Entry
Name
tRNA (cytidine34-2'-O)-methyltransferase;
yibK (gene name);
methyltransferase yibK;
TrmL;
tRNA methyltransferase L;
tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + cytidine34 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine34 in tRNA;
(2) S-adenosyl-L-methionine + 5-carboxymethylaminomethyluridine34 in tRNALeu = S-adenosyl-L-homocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNALeu
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
cytidine34 in tRNA;
5-carboxymethylaminomethyluridine34 in tRNALeu
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
2'-O-methylcytidine34 in tRNA;
5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNALeu
Comment
The enzyme from Escherichia coli catalyses the 2'-O-methylation of cytidine or 5-carboxymethylaminomethyluridine at the wobble position at nucleotide 34 in tRNALeuCmAA and tRNALeucmnm5UmAA. The enzyme is selective for the two tRNALeu isoacceptors and only methylates these when they present the correct anticodon loop sequence and modification pattern. Specifically, YibK requires a pyrimidine nucleoside at position 34, it has a clear preference for an adenosine at position 35, and it fails to methylate without prior addition of the N6-(isopentenyl)-2-methylthioadenosine modification at position 37.
History
EC 2.1.1.207 created 2011
Orthology
K03216 tRNA (cytidine/uridine-2'-O-)-methyltransferase
Genes
CSAT : 104699514 104788699
BNA : 106389160 106390452 106390453 125584496
HSYR : 120128473 120199538
LJA : Lj0g3v0181439.1(Lj0g3v0181439.1)
PCIN : 129312903 129315789
SSPL : 121780371 121783060
PSOM : 113313511 113323025
DOSA : Os08t0506500-00(Os08g0506500)
TAES : 123151176 123160750 123166768
PVIR : 120679704 120712791
MSIN : 131220733 131222479
SMO : SELMODRAFT_47811 SELMODRAFT_67834
MPP : MICPUCDRAFT_8460(JGI:MicpuC2_8460)
ECOO : ECRM13514_4598(yibK)
ECOH : ECRM13516_4396(yibK)
EDJ : ECDH1ME8569_3491(yibK)
ECOI : ECOPMV1_03942(trmL)
REE : electrica_00139(trmL)
RTG : NCTC13098_00162(trmL)
CLAP : NCTC11466_04514(trmL)
KIE : NCTC12125_03955(trmL_1) NCTC12125_03956(trmL_2)
AHN : NCTC12129_04863(trmL)
METY : MRY16398_01440(yibK)
PSHI : SAMEA2665130_2871(trmL)
SMW : SMWW4_v1c47430(trmL)
SFJ : SAMEA4384070_4746(trmL)
SOF : NCTC11214_01601(trmL)
TPTY : NCTC11468_03708(trmL)
PHEI : NCTC12003_03892(trmL)
PRJ : NCTC6933_03909(trmL)
LRI : NCTC12151_00153(trmL)
HIC : NTHIC486_00213(trmL)
