Entry |
|
Name |
L-histidine Nalpha-methyltransferase;
dimethylhistidine N-methyltransferase;
dimethylhistidine methyltransferase;
histidine-alpha-N-methyltransferase;
S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase;
S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase
|
Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
Sysname |
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase (hercynine-forming)
|
Reaction(IUBMB) |
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine (overall reaction) [RN: R01169];
(1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine [RN: R10523];
(1b) S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine [RN: R10524];
(1c) S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine [RN: R04436]
|
Reaction(KEGG) |
|
Substrate |
S-adenosyl-L-methionine [CPD: C00019];
L-histidine [CPD: C00135];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD: C04259]
|
Product |
S-adenosyl-L-homocysteine [CPD: C00021];
hercynine [CPD: C05575];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD: C04259]
|
Comment |
Part of the biosynthetic pathway of ergothioneine.
|
History |
EC 2.1.1.44 created 1976, modified 2013
|
Pathway |
|
Orthology |
K18911 | L-histidine Nalpha-methyltransferase |
K20246 | L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase |
|
Genes |
NTE: | NEUTE1DRAFT145472(NEUTE1DRAFT_145472) |
FGR: | FGSG_03421 FGSG_11987 FGSG_12773 |
FPU: | FPSE_06241 FPSE_08378 FPSE_11477 |
FPOA: | FPOAC1_005802 FPOAC1_008076(EGT1) |
FVN: | FVRRES_06401 FVRRES_08641 |
NHE: | NECHADRAFT_70968 NECHADRAFT_97208 |
FKR: | NCS57_01018600 NCS57_01307200 |
PTKZ: | JDV02_003062(EGT1_2) |
AOR: | AO090012000265 AO090023000415 |
AFV: | AFLA_001980 AFLA_006763 |
ACHE: | ACHE_10907A ACHE_60451S |
PNO: | SNOG_13930(SNOG_13929) |
ABP: | AGABI1DRAFT120644(AGABI1DRAFT_120644) |
ABV: | AGABI2DRAFT186400(AGABI2DRAFT_186400) |
SCM: | SCHCO_02619710(SCHCODRAFT_02619710) |
CPUT: | CONPUDRAFT_77468 CONPUDRAFT_85801 |
PTRC: | PtA15_2A358 PtA15_9A275 |
XPH: | XppCFBP6546_11000(egtD) |
XVA: | C7V42_00720(egtD) C7V42_00735(egtD) |
XHD: | LMG31886_02060(egtD) |
LLZ: | LYB30171_00132(egtD) |
HMI: | soil367_11445(egtD) soil367_18465(egtD) |
LLG: | 44548918_01364(egtD) |
LJR: | NCTC11533_01340(egtD) |
LSS: | NCTC12082_00682(egtD) |
TFRI: | Thiofri_02854(egtD) |
TNI: | TVNIR_2413(egtD_[H]) |
APRS: | BI364_03780 BI364_08295 |
ALCA: | ASALC70_00988(egtD) |
REH: | H16_A2701(h16_A2701) |
PDIO: | PDMSB3_1096(egtD) PDMSB3_3352.1(egtD) |
AXX: | ERS451415_01837(egtD) |
ACRA: | BSY15_3003(egtD) BSY15_3490(egtD) |
LIH: | L63ED372_02888(egtD) |
DIH: | G7047_12315(egtD) G7047_22070(egtD) |
ATER: | MW290_14320(egtD) MW290_32425(egtD) |
TCT: | PX653_11125(egtD) PX653_19120(egtD) |
URU: | DSM104443_01492(egtD) |
UPL: | DSM104440_01401(egtD) |
RBS: | RHODOSMS8_03037(egtD) |
BJU: | BJ6T_33160 BJ6T_40160 BJ6T_85440 |
BJP: | RN69_16080 RN69_19490 RN69_41265 |
BSEP: | HAP48_0046185(egtD) |
BBAN: | J4G43_034240(egtD) J4G43_047820(egtD) |
BCAN: | BcanWSM471_25355(egtD) |
BPAH: | QA639_27840(egtD) QA639_37810(egtD) |
VGO: | GJW-30_1_01425(egtD) |
MEA: | Mex_1p2425 Mex_1p3430 |
MZA: | B2G69_19740 B2G69_23660 |
MRD: | Mrad2831_0783 Mrad2831_4913 |
