1.1.2 created 1961

Pathway

ec00260

Glycine, serine and threonine metabolism

ec00330

Arginine and proline metabolism

ec01100

Metabolic pathways

Orthology

K00542

guanidinoacetate N-methyltransferase

Genes

HSA:	2593(GAMT)

PTR:	749982(GAMT)

PPS:	100973784(GAMT)

GGO:	101150449(GAMT)

PON:	100434735(GAMT)

NLE:	100604929 115830901(GAMT)

HMH:	116484169(GAMT)

MCC:	721263(GAMT)

MCF:	102120326(GAMT)

MTHB:

126942750

MNI:	105486165(GAMT)

CSAB:

103233606(GAMT)

CATY:

105591715(GAMT)

TGE:	112613537(GAMT)

MLEU:

105551990(GAMT)

RRO:	104671415(GAMT)

RBB:	108530253(GAMT)

TFN:	117076662(GAMT)

PTEH:

111526807(GAMT)

CANG:

105527684(GAMT)

CJC:	100394705(GAMT)

SBQ:	101034312(GAMT)

CIMI:

108293149(GAMT) 119469187

MMUR:

105860790(GAMT)

LCAT:

123632776(GAMT)

PCOQ:

105811288(GAMT)

OGA:	100965714(GAMT)

MMU:	14431(Gamt)

MCAL:

110303213(Gamt)

MPAH:

110326803(Gamt)

RNO:	25257(Gamt)

MCOC:

116075722(Gamt)

ANU:	117696447(Gamt)

MUN:	110551319(Gamt)

CGE:	100755964(Gamt)

MAUA:

101833877(Gamt)

PROB:

127216629(Gamt)

PLEU:

114684128(Gamt)

MORG:

121459656(Gamt)

MFOT:

126489274

AAMP:

119821293(Gamt)

NGI:	103737328(Gamt)

HGL:	101701700(Gamt)

CPOC:

100735222(Gamt)

CCAN:

109691010(Gamt)

DORD:

105990418(Gamt)

DSP:	122122772(Gamt)

PLOP:

125348503(Gamt)

NCAR:

124968481

MMMA:

107157248(Gamt)

OPI:	101532561(GAMT)

TUP:	102486225(GAMT)

GVR:	103586721(GAMT)

CFA:	485085(GAMT)

CLUD:

112666184(GAMT)

VVP:	112935562(GAMT)

VLG:	121495614(GAMT)

NPO:	129521660(GAMT)

AML:	100478678(GAMT)

UMR:	103681783(GAMT)

UAH:	113242729(GAMT)

UAR:	123794023(GAMT)

ELK:

111161694

LLV:

125089119

MPUF:

101676213(GAMT)

MNP:	132010706(GAMT)

MLK:	131823198(GAMT)

NVS:	122910830(GAMT)

ORO:	101373126(GAMT)

EJU:	114226197(GAMT)

ZCA:	113916152(GAMT)

MLX:	118005113(GAMT)

NSU:	110593865(GAMT)

LWW:	102730382(GAMT)

FCA:	101096703(GAMT)

PYU:	121021302(GAMT)

PBG:	122488598(GAMT)

PVIV:

125159705(GAMT)

LRUF:

124527706

PTG:	102972234(GAMT)

PPAD:

109257654(GAMT)

PUC:

125928802

AJU:

106983718

HHV:	120242358(GAMT)

BTA:	515270(GAMT)

BOM:	102277266(GAMT)

BIU:	109561988(GAMT)

BBUB:

102411011(GAMT)

BBIS:

104991891(GAMT)

CHX:	102176603(GAMT)

OAS:	101114955(GAMT)

BTAX:

128050798(GAMT)

ODA:	120863702(GAMT)

CCAD:

122439961(GAMT)

MBEZ:

129558788(GAMT)

SSC:	100625146(GAMT)

CFR:	102522185(GAMT)

CBAI:

105078135(GAMT)

CDK:	105104108(GAMT)

VPC:	102544140(GAMT)

BACU:

102999076(GAMT)

BMUS:

118893576(GAMT)

LVE:	103069008(GAMT)

OOR:	101289055(GAMT)

DLE:	111170486(GAMT)

PCAD:

102991016(GAMT)

PSIU:

116751826(GAMT) 116754479

NASI:

112396303(GAMT)

ECB:	100068840(GAMT)

EPZ:	103544271(GAMT)

EAI:	106834186(GAMT)

MYB:	102240125(GAMT)

MYD:	102765033(GAMT)

MMYO:

118658661(GAMT)

MLF:	102424140(GAMT)

PKL:	118711785(GAMT)

EFUS:

103294304(GAMT)

MNA:	107534553(GAMT)

DRO:	112312443(GAMT)

SHON:

118984405(GAMT)

AJM:	119044189(GAMT)

PDIC:

114503029(GAMT)

PHAS:

123813922(GAMT)

MMF:	118615577(GAMT)

PPAM:

129080071(GAMT)

HAI:	109390668(GAMT)

RFQ:	117037420(GAMT)

PALE:

102878441(GAMT)

PGIG:

120583688(GAMT)

PVP:	105302239(GAMT)

RAY:	107500940(GAMT)

MJV:	108399435(GAMT)

TOD:	119240503(GAMT)

SARA:

101539449(GAMT)

TMU:

101353747

ETF:	101640457(GAMT)

DNM:	101446379(GAMT)

MDO:	100015231(GAMT)

GAS:	123256775(GAMT)

SHR:	100926458(GAMT)

AFZ:

127545116

PCW:	110223482(GAMT)

OAA:	103164686(GAMT)

GGA:	770737(GAMT)

MGP:	100544992(GAMT)

CJO:	107325467(GAMT)

TPAI:

128088938(GAMT)

LMUT:

125685065(GAMT)

NMEL:

110388919(GAMT)

APLA:

101803779(GAMT)

ACYG:

106048218(GAMT)

CATA:

118260850(GAMT)

AFUL:

116499105(GAMT)

TGU:	100218458(GAMT)

LSR:	110480203(GAMT)

SCAN:

103822054 115484542

PMOA:

120513507(GAMT)

OTC:	121341778(GAMT)

PRUF:

121355110 121361133(GAMT)

GFR:	102031970(GAMT)

FAB:	101818937(GAMT)

OMA:	130264580(GAMT)

PHI:	102112087(GAMT)

PMAJ:

107215490(GAMT)

CCAE:

111940328(GAMT)

CCW:	104697066(GAMT)

CBRC:

103622191(GAMT)

ETL:	114066419(GAMT)

ZAB:	102070095(GAMT)

ACHL:

103803307(GAMT)

SVG:	106857116(GAMT)

MMEA:

130580190(GAMT)

HRT:	120763487(GAMT)

FPG:	101922263(GAMT)

FCH:	102052811(GAMT)

CLV:	102093632(GAMT)

EGZ:	104128293(GAMT)

NNI:	104016283(GAMT)

PLET:

104625874(GAMT)

ACUN:

113489307(GAMT)

TALA:

116960396(GAMT)

AFOR:

103899405(GAMT)

ACHC:

115348863(GAMT)

HLE:	104829100(GAMT)

AGEN:

126041566

GCL:

127025550

CSTI:

104555403(GAMT)

SHAB:

115618036(GAMT)

DPUB:

104299061(GAMT)

CVF:	104286016(GAMT)

RTD:	128900748(GAMT)

CUCA:

104065791(GAMT)

AAM:	106486552(GAMT)

AROW:

112965667(GAMT)

NPD:	112946913(GAMT)

DNE:	112993212(GAMT)

ASN:	102376844(GAMT)

AMJ:	102571343(GAMT)

CPOO:

109312314(GAMT)

