Entry
Name
16S rRNA (cytidine1409-2'-O)-methyltransferase;
TlyA (ambiguous)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:16S rRNA (cytidine1409-2'-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytidine1409 in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
cytidine1409 in 16S rRNA
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
2'-O-methylcytidine1409 in 16S rRNA
Comment
The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1409 in helix 44 of 16S rRNA and cytidine1920 in helix 69 of 23S rRNA (cf. EC
2.1.1.226 , 23S rRNA (cytidine1920-2'-O)-methyltransferase).
History
EC 2.1.1.227 created 2011
Orthology
K06442 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase
Genes
CSAT : 104747089 104790171 109124501
BNA : 106361812 106366678 106403013 106435917
CIC : CICLE_v10015989mg CICLE_v10018050mg
MINC : 123195599 123203745
TPRA : 123883277 123883893
MCHA : 111024489 111025647
CANN : 107842396 124885136
SSPL : 121740853 121744129
CSIN : 114257566 114272571
PSOM : 113320137 113330175
DOSA : Os11t0247400-01(Os11g0247400)
TAES : 123086774 123091205
SMO : SELMODRAFT_107026 SELMODRAFT_47053 SELMODRAFT_57075
MPP : MICPUCDRAFT_5637(JGI:MicpuC2_5637)
LMIR : NCTC12852_00330(tlyA)
LIM : L103DPR2_02825(tlyA)
LIH : L63ED372_03205(tlyA)
RBS : RHODOSMS8_00322(tlyA)
SFD : USDA257_c05930(yqxC)
AGR : AGROH133_04342(tlyA)
REC : RHECIAT_CH0001003(tlyA)
REL : REMIM1_CH00926(tlyA)
REP : IE4803_CH00924(tlyA)
REI : IE4771_CH00953(tlyA)
RTR : RTCIAT899_CH04390(rrmJ1)
RGA : RGR602_CH00971(tlyA)
RPHA : AMC79_CH00939(tlyA)
NGL : RG1141_CH05460(hlyA)
BVL : BF3285c1_1330(tlyA2)
BIO : BR141012304_10124(tlyA)
VGO : GJW-30_1_00902(tlyA)
BHS : BM1374165_00415(tlyA)
BTX : BM1374166_00607(tlyA)
BEZ : NCTC12898_00288(tlyA)
MTUN : MTUNDRAET4_1164(tlyA)
FIL : BN1229_v1_1099(tlyA)
FIY : BN1229_v1_1100(tlyA)
BVY : NCTC9239_01785(tlyA)
TSV : DSM104635_02578(tlyA)
RDI : CMV14_18435 CMV14_18805
SMY : BJP26_14655 BJP26_16225
SFLA : SPHFLASMR4Y_02768(tlyA)
HPO : HMPREF4655_20606(rrmJ)
HPX : HMPREF0462_0420(rrmJ)
HCL : NCTC13205_00158(tlyA)
HSH : NHP194022_01270(tly)
HPUL : NCTC13154_00931(tlyA)
CJV : MTVDSCj20_0608(tlyA)
CFV : CFVI03293_1108(tlyA)
CAMP : CFT03427_1088(tlyA)
CCOC : CCON33237_1308(tlyA)
CLR : UPTC16701_0680(tlyA)
CLM : UPTC16712_0685(tlyA)
CAMR : CAQ16704_0858(tlyA)
CHV : CHELV3228_1307(tlyA)
CPIN : CPIN18020_1121(tlyA)
