KEGG   ENZYME: 2.4.1.222
Entry
EC 2.4.1.222                Enzyme                                 
Name
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;
O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase;
fringe;
UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:[protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + [protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) = UDP + [protein with EGF-like domain]-3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl]-(L-serine/L-threonine) [RN:R09296]
Reaction(KEGG)
R09296(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
[protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine)
Product
UDP [CPD:C00015];
[protein with EGF-like domain]-3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl]-(L-serine/L-threonine)
Comment
The enzyme, found in animals and plants, is involved in the biosynthesis of the tetrasaccharides alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc and alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc, which are attached to L-Ser or L-Thr residues within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys in EGF-like domains in Notch and Factor-X proteins, respectively. The substrate is provided by EC 2.4.1.221, peptide-O-fucosyltransferase.
History
EC 2.4.1.222 created 2002, modified 2022
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K05948  fringe
Genes
HSA: 3955(LFNG) 4242(MFNG) 5986(RFNG)
PTR: 458811(MFNG) 472272(LFNG) 747153(RFNG)
PPS: 100977920(LFNG) 100980961(RFNG) 100995551(MFNG)
GGO: 101145692(LFNG) 101150690(RFNG)
PON: 100433262(MFNG) 100453406(RFNG) 100457821(LFNG)
NLE: 100590152(LFNG) 100599575(MFNG) 100603704(RFNG)
HMH: 116458583(MFNG) 116462859(LFNG) 116483004(RFNG)
MCC: 100428736(LFNG) 699530(MFNG) 719330(RFNG)
MCF: 101865860(RFNG) 102122259(LFNG) 102132366(MFNG)
MTHB: 126939112 126951486 126963749
MNI: 105464487(MFNG) 105469329(RFNG) 105483398(LFNG)
CSAB: 103223279(MFNG) 103243752(RFNG) 103246864(LFNG)
CATY: 105571746(LFNG) 105575827(MFNG) 105588569(RFNG)
PANU: 101011968(LFNG) 101013421(RFNG) 101018492(MFNG)
TGE: 112610374(RFNG) 112621031(LFNG) 112633581(MFNG)
MLEU: 105537347(LFNG) 105539034(MFNG) 105552392(RFNG)
RRO: 104654981(RFNG) 104664990 104682508(MFNG)
RBB: 108512800(MFNG) 108534090(RFNG) 108543803(LFNG)
TFN: 117066370(RFNG) 117070066(MFNG) 117072008(LFNG)
PTEH: 111523718(LFNG) 111527644(RFNG) 111549040(MFNG)
CANG: 105500659(RFNG) 105522438(LFNG) 105527803(MFNG)
CJC: 100394244(RFNG) 100397083(MFNG) 100397710(LFNG)
SBQ: 101028632(MFNG) 101031267(RFNG) 101052656(LFNG)
CIMI: 108289452(MFNG) 108293013(LFNG) 108301635(RFNG)
CSYR: 103251328(RFNG) 103269780(MFNG) 103273020
MMUR: 105868435(LFNG) 105878072(RFNG) 105883754(MFNG)
LCAT: 123632569(LFNG) 123639288(MFNG) 123650730(RFNG)
PCOQ: 105805200(MFNG) 105806080(LFNG) 105820019(RFNG)
OGA: 100947634(RFNG) 100956337(MFNG) 100965012(LFNG)
MMU: 16848(Lfng) 17305(Mfng) 19719(Rfng)
MCAL: 110294717(Lfng) 110304960(Rfng) 110310660(Mfng)
MPAH: 110312801(Lfng) 110331255(Rfng) 110334897(Mfng)
RNO: 170905(Lfng) 315119(Mfng) 60433(Rfng)
MCOC: 116068671(Lfng) 116075628(Mfng) 116077482(Rfng)
ANU: 117698372(Lfng) 117711743(Rfng) 117718792(Mfng)
MUN: 110548858(Rfng) 110554724(Lfng) 110558853(Mfng)
CGE: 100762397(Lfng) 100762875(Mfng) 100771257(Rfng)
MAUA: 101825685(Lfng) 101831994(Mfng) 101835058(Rfng)
PROB: 127220540(Rfng) 127225760(Mfng) 127237151(Lfng)
