Entry |
|
Name |
aklanonic acid methyltransferase;
DauC;
AAMT
|
Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
Sysname |
S-adenosyl-L-methionine:aklanonate O-methyltransferase
|
Reaction(IUBMB) |
S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate [RN: R06680]
|
Reaction(KEGG) |
|
Substrate |
S-adenosyl-L-methionine [CPD: C00019];
aklanonate [CPD: C12421]
|
Product |
S-adenosyl-L-homocysteine [CPD: C00021];
methyl aklanonate [CPD: C12422]
|
Comment |
The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin.
|
History |
EC 2.1.1.288 created 2013
|
Pathway |
ec01057 | Biosynthesis of type II polyketide products |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K15942 | O-methyltransferase / aklanonic acid methyltransferase |
|
Genes |
» show all
|
Reference |
|
Authors |
Dickens ML, Ye J, Strohl WR |
Title |
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.1.1.288 |
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