HPIT : NCTC13334_00804(trmL)
HHZ : NCTC10839_00329(trmL)
HAEG : NCTC8502_00234(trmL)
PDAG : 4362423_01837(trmL)
ADP : NCTC12871_00935(trmL)
ALIG : NCTC10568_00065(trmL)
ASEG : NCTC10977_00583(trmL)
AVT : NCTC3438_00316(trmL)
RPNE : NCTC8284_00647(trmL)
PAET : NCTC13378_02001(trmL)
XPH : XppCFBP6546_10765(XppCFBP6546P_10765)
XHD : LMG31886_02480(trmL)
LLZ : LYB30171_00189(trmL)
VAU : VANGNB10_cI2442(yibK)
VAS : GT360_01420 GT360_01425
VPL : SA104470976_00142(trmL)
PAEB : NCGM1900_5885(trmH)
PVD : CFBP1590__5138(trmL)
PPRC : PFLCHA0_c03820(trmL)
PMUD : NCTC8068_00347(trmL)
PTW : TUM18999_56910(trmL)
PTAE : NCTC10697_04263(trmL)
MSHE : MAALD49_32160(yibK)
PSYC : DABAL43B_1666(spoU)
ACUM : C9E88_015875 C9E88_17110
MCAT : MC25239_00984(trmL)
MCUN : NCTC10297_00091(trmL)
SCAA : TUM17387_36550(trmL)
SALH : HMF8227_02766(trmL)
LLG : 44548918_00706(trmL)
LJR : NCTC11533_00683(trmL)
LCJ : NCTC11976_02873(yibK)
LWA : SAMEA4504053_3056(trmL)
LSS : NCTC12082_02832(trmL)
LADL : NCTC12735_00229(trmL)
LANT : TUM19329_32630(trmL)
MISZ : MishRS11D_10260(trmL)
TIB : THMIRHAM_20120(trmL)
TSE : THMIRHAS_23270(trmL)
TZO : THMIRHAT_02460(trmL)
TFRI : Thiofri_04599(trmL)
TNI : TVNIR_3734(trmL_[H])
GAI : IMCC3135_30975(trmL)
THIC : TspCOW1_25590(yibK)
HAXI : HAALTHF_10030n(trmL)
ALCA : ASALC70_01749(trmL)
AEL : NCTC12917_03967(trmL)
CHJ : NCTC10426_01749(trmL)
CDIZ : CEDIAZO_00606(trmL)
NWE : SAMEA3174300_1726(trmL)
NZO : SAMEA4504057_0252(trmL)
NCI : NCTC10296_00729(trmL)
NCZ : NCTC10294_01507(trmL)
NANI : NCTC12227_01919(trmL)
ECOR : SAMEA4412678_2102(trmL)
REH : H16_A0338(h16_A0338)
BUE : BRPE67_ACDS01970(trmH)
PLG : NCTC10937_00451(trmL)
LMIR : NCTC12852_00272(trmL)
BTRM : SAMEA390648701474(trmL)
AXX : ERS451415_05846(trmL)
LIM : L103DPR2_02540(trmL)
LIH : L63ED372_02435(trmL)
MTIM : DIR46_09270(trmL) DIR46_09315
URU : DSM104443_00714(trmL_1)
UPL : DSM104440_00670(trmL)
FPHO : SHINM1_001510(trmL)
RBS : RHODOSMS8_02063(trmL)
SFH : SFHH103_01556(spou3)
SFD : USDA257_c40990(trmL)
SAME : SAMCFNEI73_Ch2054(trmL)
AVV : RvVAT039_05970(trmL)
AVF : RvVAR031_25910(trmL)
REL : REMIM1_CH03090(trmL)
REP : IE4803_CH03264(trmL)
REI : IE4771_CH03300(trmL)
RGA : RGR602_CH02674(trmL)
RPHA : AMC79_CH03203(trmL)
NEN : NCHU2750_23020(trmL)
VGO : GJW-30_1_01738(trmL)
BEZ : NCTC12898_00388(trmL)
MAQU : Maq22A_c09110(cspR)
MTUN : MTUNDRAET4_0340(trmL)
FIL : BN1229_v1_3509(trmL)