PLEU: 114694235(Mfng) 114703908(Rfng) 114705506(Lfng)
MORG: 121444099 121444594 121446582 121461287(Mfng) 121464623
MFOT: 126500390 126514322 126515816
AAMP: 119811847(Rfng) 119823893(Mfng) 119825059(Lfng)
NGI: 103730070(Rfng) 103748612(Mfng) 103748675(Lfng)
HGL: 101699763(Lfng) 101722987(Mfng) 101725480(Rfng)
CPOC: 100715492(Rfng) 100722901 100727311 100730084 100731745(Mfng)
CCAN: 109683509(Lfng) 109697229(Mfng) 109702741(Rfng)
DORD: 105990865(Lfng) 105991967(Mfng)
DSP: 122098337(Rfng) 122113852(Lfng) 122119310(Mfng)
PLOP: 125339212(Lfng) 125358592(Mfng) 125365470(Rfng)
NCAR: 124970295 124978941 124983959
MMMA: 107139661(Mfng) 107157674(Rfng) 107161091(Lfng)
OCU: 100355921 100357457
OPI: 101528974(RFNG) 101531267(MFNG) 101532339(LFNG)
TUP: 102491172(LFNG) 102493487(RFNG) 102497808(MFNG)
GVR: 103585714(LFNG) 103588151(MFNG) 103593319(RFNG)
CFA: 483376(RFNG) 489891(LFNG) 610303(MFNG)
CLUD: 112640204(LFNG) 112668421(MFNG) 112672966(RFNG)
VVP: 112920916(RFNG) 112929107(MFNG) 112929356(LFNG)
VLG: 121472707(RFNG) 121488152(LFNG) 121491363(MFNG)
NPO: 129503081(RFNG) 129512035(MFNG) 129520131(LFNG)
AML: 100468722(RFNG) 100470247(MFNG) 100479208(LFNG)
UMR: 103666011(RFNG) 103670070(LFNG) 103676401(MFNG)
UAH: 113241808(MFNG) 113244483(RFNG) 113247705(LFNG)
UAR: 123777908(RFNG) 123780761(MFNG) 123802560(LFNG)
ELK: 111146201 111157518 111160292
LLV: 125087730 125090538 125106480
MPUF: 101677000(LFNG) 101678112(MFNG) 101687676(RFNG)
MNP: 132003411(RFNG) 132019249(MFNG) 132026436(LFNG)
MLK: 131815853(RFNG) 131819211(LFNG) 131839443(MFNG)
NVS: 122891374(MFNG) 122895654(LFNG) 122905869(RFNG)
ORO: 101370080(LFNG) 101373562(RFNG) 101384739(MFNG)
EJU: 114199923(LFNG) 114216196(RFNG) 114218332(MFNG)
ZCA: 113922684(MFNG) 113933221(LFNG) 113939623(RFNG)
MLX: 117998712(MFNG) 117999295(LFNG) 118024152(RFNG)
NSU: 110571887(LFNG) 110572417(RFNG) 110578117(MFNG)
LWW: 102732306(MFNG) 102738454(LFNG) 102747107(RFNG)
FCA: 101080753(RFNG) 101092320(LFNG) 101097256(MFNG)
PYU: 121018138(RFNG) 121040390(MFNG)
PCOO: 112863852(MFNG) 112864629(RFNG)
PBG: 122471220(LFNG) 122472714(MFNG) 122485976(RFNG)
PVIV: 125151658(RFNG) 125154755(LFNG) 125169770(MFNG)
LRUF: 124502536 124519176 124522500
PTG: 102956076(RFNG) 102961069(MFNG) 102962200(LFNG)
PPAD: 109251132(LFNG) 109265536(MFNG) 109276754(RFNG)
PUC: 125919575 125926226 125928431
AJU: 106984500 106986348 113602730
HHV: 120227953(LFNG) 120228186(RFNG) 120241170(MFNG)
BTA: 505267(MFNG) 516209(LFNG) 532242(RFNG)
BOM: 102276513(MFNG) 102286691(RFNG) 102288229(LFNG)
BIU: 109559537(MFNG) 109573332(RFNG)
BBUB: 102394903(RFNG) 102410037(LFNG) 102415597(MFNG)
BBIS: 105000596(RFNG) 105003417(MFNG)
CHX: 102169449(LFNG) 102178013(RFNG) 102178708(MFNG)
OAS: 101103554(MFNG) 101106785(RFNG) 101112372(LFNG)
BTAX: 128047748(MFNG) 128064569(RFNG) 128070865(LFNG)
ODA: 120858553 120861176 120866874(RFNG) 120883260(LFNG)
CCAD: 122423402(MFNG) 122433209(LFNG)
MBEZ: 129536464(MFNG) 129544588(RFNG) 129545786(LFNG)
SSC: 100524978(LFNG) 102161832(MFNG) 110255925(RFNG)
CFR: 102506111(LFNG) 102509192(RFNG) 102518312(MFNG)
CBAI: 105073150(MFNG) 105078190(LFNG)
CDK: 105091974(MFNG) 105102217(RFNG) 105105769(LFNG)
VPC: 102527071(LFNG) 102542233(MFNG) 102546125(RFNG)
BACU: 103005287(MFNG) 103009108(LFNG) 103019781(RFNG)
BMUS: 118882085(LFNG) 118886459(RFNG) 118901493(MFNG)
LVE: 103075553(MFNG) 103076301(RFNG) 103089921(LFNG)
OOR: 101270479(MFNG) 101278665(RFNG) 101282067(LFNG)
