Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy

acetyl-CoA:N-terminal-Met-Leu/Ile/Phe/Trp/Tyr-[protein] Met Nalpha-acetyltransferase

(1) acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-leucyl-[protein] + CoA;
(2) acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA;
(3) acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA;
(4) acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA;
(5) acetyl-CoA + an N-terminal-L-methionyl-L-tyrosyl-[protein] = an N-terminal-Nalpha-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA

acetyl-CoA [CPD:C00024];
N-terminal-L-methionyl-L-leucyl-[protein];
N-terminal-L-methionyl-L-isoleucyl-[protein];
N-terminal-L-methionyl-L-phenylalanyl-[protein];
N-terminal-L-methionyl-L-tryptophyl-[protein];
N-terminal-L-methionyl-L-tyrosyl-[protein]

N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues.

EC 2.3.1.256 created 1989 as EC 2.3.1.88, part transferred 2016 to EC 2.3.1.256

1  [PMID:11274203]

2  [PMID:12890471]

3  [PMID:12897255]

4  [PMID:16484612]