KEGG   ENZYME: 2.3.1.108
Entry
EC 2.3.1.108                Enzyme                                 
Name
alpha-tubulin N-acetyltransferase;
ATAT1 (gene name);
MEC17 (gene name);
alpha-tubulin acetylase;
TAT;
alpha-tubulin acetyltransferase;
tubulin N-acetyltransferase (ambiguous);
acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase;
acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N6-acetyl-L-lysine [RN:R04192]
Reaction(KEGG)
R04192
Substrate
acetyl-CoA [CPD:C00024];
[alpha-tubulin]-L-lysine [CPD:C03318]
Product
CoA [CPD:C00010];
[alpha-tubulin]-N6-acetyl-L-lysine [CPD:C04149]
Comment
The enzyme is conserved from protists to mammals and is present in flowering plants. In most organisms it acetylates L-lysine at position 40 of alpha-tubulin.
History
EC 2.3.1.108 created 1989, modified 2021
Orthology
K19573  alpha-tubulin N-acetyltransferase 1
Genes
HSA79969(ATAT1)
PTR100612548(ATAT1)
PPS100975033(ATAT1)
GGO101125931(ATAT1)
PON100190967(ATAT1)
NLE100595319(ATAT1)
HMH116460080(ATAT1)
MCC100141388(ATAT1)
MTHB126953104
MNI105498610(ATAT1)
CSAB103221829(ATAT1)
CATY105600029(ATAT1)
PANU101025462(ATAT1)
TGE112622364 112623033
MLEU105553117(ATAT1)
RRO104666191(ATAT1)
RBB108522570(ATAT1)
TFN117088379(ATAT1)
PTEH111534440(ATAT1)
CANG105513991(ATAT1)
CJC100388531(ATAT1)
SBQ101037052(ATAT1)
CIMI108290611(ATAT1)
CSYR103249229(ATAT1)
MMUR105855392(ATAT1)
LCAT123631692(ATAT1)
PCOQ105817287(ATAT1)
OGA100950093(ATAT1)
MMU73242(Atat1)
MCAL110284357(Atat1)
MPAH110335546(Atat1)
RNO361789(Atat1)
MCOC116074613(Atat1)
ANU117724213(Atat1)
MUN110557137(Atat1)
CGE100764669(Atat1)
MAUA101826157(Atat1)
PROB127224374(Atat1)
PLEU114687012(Atat1)
MORG121435419(Atat1)
MFOT126494399
AAMP119822967(Atat1)
NGI103740567(Atat1)
HGL101705887(Atat1)
CPOC100719818(Atat1)
CCAN109693536(Atat1)
DORD105996955(Atat1)
DSP122111311(Atat1)
PLOP125352768
NCAR124988608
MMMA107160426(Atat1)
OCU100358006
OPI101531705(ATAT1)
TUP102486128(ATAT1)
GVR103592545(ATAT1)
CFA477580(ATAT1) 609464
CLUD112641245(ATAT1) 112656233
VVP112913564(ATAT1)
VLG121501255(ATAT1)
NPO129512610(ATAT1)
AML100473989(ATAT1)
UMR103664999(ATAT1)
UAH113264359(ATAT1)
UAR123794284(ATAT1)
ELK111152370
LLV125101805
MPUF101679281(ATAT1)
MNP132017752(ATAT1)
MLK131834419(ATAT1)
NVS122912100(ATAT1)
ORO101368740(ATAT1)
EJU114199234(ATAT1)
ZCA113926329(ATAT1)
MLX118027369(ATAT1)
NSU110578840 110586666(ATAT1)
LWW102741914
FCA101093356(ATAT1)
PYU121023110(ATAT1)
PCOO112853542(ATAT1)
PBG122489321(ATAT1)
LRUF124528532
PTG102966181(ATAT1)
PPAD109249510(ATAT1)
PUC125938492
AJU106966611
HHV120222646(ATAT1)
BTA786491(ATAT1)
BOM102275558(ATAT1)
BIU109577111(ATAT1)
BBUB102405703(ATAT1)
BBIS104994570(ATAT1)
CHX102183555(ATAT1)