DLE: 111169357(LFNG) 111182674(RFNG) 111186217(MFNG)
PCAD: 102977711(RFNG) 102989837(MFNG) 102990636(LFNG)
PSIU: 116740198(LFNG) 116746374(RFNG) 116760549(MFNG)
NASI: 112410532(RFNG) 112410776(MFNG) 112412047(LFNG)
ECB: 100057395(RFNG) 100069766(MFNG) 100147464(LFNG)
EPZ: 103551123(RFNG) 103566953(LFNG) 103567118(MFNG)
EAI: 106834776(LFNG) 106837591(MFNG) 106846141(RFNG)
MYB: 102238965(MFNG)
MYD: 102764930(LFNG) 102767457(MFNG)
MMYO: 118651215(MFNG) 118658757(LFNG) 118671602(RFNG)
MLF: 102420819(MFNG) 102421262(RFNG)
PKL: 118704530(RFNG) 118711340(LFNG) 118729310(MFNG)
EFUS: 103288889(MFNG) 103298337(RFNG) 103299200(LFNG)
MNA: 107537047(LFNG) 107539057(RFNG) 107545234(MFNG)
DRO: 112298814(RFNG) 112319527(LFNG) 112321833(MFNG)
SHON: 118995038(LFNG) 119002171(MFNG) 119002771(RFNG)
AJM: 119043787(LFNG) 119058575(RFNG) 119060375(MFNG)
PDIC: 114503244(RFNG) 114509647(LFNG) 114513460(MFNG)
PHAS: 123809608(LFNG) 123816238(MFNG) 123817111(RFNG)
MMF: 118616306(LFNG) 118624274(MFNG) 118634311(RFNG)
PPAM: 129063387(LFNG) 129071247(MFNG) 129086615(RFNG)
HAI: 109380238(LFNG) 109393064(RFNG) 109394533(MFNG)
RFQ: 117014026(RFNG) 117016784(LFNG) 117029352(MFNG)
PALE: 102879652(RFNG) 102885010(MFNG) 102892443(LFNG)
PGIG: 120600325(RFNG) 120614843(MFNG) 120615783(LFNG)
PVP: 105294596(LFNG) 105301167(RFNG) 105311554(MFNG)
RAY: 107519247(MFNG) 107520206(RFNG) 107521424(LFNG)
MJV: 108392670(MFNG) 108395246(RFNG) 108398746(LFNG)
TOD: 119231057(RFNG) 119241419(LFNG) 119248239(MFNG)
SARA: 101541708(MFNG) 101545521(LFNG) 101554530(RFNG)
LAV: 100655946(LFNG) 100669607(MFNG)
TMU: 101356202
ETF: 101656253(MFNG) 101659758(RFNG) 101663521(LFNG)
DNM: 101437450(MFNG)
MDO: 100012518(LFNG) 100025532(MFNG) 100029839(RFNG)
GAS: 123231173(LFNG) 123245018(RFNG) 123248955(MFNG)
SHR: 100914846(MFNG) 100930580(LFNG)
AFZ: 127538201 127560603 127563813
PCW: 110200103(LFNG) 110205752(MFNG) 110218311(RFNG)
OAA: 100078922(LFNG) 100088145(RFNG) 100093244(MFNG)
GGA: 395789(RFNG) 395790(LFNG) 418042(MFNG)
PCOC: 116232573(RFNG) 116233313(MFNG) 116237377(LFNG)
MGP: 100539077(MFNG) 100544514(RFNG) 100549739(LFNG)
CJO: 107313900(MFNG) 107320761(LFNG) 107322080(RFNG)
TPAI: 128073644(MFNG) 128078840(LFNG) 128083201(RFNG)
LMUT: 125700498(LFNG) 125702011(RFNG) 125703448(MFNG)
NMEL: 110393122(MFNG) 110405902(LFNG)
APLA: 101790022(MFNG) 101797427(LFNG) 101800803(RFNG)
ACYG: 106033576(LFNG) 106035911(MFNG) 106046760(RFNG)
CATA: 118249275(LFNG) 118250685(MFNG) 118259236(RFNG)
AFUL: 116495399(LFNG) 116496547(RFNG) 116501050(MFNG)
TGU: 100218383(LFNG) 100232033(MFNG) 100232663(RFNG)
LSR: 110472408(RFNG) 110475488(LFNG) 110483830(MFNG)
SCAN: 103813595(MFNG) 103817861(LFNG) 103819909(RFNG)
PMOA: 120505628(RFNG) 120510115(MFNG) 120513080(LFNG)
OTC: 121334479(LFNG) 121338240(RFNG) 121342381(MFNG)
PRUF: 121350779(LFNG) 121352781(RFNG) 121361163(MFNG)
GFR: 102032502(MFNG) 102045456(LFNG) 102045657(RFNG)
FAB: 101808008(MFNG) 101818865(LFNG) 101819642(RFNG)
OMA: 130248458(MFNG) 130259279(LFNG) 130260474(RFNG)
PHI: 102103333(RFNG) 102104211(LFNG) 102107617(MFNG)
PMAJ: 107205151(MFNG) 107211349(LFNG) 107212318(RFNG)
CCAE: 111931257 111936281(LFNG) 111937595(RFNG)
CCW: 104685032(LFNG) 104696299(MFNG) 104698221(RFNG)
CBRC: 103613391(RFNG) 103615584(LFNG) 103618073(MFNG)
ETL: 114055408(MFNG) 114060198(LFNG) 114060327(RFNG)
ZAB: 102061325(LFNG) 102072860(RFNG) 102073191(MFNG)
