Entry
Name
2-acylglycerol-3-phosphate O-acyltransferase;
2-acylglycerophosphate acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate [RN:
R02242 ]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:
C00040 ];
2-acyl-sn-glycerol 3-phosphate [CPD:
C03974 ]
Product
CoA [CPD:
C00010 ];
1,2-diacyl-sn-glycerol 3-phosphate [CPD:
C00416 ]
Comment
Saturated acyl-CoA thioesters are the most effective acyl donors.
History
EC 2.3.1.52 created 1976
Pathway
ec00564 Glycerophospholipid metabolism
ec01110 Biosynthesis of secondary metabolites
Reference
Authors
Yamashita S, Hosaka K, Numa S.
Title
Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.52
ExPASy - ENZYME nomenclature database: 2.3.1.52