KEGG   ENZYME: 2.4.1.284
Entry
EC 2.4.1.284                Enzyme                                 
Name
2-deoxystreptamine glucosyltransferase;
kanF (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:2-deoxystreptamine 6-alpha-D-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + 2-deoxystreptamine = UDP + 2'-deamino-2'-hydroxyparomamine [RN:R10096]
Reaction(KEGG)
R10096
Substrate
UDP-alpha-D-glucose [CPD:C00029];
2-deoxystreptamine [CPD:C02627]
Product
UDP [CPD:C00015];
2'-deamino-2'-hydroxyparomamine [CPD:C20353]
Comment
Involved in the biosynthesis of kanamycin B and kanamycin C. Also catalyses EC 2.4.1.283, 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase, but activity is only one fifth of that with UDP-alpha-D-glucose.
History
EC 2.4.1.284 created 2012
Pathway
ec00524  Neomycin, kanamycin and gentamicin biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13550  2-deoxystreptamine N-acetyl-D-glucosaminyltransferase / 2-deoxystreptamine glucosyltransferase
Genes
PALRHGI30_01160
SRNA4G23_05127(neoD)
SBROGQF42_00970
SFBCP974_27360
MSAGGCM10017556_22620
DVCDvina_05405
Reference
1  [PMID:21983602]
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.284
IUBMB Enzyme Nomenclature: 2.4.1.284
ExPASy - ENZYME nomenclature database: 2.4.1.284
BRENDA, the Enzyme Database: 2.4.1.284

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