FIY : BN1229_v1_2412(trmL)
BVY : NCTC9239_01000(trmL)
TSV : DSM104635_00714(trmL)
SBIN : SBA_ch1_12490(trmL)
SFLA : SPHFLASMR4Y_00741(trmL)
HCL : NCTC13205_00466(trmL)
HPUL : NCTC13154_01080(trmL)
GBN : GEOBRER4_08890(trmL)
PPOR : JCM14722_04600(trmL)
BAZ : BAMTA208_04160(cspR)
BSON : S101395_03887(trmL)
BFD : NCTC4823_02917(cspR)
GST : HW35_01600 HW35_14590
BCIR : C2I06_15450(trmL) C2I06_24030(trmL)
BON : A361_03920 A361_06390
CSUA : IM538_03425(trmL) IM538_14660(trmL)
CFIR : NAF01_03860 NAF01_06050(trmL)
PARG : PspKH34_32490(cspR)
PASA : BAOM_0817(trmL) BAOM_1216(trmL)
NMK : CHR53_04615(trmL) CHR53_06930(trmL)
NDT : L1999_05380(trmL) L1999_17400(trmL)
BLEN : NCTC4824_03097(cspR)
SDP : NCTC12225_00995(trmL)
SSH : NCTC13712_01844(trmL)
SSIM : SAMEA4384339_1742(trmL)
SSTE : SAMEA4384403_0885(trmL)
BAYD : BSPP4475_16540(trmL)
PPQ : PPSQR21_015560(cspR)
PCHI : PC41400_07350(trmL)
PNK : AASFL403_12440(trmL)
COHN : KCTCHS21_16410(cspR)
EFF : skT53_19460 skT53_19470
SVB : NCTC12167_00306(trmL)
SPSU : NCTC13786_01709(trmL)
SPOC : NCTC10925_01446(trmL)
LPW : LpgJCM5343_13440(cspR)
LOR : AYI71_03555 AYI71_06115
LHO : LOOC260_113910(cspR)
ECEC : NCTC12421_00613(trmL)
AMIT : DBT49_0007115(trmL)
CCOH : SAMEA4530647_0234(trmL)
CGEL : psyc5s11_09040(cspR)
BPRO : PMF13cell1_05509(trmL)
BLUI : Blut17040_07500(trmL)
CSCI : HDCHBGLK_00914(trmL)
AMIC : Ami3637_12675(trmL)
ABUT : Ami103574_12075(trmL)
PHX : KGNDJEFE_02104(trmL)
PHAR : NCTC13077_01237(trmL)
PIV : NCTC13079_01058(trmL)
VRM : 44547418_01407(trmL)
VDN : NCTC11831_00495(trmL)
MANA : MAMMFC1_03383(trmL)
PFAC : PFJ30894_01384(trmL)
AARG : Aargi30884_08970(cspR)
ABSI : A9CBEGH2_10160(cspR)
MCAP : MCCPF38_00452(trmL)
MCAR : MCCPILRI181_00448(trmL)
AHK : NCTC10172_00240(trmL)
MTAB : MTABA_v1c04190(cspR)
MCOL : MCOLE_v1c03870(cspR)
EML : EMELA_v1c05250(cspR)
EFR : EFREU_v1c04390(cspR)
ELJ : ELUMI_v1c05580(cspR)
ESX : ESOMN_v1c03290(cspR)
SCR : SCHRY_v1c03940(cspR)
SSYR : SSYRP_v1c03990(cspR)
SDI : SDIMI_v3c03450(cspR)
STAI : STAIW_v1c03940(cspR)
SAPI : SAPIS_v1c04080(cspR)
SCQ : SCULI_v1c04600(cspR)
SSAB : SSABA_v1c05530(cspR)
SATR : SATRI_v1c07240(cspR)
SERI : SERIO_v1c07040(cspR)
SLL : SLITO_v1c03550(cspR)
SCJ : SCANT_v1c03650(cspR)
SHJ : SHELI_v1c03830(trmL)
SFZ : SFLOR_v1c04160(cspR)
SCOU : SCORR_v1c03410(cspR)
SCLA : SCLARK_001099(cspR)
SPRN : S100390_v1c04290(trmL)
SPIT : STU14_v1c04290(trmL)
STAB : STABA_v1c05050(trmL)
