KEGG   ENZYME: 2.2.1.10
Entry
EC 2.2.1.10                 Enzyme                                 
Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
ADH synthase;
ADHS;
MJ0400 (gene name)
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
Sysname
L-aspartate 4-semialdehyde:1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate methylglyoxaltransferase
Reaction(IUBMB)
L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate = 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl phosphate [RN:R08568]
Reaction(KEGG)
R08568
Substrate
L-aspartate 4-semialdehyde [CPD:C00441];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848]
Product
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
2,3-dioxopropyl phosphate [CPD:C16849]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.10 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16306  fructose-bisphosphate aldolase / 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Genes
PAKH: B0X70_03095
PLUI: CE143_03080
PTW: TUM18999_11980
PSOA: PSm6_31320
MANC: IV454_17575
HTQ: FRZ44_21680
HADH: FRZ61_25400
DDS: Ddes_0338
DFI: AXF13_12000
DPG: DESPIGER_2218
DEF: CNY67_12565
DTR: RSDT_0006(fbaB)
DFL: DFE_1897 DFE_3005
PSYF: N1030_15290 N1030_15295
DSB: LN040_08755 LN040_08760
DMA: DMR_05370 DMR_19010
DCB: C3Y92_08785 C3Y92_17720
DGG: DGI_0591(fbaB) DGI_0592(fbaB2)
DDE: Dde_3489 Dde_3490
DMS: E8L03_13380 E8L03_13385
DSA: Desal_3065
DHY: DESAM_21548
DAF: Desaf_1881 Desaf_2585 Desaf_2868
DAS: Daes_0956 Daes_2038
DPI: BN4_10049 BN4_11436
DEJ: AWY79_10300 AWY79_15685
PPRF: DPRO_0054(aroA) DPRO_2850(aroA)
PSEL: GM415_01295 GM415_12265
DDN: DND132_0792 DND132_3203
PSEF: PSDVSF_08020(aroA'_1) PSDVSF_32840(aroA'_3)
PPOR: JCM14722_05550(aroA'_1) JCM14722_26380(aroA'_3)
PNW: SYK_09670(aroA'_1) SYK_31790(aroA'_3)
PTHE: LF599_04815 LF599_11165
DSX: GD604_03180 GD604_07375
DSD: GD606_01860 GD606_15915
PBIZ: LWC08_08350 LWC08_10800
DVU: DVU_0460
DVL: Dvul_2477
DVM: DvMF_1751
DVG: Deval_0421
CLIH: KPS_001997
TMUR: JBF11_09505
DBA: Dbac_2807
DOA: AXF15_05895
DESU: NLA06_14000
THEW: TDMWS_00170(aroA') TDMWS_03230
DRT: Dret_0114
DOL: Dole_1952 Dole_3187
DAL: Dalk_1758 Dalk_5262
DMM: dnm_037710(aroA2) dnm_078980(aroA')
DEK: DSLASN_18980(aroA'_1) DSLASN_40230(aroA'_2)
DAO: Desac_0652
MRM: A7982_01287
BMET: BMMGA3_07340
BWH: A9C19_08410
MEKU: HUW50_25365
MLIT: KDJ21_015690
PTJ: JRJ22_24810
CCE: Ccel_2373
DDL: Desdi_3051
HMO: HM1_1787
SINT: K5I26_08870
FCZ: IMF26_04705
