Entry
Name
2-methylcitrate synthase;
2-methylcitrate oxaloacetate-lyase;
MCS;
methylcitrate synthase;
methylcitrate synthetase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)
Reaction(IUBMB)
propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA [RN:
R00931 ]
Reaction(KEGG)
Substrate
Product
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate [CPD:
C02225 ];
CoA [CPD:
C00010 ]
Comment
The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC
2.3.3.1 , citrate (Si)-synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.
History
EC 2.3.3.5 created 1978 as EC 4.1.3.31, transferred 2002 to EC 2.3.3.5, modified 2015
Pathway
Orthology
K01659 2-methylcitrate synthase
Genes
PTM : GSPATT00014981001 GSPATT00031721001
ECOC : C3026_01630 C3026_24800
ECOO : ECRM13514_0518(prpC)
ECOH : ECRM13516_0310(prpC)
ECW : EcE24377A_0357(prpC)
EDJ : ECDH1ME8569_0320(prpC)
ECOI : ECOPMV1_00339(prpC)
PSHI : SAMEA2665130_1485(prpC)
SMW : SMWW4_v1c14450(prpC)
SFJ : SAMEA4384070_1514(prpC)
PHEI : NCTC12003_01323(prpC)
PRJ : NCTC6933_02689(prpC)
XFU : XFF4834R_chr11320(prpC)
XPH : XppCFBP6546_05895(prpC)
XHD : LMG31886_32100(prpC_1)
SINC : DAIF1_31520(prpC_2)
LLZ : LYB30171_02035(prpC_2)
RGL : CS053_01920(prpC) CS053_12625(prpC)
VAU : VANGNB10_cI1219(prpC)
VPL : SA104470976_01085(prpC)
PPR : PBPRA1247(CBU0772) PBPRB0236(CBU0772)
PGB : H744_1c1147 H744_2c2474
PGH : FH974_06115(prpC) FH974_18245(prpC)
PAEB : NCGM1900_1981(prpC)
PSYR : N018_09750 N018_17610
PVD : CFBP1590__2136(prpC)
PPRC : PFLCHA0_c18930(prpC1)
PMUD : NCTC8068_01565(prpC)
PFW : PF1751_v1c41390(prpC)
PPUU : PputUW4_03657(prpC)
PTRT : HU722_0021835(prpC)
PTW : TUM18999_19700(prpC)
PTAE : NCTC10697_01187(prpC)
PSYC : DABAL43B_1464(prpC)
ACV : AMD27_05655 AMD27_08930
ABOU : ACBO_10310(prpC_1) ACBO_14660(prpC_2)
MCUN : NCTC10297_00852(prpC)
SCAA : TUM17387_03130(prpC)
SALH : HMF8227_00162(prpC)
CBS : COXBURSA331_A1176(prpC)
LLG : 44548918_01498(prpC)
LJR : NCTC11533_01460(prpC)
LCJ : NCTC11976_02197(prpC_2)
LWA : SAMEA4504053_1762(gltA_2)
LSS : NCTC12082_00605(gltA_2)
LADL : NCTC12735_00656(gltA)
TFRI : Thiofri_04766(prpC)
HHC : M911_07945 M911_07950
TNI : TVNIR_3341(prpC_[H])
ALCA : ASALC70_00055(prpC)
AEL : NCTC12917_02496(prpC)
OPE : PU634_05735(prpC) PU634_07595(prpC)
NMQ : NMBM04240196_0438(prpC)
NMZ : NMBNZ0533_1819(prpC)
NMX : NMA510612_2316(prpC)
NWE : SAMEA3174300_1283(prpC)
NZO : SAMEA4504057_2053(prpC)
NCI : NCTC10296_00750(prpC)
RSL : RPSI07_1428(prpC) RPSI07_mp0086(prpC)
RSN : RSPO_c01436(prpC) RSPO_m00104(prpC)
RSY : RSUY_23090(prpC_1) RSUY_32930(prpC_2)
RSG : JK151_21265(prpC) JK151_22970(prpC)
RPJ : N234_11040 N234_14945
REH : H16_A1906(prpC1) H16_A2636(prpC2)
CNC : CNE_1c18850(prpC1) CNE_1c25190(prpC2)
CUH : BJN34_10085 BJN34_14120
REU : Reut_A1809 Reut_A2329
CTI : RALTA_A1600(prpC) RALTA_A2135(prpC2)
CBW : RR42_m2272 RR42_m2939
CCUP : BKK81_10135 BKK81_14965
CUP : BKK80_10575 BKK80_15915
CUU : BKK79_02555 BKK79_17035
COX : E0W60_19235 E0W60_22510
CUK : KB879_21825(prpC) KB879_25090(prpC)
CNAN : A2G96_12245 A2G96_16415
BPM : BURPS1710b_A1737(prpC)
BPL : BURPS1106A_A0289(prpC)
BPD : BURPS668_A0383(prpC)
BPZ : BP1026B_II0230(prpC)
BUG : BC1001_4883 BC1001_5155
