KEGG ENZYME: 2.3.1.59

ENZYME: 2.3.1.59

Entry

EC 2.3.1.59                 Enzyme

Name

gentamicin 2'-N-acetyltransferase;
gentamycin acetyltransferase II;
gentamycin 2'-N-acetyltransferase;
acetyl-CoA:gentamycin-C1a N2'-acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:gentamicin-C1a N2'-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + gentamicin C1a = CoA + N2'-acetylgentamicin C1a [RN:R03056]

Reaction(KEGG)

R03056

Substrate

acetyl-CoA [CPD:C00024];
gentamicin C1a [CPD:C00908]

Product

CoA [CPD:C00010];
N2'-acetylgentamicin C1a [CPD:C03524]

Comment

The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.

History

EC 2.3.1.59 created 1976

Orthology

K17840

aminoglycoside 2'-N-acetyltransferase I

Genes

PCIB:

F9282_06485

PSI:

S70_17610

PSX:

DR96_2475

PSTA:

BGK56_19845

PTHA:

OI982_05740(aac(2')-Ia)

PRG:	RB151_031910(aac)

PRQ:	CYG50_22025

PVC:	G3341_13465(aac(2')-Ia)

PAEU:

BN889_06966(aac)

CHRO:

CXB49_21390

CHRI:

DK842_07705

CHRB:

DK843_13255

DUG:	HH213_17300

BBT:	BBta_1334 BBta_2407

BRS:

S23_63390

AOL:

S58_64430

BRK:	CWS35_11955

BOT:	CIT37_16855

BGQ:	X265_32670

BSYM:

CIT39_01515

BARH:

WN72_43660

VCP:	H9L18_07100

VHY:	G7082_13800

ERZ:	ER308_09125

MTU:	Rv0262c(aac)

MTV:	RVBD_0262c

MTC:	MT0275(aac)

MRA:	MRA_0270(aac)

MTF:	TBFG_10266

MTB:	TBMG_00264

MTK:	TBSG_00268

MTZ:	TBXG_000265

MTG:	MRGA327_01675

MTE:	CCDC5079_0244

MTUR:

CFBS_0279(aac)

MTL:	CCDC5180_0243

MTO:	MTCTRI2_0267(aac)

MTD:	UDA_0262c(aac)

MTN:	ERDMAN_0290(aac)

MTJ:	J112_01410

MTUB:

MT7199_0267

MTUE:

J114_01420

MTX:	M943_01385

MTUH:

I917_01870

MTUL:

TBHG_00262

MTUT:

HKBT1_0279(aac)

MTUU:

HKBT2_0279(aac)

MTQ:	HKBS1_0279(aac)

MBO:	BQ2027_MB0268C(aac)

MBB:	BCG_0300c(aac)

MBT:	JTY_0269(aac)

MBM:	BCGMEX_0269c(aac)

MBK:	K60_002830

MBX:

BCGT_0027

MAF:	MAF_02630(aac)

MMIC:

RN08_0294

MCE:	MCAN_02691(aac)

MCQ:	BN44_10301(aac)

MCV:	BN43_10296(aac)

MCX:	BN42_10308(aac)

MCZ:	BN45_10288(aac)

MORY:

MO_000277(aac(2')-Ic)

MLE:	ML2551(aac)

MLB:	MLBr02551(aac)

MSA:	Mycsm_00227

MUL:	MUL_1185(aac)

MMI:	MMAR_0522(aac)

MMAE:

MMARE11_04790(aac)

MLI:	MULP_00526(aac)

MPSE:

MPSD_06390(aac)

MSHO:

MSHO_19270(aac)

MMC:

Mmcs_0265

MKM:

Mkms_0275

MJL:

Mjls_0255

MKN:	MKAN_16860

MYV:	G155_01705

MYE:	AB431_02080

MHAD:

B586_00975

MDX:	BTO20_34295

MSHG:

MSG_00462(aac)

MFJ:	MFLOJ_30410(aac)

MSTO:

MSTO_34300(aac)

MSIM:

MSIM_20050(aac)

MSAK:

MSAS_38490(aac)

MLW:	MJO58_02450

MXE:	MYXE_46010(aac)

MNV:	MNVI_20170(aac)

MPAG:

C0J29_02945

MGOR:

H0P51_02955

MCOO:

MCOO_36180(aac)

MBAI:

MB901379_00432(aac)

MHEK:

JMUB5695_04447(aac)

MGAU:

MGALJ_47570(aac)

MLJ:	MLAC_39280(aac)

MBRD:

MBRA_12110(aac)

MSHJ:

MSHI_32180(aac)

MMAM:

K3U93_02310

MSPG:

F6B93_02005

MOT:	LTS72_23315

MLM:	MLPF_2801(aac)

MPAA:

MKK62_22905

MMEH:

M5I08_23170

MKY:	IWGMT90018_05420(aac)

MADI:

A7U43_00890

MWU:	PT015_19665

MSM:	MSMEG_0434

MSG:	MSMEI_0423

MSB:	LJ00_02155

MSN:	LI99_02155

MSH:	LI98_02155

MVA:

Mvan_0302

MGI:

Mflv_0379

MSP:	Mspyr1_03760

MCB:	Mycch_0260

MNE:	D174_03155

MYN:	MyAD_03080

MFT:	XA26_03650

MPHL:

MPHLCCUG_04827(aac)

MVQ:

MYVA_0296

MLL:	B1R94_00295 B1R94_01695

MRH:	MycrhN_1459

MTHN:

4412656_00273(aac)

MHAS:

MHAS_04592(aac)

MDU:	MDUV_40340(aac)

MCHT:

MCHIJ_06670(aac)

MDR:	MDOR_01050(aac)

MAUU:

NCTC10437_00295(aac)

MMAG:

MMAD_05630(aac)

MMOR:

MMOR_01610(aac)

MAIC:

MAIC_52800(aac)

MALV:

MALV_32270(aac)

MTY:	MTOK_10120(aac)

MPSC:

MPSYJ_06060(aac)

MARZ:

MARA_35100(aac)

MGAD:

MGAD_45920(aac)

MHEV:

MHEL_18440(aac_1) MHEL_23040(aac_2)

MSAR:

MSAR_19180(aac) MSAR_20920

MANY:

MANY_44170(aac)

MAUB:

MAUB_37170(aac)

MPOF:

MPOR_08330(aac)

MPHU:

MPHO_33280(aac)

MMUC:

C1S78_001445

MMAT:

MMAGJ_17760(aac)

MBOK:

MBOE_15910(aac) MBOE_22630

MFG:	K6L26_29690(aac(2')-Ib)

MSEI:

MSEDJ_16550(aac)

MFLV:

NCTC10271_04847(aac)

MCEE:

MCEL_29590(aac)

MMON:

EWR22_01420

MGO:	AFA91_09090

MHOL:

K3U96_25045

MSEN:

K3U95_01765(aac(2')-Ib)

MPAE:

K0O64_01720

MRF:	MJO55_01400

MDF:	K0O62_02125

MCRO:

MI149_02290

MGRO:

FZ046_08145

MKR:	MKOR_28230(aac)

MPAK:

MIU77_17555

MAB:

MAB_4395

MABB:

MASS_4433

MIZ:	BAB75_24985

MSTE:

MSTE_04563

MSAL:

DSM43276_04253(aac_2)

MTER:

4434518_00231(aac)

MMIN:

MMIN_19790(aac)

MHIB:

MHIB_32720(aac)

MHER:

K3U94_01390

MVM:	MJO54_01245

CFN:	CFAL_07935

RHU:	A3Q40_02318(aac)

WHR:	OG579_04515

GOQ:	ACH46_12705

GOC:	CXX93_10645

GOI:	LK459_19215

GSI:	P5P27_11495

SMA:	SAVERM_2721(aac1)

SGR:

SGR_1985

SGB:

WQO_25540

SFI:

SFUL_5379

SANL:

KZO11_27070

SGRF:

SGFS_096600

SCYE:

R2B67_08770

SHY:

SHJG_6618

SHO:	SHJGH_6378

SBH:

SBI_09091

SVE:

SVEN_5199

SGU:	SGLAU_23715

SVT:	SVTN_26725

STRE:

GZL_02854

SCW:	TU94_23310

SLD:

T261_2154

SLC:	SL103_26740

SXI:	SXIM_14240 SXIM_23280

STRM:

M444_24330

SAMB:

SAM23877_5271(aac)

SCZ:	ABE83_09775

SRW:	TUE45_06019(aac_2)

SLE:	sle_21330(sle_21330)

SRN:	A4G23_04081(aac_2)

STRT:

A8713_22410

SCLF:

BB341_06610

SGS:	AVL59_08650

STSI:

A4E84_28255

SALW:

CP975_25375

SCAD:

DN051_12675

SNR:	SNOUR_12305

SALU:

DC74_5946

SALL:

SAZ_12180

SNW:	BBN63_09105

SSIA:

A7J05_11225

SVU:	B1H20_26100

SPUN:

BFF78_13485

SGV:	B1H19_30025

SALF:

SMD44_06140(aac)

SALJ:

SMD11_1742(aac)