OAS101106803(ATAT1)
BTAX128056518(ATAT1)
ODA120870501(ATAT1)
MBEZ129543149(ATAT1)
SSC100144480(ATAT1)
CFR102504889(ATAT1)
CBAI105074093(ATAT1)
CDK105087501(ATAT1) 116147121
VPC102534879(ATAT1)
BACU103016955(ATAT1)
LVE103083275(ATAT1)
OOR101273516(ATAT1)
DLE111170678(ATAT1)
PCAD102974761(ATAT1)
PSIU116761964(ATAT1)
NASI112395449(ATAT1)
ECB100055595(ATAT1)
EPZ103567174(ATAT1)
EAI106825481(ATAT1)
MYB102240400(ATAT1)
MYD102762964(ATAT1)
MMYO118679502
MLF102437350(ATAT1)
MNA107538522(ATAT1)
PKL118714058(ATAT1)
EFUS103300496(ATAT1)
HAI109376104(ATAT1)
DRO112302335(ATAT1)
SHON118987617(ATAT1)
AJM119046339(ATAT1)
PDIC114494485(ATAT1)
PHAS123810481(ATAT1)
MMF118620698(ATAT1)
RFQ117020239(ATAT1)
PPAM129067287(ATAT1)
PALE102879916(ATAT1)
PGIG120593370(ATAT1)
PVP105308145(ATAT1)
RAY107498064(ATAT1)
MJV108384338(ATAT1)
TOD119252107(ATAT1)
SARA101545003(ATAT1)
LAV100664992(ATAT1)
TMU101361158
ETF101647457(ATAT1)
DNM101421604
MDO100024215(ATAT1)
GAS123245054(ATAT1)
SHR100919522(ATAT1)
AFZ127561043
PCW110199408(ATAT1)
OAA103166272(ATAT1)
TGU115492253(ATAT1)
LSR110482313(ATAT1)
PMOA120503966
PHI102104188(ATAT1)
CCAE111942560(ATAT1)
CBRC108448297(ATAT1)
SVG106863338(ATAT1)
ACHC115337893(ATAT1)
HLE104838035(ATAT1)
AGEN126034975
SHAB115618858(ATAT1)
ASN102379630(ATAT1)
AMJ102573069(ATAT1)
PSS102444571(ATAT1)
CMY102941891(ATAT1)
CCAY125621589(ATAT1)
DCC119843044(ATAT1)
CPIC101936201(ATAT1)
TST117870426(ATAT1)
CABI116836708(ATAT1)
MRV120383876(ATAT1)
ACS100561358(atat1)
ASAO132765163(ATAT1)
PVT110089317(ATAT1)
SUND121920245(ATAT1)
PBI103048020 103064160
PMUR107297734(ATAT1)
CTIG120307286(ATAT1)
TSR106550119(ATAT1)
PGUT117667981(ATAT1)
APRI131193607(ATAT1)
PTEX113449636(ATAT1)
NSS113424281
VKO123019525(ATAT1)
PMUA114588270(ATAT1)
PRAF128408619(ATAT1)
ZVI118081085(ATAT1)
HCG128344382(ATAT1)
GJA107111806(ATAT1)
STOW125427701(ATAT1) 125427707
EMC129328088(ATAT1)
XLA734258(atat1.L) 735057(atat1.S)
XTR100038151(atat1)
NPR108790405(ATAT1)
RTEM120913493(ATAT1)
BBUF121009153(ATAT1)
BGAR122946163(ATAT1)
MUO115464949(ATAT1)
GSH117346803(ATAT1)
DRE406389(atat1)
SRX107711335 107754836
SANH107677465 107677472 107694337
SGH107584296 107595600
CCAR109063750 109063757
CAUA113090768 113119529
CGIB127935572 127979007
PTET122323438(atat1)
LROH127182024(atat1)
OMC131525523(atat1)
PPRM120485060(atat1)
RKG130087917(atat1)
MAMB125274767(atat1)
CIDE127500518
MASI127421051 127425466
TROS130566636(atat1)
TDW130415935(atat1)
MANU129454538(atat1)
IPU108272794
IFU128615746(atat1)
PHYP113543803(atat1)
SMEO124381921(atat1)
TFD113634692(atat1)
TVC132842766(atat1)
AMEX103043739(atat1)
CMAO118805417(atat1)
EEE113590338(atat1)
CHAR105904694(atat1)
TRU101074501 115251809(atat1)
