Entry
Name
tRNA (cytosine38-C5)-methyltransferase;
hDNMT2 (gene name);
DNMT2 (gene name);
TRDMT1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA [RN:
R00595 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
cytosine38 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
5-methylcytosine38 in tRNA
Comment
The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3].
History
EC 2.1.1.204 created 1976 as EC 2.1.1.29, part transferred 2011 to EC 2.1.1.204
Orthology
K15336 tRNA (cytosine38-C5)-methyltransferase
Genes
PCOQ : 105823674(TRDMT1) 105827113
NCAR : 124962204 124992575
MUO : 115458734 115468058(TRDMT1)
SRX : 107712773 107732079(trdmt1)
SANH : 107657754(trdmt1) 107677147
CAUA : 113042544 113042564 113045037
CGIB : 127946616 128013459
MASI : 127431815 127434532
GAT : 120811352 120812006 120813215 120814357 120815236
LCF : 108874197 108898777(trdmt1)
XGL : 120787902 120789719(trdmt1)
LPIC : 129263324 129263784
APLC : 110987477 110987752
DSI : Dsimw501_GD23816(Dsim_Mt2)
CLON : 129618102 129618105 129618994
MGEN : 117225924 117226280 117228257
DPX : DAPPUDRAFT_187425(DNMT2)
ABRU : 129958280 129958809
SMM : Smp_145390 Smp_198180
SHX : MS3_00007655(TRDMT1_1)
CSAT : 104706869 104736574 104771030
HSYR : 120134477 120144620 120196371
TPRA : 123910614 123911058
LJA : Lj6g3v2204760.1(Lj6g3v2204760.1)
AHF : 112714835 112785319 112805245
MSYL : 126602121 126603274 126631132
CSAV : 115708999 115709402
CCAV : 112521000 112521001
PSOM : 113341041 113361076
DOSA : Os01t0612000-01(Os01g0612000)
TAES : 100859954 123061457 123070101
SMO : SELMODRAFT_105635 SELMODRAFT_98974
OLU : OSTLU_16070(DMT3502) OSTLU_87597(DMT3501)
OTA : OT_ostta06g03670 OT_ostta07g01440
MIS : MICPUN_79083 MICPUN_84170
MPP : MICPUCDRAFT_45851(JGI:MicpuC2_45851) MICPUCDRAFT_57303(JGI:MicpuC2_57303)
ABP : AGABI1DRAFT123710(AGABI1DRAFT_123710)
ABV : AGABI2DRAFT198459(AGABI2DRAFT_198459)
SCM : SCHCO_01194045(SCHCODRAFT_01194045)
SRE : PTSG_05624 PTSG_11488
EHI : EHI_069140(32.t00050)
SMIN : v1.2.011495.t1(symbB.v1.2.011495.t1) v1.2.012243.t1(symbB.v1.2.012243.t1) v1.2.025625.t1(symbB.v1.2.025625.t1)
EHX : EMIHUDRAFT_310514 EMIHUDRAFT_44391
GTT : GUITHDRAFT_107597 GUITHDRAFT_137189
» show all
Taxonomy
Reference
Authors
Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH
Title
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
Journal
Sequence
Reference
Authors
Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A
Title
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
Journal
Reference
Authors
Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F
Title
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.204