MHEV: MHEL_37860
NIE: KV110_32290
RKO: JWS14_15760 JWS14_20865
GOI: LK459_04835
GMG: NWF22_16005
GSI: P5P27_03650
SRW: TUE45_01349(lsrF)
PSIC: J4E96_11100
MPRO: BJP34_11730
PSUB: Pelsub_P0311 Pelsub_P1007
AAE: aq_1554
HYA: HY04AAS1_1586
HHO: HydHO_1566
HYS: HydSN_1610
HTH: HTH_0010
HTE: Hydth_0011
TAL: Thal_0539
TRD: THERU_03185
SUL: SYO3AOP1_0914
SAF: SULAZ_0629
PMX: PERMA_1749
TAM: Theam_0441
DTE: Dester_0321
TTK: TST_1080
MINF: MESINF_1405
MJA: MJ_0400
MFE: Mefer_1187
MVU: Metvu_1437
MFS: MFS40622_1668
MIF: Metin_0016
MJH: JH146_1314
MESG: MLAUSG7_1335(aroA)
MESA: MLASG1_0944(aroA)
MIG: Metig_0643
MMP: MMP0686
MMQ: MmarC5_0890
MMX: MmarC6_0201
MMZ: MmarC7_1710
MMD: GYY_02835
MMAK: MMKA1_07380
MMAO: MMOS7_07320
MMAD: MMJJ_02920(griI)
MAE: Maeo_0316
MVN: Mevan_1506
MVO: Mvol_0365
MOK: Metok_1495
METF: CFE53_05110
MTH: MTH_579
MMG: MTBMA_c09600(fbaB)
MWO: MWSIV6_0939(aroA')
MTEE: MTTB_10050
METC: MTCT_0503
METE: tca_00548(griI)
METZ: METMT2_0849
METK: FVF72_08665
MTHM: FZP57_04495
METJ: FZP68_04960
MST: Msp_0091
METB: AW729_06715
MEIS: PXD04_04260
MRU: mru_0997
MSI: Msm_0056
MEB: Abm4_0656
MMIL: sm9_1016
MEYE: TL18_05340
MOL: YLM1_0540
MARO: MarbSA_04640
METV: K4897_00700
MEL: Metbo_1361
MEW: MSWAN_0907
METH: MBMB1_1070
MFC: BRM9_1272
MFI: DSM1535_1956
MCUB: MCBB_0939(aroA')
MSUB: BK009_02850
METN: BK008_10575
METT: CIT01_09455
METO: CIT02_02135
MEME: HYG87_09830
MFEG: GCM10025860_20010
MFV: Mfer_0600
MKA: MK1409(fbaB)
AFU: AF_0108
AFG: AFULGI_00001050
APO: Arcpr_0817
AVE: Arcve_1168
AST: Asulf_00941
FPL: Ferp_0600
GAC: GACE_1261
GAH: GAH_01502
MBA: Mbar_A0753 Mbar_A0920
MBY: MSBRM_0075 MSBRM_0291
MBW: MSBRW_0078 MSBRW_0247
MBAR: MSBR2_2087 MSBR2_2305
MBAK: MSBR3_2087 MSBR3_2364
MAC: MA_0439 MA_4591(deoC)
MMA: MM_1271 MM_1627
MMAZ: MmTuc01_1317 MmTuc01_1701
MMJ: MSMAS_0045 MSMAS_3044
MMAC: MSMAC_0045 MSMAC_1391
MVC: MSVAZ_0309 MSVAZ_3439
MEK: MSKOL_0292 MSKOL_3399
MLS: MSLAZ_0044 MSLAZ_0176
METM: MSMTP_0060 MSMTP_2943
MEF: MSWH1_0053 MSWH1_0299
MEQ: MSWHS_0056 MSWHS_0301
MSJ: MSSAC_0062 MSSAC_0390
MSZ: MSSIH_0055 MSSIH_0359
MSW: MSSIT_0055 MSSIT_0365
MTHR: MSTHT_1780 MSTHT_2145
MTHE: MSTHC_1138 MSTHC_1506
MHOR: MSHOH_0050 MSHOH_3760
MFZ: AOB57_005170 AOB57_008125
MBU: Mbur_0917 Mbur_2001
MMET: MCMEM_0229 MCMEM_1419
MELO: J7W08_05825 J7W08_11215
MMH: Mmah_0241 Mmah_0691
MHAZ: BHR79_02305 BHR79_10150
MPOT: BKM01_06045 BKM01_09850
MEV: Metev_1692 Metev_1714
MZH: Mzhil_0254 Mzhil_0268
MPY: Mpsy_1418 Mpsy_1446
