KEGG ENZYME: 2.4.1.115

ENZYME: 2.4.1.115

Entry

EC 2.4.1.115                Enzyme

Name

anthocyanidin 3-O-glucosyltransferase;
uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase;
UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase;
UDP-glucose:cyanidin-3-O-glucosyltransferase;
UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase;
3-GT

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase

Reaction(IUBMB)

UDP-D-glucose + an anthocyanidin = UDP + an anthocyanidin-3-O-beta-D-glucoside [RN:R03797]

Reaction(KEGG)

R03797 > R06534 R06535 R06536

Substrate

UDP-D-glucose [CPD:C00029];
anthocyanidin [CPD:C02003]

Product

UDP [CPD:C00015];
anthocyanidin-3-O-beta-D-glucoside

Comment

The anthocyanidin compounds cyanidin, delphinidin, peonidin and to a lesser extent pelargonidin can act as substrates. The enzyme does not catalyse glucosylation of the 5-position of cyanidin and does not act on flavanols such as quercetin and kaempferol (cf. EC 2.4.1.91 flavonol 3-O-glucosyltransferase). In conjunction with EC 1.14.20.4, anthocyanidin oxygenase, it is involved in the conversion of leucoanthocyanidin into anthocyanidin 3-glucoside. It may act on the pseudobase precursor of the anthocyanidin rather than on the anthocyanidin itself [3].

History

EC 2.4.1.115 created 1984 (EC 2.4.1.233 created 2004, incorporated 2005), modified 2005

Pathway

ec00942

Anthocyanin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12930

anthocyanidin 3-O-glucosyltransferase

Genes

PMEO:

129587527

CIT:

102609299

CIC:	CICLE_v10019770mg

PVY:

116144649

MINC:

123220308

TCC:	18599492 18599494

GRA:

105787922

GHI:	107924731 107950567

GAB:

108466937

HSYR:

120213540

DZI:

111296738

EGR:	104450361 104450379

GMX:

100795736

GSJ:

114417828

PVU:	PHAVU_002G214300g PHAVU_002G214500g

VRA:

106766336

VAR:

108320291

VUN:	114176045 114179836

VUM:

124846600

CCAJ:

109804763

CAM:	101489215(UGT78K4)

ADU:

107480473

AIP:

107631056

AHF:	112733385 112791318

QSA:	O6P43_030143

FVE:

101300000

RCN:

112185370

PPER:

18785045 18791494

PMUM:

103323505 103333513

PAVI:

110749579 110752521

PDUL:

117617836

MDM:	103420802 103440008

MSYL:

126625777 126628724

PXB:

103951514

ZJU:

107414867

MNT:

21402630

RCU:

8283075

HBR:

110667678

MESC:

110621779

POP:	18104516 7497385

PEU:	105135163 105140379

PALZ:

118028146 118043647

QSU:

111985672

QLO:

115960228

TWL:

119995922

VVI:	100233099(UFGT) 100244489(VVGT6) 100247914 100249544 100249635 100254753 100258170

VRI:	117916640 117916949 117924467 117924658 117925321 117925327 117925990 117933447

SLY:

101260093

SPEN:

107002755 107025544

SOT:

102577753

SSTN:

125865949

SDUL:

129877426

CANN:

107843659 107843660 107872096 107876989

LBB:

132607181

NTA:	107781346(Nt3GT2) 107822886(Nt3GT1) 107823155 107824715

NSY:	104222537 104245263

NTO:	104093878 104111088

NAU:	109205262 109215787

INI:	109182028(UF3GT) 109191717

ITR:	116005478 116006041

SIND:

105155667 105162857

OEU:	111374585 111404029

EGT:

105952305

SSPL:

121788781 121788785 121794192 121797198

SMIL:

131003928 131004965

SHIS:

125203761 125204438 125205011 125211328

APAN:

127243980

HAN:	110873488 110873490 110873554 110873558 110881267 110940191

LSV:	111884088 111894781

CCAV:

112507289

DCR:	108213096 108221067 108225279

CSIN:

114285774 114288492 114310104 114310133

RVL:

131333982

AEW:	130770567 130781191

BVG:

104888025

SOE:

110803459

CQI:	110692996 110692997 110693001 110693002 110713003 110725973

ATRI:

130818663

MOF:

131159673

NNU:	104603221 104605389 104611375 104613452 104613453

MING:

122060248 122066715 122086308

TSS:	122645208 122645344 122645345 122645348 122646259 122646260

PSOM:

113272402 113272403 113272404 113279548 113279549 113282609 113299339 113358582

OSA:	4340373 4342400

DOSA:

Os06t0192100-00(Os06g0192100) Os07t0148200-01(Os07g0148200)

OBR:	102711363 121054737

OGL:	127775982 127778834

BDI:

100841090

ATS:	109740107 109747995 109747997

TDC:	119299528 119303381 119304303 119316086 119328150 119335763 119361551

TAES:

123068626 123068756 123075718 123084311 123150203 123157851 123162466 123166533 123179872

TUA:	125521043 125542754 125542763

LPER:

127311709 127317887 127336551

LRD:

124706516

SBI:	8065445 8081542

ZMA:	100217238 732800

SITA:

101752764 101786047

SVS:	117851582 117865125

PVIR:

120670357 120702884 120702885 120709204

PHAI:

112889920

PDA:	103715944 103718397

EGU:	105039250 105039612

MUS:	103969068 103969873 103975050 103976895 108953348

ZOF:	122042637 122044112 122047145

DCT:

110095211

PEQ:

110031211

AOF:	109821966 109841711

MSIN:

131256332

NCOL:

116249851

» show all

Reference

1 [PMID:751640]

Authors

Kamsteeg J, van Brederode J, van Nigtevecht G.

Title

Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica).

Journal

Biochem Genet 16:1045-58 (1978)
DOI:10.1007/bf00484525

Reference

2 [PMID:9535914]

Authors

Ford CM, Boss PK, Hoj PB

Title

Cloning and characterization of Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, a homologue of the enzyme encoded by the maize Bronze-1 locus that may primarily serve to glucosylate anthocyanidins in vivo.

Journal

J Biol Chem 273:9224-33 (1998)
DOI:10.1074/jbc.273.15.9224

Sequence

[vvi:100233099]

Reference

3 [PMID:11316805]

Authors

Nakajima J, Tanaka Y, Yamazaki M, Saito K.

Title

Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis.

Journal

J Biol Chem 276:25797-803 (2001)
DOI:10.1074/jbc.M100744200