TFS130517827(atat1)
TNGGSTEN00004688G001
LCO104931069(atat1)
NCC104951400
TBEN117477934(atat1)
CGOB115015403(atat1)
PGEO117455041(atat1)
GACU117535958(atat1)
ELY117263696(atat1)
EFO125904576(atat1)
PLEP121957568(atat1)
SLUC116035741(atat1)
ECRA117957345(atat1)
ESP116701254(atat1)
PFLV114568380(atat1)
GAT120826705(atat1)
PPUG119218791(atat1)
AFB129097636(atat1)
CLUM117738580(atat1)
MSAM119907190(atat1)
SCHU122864202(atat1)
CUD121524078(atat1)
ALAT119016821(atat1)
MZE101473057(atat1)
ONL100698811(atat1)
OAU116317007(atat1)
OLA101172832(atat1)
OML112137782(atat1)
XMA102224331(atat1)
XCO114156469(atat1)
XHE116731875(atat1)
PRET103471914(atat1)
PFOR103142785(atat1)
PLAI106937899(atat1)
PMEI106912443(atat1)
GAF122843996(atat1)
PPRL129352762(atat1)
CVG107105221(atat1)
CTUL119784059(atat1)
GMU124879430(atat1)
NFU107383265(atat1)
KMR108248583(atat1)
ALIM106531007(atat1)
NWH119426110(atat1)
AOCE111575171(atat1)
MCEP125019810(atat1)
CSEM103384383 103394495(atat1)
POV109643172(atat1)
SSEN122783133 122786311(atat1)
HHIP117771129(atat1)
HSP118125029(atat1)
LCF108896379
SDU111220869(atat1)
SLAL111645636(atat1)
XGL120786372(atat1)
HCQ109515158(atat1)
SBIA133507336(atat1)
PEE133395912(atat1)
PTAO133470948(atat1)
BPEC110161191(atat1)
MALB109974587(atat1)
BSPL114865643(atat1)
SJO128374746(atat1)
SASA106570679 106589060(atat1)
STRU115174126 115175310(atat1)
OTW112238603 112247208
OMY110496896(atat1)
OGO124012771 124043077
ONE115116544 115125001
OKI109881871 109882165
OKE118378726 118380316(atat1)
SALP111974506
SNH120021996(atat1) 120027367
CCLU121572234 121586834
ELS105012343(atat1)
SFM108935682(atat1)
PKI111842741(atat1)
AANG118234692(atat1)
PSPA121298671(atat1)
ARUT117433594 117964778
PSEX120539678(atat1)
LCM102353700(ATAT1)
RTP109912442(atat1)
CPLA122541342(atat1)
HOC132832415(atat1)
LERI129694427(atat1)
BFO118407743
BBEL109462042
CIN100180842
SCLV120344733
SPU115929226 581275
APLC110976410
SKO100372923
DMEDmel_CG17003(lky) Dmel_CG3967(Atat)
DER6545641 6550395
DSE6605026
DSIDsimw501_GD12926(Dsim_GD12926) Dsimw501_GD15558(Dsim_GD15558)
DYADyak_GE17347 Dyak_GE21245
DAN6506373
DSR110184175 110190629
DPO6900997 6900998 6901295
DPE113566753 6598554 6599632
DMN108151967 108151969 108156830
DWI6638791 6644873
DGR6557341
DMODmoj_GI13265 Dmoj_GI14817
DAZ108613148 108618396
DNV108650490 108655956
DHE111602819 111603737
DVI6623141
CCAT101451142 101452477
BOD106621507 106624106
BDR105221972
RZE108359899
AOQ129244456
TDA119668974
SCAC106084962
LCQ111684277
LSQ119606319
GFS119632459
ECOE129948605
CLON129614771
AGA1276496
ACOZ120947541
AARA120898274
AMER121591919 121602792
ASTE118511483
AFUN125768011
AMOU128300850
AAG5570947
AALB109409698 109411441