ACHL: 103799200(LFNG) 103809214(MFNG) 103809842(RFNG)
SVG: 106849627(LFNG) 106858539(MFNG) 106859950(RFNG)
MMEA: 130575731(LFNG) 130581992(RFNG) 130586894(MFNG)
HRT: 120751995(MFNG) 120759597(LFNG) 120760850(RFNG)
FPG: 101914835(RFNG) 101916406(MFNG) 101916735(LFNG)
FCH: 102047108(LFNG) 102054672(RFNG) 102059881(MFNG)
CLV: 102084027(LFNG) 102092690(MFNG) 102094918(RFNG)
EGZ: 104131255(RFNG) 104132617(LFNG) 104134305(MFNG)
NNI: 104014390(RFNG) 104015089(LFNG) 104021594(MFNG)
PCRI: 104024855(LFNG) 104034087(RFNG) 104038599(MFNG)
PLET: 104615066(RFNG) 104622433(MFNG) 104626940(LFNG)
EHS: 104516807(MFNG)
PCAO: 104040088(RFNG) 104042638 104050867(MFNG)
ACUN: 113485767(LFNG) 113486842(RFNG) 113491499(MFNG)
TALA: 104355857(RFNG) 104361276(LFNG) 104363928(MFNG)
PADL: 103913573(LFNG) 103917468(RFNG) 103924151(MFNG)
AFOR: 103899066(RFNG) 103904993(LFNG) 103907847(MFNG)
ACHC: 115335909(LFNG) 115340956(RFNG) 115352646(MFNG)
HALD: 104311826(RFNG) 104317748
HLE: 104832144(RFNG) 104833560(LFNG) 104842815(MFNG)
AGEN: 126034071 126043783 126048097
GCL: 127022533 127024075 127029652
CCRI: 104159202(LFNG) 104163981(MFNG) 104165081(RFNG)
CSTI: 104549475(LFNG) 104550454(RFNG) 104560035(MFNG)
CMAC: 104473466(MFNG) 104474295(RFNG) 104478516
MUI: 104545376(LFNG) 104545859(RFNG) 104548783(MFNG)
BREG: 104630444(RFNG) 104637706(LFNG) 104642326(MFNG)
FGA: 104070916(RFNG) 104074135(MFNG) 104081624(LFNG)
GSTE: 104251598(RFNG) 104254882(MFNG) 104258205
LDI: 104343194(RFNG) 104350611(LFNG) 104351065(MFNG)
MNB: 103777044(RFNG) 103778708(MFNG)
OHA: 104327767(RFNG) 104331237(LFNG) 104332371(MFNG)
NNT: 104400482(RFNG) 104402227(LFNG) 104409284(MFNG)
SHAB: 115605671(MFNG) 115607142(LFNG) 115616603(RFNG)
DPUB: 104297148(LFNG) 104297993(RFNG) 104302038(MFNG)
PGUU: 104457445(MFNG) 104459214(RFNG) 104461925(LFNG)
ACAR: 104517408(MFNG) 104521722(RFNG) 104527619(LFNG)
CPEA: 104385272(LFNG) 104396057(MFNG) 104398572(RFNG)
AVIT: 104268049 104276059(MFNG) 104280226(LFNG)
CVF: 104283128(RFNG) 104283642(MFNG) 104287706(LFNG)
RTD: 128904191(MFNG) 128914178(LFNG) 128917829(RFNG)
CUCA: 104057614(RFNG) 104059220(LFNG) 104065868(MFNG)
TEO: 104370477(RFNG) 104371524
BRHI: 104488369(RFNG) 104494085(LFNG) 104495836(MFNG)
AAM: 106487094(RFNG) 106488480(MFNG) 106496125
AROW: 112969355(MFNG) 112974227(LFNG) 112974799(RFNG)
NPD: 112945271(RFNG) 112947759(MFNG) 112959927(LFNG)
TGT: 104565619(LFNG) 104570229(RFNG) 104576737(MFNG)
DNE: 112990701(MFNG) 112990972(RFNG) 112992921(LFNG)
SCAM: 104137849(MFNG) 104140219(RFNG)
ASN: 102381094(LFNG) 102386399(RFNG) 102388348(MFNG)
AMJ: 102566885(LFNG) 102567014(MFNG) 102571352(RFNG)
CPOO: 109314720(LFNG) 109316646(MFNG) 109324495(RFNG)
GGN: 109286886(RFNG) 109294538(LFNG) 109296045(MFNG)
PSS: 102443867(LFNG) 102455692 102458358(MFNG)
CMY: 102931854(LFNG) 102932974(RFNG) 122461360(MFNG)
CCAY: 125621196(RFNG) 125628299(MFNG) 125644288(LFNG)
DCC: 119842957(RFNG) 119847050(MFNG) 119862776(LFNG)
CPIC: 101934811(MFNG) 101940585(RFNG) 101950276(LFNG)
TST: 117880716(MFNG) 117886896(RFNG)
CABI: 116815821(RFNG) 116824111(MFNG) 116832951(LFNG)
MRV: 120371489(MFNG) 120373583(LFNG) 120383181(RFNG)
ACS: 100561637(mfng) 100565009(lfng) 100567901(rfng)
ASAO: 132768691(RFNG) 132775916(MFNG) 132782161(LFNG)
PVT: 110075969(MFNG) 110090776(RFNG) 110091685(LFNG)
SUND: 121914534(LFNG) 121922810(RFNG) 121932279(MFNG)
PBI: 103060821 103063742(RFNG)
PMUR: 107288860(RFNG) 107290633(LFNG)