SMOO : SMONO_v1c03400(cspR)
SALX : SALLE_v1c05720(trmL)
SGQ : SGLAD_v1c04270(trmL)
SCHI : SCHIN_v1c05470(trmL)
MNU : NCTC10166_00081(trmL)
MOE : NCTC10151_00260(trmL)
MGLY : NCTC10194_00719(trmL)
MCOU : NCTC10179_00507(trmL)
MCOM : NCTC10178_00625(trmL)
MPU : MYPU_3030(MYPU_3030)
MEDW : NCTC10132_01230(trmL_2)
MGAL : NCTC10186_00015(trmL_1) NCTC10186_00480(trmL_2)
MCIT : NCTC10181_00581(trmL)
MMAU : NCTC10168_00424(trmL)
MMEL : NCTC10153_00432(trmL)
MCOB : NCTC10184_00392(trmL)
MALA : NCTC10135_00613(trmL)
MSAI : NCTC10113_01099(trmL_2)
MGN : HFMG06NCA_2368(cspR)
MGS : HFMG95NCA_2413(cspR)
MGT : HFMG01NYA_2427(cspR)
MGV : HFMG94VAA_2486(cspR)
MGW : HFMG01WIA_2361(cspR)
MGAC : HFMG06CAA_2366(cspR)
MGAN : HFMG08NCA_2369(cspR)
MGNC : HFMG96NCA_2412(cspR)
PCAT : Pcatena_07240(cspR)
ATB : J4859_05370 J4859_12345
MMAE : MMARE11_11230(spoU)
MBAI : MB901379_01028(trmL)
MHEK : JMUB5695_03763(spoU)
MKY : IWGMT90018_11920(spoU)
MPHL : MPHLCCUG_01472(trmL)
MTHN : 4412656_01083(trmL)
MAUU : NCTC10437_01250(trmL)
MFLV : NCTC10271_03974(trmL)
MSAL : DSM43276_03500(trmL)
MTER : 4434518_03188(spoU)
CDIP : ERS451417_01240(cspR)
CUN : Cul210932_0516(spoU1)
CUQ : Cul210931_0498(spoU1)
CUZ : Cul05146_0530(spoU1)
CUJ : CUL131002_0498c(spoU1)
CUS : CulFRC11_0495(spoU1)
CMIN : NCTC10288_02040(cspR)
CRL : NCTC7448_01330(cspR)
CCYS : SAMEA4530656_1918(trmL)
NFR : ERS450000_03197(trmL)
NAD : NCTC11293_01741(trmL)
RCR : NCTC10994_03822(trmL)
AAGI : NCTC2676_1_02061(trmL)
GCR : GcLGCM259_1889(trmL)
RSA : RSal33209_1285(cspR)
TBW : NCTC13354_00033(trmL)
AHW : NCTC11636_00502(trmL)
AIR : NCTC12972_00951(trmL)
ASLA : NCTC11923_01735(trmL)
AVC : NCTC10951_00598(trmL_1) NCTC10951_00604(trmL_2)
SYY : SYNGTS_2049(slr0992)
SYT : SYNGTI_2048(slr0992)
SYS : SYNPCCN_2047(slr0992)
SYQ : SYNPCCP_2047(slr0992)
SYH : Syncc8109_1335(spoU)
LET : O77CONTIG1_02414(trmL)
NSPH : BDGGKGIB_03124(trmL)
CSUI : Chls_887(tRNA_(cytlocus_tagine(34)-2'-O)-methyltransferase)
OBG : Verru16b_02569(trmL)
ABIW : Abiwalacus_01700(trmL)
LCRE : Pla8534_10320(trmL)
FPOL : ERS445057_01411(trmL)
KOS : KORDIASMS9_04607(trmL)
KAN : IMCC3317_17130(trmL)
CGLE : NCTC11432_00071(trmL)
CTAI : NCTC12078_00429(trmL)
CHRJ : CHRYMOREF3P_4617(trmL)
» show all
Taxonomy
Reference
Authors
Benitez-Paez A, Villarroya M, Douthwaite S, Gabaldon T, Armengod ME
Title
YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.207