CQUCpipJ_CPIJ002083
CPII120428697
CNS116352492
BCOO119082181 119082516
AME726664
ACER107994214
ALAB122719667
ADR102679431
AFLR100864794
BIM100743036
BBIF117210303
BVK117242106
BVAN117159463
BTER100649139
BAFF126916136
BPYO122569280
BPAS132916264
FVI122532875
CCAL108628030
OBB114880120
OLG117605786
MGEN117228575
NMEA116424230
CGIG122403630
SOC105201818
MPHA105838369
AEC105145755
ACEP105624179
PBAR105428664
VEM105567303
HST105190371
DQU106742357
CFO105252940
FEX115239043
LHU105678633
PGC109859797
OBO105282139
PCF106787522
PFUC122524124
VPS122637338
VCRB124432510
VVE124957294
NVI100121551
CSOL105365137
TPRE106652111
LHT122500283
LBD127288599
MDL103573516
CGLO123266445
FAS105274088
DAM107045275
AGIF122859577
CINS118072198
VCAN122417545
CCIN107273868
AROA105684983
TCA660866
DPA109541846
SOY115885965
ATD109602224 109608541 109608563 109608617
AGB108911158
NVL108569703
PPYR116175155
BMOR101741407
BMAN114246874
MSEX115441429
DPLKGM_200100
BANY112047971
MJU123880086
NIQ126780703
VCD124543127
MCIX123668614
PMAC106719746 106719891
PPOT106102600 106102989
PXU106113651 106113885
PRAP110999361
ZCE119835601
CCRC123705226
LSIN126978862
HAW110381403
HZE124645118
SLIU111360630
OFU114359327
PGW126379943
CFEL113369258 113377702 113385498
CCRN123295394
API100162553 100168047 100169461 100570380 100570471 100570672 100575498
DNX107164488 107173589 107173592 107174168 107174192
AGS114123315 114123904 114125016 114132529 114132549
RMD113548079 113549333 113556182 113556835 113557143 113557201
ACOO126842722 126842723 126846216 126846402 126846710
DVT126894176 126903274 126903275
BTAB109031895
DCI103517182
CLEC106668236 106668237
HHAL106691548
NLU111050069 120349759
HVI124357217
MQU128994330 128994388 128995325 128995724 128995734 128995878
PHUPhum_PHUM581120
FOC113206970 113212172
TPAL117653839 117654003
ZNE110831576
CSEC111875230
SGRE126365854
IEL124163145
FCD110855937
DPXDAPPUDRAFT_304907
DMK116933661
DPZ124336719
PVM113827729
PJA122251437
PCHN125039015
PMOO119575527
HAME121861834
PCLA123775095
PTRU123514809
EAF111707382
LSM121123646
TCF131877686
PPOI119100937
DSV119435395
RSAN119378785 119406384
RMP119177238
VDE111243297
VJA111264289
TUT107361133
DPTE113797776
DFR124499996
CSCU111618355
PTEP107436987
UDV129224103
SDM118197569
LPOL106475838
PMEO129602602
CELCELE_F57H12.7(mec-17) CELE_W06B11.1(atat-2)
CBRCBG_14763(Cbr-atat-2) CBG_17726(Cbr-mec-17)
CRQGCK72_014792 GCK72_024480
NAINECAME_01566
BMYBM_BM6206(Bm6206)
LOALOAG_13260
HROHELRODRAFT_188468
LGILOTGIDRAFT_109299 LOTGIDRAFT_148609
PVUL126814415
PCAN112575932
BGT106059352
GAE121383091
HRF124139272
HRJ124275917
CRG105336584
CVN111124186 111125721
CANU128155529
OED125680974
MYI110464956
PMAX117321625
RPHI132721691