GGN:	109294948(GAMT)

PSS:	102458769(GAMT)

CMY:	102941606(GAMT)

CCAY:

125627307(GAMT)

DCC:	119848316(GAMT)

CPIC:

101931504(GAMT)

TST:	117868860(GAMT)

CABI:

116831036(GAMT)

MRV:	120391569(GAMT)

ACS:	100566527(gamt)

ASAO:

132781077(GAMT)

PVT:	110072519(GAMT)

SUND:

121937122(GAMT)

PMUR:

107282878(GAMT)

CTIG:

120310738(GAMT)

TSR:	106546392(GAMT)

PGUT:

117668564(GAMT)

APRI:

131188311(GAMT)

PTEX:

113434982(GAMT)

NSS:	113423657(GAMT)

VKO:	123036596(GAMT)

PMUA:

114588427(GAMT)

PRAF:

128405766(GAMT)

ZVI:	118087963(GAMT)

HCG:	128346222(GAMT)

GJA:	107115757(GAMT)

STOW:

125433489(GAMT)

EMC:	129329798(GAMT)

XLA:	380384(gamt.S) 733150(gamt.L)

XTR:	394491(gamt)

NPR:	108792400(GAMT)

RTEM:

120913463(GAMT)

BBUF:

120989441(GAMT)

BGAR:

122930178(GAMT)

MUO:	115479445(GAMT)

GSH:	117364617(GAMT)

DRE:	796865(gamt)

SRX:	107747596 107747770 107757934

SANH:

107680536 107685360

SGH:	107553529 107597217

CCAR:

109063324 109106221

CAUA:

113110737(gamt)

CGIB:

127968310

PTET:

122353526(gamt)

LROH:

127173406(gamt)

OMC:	131549858(gamt)

PPRM:

120476410(gamt)

RKG:	130100877(gamt)

MAMB:

125256963(gamt)

CIDE:

127522589

MASI:

127426594 127427677

TROS:

130571317(gamt)

TDW:	130410373(gamt)

MANU:

129427127 129428068

IPU:	100528342(gamt)

IFU:	128613911(gamt)

PHYP:

113531337(gamt)

SMEO:

124391541(gamt)

TFD:	113657791(gamt)

TVC:	132852155(gamt)

AMEX:

103023041(gamt)

CMAO:

118818792(gamt)

EEE:	113574537(gamt)

CHAR:

122129095(gamt)

TRU:	101067635(gamt)

TFS:	130528241(gamt)

TNG:	GSTEN00019326G001

LCO:	104928396(gamt)

NCC:	104946919(gamt)

TBEN:

117495741(gamt)

CGOB:

115007149(gamt)

PGEO:

117445698(gamt)

GACU:

117544219(gamt)

EMAC:

134869791(gamt)

ELY:	117253519(gamt)

EFO:	125896270(gamt)

PLEP:

121941105(gamt)

SLUC:

116053066(gamt)

ECRA:

117950909(gamt)

ESP:	116695996(gamt)

PFLV:

114561283(gamt)

GAT:	120824493(gamt)

PPUG:

119216832(gamt)

AFB:	129094519(gamt)

CLUM:

117729740(gamt)

PSWI:

130191631 130194123(gamt)

MSAM:

119900510(gamt)

SCHU:

122878137(gamt)

CUD:	121512853(gamt)

ALAT:

119028000(gamt)

MZE:	101466486(gamt)

ONL:	100693706(gamt)

OAU:	116318306(gamt)

OLA:	101166292(gamt)

OML:	112150104(gamt)

CSAI:

133457850(gamt)

XMA:	102217090(gamt)

XCO:	114150327(gamt)

XHE:	116726186(gamt)

PRET:

103463348(gamt)

PFOR:

103143846(gamt)

PLAI:

106962614(gamt)

PMEI:

106920103(gamt)

GAF:	122839102(gamt)

PPRL:

129378240(gamt)