META: | Y590_11710 Y590_15715 |
MAQU: | Maq22A_1p31890(egtD) |
METD: | C0214_13945(egtD) C0214_17830(egtD) |
METS: | DK389_10220(egtD) DK389_24600(egtD) |
METI: | DK427_14520(egtD) DK427_17110 |
MMES: | MMSR116_19855(egtD) MMSR116_28525(egtD) |
MOG: | MMB17_00100(egtD) MMB17_10630(egtD) |
MTAD: | M6G65_03230(egtD) M6G65_22640(egtD) |
MTUN: | MTUNDRAET4_3350(egtD) |
FIL: | BN1229_v1_3082(egtD) |
FIY: | BN1229_v1_2836(egtD) |
SPHU: | SPPYR_1207(egtD) SPPYR_3476 |
SFLA: | SPHFLASMR4Y_01850(egtD) |
MBAI: | MB901379_04622(egtD) |
MHEK: | JMUB5695_00322(egtD) |
MKY: | IWGMT90018_18990 IWGMT90018_59420(egtD) |
MPHL: | MPHLCCUG_00354(egtD) |
MTHN: | 4412656_04306(egtD) |
MAUU: | NCTC10437_05228(egtD) |
MFLV: | NCTC10271_00327(egtD) |
MSAL: | DSM43276_00322(egtD) |
MTER: | 4434518_03928(egtD) |
NFR: | ERS450000_05025(egtD) |
NSL: | BOX37_13640 BOX37_27025 |
NTP: | CRH09_33200(egtD) CRH09_34695(egtD) |
NAD: | NCTC11293_06258(egtD) |
NWL: | NWFMUON74_10250(egtD) |
NSPU: | IFM12276_06340(egtD) |
RCR: | NCTC10994_01623(egtD) |
RANT: | RHODO2019_07240(egtD) |
TPUL: | TPB0596_00170(egtD) |
SLC: | SL103_16955 SL103_23145 |
SAMB: | SAM23877_6627(egtD) |
SLE: | sle_06860(sle_06860) |
SGM: | GCM10017557_08730(egtD) |
SALL: | SAZ_01310 SAZ_35720 |
SALJ: | SMD11_0418 SMD11_0807 |
SRK: | FGW37_27930(egtD) FGW37_32380 |
STUI: | GCM10017668_06280(egtD) |
SGOB: | test1122_11450(egtD) |
SAKB: | K1J60_03885(egtD) K1J60_05755(egtD) |
SXT: | KPP03845_106339(egtD) |
NAQU: | ENKNEFLB_01971(egtD) |
AGRA: | AGRA3207_006138(egtD) |
SPIQ: | OHA34_10625 OHA34_32130(egtD) |
FRI: | FraEuI1c_6654 FraEuI1c_7155 |
PAUT: | Pdca_32250 Pdca_32260 |
KBU: | Q4V64_04985 Q4V64_04990(egtD) |
MSAG: | GCM10017556_54360(egtD) |
ACTN: | L083_5287 L083_7398 |
ACTR: | Asp14428_55950(egtD) |
AOU: | ACTOB_000574 ACTOB_006695(egtD) |
PLAB: | C6361_00300 C6361_04525(egtD) |
PLAT: | C6W10_01050(egtD) C6W10_21350 |
GLY: | K3N28_07610(egtD) K3N28_10175(egtD) |
BALA: | DSM104299_01322(egtD) |
SBAE: | DSM104329_01348(egtD) |
SYY: | SYNGTS_1235(slr0865) |
SYT: | SYNGTI_1235(slr0865) |
SYS: | SYNPCCN_1234(slr0865) |
SYQ: | SYNPCCP_1234(slr0865) |
SYNW: | SynWH8103_00137(egtD) |
CMP: | Cha6605_0183 Cha6605_0924 Cha6605_6115 |
LET: | O77CONTIG1_03101(egtD) |
LBO: | LBWT_13420 LBWT_55940 |
PRUN: | PCC7821_03819(egtD) |
NPU: | Npun_F2219 Npun_R3624 |
NED: | HUN01_13950(egtD) HUN01_34300(egtD) |
NSPH: | BDGGKGIB_04273(egtD) |
LCRE: | Pla8534_28590(egtD) |
AMOB: | HG15A2_21560(egtD_1) |
PFER: | IRI77_13455(egtD) IRI77_22240(egtD) |
MSAB: | SNE25_01075 SNE25_04555(egtD) SNE25_15550 SNE25_19865 |
ECHI: | FKX85_05685 FKX85_14085(egtD) |
PKO: | PKOR_03290 PKOR_17700 |
GRS: | C7S20_07230(egtD) C7S20_09335(egtD) |
AALG: | AREALGSMS7_03795(egtD) |
SPON: | HME9304_02218(egtD) |
CGLE: | NCTC11432_01867(egtD) |
CJG: | NCTC13459_02067(egtD) |
CANT: | NCTC13489_02180(egtD) |
NALL: | PP769_01525(egtD) PP769_14850 |
» show all
|
Reference |
|
Authors |
Ishikawa Y, Melville DB. |
Title |
The enzymatic alpha-N-methylation of histidine. |
Journal |
|
Reference |
|
Authors |
Seebeck FP |
Title |
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.1.1.44 |
ExPASy - ENZYME nomenclature database: | 2.1.1.44 |
|