CTIG: 120308369(RFNG) 120315874(LFNG)
TSR: 106551147(RFNG)
PGUT: 117663058(RFNG) 117677573(LFNG)
APRI: 131185219(LFNG) 131190086(RFNG)
PTEX: 113437080(RFNG) 113438811(LFNG)
NSS: 113412013(RFNG) 113423708(LFNG)
VKO: 123018127(RFNG) 123025021(LFNG) 123028880(MFNG)
PMUA: 114584152(LFNG) 114589787(RFNG) 114605544(MFNG)
PRAF: 128401407(LFNG) 128407395(RFNG) 128422708(MFNG)
ZVI: 118079763(RFNG) 118091383(MFNG) 118092778(LFNG)
HCG: 128327444(MFNG) 128336738(LFNG) 128344466(RFNG)
GJA: 107105918(MFNG) 107118125(RFNG) 107122012(LFNG)
STOW: 125430294(RFNG) 125430632(LFNG) 125434181(MFNG)
EMC: 129328938(RFNG) 129335987(MFNG) 129338837(LFNG)
XLA: 100036937(lfng.L) 394282(rfng.L) 397855(lfng.S)
XTR: 100486895(rfng) 549805(lfng)
NPR: 108786198(LFNG) 108791320(RFNG)
RTEM: 120918908(RFNG) 120943397(LFNG)
BBUF: 121004641(RFNG) 121007811(LFNG)
BGAR: 122944905(LFNG)
MUO: 115471556(RFNG) 115474676(MFNG) 115476246(LFNG)
GSH: 117345841(LFNG) 117353689(MFNG) 117368492(RFNG)
DRE: 30158(lfng) 414848(rfng) 493633(mfng)
SRX: 107708990 107715074 107753450(lfng) 107757470 107758333
SANH: 107653613 107665528 107674646 107693671(rfng) 107703400
SGH: 107561915 107562029 107581707(lfng) 107600994
CCAR: 109046565 109047918 109063455 109083482 109099366(rfng)
CAUA: 113040249 113050147 113050483 113056435(rfng) 113064821 113092142
CGIB: 127943399 127952174 127953246 127988084 128025091
PTET: 122327250 122327883(mfng) 122333358(rfng) 122341706(lfng)
LROH: 127153757(mfng) 127163071(lfng) 127174236(rfng)
OMC: 131530089(mfng) 131538022(lfng) 131551304(rfng)
PPRM: 120468972 120469034 120486334(mfng) 120489737(lfng)
RKG: 130080628(rfng) 130089323(mfng) 130095028(lfng)
MAMB: 125250987(mfng) 125255023(rfng) 125269763(lfng)
CIDE: 127508372 127521405 127523901
MASI: 127422798 127427398 127437931 127439033 127450195 127452348
TROS: 130549105(mfng) 130561990(lfng) 130569427(rfng)
TDW: 130426761(lfng) 130430725(mfng) 130439360(rfng)
MANU: 129420852(rfng) 129432408(lfng) 129453865(mfng)
IPU: 108257411 108259517(mfng) 108273644
IFU: 128600127(lfng) 128603059(mfng) 128617227(rfng)
PHYP: 113527078(rfng) 113536168(lfng)
SMEO: 124376366(lfng) 124379746(mfng) 124389136(rfng)
TFD: 113647081(mfng) 113653605(rfng) 113660403(lfng)
TVC: 132838924(mfng) 132841540(rfng) 132864128(lfng)
AMEX: 103025168(lfng) 103035856(mfng) 103037421(rfng)
CMAO: 118803822(mfng) 118805732(lfng) 118809798(rfng)
EEE: 113571376(lfng) 113574297 113589668
CHAR: 105890720(lfng) 105891205(rfng) 105900239
TRU: 101066309 101067911(lfng) 101073166 101073848
TFS: 130514991(lfng) 130526900 130527076(mfng) 130538931(rfng)
TNG: GSTEN00005496G001 GSTEN00006372G001 GSTEN00015727G001 GSTEN00034798G001
LCO: 104918731(lfng) 104921160 104925295 104929533(rfng)
NCC: 104940897 104964482(lfng)
TBEN: 117474096(rfng) 117482090(mfng) 117482395 117493663(lfng)
CGOB: 115006363 115012806(lfng) 115025014(rfng)
PGEO: 117449709 117451449(mfng) 117451485(lfng) 117464938(rfng)
GACU: 117534031(mfng) 117537671(rfng) 117548769(lfng) 117555343
EMAC: 134864128 134864169(mfng) 134871173(rfng) 134878650(lfng)
ELY: 117247195(rfng) 117254949 117255462(mfng) 117268911(lfng)
EFO: 125879880(lfng) 125881008(rfng) 125885945(mfng) 125886200
PLEP: 121941589 121942114 121956644(lfng) 121958539(rfng)
SLUC: 116042554(mfng) 116043029 116059588(lfng) 116067493(rfng)
ECRA: 117937138(rfng) 117937768 117958377(lfng) 117960572(mfng)
ESP: 116671531 116697601 116703169(lfng) 116704611