CVG:	107096976(gamt)

CTUL:

119783843(gamt)

GMU:	124873691(gamt)

NFU:	107392816(gamt)

KMR:	108234267(gamt)

ALIM:

106519249(gamt)

NWH:	119407686(gamt)

AOCE:

111582783(gamt)

MCEP:

125010011(gamT)

CSEM:

103395941(gamt)

POV:	109636527(gamt)

SSEN:

122780964(gamt)

HHIP:

117759723(gamt)

HSP:	118120656(gamt)

SMAU:

118317790(gamt)

LCF:

108877437

SDU:	111216321(gamt)

SLAL:

111670011(gamt)

XGL:	120790433(gamt)

HCQ:	109519128(gamt)

SSCV:

125976197

SBIA:

133503898(gamt)

PEE:	133406330(gamt)

PTAO:

133480856(gamt)

BPEC:

110167651(gamt)

MALB:

109966838(gamt)

BSPL:

114854827(gamt)

SJO:	128361605(gamt)

SASA:

100196494(gamt) 106573878

STRU:

115151701 115158120

OTW:	112250754 112252153

OMY:	110495805 110524165(gamt)

OGO:	123991489 123998045

ONE:	115108197 115109169

OKI:	109889144 109902393

OKE:	118388482 118401441(gamt)

SALP:

111952574 111975887

SNH:	120053391(gamt) 120054431

CCLU:

121533646 121576847(gamt)

ELS:	105029301(gamt)

SFM:	108930551(gamt)

PKI:	111860201(gamt)

AANG:

118224621(gamt)

LOC:	102690964(gamt)

PSPA:

121301522 121301551

ARUT:

117401388 117966392

PSEX:

120537883(gamt)

LCM:	102360926(GAMT)

CMK:	103181936(gamt)

RTP:	109915729 109915730

CPLA:

122565398

HOC:	132829190(gamt)

LERI:

129711355(gamt)

PMRN:

116943668 116953525

LRJ:	133349902 133355045

BFO:	118405309 118406015 118411989

BBEL:

109468742 109472687

CIN:	100176150 100181581

SCLV:

120340781

SPU:	115919361 578397

LPIC:

129257300

APLC:

110978082

AJC:

117101973

SKO:

100376150

GAE:

121392167

LAK:

106178783

NVE:

5518556

EPA:

110239991

ATEN:

116298450

ADF:

107336691

AMIL:

114957391

PDAM:

113672541

SPIS:

111335936

DGT:

114525313

XEN:

124450373

HSY:

130654374

AQU:

100636366

BVG:

104885916

AAF:	AURANDRAFT_68827

PIF:	PITG_10477

PSOJ:

PHYSODRAFT_462469

SPAR:

SPRG_14186

THIS:

HZT40_06130

THIP:

N838_28140

DMM:	dnm_038680 dnm_076910

SKY:	D0C37_30560

FRA:	Francci3_3001

FRE:	Franean1_1949

AOI:

AORI_2931

AJA:	AJAP_12340

PFLA:

Pflav_057100

PSUU:

Psuf_016690

MPRO:

BJP34_00295

HBQ:	QI031_13835

WIN:

WPG_0392

» show all

Reference

Authors

Cantoni, G.L. and Scarano, E.

Title

The formation of S-adenosylhomocysteine in enzymatic transmethylation reactions.

Journal

J Am Chem Soc 76:4744 (1954)

Reference

2 [PMID:13192118]

Authors

CANTONI GL, VIGNOS PJ Jr.

Title

Enzymatic mechanism of creatine synthesis.

Journal

J Biol Chem 209:647-59 (1954)

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.2

IUBMB Enzyme Nomenclature:

2.1.1.2

ExPASy - ENZYME nomenclature database:

2.1.1.2

BRENDA, the Enzyme Database:

2.1.1.2

CAS:

9029-75-8

DBGET integrated database retrieval system