CAMZ : CVIC12175_0864(tlyA)
SMAB : LN246_02305 LN246_14940
BAZ : BAMTA208_12475(yqxC)
BSON : S101395_02000(tlyA)
BFD : NCTC4823_01903(tlyA)
BLEN : NCTC4824_01768(tlyA)
LMOC : LMOSLCC5850_1425(tlyA)
LMQ : LMM7_1451(tylA_prmA)
LMW : LMOSLCC2755_1368(tlyA)
LMX : LMOSLCC2372_1427(tlyA)
LMZ : LMOSLCC2482_1418(tlyA)
LMON : LMOSLCC2376_1320(tlyA)
LMOS : LMOSLCC7179_1336(tlyA)
LMOO : LMOSLCC2378_1379(tlyA)
LMOY : LMOSLCC2479_1426(tlyA)
LMOT : LMOSLCC2540_1416(tlyA)
LMOA : LMOATCC19117_1373(tlyA)
LGZ : NCTC10812_01306(tlyA)
GMO : NCTC11323_01022(tlyA)
GHA : NCTC10459_01075(tlyA)
POW : IJ21_17200 IJ21_29980
PTHI : NDS46_18370 NDS46_28945
PDY : QJQ58_03675 QJQ58_23420
ACUR : JZ785_05585 JZ785_19915
SNC : HMPREF0837_11295(rrmJ)
SVB : NCTC12167_01138(tlyA)
SMEN : SAMEA4412692_0069(tlyA)
SFER : NCTC12278_00542(tlyA)
SCAI : NCTC12191_01261(tlyA)
SPSU : NCTC13786_00689(tlyA)
SPOC : NCTC10925_00556(tlyA)
SAUP : NCTC3168_00167(hlyA)
SURN : NCTC13766_00565(tlyA)
SVF : NCTC3166_00606(hlyA)
SMIE : NCTC11169_01321(tlyA)
LPW : LpgJCM5343_07080(ftsJ)
LRU : HMPREF0538_20185(rrmJ)
EFU : HMPREF0351_10782(hlyA)
ECEC : NCTC12421_01758(tlyA)
CCOH : SAMEA4530647_1344(tlyA)
CTHD : CDO33_06830 CDO33_20170 CDO33_20200
BPRO : PMF13cell1_04696(tlyA)
CSCI : HDCHBGLK_03106(tlyA)
CBAR : PATL70BA_0010(yqxC)
PHX : KGNDJEFE_00931(tlyA)
FAA : HMPREF0389_00509(rrmJ)
PHAR : NCTC13077_00610(tlyA)
PIV : NCTC13079_00741(tlyA)
VRM : 44547418_00940(tlyA)
VDN : NCTC11831_01023(tlyA)
MANA : MAMMFC1_03633(tlyA)
PFAC : PFJ30894_01477(tlyA)
FIT : Fi14EGH31_15140(hlyA)
MMYI : mycmycITA_00101(tlyA_2)
MCAP : MCCPF38_00075(tlyA)
MCAR : MCCPILRI181_00069(tlyA)
AHK : NCTC10172_00185(tlyA)
MTAB : MTABA_v1c03650(tlyA)
MCOL : MCOLE_v1c03430(tlyA)
EML : EMELA_v1c04730(tlyA)
SCR : SCHRY_v1c04810(yqxC)
SSYR : SSYRP_v1c05230(yqxC)
SDI : SDIMI_v3c04390(yqxC)
STAI : STAIW_v1c05990(yqxC)
SAPI : SAPIS_v1c05900(yqxC)
SCQ : SCULI_v1c05730(yqxC)
SSAB : SSABA_v1c04870(yqxC)
SATR : SATRI_v1c05530(yqxC)
SERI : SERIO_v1c05140(yqxC)
SLL : SLITO_v1c04790(tlyA)
SCJ : SCANT_v1c05310(tlyA)
SHJ : SHELI_v1c05640(tlyA)
SFZ : SFLOR_v1c05990(tlyA)
SCOU : SCORR_v1c04800(tlyA)
SPRN : S100390_v1c05380(tlyA)
SPIT : STU14_v1c05380(tlyA)
STAB : STABA_v1c05860(tlyA)
SMOO : SMONO_v1c04310(tlyA)
SALX : SALLE_v1c04950(tlyA)
SGQ : SGLAD_v1c05100(tlyA)
SCHI : SCHIN_v1c06840(tlyA)