BGF : BC1003_4324 BC1003_4610
BYI : BYI23_B009450 BYI23_B011910
BUE : BRPE67_BCDS13530 BRPE67_BCDS15690
BUQ : AC233_24300 AC233_25670
BUM : AXG89_19950 AXG89_21695
BUI : AX768_22865 AX768_24230
BGE : BC1002_3338 BC1002_5193
BPY : Bphyt_6081 Bphyt_6860
BUZ : AYM40_22065 AYM40_23135 AYM40_32930
BCAI : K788_0000946 K788_0005067
PSPW : BJG93_18890(prpC) BJG93_21090(prpC)
PARA : BTO02_20645 BTO02_30060
PARB : CJU94_29160 CJU94_32080
PHS : C2L64_31975 C2L64_36165
PTER : C2L65_28710 C2L65_31375
PGP : CUJ91_19275 CUJ91_30550
PCJ : CUJ87_27440 CUJ87_30010
PTS : CUJ90_24275 CUJ90_26660
PCAF : DSC91_002249 DSC91_002886
PMEG : FNZ07_06020(prpC) FNZ07_10640(prpC)
PGIS : I6I06_17195(prpC) I6I06_18885(prpC)
PEW : KZJ38_31115(prpC) KZJ38_36270(prpC)
PDIO : PDMSB3_0149.1(prpC) PDMSB3_0792.1(prpC)
PBRY : NDK50_33600(prpC) NDK50_35555(prpC)
PSAA : QEN71_17550(prpC) QEN71_31060(prpC)
PKF : RW095_12235(prpC) RW095_15670(prpC)
PLG : NCTC10937_02039(prpC)
CABA : SBC2_37200(prpC_1) SBC2_55660(prpC_3)
BUO : BRPE64_BCDS03630 BRPE64_BCDS13010
CABK : NK8_30390(prpC) NK8_79460(prpC)
TVL : FAZ95_15295(prpC) FAZ95_32530(prpC) FAZ95_37780(prpC)
TCAR : U0034_20305(prpC) U0034_26840(prpC)
BTRM : SAMEA390648702639(prpC)
AXX : ERS451415_01524(prpC)
PUD : G9Q38_01245(prpC) G9Q38_13015(prpC)
AKA : TKWG_16615 TKWG_19980
AMIM : MIM_c13200(prpC1) MIM_c31350(prpC2)
MUM : FCL38_05860(prpC) FCL38_28415(prpC)
URU : DSM104443_01834(prpC_2)
UPL : DSM104440_01701(prpC_2)
BSEP : HAP48_0038500(prpC)
HSH : NHP194022_12920(gltA_2)
CAMZ : CVIC12175_1097(prpC)
CGL : Cgl0659(Cgl0659) Cgl0696(Cgl0696)
CGB : cg0762(prpC2) cg0798(prpC1)
CGU : WA5_0630(PrpC2) WA5_0666(PrpC1)
CGS : C624_04090 C624_04300
CGG : C629_04090 C629_04300
CGM : cgp_0762(prpC2) cgp_0798(prpC1)
CGQ : CGLAR1_03745 CGLAR1_03930
CGX : SB89_03495 SB89_03675
CMIN : NCTC10288_02000(prpC)
CCYS : SAMEA4530656_1889(prpC2)
CAUI : CAURIS_02600(prpC2)
CAUS : CAURIC_09070(prpC2)
BFV : C628_03740 C628_03925
ARQ : BWQ92_00090 BWQ92_02395
AAGI : NCTC2676_1_01042(gltA)
AAU : AAur_1660(gltA) AAur_pTC20150(gltA)
KVR : CIB50_0001569(gltA_2)
SMIZ : 4412673_02506(prpC)
SDJ : NCTC13534_01529(prpC)
STHA : NCTC11429_04835(prpC)
CHRJ : CHRYMOREF3P_4845(prpC)
» show all
Taxonomy
Reference
1
Authors
Uchiyama, H. and Tabuchi, T.
Title
Properties of methylcitrate synthase from Candida lipolytica.
Journal
Agric Biol Chem 40:1411-1418 (1976)
Reference
Authors
Textor S, Wendisch VF, De Graaf AA, Muller U, Linder MI, Linder D, Buckel W.
Title
Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria.
Journal
Sequence
Reference
Authors
Horswill AR, Escalante-Semerena JC
Title
Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle.
Journal
Sequence
Reference
Authors
Brock M, Maerker C, Schutz A, Volker U, Buckel W
Title
Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase.
Journal
Sequence
Reference
Authors
Domin N, Wilson D, Brock M
Title
Methylcitrate cycle activation during adaptation of Fusarium solani and Fusarium verticillioides to propionyl-CoA-generating carbon sources.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.5
ExPASy - ENZYME nomenclature database: 2.3.3.5
BRENDA, the Enzyme Database: 2.3.3.5