KEGG ENZYME: 2.1.3.9

ENZYME: 2.1.3.9

Entry

EC 2.1.3.9                  Enzyme

Name

N-acetylornithine carbamoyltransferase;
acetylornithine transcarbamylase;
N-acetylornithine transcarbamylase;
AOTC;
carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase;
AOTCase

Class

Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases

Sysname

carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase

Reaction(IUBMB)

carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline [RN:R07245]

Reaction(KEGG)

R07245

Substrate

carbamoyl phosphate [CPD:C00169];
N2-acetyl-L-ornithine [CPD:C00437]

Product

phosphate [CPD:C00009];
N-acetyl-L-citrulline [CPD:C15532]

Comment

Differs from EC 2.1.3.3, ornithine carbamoyltransferase. This enzyme replaces EC 2.1.3.3 in the canonic arginine biosynthetic pathway of several Eubacteria and has no catalytic activity with L-ornithine as substrate.

History

EC 2.1.3.9 created 2005

Pathway

ec00220

Arginine biosynthesis

ec01100

Metabolic pathways

Orthology

K09065

N-acetylornithine carbamoyltransferase

Genes

XFA:

XF_0998

XFT:	PD_0290(argF)

XFM:	Xfasm12_0314

XFN:	XfasM23_0284

XFF:	XFLM_06825

XFL:	P303_00885

XFS:	D934_02520

XFH:	XFHB_10450

XTW:	AB672_01675

XCC:	XCC2249(argF)

XCB:

XC_1869

XCA:	xcc-b100_1930

XCP:

XCR_2518

XCV:	XCV2551(argF)

XAX:	XACM_2361(argF)

XAC:	XAC2352(argF)

XCI:	XCAW_02017(argF)

XCT:	J151_02525

XCJ:	J158_02515

XCU:	J159_02513

XCN:	J169_02522

XCW:	J162_02514

XCR:	J163_02509

XCM:	J164_02511

XCF:	J172_02516

XFU:	XFF4834R_chr23570(argF)

XAO:	XAC29_11920

XOM:	XOO2522(XOO2522)

XOO:	XOO2676(argF)

XOP:

PXO_00353

XOY:	AZ54_10760

XOR:

XOC_2751

XOZ:	BE73_13320

XAL:	XALC_1896(argF)

XSA:	SB85_18590

XTN:	FD63_07480

XFR:	BER92_11890

XVE:	BJD12_02825

XPE:	BJD13_04640

XHR:	XJ27_05360

XGA:	BI317_11400

XPH:	XppCFBP6546_01255(XppCFBP6546P_01255)

XVA:	C7V42_10385

XAN:	AC801_12100

XAR:	XB05_06835

XHY:	FZ025_17105

XCZ:	EBN15_10550

XTH:	G4Q83_12335

XEU:	XSP_002367

XHD:	LMG31886_19220(argF')

XPR:	MUG10_19790

XAG:	HEP73_02672

XDY:	NYR95_12760

XAS:	HEP74_02506

SML:

Smlt3302

SMT:

Smal_2729

BUJ:	BurJV3_2745

SMZ:

SMD_2874

SACZ:

AOT14_15980(pyrB_2)

STEK:

AXG53_02270

SRH:	BAY15_2472

SLM:	BIZ42_03290

STEN:

CCR98_14170

STEM:

CLM74_14470

STES:

MG068_14130

SINC:

DAIF1_28330(argF')

SPAQ:

STNY_R29170

STEQ:

ICJ04_06485

SGEN:

RKE57_14275

PSU:	Psesu_1224

PSUW:

WQ53_01270

PSD:

DSC_08070

PMEX:

H4W19_02430

PJP:	LAG73_09600

PDD:	MNQ95_00280

PWI:	MWN52_11120

LAB:	LA76x_3276(argF)

LAQ:	GLA29479_4813(argF')

LCP:	LC55x_3309(argF)

LGU:	LG3211_1887(argF)

LEZ:

GLE_1836

LEM:

LEN_3148

LMB:	C9I47_1932

LYT:	DWG18_08150

LUE:	DCD74_05345

LYJ:	FKV23_10185

LSOL:

GOY17_12170

LSX:	H8B22_13445

LARE:

HIV01_002490

LHX:	LYSHEL_01260(argF')

LCAS:

LYSCAS_01260(argF')