SLX:	SLAV_12125(aac)

STRO:

STRMOE7_28605

SFK:

KY5_5685

SNZ:	DC008_24765

SLK:	SLUN_27960

SQZ:	FQU76_24645

STIR:

DDW44_21825

SKA:	CP970_12650

SGZ:	C0216_06380

SVN:	CP980_09865

SHAW:

CEB94_28875

SRK:	FGW37_24710

SFIC:

EIZ62_08895

SSPO:

DDQ41_20565

SFY:	GFH48_13355

SCAV:

CVT27_24930

SBY:	H7H31_06960

SRIM:

CP984_09780

SSUB:

CP968_10135

SCIN:

CP977_24415 CP977_30300

STSU:

B7R87_24665

SCHA:

CP983_13055

SGX:	H4W23_28230

SCOE:

CP976_30475

SSPB:

CP982_29475

SNF:	JYK04_05918(aac_2)

SPLA:

CP981_28995

STUI:

GCM10017668_50250(aac)

SATA:

C5746_29345

SCHF:

IPT68_26185

SHAR:

HUT13_07825 HUT13_12290

SCYG:

S1361_27380(aac2)

SFEU:

IM697_35645

SDW:	K7C20_27730

SCAL:

I6J39_25795

SAUH:

SU9_026395

SFB:	CP974_22055

SANU:

K7396_09150

SMAO:

CAG99_20600

SINE:

KI385_33060

SLF:	JEQ17_14885

SAOV:

G3H79_10150

SDUR:

M4V62_13850

SYAN:

NRK68_24235

STAA:

LDH80_12670

SNIG:

HEK616_51950(aac)

SCIR:

STRCI_005698

SXT:	KPP03845_105260(aac_2)

SLON:

LGI35_30285

STUD:

STRTU_001700

SGK:	PET44_23100

SYUN:

MOV08_12115

SARG:

HKX69_10075

SJN:	RI060_11925

SCYN:

N8I84_27950

SOV:	QZH56_07345

SHAU:

K9S39_13020

SKG:	KJK29_10030

SROC:

RGF97_08685

SFP:	QUY26_10825

SCHG:

NRO40_21330

STTN:

BSL84_23695

STRZ:

OYE22_06775

KSK:

KSE_68370

KAB:	B7C62_26815

KIS:	HUT16_32425

ABRY:

NYE86_06515

MFOL:

DXT68_08230

KFV:	AS188_13555

KII:	KocCE7_08400

DNI:	HX89_14335

BCAU:

I6G59_10495

NCA:

Noca_3357

NDK:

I601_2761

NOO:	FE634_15020

NMES:

H9L09_04580

NAQU:

ENKNEFLB_01313(aac)

NMAR:

HPC71_06815

NGV:	CDO52_22840

MMAR:

MODMU_5198

SACG:

FDZ84_01115

AOI:

AORI_7879

AJA:	AJAP_41090

AMQ:	AMETH_1520

AMYB:

BKN51_32705

AAB:	A4R43_05940

AORI:

SD37_01225

AACD:

LWP59_15630

AROO:

NQK81_24425

ATHM:

L1857_10245

PSEA:

WY02_28020

PSEE:

FRP1_14705

PSEH:

XF36_14960

PSEQ:

AD006_22370

PECQ:

AD017_01955

PHH:	AFB00_22920

PAUT:

Pdca_41060(aac)

SESP:

BN6_71470

SSYI:

EKG83_40005

KBU:	Q4V64_37330 Q4V64_37335

KPHY:

AOZ06_09845

SACE:

GIY23_03690

CROS:

N8J89_22280

ASE:	ACPL_6034(aac)

ACTS:

ACWT_5902

AIH:	Aiant_17820(aac)

ACTL:

L3i22_085640(aac)

AOU:	ACTOB_006447

CATI:

CS0771_50830(aac)

DVC:	Dvina_34805

DFU:	Dfulv_44905

DROS:

Drose_34740

DMAT:

Dmats_29620

BALA:

DSM104299_00272(aac)

IAM:	HC251_16025

DWU:	DVJ83_16985

HQI:	H9L05_21605

» show all

Reference

1 [PMID:4209515]

Authors

Benveniste R, Davies J.

Title

Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.

Journal

Proc Natl Acad Sci U S A 70:2276-80 (1973)
DOI:10.1073/pnas.70.8.2276

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.59

IUBMB Enzyme Nomenclature:

2.3.1.59

ExPASy - ENZYME nomenclature database:

2.3.1.59

BRENDA, the Enzyme Database:

2.3.1.59

CAS:	50864-40-9

DBGET integrated database retrieval system