| Entry |
|
|---|
| Name |
tRNAThr (cytosine32-N3)-methyltransferase;
ABP140;
Trm140p
|
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
|---|
| Sysname |
S-adenosyl-L-methionine:tRNAThr (cytosine32-N3)-methyltransferase
|
|---|
| Reaction(IUBMB) |
(1) S-adenosyl-L-methionine + cytosine32 in tRNAThr = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNAThr;
(2) S-adenosyl-L-methionine + cytosine32 in tRNASer = S-adenosyl-L-homocysteine + N3-methylcytosine32 in tRNASer
|
|---|
| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
cytosine32 in tRNAThr;
cytosine32 in tRNASer
|
|---|
| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N3-methylcytosine32 in tRNAThr;
N3-methylcytosine32 in tRNASer
|
|---|
| Comment |
The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer.
|
|---|
| History |
EC 2.1.1.268 created 2013
|
|---|
| Orthology |
| K17053 | tRNAThr (cytosine32-N3)-methyltransferase |
|
|---|
| Genes |
| BMY: | BM_BM6765(Bma-metl-2) |
| NDI: | NDAI_0E01210(NDAI0E01210) |
| TPF: | TPHA_0D01190(TPHA0D01190) |
| TBL: | TBLA_0B03890(TBLA0B03890) TBLA_0C01800(TBLA0C01800) |
| TDL: | TDEL_0A06110(TDEL0A06110) |
| KAF: | KAFR_0A03810(KAFR0A03810) |
| KNG: | KNAG_0A02950(KNAG0A02950) |
| CAL: | CAALFM_C102190WA(ABP140) |
| NTE: | NEUTE1DRAFT77456(NEUTE1DRAFT_77456) |
| CCAC: | CcaHIS019_0106090(ABP140) |
| ABP: | AGABI1DRAFT69948(AGABI1DRAFT_69948) |
| ABV: | AGABI2DRAFT205628(AGABI2DRAFT_205628) |
| MORE: | E1B28_007789 E1B28_007805 |
|
|---|
| Reference |
|
|---|
| Authors |
Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T |
|---|
| Title |
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
D'Silva S, Haider SJ, Phizicky EM |
|---|
| Title |
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.268 |
|
|---|
