Entry
Name
D-glutamyltransferase;
D-glutamyl transpeptidase;
D-gamma-glutamyl transpeptidase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
glutamine:D-glutamyl-peptide 5-glutamyltransferase
Reaction(IUBMB)
(1) D-glutamine + D-glutamate = NH3 + gamma-D-glutamyl-D-glutamate [RN:
R04011 ];
(2) L(or D)-glutamine + (gamma-D-glutamyl)n-[peptide] = NH3 + (gamma-D-glutamyl)n+1-[peptide] [RN:
R04012 ]
Reaction(KEGG)
Substrate
D-glutamine [CPD:
C00819 ];
D-glutamate [CPD:
C00217 ];
L-glutamine [CPD:
C00064 ];
(gamma-D-glutamyl)n-[peptide]
Product
NH3 [CPD:
C00014 ];
gamma-D-glutamyl-D-glutamate;
(gamma-D-glutamyl)n+1-[peptide]
Comment
The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a gamma linkage, forming gamma-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain.
History
EC 2.3.2.1 created 1961, modified 1976, modified 2013
Pathway
Reference
Authors
WILLIAMS WJ, THORNE CB
Title
Biosynthesis of glutamyl peptides from glutamine by a transfer reaction.
Journal
J Biol Chem 210:203-17 (1954)
Reference
Authors
WILLIAMS WJ, LITWIN J, THORNE CB.
Title
Further studies on the biosynthesis of gamma-glutamyl peptides by transfer reactions.
Journal
J Biol Chem 212:427-38 (1955)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.1
ExPASy - ENZYME nomenclature database: 2.3.2.1
BRENDA, the Enzyme Database: 2.3.2.1