MZI: HWN40_01580 HWN40_01705
MMAV: RE476_08610 RE476_08705
MSEB: RE474_05170 RE474_05260
MHZ: Metho_0254 Metho_0268
MEHF: MmiHf6_11930(griI)
MEES: MmiEs2_14760(griI)
MTP: Mthe_0532 Mthe_0617
MCJ: MCON_1478 MCON_3321
MHI: Mhar_1906 Mhar_2111
MHU: Mhun_1035 Mhun_1036
MRTJ: KHC33_11765 KHC33_11770
MLA: Mlab_0600 Mlab_1654
MEM: Memar_1302 Memar_1303
MBG: BN140_2035(fbaA1) BN140_2036(fbaA3)
MEMA: MMAB1_2640 MMAB1_2641
MCHK: MchiMG62_14880 MchiMG62_14890
MSUM: OH143_00745 OH143_00750
MRC: R6Y96_03100 R6Y96_03105
MPI: Mpet_2705 Mpet_2706
MEND: L6E24_08060 L6E24_08065
MEFW: F1737_11240 F1737_11245
MAQE: RJ40_08670 RJ40_08675
MFK: E2N92_08845 E2N92_08850
MOU: OU421_03445 OU421_03450
MESB: L1S32_07045 L1S32_07050
MANQ: L1994_00985 L1994_00990
MBN: Mboo_1557 Mboo_1558
MFO: Metfor_1589 Metfor_1590
MPL: Mpal_2610 Mpal_2611
MPD: MCP_1367 MCP_1669
MEZ: Mtc_1383(aroF) Mtc_1667
RCI: RRC153(aroF)
HAL: VNG_0309C
HSL: OE_1472F(fba2)
HANR: LJ422_01350
HDL: HALDL1_05725
HHB: Hhub_1454
HAGS: JT689_02635
HABO: JRZ79_01140
HNO: LT974_02305
HLU: LT972_11245
HALH: HTSR_1439(fba2)
HHSR: HSR6_1511(fba2)
HSU: HLASF_0623(fba1)
HSF: HLASA_0619(fba1)
HAHS: HSRCO_0970
SALR: FQU85_02205
HALR: EFA46_006155
HJE: HacjB3_14310
HDO: MUK72_03645
HALX: M0R89_11070
HAXZ: M0R88_11525
HAYC: NGM10_05020
HAXY: NGM07_17085
SALI: L593_00075
SAIM: K0C01_01385
HARA: AArcS_2621
HMA: rrnAC1881(deoC2)
HHI: HAH_2396(fbaB2)
HHN: HISP_12200
HAB: SG26_04510
HTA: BVU17_11665
HALJ: G9465_07475
HSIN: KDQ40_01440
NPH: NP_3160A(fba2)
NMO: Nmlp_1197(fba2)
NHO: HWV23_11585
NSAL: HWV07_13660
HUT: Huta_1178
HTI: HTIA_1098
HALA: Hrd1104_09430
HASV: SVXHr_0435
HABN: HBNXHr_0421
HMU: Hmuk_3036
HALZ: E5139_02445
HALL: LC1Hm_2379
HAZP: GBQ70_02445
HALI: BV210_04645
HSN: DV733_05035
HDS: HSR122_0656
HRR: HZS55_09305
HPEL: HZS54_13385
HLT: I7X12_04925
HARC: HARCEL1_00665
SSAI: N0B31_02060
HAAD: MW046_10360
HWA: HQ_1156A(fba2)
HWC: Hqrw_1193(fba2)
HVO: HVO_0790(fba2)
HME: HFX_0749(fbaB)
HGI: ABY42_03765
HALE: G3A49_03975
HLS: KU306_08485
HLN: SVXHx_0749
HBO: Hbor_24270
HAQ: DU484_08625
HAJ: DU500_08665
HAER: DU502_05965
HRA: EI982_07830
HLM: DV707_12100
HALM: FCF25_10565
HLA: Hlac_1274
HALP: DOS48_06125
HALB: EKH57_03855
HEZZ: EO776_07625
HALQ: Hrr1229_015385
HSS: J7656_08775
HSAI: HPS36_14190
HAZZ: KI388_05335
SRUB: C2R22_04735
HAE: halTADL_0575
HALN: B4589_008625
HALG: HUG10_01095
HALU: HUG12_16500
HMP: K6T50_14120
HRE: K6T36_14065
HRM: K6T25_02715
HACB: Hbl1158_05910
HDF: AArcSl_0487