MNU : NCTC10166_00280(hlyA)
MOE : NCTC10151_00123(tlyA)
MPU : MYPU_1710(MYPU_1710)
MALA : NCTC10135_01183(ftsJ)
MSAI : NCTC10113_01559(ftsJ)
MOB : NCTC10112_00071(ftsJ)
PCAT : Pcatena_09250(ftsJ)
SHI : Shel_08030 Shel_16680
MMAE : MMARE11_24270(tlyA)
MNM : MNVM_00170 MNVM_42020(tlyA)
MBAI : MB901379_02325(tlyA)
MHEK : JMUB5695_02627(tlyA)
MPHL : MPHLCCUG_02272(tlyA)
MTHN : 4412656_02131(tlyA)
MAUU : NCTC10437_03135(tlyA)
MFLV : NCTC10271_02653(tlyA)
MSAL : DSM43276_02079(tlyA)
MTER : 4434518_01803(tlyA)
CDIP : ERS451417_01177(tlyA)
CUN : Cul210932_1070(tlyA)
CUQ : Cul210931_1025(tlyA)
CUJ : CUL131002_1055(tlyA)
CMIN : NCTC10288_01185(tlyA)
CRL : NCTC7448_01858(tlyA)
CCYS : SAMEA4530656_1175(tlyA)
NFR : ERS450000_02114(tlyA)
NAD : NCTC11293_03115(tlyA)
NSPU : IFM12276_42110(tlyA)
RCR : NCTC10994_00284(tlyA)
TPUL : TPB0596_22040(tlyA)
SAMB : SAM23877_1847(tlyA)
SLE : sle_53490(sle_53490)
SXT : KPP03845_102019(tlyA)
FSB : GCM10025867_24470(tlyA)
AMAU : DSM26151_12370(tlyA)
PSEV : USB125703_02086(tlyA)
NAEI : GCM126_34320 GCM126_34330
AAGI : NCTC2676_1_01035(tlyA)
GCR : GcLGCM259_0945(tlyA)
BEI : GCM100_19840 GCM100_19850
DCO : SAMEA4475696_1209(tlyA)
PAK : HMPREF0675_4445(rrmJ)
CGRN : 4412665_01514(tlyA)
PAUS : NCTC13651_02295(tlyA)
PPC : HMPREF9154_2016(rrmJ)
TDF : H9L22_07140 H9L22_07150
NAQU : ENKNEFLB_02051(tlyA)
TBW : NCTC13354_00005(tlyA)
ACTO : C3V41_02375 C3V41_12670
AHW : NCTC11636_00653(tlyA)
AIR : NCTC12972_00666(tlyA)
ASLA : NCTC11923_02123(tlyA)
AVC : NCTC10951_00994(tlyA)
GVG : HMPREF0421_20593(rrmJ)
GVA : HMPREF0424_0679(rrmJ)
GVH : HMPREF9231_0958(rrmJ)
BALA : DSM104299_03101(tlyA)
SBAE : DSM104329_03522(tlyA)
SYY : SYNGTS_1839(slr0950)
SYT : SYNGTI_1839(slr0950)
SYS : SYNPCCN_1838(slr0950)
SYQ : SYNPCCP_1838(slr0950)
LET : O77CONTIG1_00898(tlyA)
PRUN : PCC7821_04512(yqxC)
NSPH : BDGGKGIB_03666(tlyA)
OBG : Verru16b_03419(tlyA)
BAFH : BafHLJ01_0552(tlyA)
SCOR : J3U87_11120 J3U87_20080
FPOL : ERS445057_00990(tlyA)
DPB : BABL1_gene_751(tlyA)
WBA : UR17_C0001G0325(ine192)
LOKI : Lokiarch_07420(tlyA_1) Lokiarch_25140(tlyA_2)
» show all
Taxonomy
Reference
Authors
Johansen SK, Maus CE, Plikaytis BB, Douthwaite S
Title
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs.
Journal
Sequence
Reference
Authors
Maus CE, Plikaytis BB, Shinnick TM
Title
Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.227