PFLV: 114548122(rfng) 114551702 114569526 114569561 114570318
GAT: 120815096(mfng) 120819026(rfng) 120825560 120828401(lfng)
PPUG: 119213257(rfng) 119217993 119218007(mfng) 119220927(lfng)
AFB: 129093196(rfng) 129095550(mfng) 129095864 129098334(lfng)
CLUM: 117735637(lfng) 117736090 117748604(rfng)
PSWI: 130189254(lfng) 130190598 130190749(mfng) 130203282(rfng)
MSAM: 119881907 119892040(lfng) 119898584(mfng) 119898693 119915967(rfng)
SCHU: 122867492(rfng) 122868369(lfng) 122873444(mfng) 122873651
CUD: 121503818(lfng) 121508129(mfng) 121508164 121528288(rfng)
ALAT: 119009645(rfng) 119014792(lfng) 119017298 119026242(mfng)
MZE: 101466218(rfng) 101467699 101469344 101485425
ONL: 100696743(rfng) 100697735 100707701 100708834
OAU: 116312496(lfng) 116317355(mfng) 116320071(rfng) 116323527
OLA: 101155324 101156689(rfng) 101169038(lfng) 101174979
OML: 112137176 112141692(mfng) 112146906(lfng) 112162334(rfng)
CSAI: 133419848 133421930(lfng) 133442136 133442954(mfng)
XMA: 102219280(rfng) 102225648 102230356(lfng)
XCO: 114145337 114150882(rfng) 114160037(lfng)
XHE: 116720163 116726860(rfng) 116735665(lfng)
PRET: 103468664(lfng) 103480636 103482187(rfng)
PFOR: 103136457 103142244(lfng) 103142448(rfng)
PLAI: 106936426 106957747 106960501(lfng)
PMEI: 106909996 106923349 106925146
GAF: 122821475(lfng) 122823239(rfng) 122830348(mfng)
PPRL: 129352231(rfng) 129352564(lfng) 129376825(mfng)
CVG: 107084259 107084747(lfng) 107087619(rfng) 107099338
CTUL: 119778848(lfng) 119783681 119786990(mfng) 119796121(rfng)
GMU: 124863519 124863705 124868493 124869218(mfng) 124875060(rfng)
NFU: 107372602 107378430(lfng) 107389966 107391332
KMR: 108237295(mfng) 108245159(rfng) 108245271 108246120(lfng)
ALIM: 106522721(lfng) 106527238 106532938 106537334
NWH: 119421400(lfng) 119422929(mfng) 119422971 119423737(rfng)
AOCE: 111565184(rfng) 111566263 111569841 111581680
MCEP: 124998144(lfnG) 125003989(mfnG) 125004537 125022843(rfnG)
CSEM: 103381663(rfng) 103383433 103383472 103392616
POV: 109627033 109639604(lfng) 109640166 109646450
SSEN: 122759731(rfng) 122760876 122771443 122771619(mfng) 122784823(lfng)
HHIP: 117752504(rfng) 117766531(lfng) 117770457
HSP: 118099116(mfng) 118100757(rfng) 118123731(lfng) 118124381
SMAU: 118287609(rfng) 118289228(lfng) 118312020(mfng) 118312946
LCF: 108876800 108880842(mfng) 108894766 108900781
SDU: 111216706 111217747(lfng) 111235903 111237097(rfng)
SLAL: 111657941 111660595(lfng) 111664402(rfng) 111672994
XGL: 120788454(lfng) 120794139(rfng) 120799844(mfng) 120799895
HCQ: 109511290 109511291 109513832(lfng) 109529290
SSCV: 125968477 125969011 125983877 125991072
SBIA: 133495263(rfng) 133506510 133506668(mfng) 133514420(lfng)
PEE: 133404014 133404386(mfng) 133415241(lfng) 133418121(rfng)
PTAO: 133466289(lfng) 133469611(rfng) 133476636 133476805(mfng)
BPEC: 110154327(rfng) 110165650 110167656(lfng)
MALB: 109964190(lfng) 109966694(rfng) 109970347 109973279
BSPL: 114845974(rfng) 114859896 114860343(lfng) 114861345(mfng)
SJO: 128365057 128365321 128379635(lfng) 128381022(rfng)
SASA: 106589611(rfng) 106593718 106594217 106601125 106607332 106610281
STRU: 115147657 115147658 115152889 115171151 115191205 115191206 115198390 115201410(rfng)
OTW: 112224491(rfng) 112226024(lfng) 112240162(mfng) 112245978 112259205
OMY: 110486296 110487259 110499227(rfng) 110503025 110513416 110538231(lfng) 118936550 118940346