LCIC:

INQ41_05280

LAVI:

INQ42_05050

LLZ:	LYB30171_01054(argF')

LAUX:

LA521A_23570

LYA:	RDV84_22895

LUM:	CNR27_08000

LUS:	E5843_08625

LUG:	FPZ22_11925

THES:

FHQ07_02595

THEH:

G7079_09315

TCN:	H9L16_14845

TBV:	H9L17_14625

XBC:	ELE36_07715

FAU:	Fraau_2115

FSG:	LQ771_08925

FED:	LQ772_05325

RHD:	R2APBS1_1203

RGL:	CS053_06175

RTH:	LRK53_07530

DJI:	CH75_03530

DJA:	HY57_09525

DTX:	ATSB10_16390

DYE:	EO087_06265

DCS:	ISN74_04865

DTL:	H8F01_16010

DTA:	DYST_01682

DKO:

I596_2178

LRZ:	BJI69_00695

LPY:	FIV34_14315

LANH:

KR767_14445

LFL:	IM816_11950

LAEG:

L2Y94_07530

LAEO:

L2Y97_15465

LAES:

L2Y96_15280

XBA:	C7S18_05955

RBD:

ALSL_1196

TAMN:

N4264_10075

WMA:	WM2015_184

WEZ:	IC757_00595

WOC:	BA177_02135

KKO:

Kkor_0543

KGE:

TQ33_1837

KSD:	KS2013_1901

KAM:	SR900_11910

SDF:	ACG33_14155

PPK:	U875_26890

PPNM:

LV28_25530

PRB:	X636_13010

PPUL:

RO07_10980

PSPU:

NA29_06805

POX:	MB84_07165

PFG:	AB870_13895

PNR:	AT302_10830

PAND:

DRB87_02540

MMR:	Mmar10_0364

GAK:

X907_2458

HYT:	HXX25_09465

PBR:	PB2503_11074

HFL:	PUV54_02840

MXA:	MXAN_5104(argF)

MSD:	MYSTI_05593

MYM:	A176_001781

MFB:	MFUL124B02_30515

CCX:	COCOR_02390(argF)

MFU:	LILAB_33450

MMAS:

MYMAC_004986

SUR:	STAUR_5869(argF)

SCL:	sce0074(argF1)

SCU:	SCE1572_00430

CCRO:

CMC5_043050

MRM:	A7982_00311

LLU:	AKJ09_05863

NANN:

O0S08_24895

BSED:

DN745_16955

PCAY:

FRD00_19420

BBAE:

FRD01_15835

MTA:

Moth_1996

MTHO:

MOTHE_c20390(argF')

MTHZ:

MOTHA_c21170(argF')

PSUB:

Pelsub_P2197

LEK:	hrd7_25920

ABAO:

BEQ56_08645

CAP:	CLDAP_10970

KBS:	EPA93_12415

PMET:

G4Y79_17675

UAM:	UABAM_06584

SSM:	Spirs_2731

BPO:	BP951000_0722(argF)

BPJ:	B2904_orf2101

BPIP:

BPP43_11545

BPW:	WESB_2042(argF)

CTM:	Cabther_B0219

CVL:	J8C06_12710

CHLO:

J8C02_13765

MSIL:

METEAL_32770

MSEA:

METESE_28880

RMR:

Rmar_0946

RMG:	Rhom172_1920

RLO:	GQ464_013160

RBAR:

AWN76_002220

SRU:

SRU_2218

SRM:	SRM_02445(argF)

MPZ:	Marpi_1704

MARN:

LN42_09080

MAEO:

JRV97_03955

BANA:

BARAN1_1241(argF)

SCHV:

BRCON_2776

CSU:	CSUB_C1718

BARC:

AOA65_1786(argF_3)

» show all

Reference

1 [PMID:15731101]

Authors

Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M.

Title

Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria.

Journal

J Biol Chem 280:14366-9 (2005)
DOI:10.1074/jbc.C500005200

Sequence

[xcc:XCC2249]

Reference

2 [PMID:16585758]

Authors

Morizono H, Cabrera-Luque J, Shi D, Gallegos R, Yamaguchi S, Yu X, Allewell NM, Malamy MH, Tuchman M

Title

Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis.

Journal

J Bacteriol 188:2974-82 (2006)
DOI:10.1128/JB.188.8.2974-2982.2006