HAH: Halar_3168
HTU: Htur_0853
HSAL: JMJ58_04710
HAKZ: J0X25_11090
NMG: Nmag_2815
HXA: Halxa_4013
NAT: NJ7G_4134
NPE: Natpe_3297
NVR: FEJ81_15780
NPL: FGF80_14890
NAY: HYG81_12485
HALY: HYG82_17225
HJT: DVR14_06585
HLO: J0X27_10770
NGE: Natgr_0761
HRU: Halru_2303
SAWL: NGM29_18115
HALV: NGM15_09285
NOU: Natoc_0637
HLR: HALLA_07800
HLC: CHINAEXTREME00240
NAJ: B1756_17155
NAG: AArcMg_1455
NAN: AArc1_2141
NARA: QQ977_03435
NBG: DV706_03245
NAS: GCU68_10270
HDA: BB347_01155
MELU: MTLP_01120
MEAM: MU439_07195
MEAE: QEN48_03025
TAR: TALC_00560 TALC_00670
MAX: MMALV_05100
MER: MMINT_14400
MEAR: Mpt1_c09850(aroA'1) Mpt1_c10430(aroA'2)
MEUZ: KRP56_01775 KRP56_03645
MARC: AR505_0508 AR505_0932
SACD: HS1genome_2052
THB: N186_00460
TCB: TCARB_0208 TCARB_1172
THF: MA03_02210 MA03_05420
THEL: IG193_03385
NMR: Nmar_0553
NIR: NSED_02805
NKR: NKOR_02865
NID: NPIRD3C_1721(aroA)
NIN: NADRNF5_1625(aroA)
NIW: Nisw_02100
NCL: C5F47_02845
NOX: C5F49_03025
NUE: C5F50_04220
NIP: NsoK4_05575
NZT: NZOSNM25_001459
NCT: NMSP_1118(aroA'_2)
NIC: DSQ20_03075
NGA: Ngar_c16210(aroGFH)
NVN: NVIE_005850(aroGFH)
NEV: NTE_01960
TAA: NMY3_02544(griI)
NFN: NFRAN_0128(aroA)
NCV: NCAV_0390(aroGFH)
CSY: CENSYa_0200
CSU: CSUB_C0867 CSUB_C0895
NBV: T478_0480
TAH: SU86_003320
NIU: DSQ19_02830
NDV: NDEV_0554(aroA)
CCAI: NAS2_0559
KCR: Kcr_0249
BARB: AOA66_0830(aroA')
LOKI: Lokiarch_06380(aroA'_1) Lokiarch_41970(aroA'_2)
 » show all
Reference
1  [PMID:15182204]
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_0400]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
  Sequence
[mja:MJ_0400]
Reference
3  [PMID:17713928]
  Authors
Morar M, White RH, Ealick SE.
  Title
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
  Journal
Biochemistry 46:10562-71 (2007)
DOI:10.1021/bi700934v
  Sequence
[mja:MJ_0400]
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.10
IUBMB Enzyme Nomenclature: 2.2.1.10
ExPASy - ENZYME nomenclature database: 2.2.1.10
BRENDA, the Enzyme Database: 2.2.1.10

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (4027)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (474)   
   KEGG MGENES (2998)   
   RefGene (554)   
Protein sequence (3506)   
   UniProt (1834)   
   SWISS-PROT (12)   
   RefSeq(pep) (1660)   
DNA sequence (2744)   
   RefSeq(nuc) (2488)   
   GenBank (137)   
   EMBL (119)   
Protein domain (5)   
   InterPro (5)   
All databases (10296)   

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