OGO: 124000378 124015978 124018423 124018428 124018624 124018638 124022298 124040219(rfng)
ONE: 115104164 115110309 115115732 115123394 115127654 115144263(rfng)
OKI: 109870037(rfng) 109877455 109880963 109888170 109891936 109900061 116360195 116372050
OKE: 118365292 118370993 118382903(mfng) 118384510 118402903(rfng) 127920114 127922906
SALP: 111980694 111981123 112070915 112080424(rfng)
SNH: 120023829 120028006(mfng) 120029725 120034371 120039995 120044539 120046806
CCLU: 121547559 121550607 121553934 121553961(mfng) 121569548 121577674
ELS: 105005737 105013213(lfng) 109614596 109614605(rfng)
SFM: 108922521 108926351 108927511 108939756(rfng)
PKI: 111832910 111845285(mfng) 111845492 111853276
AANG: 118217299(lfng) 118220755(rfng) 118221534 118221624(mfng)
LOC: 102684219(rfng) 102690142 102693167
PSPA: 121295762 121296349 121300883(lfng) 121306163 121331145
ARUT: 117417826 117423338 117424071 117431085
PSEX: 120517484(rfng) 120536984 120542082(lfng)
LCM: 102347945(LFNG) 102350505(MFNG) 102362901(RFNG)
CMK: 103175474(rfng) 103186827(lfng) 103189782
RTP: 109917090(lfng)
CPLA: 122542250 122560476(lfng) 122562136
HOC: 132825545(lfng) 132828037(rfng) 132831161
LERI: 129706717(lfng) 129708426(rfng) 129713935
PMRN: 116937575 116955103 116956645
LRJ: 133339065 133348015 133358695
BFO: 118428905
BBEL: 109484277
CIN: 113474334 778622 778624 778625 778626
SCLV: 120342216 120344217
SPU: 578181
LPIC: 129263772 129269081 129276506
APLC: 110981883 110989661
AJC: 117111154
SKO: 100653401(fng)
DME: Dmel_CG10580(fng)
DER: 6546161
DSE: 6616375
DSI: Dsimw501_GD28062(Dsim_GD28062)
DYA: Dyak_GE22371 Dyak_GE28150
DAN: 6493073
DSR: 110189997
DPO: 4813082
DPE: 6604426
DMN: 108153338
DGR: 6558607
DMO: Dmoj_GI16838
DAZ: 108614550
DNV: 108650377
DHE: 111592962
DVI: 6624162
CCAT: 101448383
BOD: 106621397
BDR: 105221842
RZE: 108375725 108376345 108377593 108378635
AOQ: 129241282
TDA: 119667636 119672261
MDE: 101890371
SCAC: 106093845
LCQ: 111676980
LSQ: 119607960
GFS: 119645008
ECOE: 129944346
CLON: 129606778
HIS: 119649228
AGA: 1277047
ACOZ: 120949945
AARA: 120893923
AMER: 121593002
ASTE: 118509600
AFUN: 125771984
AMOU: 128301193
AAG: 5574115
AALB: 109623129
CQU: CpipJ_CPIJ010821 CpipJ_CPIJ010824
CPII: 120423174
CNS: 116339100 116341591
BCOO: 119080341 119080342
AME: 551501
ACER: 107995872
ALAB: 122718255
ADR: 102673211
AFLR: 100870819
BIM: 100741335
BBIF: 117212676
BVK: 117231280
BVAN: 117156684
BTER: 100648290
BAFF: 126918052
BPYO: 122572420
BPAS: 132907199
CCAL: 108624015
OBB: 114878915
OLG: 117602041
MGEN: 117229939
NMEA: 116428209
CGIG: 122397305
SOC: 105201656
MPHA: 105832301
AEC: 105145067
ACEP: 105624750
PBAR: 105422509
VEM: 105562750
HST: 105185424
DQU: 106741484
CFO: 105251037
FEX: 115232699
LHU: 105675165
PGC: 109851939
OBO: 105276314
PCF: 106790982
PFUC: 122523658
VPS: 122630114
VCRB: 124425748
VVE: 124949176
NVI: 100678242
CSOL: 105361405
TPRE: 106653420 111693900
LHT: 122504358
LBD: 127288455
MDL: 103571993 106693367
CGLO: 123269289
FAS: 105267675
DAM: 107044117
AGIF: 122855200
CINS: 118064376
VCAN: 122407331
CCIN: 107272544
DSM: 124407895
NPT: 124216974
NFB: 124181658
NLO: 107222775
NVG: 124304102
TCA: 100141773
DPA: 109540120
SOY: 115876239
AGRG: 126746517
ATD: 109598146
CSET: 123314170
AGB: 108907799
LDC: 111504163
NVL: 108560087 108566740
APLN: 108745264
PPYR: 116176682 116176726 116177203 116177362 116181885
OTU: 111421150
BMOR: 100144549(Fng)
BMAN: 114243226
MSEX: 115445284
DPL: KGM_202101