OBI106875308
OSN115222942
LAK106151826 106173555
SMMSmp_166660
OVIT265_11140
EGLEGR_05466
NVE5507200
EPA110243359
ATEN116298261
AMIL114963356
PDAM113686094
SPIS111327067
DGT114518815
XEN124439183
HMG101237472
HSY130662708
TADTRIADDRAFT_35009 TRIADDRAFT_53139
AQU100640763 105315491 109587786
SMOSELMODRAFT_420234
PPP112285127 112285208
VCNVOLCADRAFT_90683
MNGMNEG_1043
MISMICPUN_85323
MPPMICPUCDRAFT_6581(JGI:MicpuC2_6581)
SREPTSG_01905
PFDPFDG_01359
PFHPFHG_01378
PKNPKNH_0722800
PVXPVX_099660
PCYPCYB_073250
TETTTHERM_00355780
PTMGSPATT00035333001 GSPATT00035468001 GSPATT00036506001 GSPATT00037844001 GSPATT00038558001
SMINv1.2.037027.t1(symbB.v1.2.037027.t1) v1.2.037027.t2(symbB.v1.2.037027.t2)
NGDNGA_0112700
PIFPITG_13069
PSOJPHYSODRAFT_347190
SPARSPRG_08206
EHXEMIHUDRAFT_204370
GTTGUITHDRAFT_72899
TBRTb927.3.1400
TBGTbgDal_III1150
TCR467287.10 509233.160
LMALMJF_25_1150
LIFLINJ_25_1190
LDOLDBPK_251190
LMILMXM_25_1150
LBZLBRM_25_1130
LPANLPMP_251180
NGRNAEGRDRAFT_58582
TVATVAG_2v0166300 TVAG_2v0307470
GLAGL50803_0016348
 » show all
Reference
1  [PMID:4066751]
  Authors
Greer K, Maruta H, L'Hernault SW, Rosenbaum JL.
  Title
Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella.
  Journal
J Cell Biol 101:2081-4 (1985)
DOI:10.1083/jcb.101.6.2081
Reference
2  [PMID:20829795]
  Authors
Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J
  Title
MEC-17 is an alpha-tubulin acetyltransferase.
  Journal
Nature 467:218-22 (2010)
DOI:10.1038/nature09324
Reference
3  [PMID:21068373]
  Authors
Shida T, Cueva JG, Xu Z, Goodman MB, Nachury MV
  Title
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.
  Journal
Proc Natl Acad Sci U S A 107:21517-22 (2010)
DOI:10.1073/pnas.1013728107
Reference
4  [PMID:23071318]
  Authors
Taschner M, Vetter M, Lorentzen E.
  Title
Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA.
  Journal
Proc Natl Acad Sci U S A 109:19649-54 (2012)
DOI:10.1073/pnas.1209343109
Reference
5  [PMID:23071314]
  Authors
Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R.
  Title
Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation.
  Journal
Proc Natl Acad Sci U S A 109:19655-60 (2012)
DOI:10.1073/pnas.1209357109
Reference
6  [PMID:23748901]
  Authors
Kalebic N, Sorrentino S, Perlas E, Bolasco G, Martinez C, Heppenstall PA.
  Title
alphaTAT1 is the major alpha-tubulin acetyltransferase in mice.
  Journal
Nat Commun 4:1962 (2013)
DOI:10.1038/ncomms2962
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.108
IUBMB Enzyme Nomenclature: 2.3.1.108
ExPASy - ENZYME nomenclature database: 2.3.1.108
BRENDA, the Enzyme Database: 2.3.1.108
CAS: 99889-90-4

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