BANY: 112056524
MJU: 123880995
NIQ: 126770049
VCD: 124533750
MCIX: 123653662
PMAC: 106718445
PPOT: 106105228
PXU: 106128246
PRAP: 110995650
PBX: 123708887
PNAP: 125049669
ZCE: 119835035
CCRC: 123691321
LSIN: 126964812
HAW: 110371554
HZE: 124631448
TNL: 113504560
SLIU: 111352092
OFU: 114350631
PXY: 105390350 105390361
PGW: 126367483
CFEL: 113376605 113378720
CCRN: 123296156
API: 100160830
DNX: 107164992
AGS: 114126629
RMD: 113553865
ACOO: 126845017
DVT: 126897063
BTAB: 109037881
DCI: 103505607
CLEC: 106661495
HHAL: 106685149
NLU: 111048523
HVI: 124367354
MQU: 128991345
PHU: Phum_PHUM014770
FOC: 113202473
TPAL: 117651573
ZNE: 110830882
CSEC: 111865356
SGRE: 126270700
BROR: 134532540
IEL: 124165063
FCD: 110847136
DPX: DAPPUDRAFT_93561
DMK: 116919626
DPZ: 124342010
PVM: 113813153
PJA: 122254503
PCHN: 125047451
PMOO: 119596405
HAME: 121864231
PCLA: 123745420 123748521 123752143
CQD: 128685453
PTRU: 123499121
ESN: 127008863
HAZT: 108669222
EAF: 111699063 111703992 111706808
LSM: 121119428 121121774
TCF: 131879374 131882153 131889136
PPOI: 119090919 119090983 119095094 119109545 119112358 119113221 119114546
DSV: 119453617
RSAN: 119399349
RMP: 119179851
VDE: 111244994 111247283
VJA: 111258969 111264582
TUT: 107360014
DPTE: 113793628
DFR: 124493845
CSCU: 111617733 111619390
PTEP: 107441830
ABRU: 129984599
UDV: 129225679
SDM: 118183468
LPOL: 106460922 106460923 106469670
PMEO: 129580839 129590124 129599678
LGI: LOTGIDRAFT_93476
PVUL: 126809664
PCAN: 112561686
BGT: 106053876
GAE: 121378484
HRF: 124132242
HRJ: 124286678
CRG: 105321777
CVN: 111118946
MYI: 110453003
PMAX: 117327462
MCAF: 127708623
MMER: 123564022
RPHI: 132748108
DPOL: 127868751
OBI: 106871323
OSN: 115215667
LAK: 106168328
NVE: 116603670
EPA: 110237675
ADF: 107346687
AMIL: 114964698
PDAM: 113678576
SPIS: 111340325
AQU: 100632073 100632325 100637378 100637506 100637631 105314240 105314592
TVA: TVAG_2v0379720
 » show all
Reference
1  [PMID:10935626]
  Authors
Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF.
  Title
Fringe is a glycosyltransferase that modifies Notch.
  Journal
Nature 406:369-75 (2000)
DOI:10.1038/35019000
  Sequence
[dme:Dmel_CG10580] [hsa:4242]
Reference
2  [PMID:10935637]
  Authors
Bruckner K, Perez L, Clausen H, Cohen S.
  Title
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.
  Journal
Nature 406:411-5 (2000)
DOI:10.1038/35019075
Reference
3  [PMID:16221665]
  Authors
Rampal R, Li AS, Moloney DJ, Georgiou SA, Luther KB, Nita-Lazar A, Haltiwanger RS.
  Title
Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.
  Journal
J Biol Chem 280:42454-63 (2005)
DOI:10.1074/jbc.M509552200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.222
IUBMB Enzyme Nomenclature: 2.4.1.222
ExPASy - ENZYME nomenclature database: 2.4.1.222
BRENDA, the Enzyme Database: 2.4.1.222
CAS: 299203-70-6

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG GLYCAN (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (3351)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1526)   
   KEGG MGENES (329)   
   RefGene (1495)   
Protein sequence (1979)   
   UniProt (1929)   
   SWISS-PROT (19)   
   RefSeq(pep) (28)   
   PDBSTR (2)   
   PMD (1)   
DNA sequence (55)   
   RefSeq(nuc) (31)   
   GenBank (18)   
   EMBL (6)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   InterPro (3)   
All databases (5397)   

Download RDF
DBGET integrated database retrieval system